[go: up one dir, main page]

AR114965A2 - Sal de clorhidrato cristalina de 4-[2-(2,4,6-trifluorofenoximetil)fenil]piperidina - Google Patents

Sal de clorhidrato cristalina de 4-[2-(2,4,6-trifluorofenoximetil)fenil]piperidina

Info

Publication number
AR114965A2
AR114965A2 ARP190101607A ARP190101607A AR114965A2 AR 114965 A2 AR114965 A2 AR 114965A2 AR P190101607 A ARP190101607 A AR P190101607A AR P190101607 A ARP190101607 A AR P190101607A AR 114965 A2 AR114965 A2 AR 114965A2
Authority
AR
Argentina
Prior art keywords
phenyl
hydrochloride salt
trifluorophenoximethyl
piperidine hydrochloride
piperidine
Prior art date
Application number
ARP190101607A
Other languages
English (en)
Inventor
Lori Jean Patterson
Robert S Chao
Miroslav Rapta
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41666409&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR114965(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of AR114965A2 publication Critical patent/AR114965A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

Reivindicación 1: Una sal de clorhidrato cristalina de 4-[2-(2,4,6-trifluorofenoximetil)fenil]-piperidina caracterizada porque presenta un patrón de difracción de rayos X en polvo que comprende picos de difracción en valores 2q de 4,44 ± 0,20, 10,22 ± 0,20, 16,06 ± 0,20 y 21,78 ± 0,20.
ARP190101607A 2008-11-14 2019-06-11 Sal de clorhidrato cristalina de 4-[2-(2,4,6-trifluorofenoximetil)fenil]piperidina AR114965A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11454108P 2008-11-14 2008-11-14

Publications (1)

Publication Number Publication Date
AR114965A2 true AR114965A2 (es) 2020-11-11

Family

ID=41666409

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP090104419A AR074128A1 (es) 2008-11-14 2009-11-13 Derivados de 4-[2-(2-fluorofenoximetil)fenil] piperidina, composiciones farmaceuticas que los contienen, metodo de preparacion, compuestos intermediarios de dicho proceso y uso de los mismos para el tratamiento de dolores neuropaticos, mal de alzheimer y otras enfermedades relacionadas con el snc.
ARP090104418A AR074350A1 (es) 2008-11-14 2009-11-13 Forma cristalina de un compuesto de 4-(2-(2- fluorofenoximetil) fenil ) pipiridina
ARP190101607A AR114965A2 (es) 2008-11-14 2019-06-11 Sal de clorhidrato cristalina de 4-[2-(2,4,6-trifluorofenoximetil)fenil]piperidina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP090104419A AR074128A1 (es) 2008-11-14 2009-11-13 Derivados de 4-[2-(2-fluorofenoximetil)fenil] piperidina, composiciones farmaceuticas que los contienen, metodo de preparacion, compuestos intermediarios de dicho proceso y uso de los mismos para el tratamiento de dolores neuropaticos, mal de alzheimer y otras enfermedades relacionadas con el snc.
ARP090104418A AR074350A1 (es) 2008-11-14 2009-11-13 Forma cristalina de un compuesto de 4-(2-(2- fluorofenoximetil) fenil ) pipiridina

Country Status (28)

