[go: up one dir, main page]

AR114803A1 - Compuestos de 4-aminoisoindolin-1,3-diona sustituida, composiciones de estos y métodos de tratamiento con dichos compuestos - Google Patents

Compuestos de 4-aminoisoindolin-1,3-diona sustituida, composiciones de estos y métodos de tratamiento con dichos compuestos

Info

Publication number
AR114803A1
AR114803A1 ARP190101050A ARP190101050A AR114803A1 AR 114803 A1 AR114803 A1 AR 114803A1 AR P190101050 A ARP190101050 A AR P190101050A AR P190101050 A ARP190101050 A AR P190101050A AR 114803 A1 AR114803 A1 AR 114803A1
Authority
AR
Argentina
Prior art keywords
compounds
aminoisoindolin
substitute
compositions
treatment
Prior art date
Application number
ARP190101050A
Other languages
English (en)
Inventor
Veronique Plantevin-Krenitsky
Mark A Nagy
Antonia Lopez-Girona
Timothy S Kercher
Dehua Huang
Roy L Harris
Joshua Hansen
Virginia Heather Sharron Grant
Matthew D Correa
Soraya Carrancio
Matthew D Alexander
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66641467&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR114803(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of AR114803A1 publication Critical patent/AR114803A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto de la fórmula (1), o una sal, un tautómero, un isotopólogo o un estereoisómero de este aceptables desde el punto de vista farmacéutico, en donde: el anillo A es un heterociclilo no aromático opcionalmente sustituido; cada R es C₁₋₃ alquilo independientemente sustituido o no sustituido, o halógeno; y n es 0, 1, 2, 3 ó 4.
ARP190101050A 2018-04-23 2019-04-22 Compuestos de 4-aminoisoindolin-1,3-diona sustituida, composiciones de estos y métodos de tratamiento con dichos compuestos AR114803A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862661525P 2018-04-23 2018-04-23

Publications (1)

Publication Number Publication Date
AR114803A1 true AR114803A1 (es) 2020-10-14

Family

ID=66641467

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101050A AR114803A1 (es) 2018-04-23 2019-04-22 Compuestos de 4-aminoisoindolin-1,3-diona sustituida, composiciones de estos y métodos de tratamiento con dichos compuestos

Country Status (30)