Country Link
US (23) US8247433B2 (es)
EP (3) EP2358675B9 (es)
JP (6) JP5598798B2 (es)
KR (3) KR101685186B1 (es)
CN (3) CN102216271B (es)
AR (3) AR074128A1 (es)
AU (3) AU2009313948B2 (es)
BR (3) BRPI0921593B8 (es)
CA (3) CA2739992C (es)
CL (2) CL2011001088A1 (es)
CO (2) CO6361988A2 (es)
CY (3) CY1113622T1 (es)
DK (3) DK2358676T3 (es)
ES (3) ES2397247T3 (es)
HR (3) HRP20120920T1 (es)
IL (2) IL212230A (es)
MX (3) MX2011005088A (es)
MY (2) MY151211A (es)
NZ (2) NZ592543A (es)
PL (3) PL2358675T3 (es)
PT (3) PT2358674E (es)
RU (2) RU2503662C2 (es)
SG (1) SG171311A1 (es)
SI (3) SI2358676T1 (es)
SM (3) SMT201200063B (es)
TW (3) TWI461407B (es)
WO (3) WO2010056941A1 (es)
ZA (1) ZA201103495B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2358675B9 (en) * 2008-11-14 2019-09-11 Theravance, Inc. 4-[2-(2-Fluorophenoxymethyl)phenyl]piperidine compounds
EP2523945A1 (en) 2010-01-11 2012-11-21 Theravance, Inc. 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
WO2011119461A1 (en) * 2010-03-22 2011-09-29 Theravance, Inc. 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
US20110263631A1 (en) * 2010-04-22 2011-10-27 Martin William J Combination of a serotonin and norepinephrine reuptake inhibitor and an opioid agonist for the treatment of pain
WO2012127506A1 (en) 2011-03-22 2012-09-27 Advinus Therapeutics Limited Substituted fused tricyclic compounds, compositions and medicinal applications thereof
US9544692B2 (en) * 2012-11-19 2017-01-10 Bitwave Pte Ltd. System and apparatus for boomless-microphone construction for wireless helmet communicator with siren signal detection and classification capability
FI3506900T3 (fi) * 2016-08-30 2024-11-29 Theravance Biopharma R&D Ip Llc Ampreloksetiini käytettäväksi neurogeenisen ortostaattisen hypotension
US10640467B2 (en) 2018-06-01 2020-05-05 Theravance Biopharma R&D Ip, Llc Process for preparing 2-(1-(tert-butoxycarbonyl)piperidine-4-yl)benzoic acid
US20230372318A1 (en) 2022-03-28 2023-11-23 Theravance Biopharma R&D Ip, Llc Methods for treating a subject having multiple system atrophy
CN114957098B (zh) * 2022-06-02 2024-03-29 和鼎（南京）医药技术有限公司 一种制备喷他佐辛中间体的方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
DE2549999A1 (de) 1975-11-07 1977-05-12 Boehringer Mannheim Gmbh Piperidin-derivate und verfahren zu ihrer herstellung
US4241071A (en) 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
IL56369A (en) 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
US4198417A (en) * 1979-01-10 1980-04-15 American Hoechst Corporation Phenoxyphenylpiperidines
EP0190496A3 (en) 1984-12-13 1987-05-27 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
DE3835291A1 (de) 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine
GB9324018D0 (en) * 1993-11-23 1994-01-12 Merck Sharp & Dohme Therapeutic agents
BR9912013A (pt) * 1998-07-10 2001-04-10 Astrazeneca Ab Composto, composição farmacêutica, método de tratar uma condição de doença, e, processo para preparar um composto
GB9922521D0 (en) 1998-10-07 1999-11-24 Zeneca Ltd Compounds
US6518284B2 (en) 1998-11-18 2003-02-11 Faes, Fabrica Espanola De Productos Quimicos Y Farmaceuticos S.A. 4-substituted piperidines
ES2157148B1 (es) * 1998-11-18 2002-03-01 Faes Fabrica Espanola De Produ Nuevas piperidinas 4-sustituidas.
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
WO2001047883A1 (fr) * 1999-12-27 2001-07-05 Japan Tobacco Inc. Composes a cycles accoles et leur utilisation comme medicaments
US6630504B2 (en) 2000-08-31 2003-10-07 Pfizer Inc. Phenoxyphenylheterocyclyl derivatives as SSRIs
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
ATE413882T1 (de) 2002-08-23 2008-11-15 Lilly Co Eli 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin- wiederaufnahme-inhibitoren
CL2004000726A1 (es) * 2003-04-04 2005-05-20 Lundbeck & Co As H Compuestos derivados de 4-[2-(feniloxi sustituido)fenil]piperidina o -1,2,3,6-tetrahidropiridina; composcion farmaceutica que los contiene; y su uso para el tratamiento de trastornos afectivos, tales como la depresion, trastornos de ansiedad, de ansi
NZ540891A (en) 2003-04-04 2008-07-31 Lundbeck & Co As H 4-(2-Phenyloxyphenyl)-piperidine or -1,2,3,6-tetrahydropyridine derivatives as serotonin reuptake inhibitors
HRP20050993A2 (en) * 2003-06-17 2006-03-31 Pfizer Inc. N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
TW200513461A (en) 2003-10-01 2005-04-16 Speedel Experimenta Ag Organische verbindungen
WO2005068447A1 (en) 2004-01-13 2005-07-28 Pfizer Limited Piperazine derivatives which exhibit activity as serotonin and noradrenaline re-upatke inhibitors
US20070072859A1 (en) * 2004-03-05 2007-03-29 Eli Lilly And Company Pharmaceutical compounds
BRPI0510453A (pt) 2004-04-30 2007-10-30 Warner Lambert Co composto substituìdos com morfolina para o tratamento de distúrbios do sistema nervoso central
GB0505437D0 (en) * 2005-03-17 2005-04-20 Merck Sharp & Dohme Therapeutic agents
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives
US20070249607A1 (en) * 2006-04-17 2007-10-25 Bristol-Myers Squibb Company Nk-1 and serotonin transporter inhibitors
EP2066630A1 (en) 2006-08-23 2009-06-10 Pfizer Products Incorporated Piperidine derivatives
WO2008039418A2 (en) * 2006-09-27 2008-04-03 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor modulators
US8026257B2 (en) * 2007-07-11 2011-09-27 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
WO2009081259A1 (en) 2007-12-21 2009-07-02 Pfizer Inc. Phenoxy-pyridyl derivatives
RU2010151352A (ru) 2008-06-20 2012-07-27 Метаболекс, Инк. (Us) Арильные агонисты grp119 и их применения
WO2010011811A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. 3-(phenoxyphenylmethyl)pyrrolidine compounds
EP2358675B9 (en) 2008-11-14 2019-09-11 Theravance, Inc. 4-[2-(2-Fluorophenoxymethyl)phenyl]piperidine compounds
EP2523945A1 (en) 2010-01-11 2012-11-21 Theravance, Inc. 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
WO2011119461A1 (en) * 2010-03-22 2011-09-29 Theravance, Inc. 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
FI3506900T3 (fi) * 2016-08-30 2024-11-29 Theravance Biopharma R&D Ip Llc Ampreloksetiini käytettäväksi neurogeenisen ortostaattisen hypotension