Country Link
US (3) US11358952B2 (es)
EP (2) EP3784663B1 (es)
JP (2) JP7458324B2 (es)
KR (1) KR102783925B1 (es)
CN (3) CN113214220B (es)
AR (1) AR114803A1 (es)
AU (2) AU2019261273B2 (es)
BR (1) BR112020021552B1 (es)
CA (1) CA3096404A1 (es)
CL (1) CL2020002696A1 (es)
CO (1) CO2020012824A2 (es)
DK (1) DK3784663T3 (es)
EA (1) EA202092248A1 (es)
ES (1) ES2959622T3 (es)
FI (1) FI3784663T3 (es)
HR (1) HRP20231199T1 (es)
HU (1) HUE064340T2 (es)
IL (1) IL277435B2 (es)
LT (1) LT3784663T (es)
MX (2) MX2020011183A (es)
MY (1) MY206796A (es)
PE (1) PE20211375A1 (es)
PL (1) PL3784663T3 (es)
PT (1) PT3784663T (es)
RS (1) RS64663B1 (es)
SG (1) SG11202009237XA (es)
SI (1) SI3784663T1 (es)
SM (1) SMT202300330T1 (es)
TW (1) TWI814815B (es)
WO (1) WO2019209692A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR119715A1 (es) * 2019-04-12 2022-01-05 Celgene Corp Métodos para tratar linfoma no hodgkin con el uso de 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona
CN114786665A (zh) * 2019-10-21 2022-07-22 新基公司 取代的4-氨基异二氢吲哚-1,3-二酮化合物和第二种活性剂的组合用途
BR112022007580A2 (pt) * 2019-10-21 2022-07-05 Celgene Corp Formas sólidas que compreendem (s)-2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)benzil)amino)isoindolino-1,3-diona e seus sais e composições que compreendem as mesmas e seus usos
DK4048278T3 (da) * 2019-10-21 2024-01-08 Celgene Corp Fremgangsmåder til behandling af hæmatologiske maligniteter under anvendelse af 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluor-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindolin-1,3-dion
KR20220103952A (ko) * 2019-10-21 2022-07-25 셀진 코포레이션 (s)-2-(2,6-디옥소피페리딘-3-일)-4-((2-플루오로-4-((3-모르폴리노아제티딘-1-일)메틸)벤질)아미노)이소인돌린-1,3-디온을 포함하는 제약 조성물 및 그의 사용 방법
JP7581345B2 (ja) * 2019-10-21 2024-11-12 セルジーン コーポレーション ２－（２，６－ジオキソピペリジン－３－イル）－４－（（２－フルオロ－４－（（３－モルホリノアゼチジン－１－イル）メチル）ベンジル）アミノ）イソインドリン－１，３－ジオンを用いて慢性リンパ性白血病を治療する方法
MX2022004688A (es) * 2019-10-21 2022-05-10 Celgene Corp Métodos para tratar un cáncer hematológico y uso de biomarcadores compañeros para 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-mor folinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona.
WO2021147889A1 (zh) * 2020-01-20 2021-07-29 康朴生物医药技术（上海）有限公司 一种异吲哚啉衍生物、其药物组合物及应用
AU2021347238A1 (en) 2020-09-23 2023-06-01 St. Jude Children's Research Hospital, Inc. Substituted n-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein
WO2022148358A1 (zh) * 2021-01-05 2022-07-14 江苏恒瑞医药股份有限公司 稠杂环基取代的环己二酰亚胺衍生物、其制备方法及其在医药上的应用
WO2022152821A1 (en) 2021-01-13 2022-07-21 Monte Rosa Therapeutics Ag Isoindolinone compounds
KR20240004390A (ko) 2021-03-29 2024-01-11 주노 쎄러퓨티크스 인코퍼레이티드 림프종의 치료를 위한 car t 세포 요법 및 면역조정 화합물의 조합
JP2024515108A (ja) * 2021-04-21 2024-04-04 セルジーン コーポレーション ２－（２，６－ジオキソピペリジン－３－イル）－４－（（２－フルオロ－４－（（３－モルホリノアゼチジン－１－イル）メチル）ベンジル）アミノ）イソインドリン－１，３－ジオンを使用して非ホジキンリンパ腫を治療する方法
CN117279640A (zh) 2021-04-21 2023-12-22 新基公司 使用组合疗法治疗b细胞淋巴瘤的方法
CA3216995A1 (en) 2021-06-21 2022-12-29 Ronald CARRASQUILLO-FLORES Processes for the preparation of (s)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl) methyl)benzyl) amino)isoindoline-1,3-dione
WO2023025136A1 (zh) * 2021-08-27 2023-03-02 杭州格博生物医药有限公司 异吲哚啉酮化合物及其用途
US20250302954A1 (en) 2022-05-11 2025-10-02 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2023220641A2 (en) 2022-05-11 2023-11-16 Juno Therapeutics, Inc. Methods and uses related to t cell therapy and production of same
CN117088864A (zh) * 2022-05-13 2023-11-21 广州智药生物科技有限公司 一种苯并[d]异恶唑类化合物及其应用
WO2024097905A1 (en) 2022-11-02 2024-05-10 Celgene Corporation Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
US20030045552A1 (en) 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
CN1981761B (zh) 2002-05-17 2011-10-12 细胞基因公司 使用免疫调节性化合物用于制备治疗和控制癌症和其它疾病药物中的应用及组合物
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
CN100398534C (zh) 2003-09-15 2008-07-02 天津和美生物技术有限公司 合成酞胺哌啶酮及其衍生物的方法
US20050143344A1 (en) 2003-12-30 2005-06-30 Zeldis Jerome B. Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases
MX2007002521A (es) 2004-09-03 2007-05-09 Celgene Corp Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1- oxoisoindolinas sustituidas.
CA2586950A1 (en) 2004-11-12 2006-05-18 Celgene Corporation Methods and compositions using immunomodulatory compounds for treatment and management of parasitic diseases
SI2380887T1 (sl) 2005-06-30 2013-12-31 Celgene Corporation Postopki priprave spojin 4-amino-2-/2,6-dioksopiperidin-3-il)izoindolin -1,3-diona
CN101291924A (zh) 2005-08-31 2008-10-22 细胞基因公司 异吲哚-酰亚胺化合物和包含它们的组合物及其使用方法
KR20080097190A (ko) 2005-12-29 2008-11-04 안트로제네시스 코포레이션 태반 줄기세포의 수집과 보존을 위한 개선된 조성물과 이조성물의 이용 방법
US20080064876A1 (en) 2006-05-16 2008-03-13 Muller George W Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
US8877780B2 (en) 2006-08-30 2014-11-04 Celgene Corporation 5-substituted isoindoline compounds
EP2057143B1 (en) 2006-08-30 2013-07-24 Celgene Corporation 5-substituted isoindoline compounds
EP2076260B1 (en) * 2006-09-15 2011-03-23 Celgene Corporation N-methylaminomethyl isoindole compounds and compositions comprising and methods of using the same
NZ599199A (en) 2007-03-20 2013-10-25 Celgene Corp 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same
US20090232776A1 (en) 2007-11-08 2009-09-17 Moutouh-De Parseval Laure A Use of immunomodulatory compounds for the treatment of disorders associated with endothelial dysfunction
SG195613A1 (en) 2008-10-29 2013-12-30 Celgene Corp Isoindoline compounds for use in the treatment of cancer
EP4289838A3 (en) * 2010-02-11 2024-03-13 Celgene Corporation Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
US20110312996A1 (en) 2010-05-17 2011-12-22 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
MX342164B (es) 2010-06-23 2016-09-19 Hanmi Science Co Ltd Derivados de pirimidina fusionados novedosos para la inhibicion de la actividad de tirosina cinasa.
US20140206629A1 (en) 2011-02-17 2014-07-24 Rhode Island Hospital Stromal Derived Factor Inhibition And CXCR4 Blockade
US9090585B2 (en) 2011-03-28 2015-07-28 Deuterx, Llc 2,6-dioxo-3-deutero-piperdin-3-yl-isoindoline compounds
WO2016040449A1 (en) 2014-09-10 2016-03-17 Raze Therapeutics, Inc. 3-phosphoglycerate dehydrogenase inhibitors and uses thereof
ES2901509T3 (es) 2014-10-30 2022-03-22 Kangpu Biopharmaceuticals Ltd Derivado de isoindolina, compuesto intermedio, métodos de preparación, composición farmacéutica y uso del mismo