Also Published As

Publication number Publication date
BRPI0921593B1 (pt) 2021-05-04
IL212452A0 (en) 2011-06-30
US11596624B2 (en) 2023-03-07
US20240316024A1 (en) 2024-09-26
TWI461407B (zh) 2014-11-21
NZ592413A (en) 2013-02-22
US8802857B2 (en) 2014-08-12
US20180055830A1 (en) 2018-03-01
ES2401224T3 (es) 2013-04-17
JP5598798B2 (ja) 2014-10-01
RU2515612C2 (ru) 2014-05-20
CN102216271A (zh) 2011-10-12
CY1113623T1 (el) 2016-06-22
US20230201181A1 (en) 2023-06-29
MX2011005090A (es) 2011-09-06
HRP20120897T1 (hr) 2012-12-31
MY151229A (en) 2014-04-30
US20120277438A1 (en) 2012-11-01
CA2742105C (en) 2016-09-13
JP5529150B2 (ja) 2014-06-25
CO6361993A2 (es) 2012-01-20
CY1113855T1 (el) 2016-07-27
CN102216271B (zh) 2013-09-25
US20190142816A1 (en) 2019-05-16
EP2358676B1 (en) 2012-10-10
MX2011005088A (es) 2011-06-01
US20100125092A1 (en) 2010-05-20
US20200316048A1 (en) 2020-10-08
US8304433B2 (en) 2012-11-06
CA2739992C (en) 2016-09-20
US20140323735A1 (en) 2014-10-30
EP2358674A1 (en) 2011-08-24
US20130030020A1 (en) 2013-01-31
CN102216272B (zh) 2014-02-05
CO6361988A2 (es) 2012-01-20
RU2011123875A (ru) 2012-12-20
US12239638B2 (en) 2025-03-04
PL2358675T3 (pl) 2013-03-29
US20180289687A1 (en) 2018-10-11
AU2009313948A1 (en) 2010-05-20
US11723900B2 (en) 2023-08-15
DK2358674T3 (da) 2013-04-08
US9162982B2 (en) 2015-10-20
DK2358675T3 (da) 2013-01-14
AR074350A1 (es) 2011-01-12
DK2358676T3 (da) 2013-01-14
AU2009313951B2 (en) 2015-03-12
CN102209712B (zh) 2016-04-06
US20200316047A1 (en) 2020-10-08
JP5506813B2 (ja) 2014-05-28
HK1160449A1 (en) 2012-08-17
US10946006B2 (en) 2021-03-16
ES2397247T3 (es) 2013-03-05
KR20110082085A (ko) 2011-07-15
KR101656339B1 (ko) 2016-09-09
BRPI0921595B8 (pt) 2021-05-25
IL212230A (en) 2014-12-31
SMT201200063B (it) 2013-01-14
US20100125141A1 (en) 2010-05-20
CA2742114A1 (en) 2010-05-20
AU2009313949B2 (en) 2015-03-19
CN102209712A (zh) 2011-10-05
CN102216272A (zh) 2011-10-12
HK1160452A1 (en) 2012-08-17
IL212230A0 (en) 2011-06-30
JP2012508759A (ja) 2012-04-12
US9187423B2 (en) 2015-11-17
KR101656338B1 (ko) 2016-09-09
HK1160448A1 (en) 2012-08-17
JP2012508760A (ja) 2012-04-12
US10576073B2 (en) 2020-03-03
EP2358674B1 (en) 2013-01-02
PT2358674E (pt) 2013-03-05
EP2358675B1 (en) 2012-10-03
TWI441810B (zh) 2014-06-21
US8592596B2 (en) 2013-11-26
CA2742105A1 (en) 2010-05-20
PL2358674T3 (pl) 2013-06-28
US20130030185A1 (en) 2013-01-31
US10946007B2 (en) 2021-03-16
PT2358676E (pt) 2012-12-06
US10722504B2 (en) 2020-07-28
KR20110082196A (ko) 2011-07-18
US10034870B2 (en) 2018-07-31
CL2011001088A1 (es) 2011-10-14
TW201024264A (en) 2010-07-01
US10226454B2 (en) 2019-03-12
US20160022660A1 (en) 2016-01-28
AU2009313948B2 (en) 2015-03-12
AR074128A1 (es) 2010-12-22
US20160184288A1 (en) 2016-06-30
US8247433B2 (en) 2012-08-21
BRPI0921596B1 (pt) 2021-10-26
ES2396583T3 (es) 2013-02-22
BRPI0921593A2 (pt) 2015-08-18
AU2009313949A1 (en) 2010-05-20
RU2503662C2 (ru) 2014-01-10
BRPI0921595B1 (pt) 2020-10-13
SMT201200065B (it) 2013-03-08
CA2742114C (en) 2016-09-13
HRP20120920T1 (hr) 2013-01-31
WO2010056939A1 (en) 2010-05-20
US9675599B2 (en) 2017-06-13
PL2358676T3 (pl) 2013-03-29
MY151211A (en) 2014-04-30
US20210290608A1 (en) 2021-09-23
JP2012508761A (ja) 2012-04-12
CL2011001093A1 (es) 2011-09-02
KR20110082197A (ko) 2011-07-18
CY1113622T1 (el) 2016-06-22
EP2358675A1 (en) 2011-08-24
US8604058B2 (en) 2013-12-10
US20190134019A1 (en) 2019-05-09
WO2010056938A1 (en) 2010-05-20
EP2358676A1 (en) 2011-08-24
US20140045892A1 (en) 2014-02-13
JP2014139209A (ja) 2014-07-31
ZA201103495B (en) 2012-01-25
TWI443087B (zh) 2014-07-01
JP2014101384A (ja) 2014-06-05
US10206913B2 (en) 2019-02-19
CA2739992A1 (en) 2010-05-20
WO2010056941A1 (en) 2010-05-20
KR101685186B1 (ko) 2016-12-09
BRPI0921593B8 (pt) 2021-05-25
NZ592543A (en) 2013-02-22
US20220087995A1 (en) 2022-03-24
MX2011005089A (es) 2011-07-29
SMT201300033B (it) 2013-05-06
HRP20130300T1 (hr) 2013-04-30
TW201022206A (en) 2010-06-16
AU2009313951A1 (en) 2010-05-20
PT2358675E (pt) 2012-12-12
EP2358675B9 (en) 2019-09-11
US20140057944A1 (en) 2014-02-27
SI2358675T1 (sl) 2013-01-31
BRPI0921596A2 (pt) 2018-03-20
RU2011123890A (ru) 2012-12-20
US20200000792A1 (en) 2020-01-02
US20100125093A1 (en) 2010-05-20
SI2358674T1 (sl) 2013-04-30
US9073859B2 (en) 2015-07-07
US10441579B2 (en) 2019-10-15
SI2358676T1 (sl) 2013-01-31
JP2014098033A (ja) 2014-05-29
SG171311A1 (en) 2011-07-28
US8304432B2 (en) 2012-11-06
US20180050024A1 (en) 2018-02-22
TW201024263A (en) 2010-07-01

Similar Documents

Publication Publication Date Title
AR114965A2 (es) Sal de clorhidrato cristalina de 4-[2-(2,4,6-trifluorofenoximetil)fenil]piperidina
NO2017036I1 (no) Daklatasvir og farmasøytisk akseptable salter derav, spesielt daklatasvir dihydroklorid
EP2085383A4 (en) Piperidin derivatives or salts thereof
ZA200801351B (en) Sulphonypyrrole hydrochloride salts as histone deacetylases inhibitors
BRPI0610418A2 (pt) utensílio tendo um corportamento de armazenamento
IL192241A0 (en) Improved process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof
IL184035A0 (en) Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
ITFI20080097A1 (it) "una testina tosaerba a filo utilizzabile alternativamente su macchine a rotazione destra o sinistra"
BRPI0818464A2 (pt) sais maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)-anilino-3]-ciano-7-etóxi-6-quinolinil}-4-(dimetilamino)-2-butenamida e suas formas cristalinas
IL261853A (en) 6-[(4-fluorophenyl)methyl]-4-(3-nitrophenyl)-1,3-benzothiazole-2-amine and its salts
IL192298A (en) Heterocyclic Compounds, Their Acceptable Salts, Pharmaceuticals Containing and Using Them
BRPI0910177A2 (pt) Composições biocidas e método para inibir crescimento bacteriano em um meio
MX2010003989A (es) Composicion zibotentan que contiene mannitol y/o celulosa microcristalina.
IL188064A0 (en) 2-(1h-indolylsulfanyl)-aryl amine derivatives
IL200959A0 (en) Liquid formulations of salts of 4-[2-(4-methylphenylfanyl)phenyl]piperidine
ITUD20060050A1 (it) Procedimento di alimentazione di barre ad una macchina di lavorazione e relativo dispositivo
FR2938428B1 (fr) Lit a barriere laterale composee de plusieurs barres s'etendant horizontalement
ITMI20061412A1 (it) Azionatore per una pettinatrice
MY150698A (en) Crystalline forms of 4- [2- (-methylphenylsulfanyl) -phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
PT1833810T (pt) Modificações cristalinas de n-alfa-(2,4,6-triisopropil-fenilsulfonil)-3-hidroxiamidino-(l)-fenilalanina-4--etoxicarbonilpiperazida e/ou seus sais
TH136553A (th) รูปผลึกของสารประกอบ a4-[2-(2-ฟลูออโรฟีนอกซีเมทิล)ฟีนิล] ไพเพอริดีน
FR2887128B1 (fr) Pince a epiler perfectionnee
UA14364S (uk) Упаковка для чаю «аскольд» середньолистовий цейлонський чай»
UA11856S (uk) Пакування для суперзірочок «start»
FR2930404B1 (fr) Outil pour l'etetage et l'extraction des visceres d'un poisson

Legal Events

Date Code Title Description
FB Suspension of granting procedure