WO2016105518A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2017007612A1 (en) 2015-07-07 2017-01-12 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2017024317A2 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
PL3357513T3 (pl) * 2015-09-29 2024-04-02 Kangpu Biopharmaceuticals, Ltd. Kompozycja farmaceutyczna i jej zastosowanie
US11001566B2 (en) 2016-01-14 2021-05-11 Kangpu Biopharmaceuticals, Ltd. Quinazolinone derivative, preparation method therefor, pharmaceutical composition, and applications
SMT202300273T1 (it) 2016-03-16 2023-09-06 Kura Oncology Inc Derivati di tieno[2,3–d]pirimidina sostituiti come inibitori di menina–mll e metodi d’uso
JP7037500B2 (ja) 2016-04-06 2022-03-16 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン Ｍｄｍ２タンパク質分解剤
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
WO2017223415A1 (en) 2016-06-23 2017-12-28 Dana-Farber Cancer Institute, Inc. Degradation of tripartite motif-containing protein 24 (trim24) by conjugation of trim24 inhibitors with e3 ligase ligand and methods of use
AU2017281903B2 (en) 2016-06-23 2020-12-24 Dana-Farber Cancer Institute, Inc. Degradation of bromodomain-containing protein 9 (BRD9) by conjugation of BRD9 inhibitors with E3 ligase ligand and methods of use
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
ES2945224T3 (es) 2016-10-11 2023-06-29 Arvinas Operations Inc Compuestos y métodos para la degradación dirigida del receptor de andrógenos
SG10202104386UA (en) 2016-10-28 2021-05-28 Icahn School Med Mount Sinai Compositions and methods for treating ezh2-mediated cancer
EP3535254A4 (en) 2016-11-01 2020-06-24 Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") COMPOUNDS FOR THE DEGRADATION OF MALT1
EP3544957B1 (en) 2016-11-22 2024-05-29 Dana-Farber Cancer Institute, Inc. Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use
CN110291087B (zh) 2016-12-01 2024-07-09 阿尔维纳斯运营股份有限公司 作为雌激素受体降解剂的四氢萘和四氢异喹啉衍生物
JP2020514252A (ja) 2016-12-08 2020-05-21 アイカーン スクール オブ メディスン アット マウント シナイ Ｃｄｋ４／６媒介性がんを治療するための組成物および方法
CN107056772A (zh) 2017-01-23 2017-08-18 中国药科大学 基于cereblon配体诱导BET降解的双功能分子及其制备和应用
US10604506B2 (en) 2017-01-26 2020-03-31 Arvinas Operations, Inc. Modulators of estrogen receptor proteolysis and associated methods of use
IL312367A (en) 2017-01-31 2024-06-01 Arvinas Operations Inc Cereblon ligands and bifunctional compounds comprising the same
CA3053805C (en) 2017-02-13 2020-06-30 Kangpu Biopharmaceuticals, Ltd. Combination treating prostate cancer, pharmaceutical composition and treatment method
CN108929307A (zh) * 2017-05-22 2018-12-04 苏州偶领生物医药有限公司 一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途
AU2018301335B2 (en) * 2017-07-10 2022-09-15 Celgene Corporation Antiproliferative compounds and methods of use thereof
US20210154184A1 (en) 2017-07-12 2021-05-27 Dana-Farber Cancer Institute, Inc. Compounds for tau protein degradation
CN107698575A (zh) 2017-09-26 2018-02-16 中国药科大学 cereblon配体介导的新型BET蛋白降解的双功能分子及其制备和应用
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
CN108715585A (zh) 2018-04-23 2018-10-30 中国药科大学 苯基联三氮唑类mll1-wdr5蛋白-蛋白相互作用抑制剂
CN108690020A (zh) 2018-07-04 2018-10-23 清华大学 一种靶向降解bet蛋白的化合物及其应用
CN108794453A (zh) 2018-07-05 2018-11-13 清华大学 一种靶向降解fak蛋白的化合物及其应用

Also Published As

Publication number Publication date
JP7458324B2 (ja) 2024-03-29
CN118344338A (zh) 2024-07-16
PT3784663T (pt) 2023-10-10
BR112020021552A2 (pt) 2021-01-19
US20190322647A1 (en) 2019-10-24
CO2020012824A2 (es) 2021-01-18
TWI814815B (zh) 2023-09-11
PE20211375A1 (es) 2021-07-27
KR102783925B1 (ko) 2025-03-21
IL277435B2 (en) 2024-10-01
FI3784663T3 (fi) 2023-10-06
MY206796A (en) 2025-01-08
HUE064340T2 (hu) 2024-03-28
CA3096404A1 (en) 2019-10-31
BR112020021552B1 (pt) 2023-04-11
AU2019261273A1 (en) 2020-10-22
IL277435B1 (en) 2024-06-01
JP7745679B2 (ja) 2025-09-29
CN111989322B (zh) 2024-04-02
SI3784663T1 (sl) 2023-11-30
DK3784663T3 (da) 2023-10-16
SG11202009237XA (en) 2020-10-29
CL2020002696A1 (es) 2021-02-19
US20220306611A1 (en) 2022-09-29
TW202003492A (zh) 2020-01-16
CN111989322A (zh) 2020-11-24
CN113214220B (zh) 2024-04-02
CN113214220A (zh) 2021-08-06
EP3784663A1 (en) 2021-03-03
WO2019209692A1 (en) 2019-10-31
SMT202300330T1 (it) 2023-11-13
JP2024073590A (ja) 2024-05-29
EP4272737A2 (en) 2023-11-08
EP4272737A3 (en) 2024-01-17
MX2020011183A (es) 2020-11-12
AU2023203504B2 (en) 2024-08-15
JP2021523885A (ja) 2021-09-09
IL277435A (en) 2020-11-30
AU2019261273B2 (en) 2023-03-09
HRP20231199T1 (hr) 2024-01-19
ES2959622T3 (es) 2024-02-27
LT3784663T (lt) 2023-10-25
EP3784663B1 (en) 2023-07-12
RS64663B1 (sr) 2023-11-30
US20240217955A1 (en) 2024-07-04
KR20210003103A (ko) 2021-01-11
EA202092248A1 (ru) 2021-02-04
AU2023203504A1 (en) 2023-06-29
MX2023005160A (es) 2023-05-29
PL3784663T3 (pl) 2023-12-27
US11358952B2 (en) 2022-06-14
US11945804B2 (en) 2024-04-02

Similar Documents

Publication Publication Date Title
AR114803A1 (es) Compuestos de 4-aminoisoindolin-1,3-diona sustituida, composiciones de estos y métodos de tratamiento con dichos compuestos
ECSP21000990A (es) Derivados de 3-(5-hidroxi-1-oxoisoindolin-2-il)piperidina-2,6-diona y su uso en el tratamiento de trastornos dependientes de la proteína con dedos de zinc 2 de la familia ikaros (ikzf2)
AR116604A1 (es) Inhibidores de kras g12c
PH12021500014A1 (en) Fused ring compounds
CO2022008968A2 (es) Nuevos derivados de metilquinazolinona
AR119057A1 (es) Compuestos de 1-oxo-isoindolin-5-carboxamida sustituida, composiciones de estos y métodos de tratamiento con dichos compuestos
DOP2020000037A (es) Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
CR20190124A (es) Inhibidores de ssao de aminopirimidina
AR111304A1 (es) Métodos para sintetizar un inhibidor de mcl-1
EA202191991A1 (ru) Новые производные гетеротрициклического соединения и их применение
AR117920A1 (es) Inhibidores de la replicación del virus de la inmunodeficiencia humana
EA202191519A1 (ru) Модуляторы trex1
PE20200333A1 (es) Compuestos y metodos para tratar infecciones bacterianas
EA202192760A1 (ru) Трициклические соединения
ECSP20066271A (es) Derivados de pirazo-tetrahidroisoquinolina como moduladores positivos del receptor de dopamina d1
EA201992771A1 (ru) Ингибитор поверхностного антигена вируса гепатита b
MX2021007258A (es) Composiciones de esparsentan amorfas.
MA50093B1 (fr) Composé pentacyclique
EA202191192A1 (ru) Кристаллические соли ингибитора плазменного калликреина
AR118141A1 (es) Compuestos para el tratamiento, alivio o prevención de trastornos asociados con los agregados de tau
AR110770A1 (es) Moduladores del canal de potasio
CO2019013254A2 (es) Compuestos bicíclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias
AR116428A1 (es) Compuestos de 6-fluoro-2-metilbenzo[d]tiazol-5-ilo
MX2021009717A (es) Sulfonamidas biciclicas.
EA202190359A1 (ru) Способы лечения нейродегенеративных расстройств