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MX2022004688A - Métodos para tratar un cáncer hematológico y uso de biomarcadores compañeros para 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-mor folinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona. - Google Patents

Métodos para tratar un cáncer hematológico y uso de biomarcadores compañeros para 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-mor folinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona.

Info

Publication number
MX2022004688A
MX2022004688A MX2022004688A MX2022004688A MX2022004688A MX 2022004688 A MX2022004688 A MX 2022004688A MX 2022004688 A MX2022004688 A MX 2022004688A MX 2022004688 A MX2022004688 A MX 2022004688A MX 2022004688 A MX2022004688 A MX 2022004688A
Authority
MX
Mexico
Prior art keywords
hematological cancer
morpholinoazetidin
dioxopiperidin
isoindoline
fluor
Prior art date
Application number
MX2022004688A
Other languages
English (en)
Inventor
Antonia Lopez-Girona
Gang Lu
Shailaja Kasibhatla
Maria Soraya Carrancio Anton
Celia Fontanillo Fontanillo
Kai Wang
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2022004688A publication Critical patent/MX2022004688A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G01N33/5758—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G01N33/57505—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)

Abstract

La presente invención se refiere a un método para identificar un sujeto que tiene un cáncer hematológico quién es probable que sea sensible a un compuesto de tratamiento, que comprende administrar el compuesto de tratamiento al sujeto que tiene el cáncer hematológico; obtener una muestra a partir del sujeto; determinar el nivel de un biomarcador en la muestra a partir del sujeto; y diagnosticar al sujeto por ser probable que sea sensible al compuesto de tratamiento si el nivel del biomarcador en la muestra del sujeto cambia comparado con un nivel de referencia del biomarcador; en donde el compuesto de tratamiento es el Compuesto 1, Compuesto 2, o Compuesto 3.
MX2022004688A 2019-10-21 2020-10-20 Métodos para tratar un cáncer hematológico y uso de biomarcadores compañeros para 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-mor folinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona. MX2022004688A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962924044P 2019-10-21 2019-10-21
PCT/US2020/056431 WO2021080950A1 (en) 2019-10-21 2020-10-20 Methods for treating a hematological cancer and the use of companion biomarkers for 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione

Publications (1)

Publication Number Publication Date
MX2022004688A true MX2022004688A (es) 2022-05-10

Family

ID=75490827

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022004688A MX2022004688A (es) 2019-10-21 2020-10-20 Métodos para tratar un cáncer hematológico y uso de biomarcadores compañeros para 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-mor folinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona.

Country Status (11)

Country Link
US (1) US20210116454A1 (es)
EP (1) EP4048668A4 (es)
JP (1) JP7662625B2 (es)
KR (1) KR20220103949A (es)
CN (1) CN115175903A (es)
AU (1) AU2020372333A1 (es)
BR (1) BR112022007386A2 (es)
CA (1) CA3154890A1 (es)
IL (1) IL292305A (es)
MX (1) MX2022004688A (es)
WO (1) WO2021080950A1 (es)

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Publication number Priority date Publication date Assignee Title
EP3917517A4 (en) 2019-01-29 2023-01-25 Foghorn Therapeutics Inc. CONNECTIONS AND USES THEREOF
US12384776B2 (en) 2019-01-29 2025-08-12 Foghorn Therapeutics Inc. Compounds and uses thereof
US11628172B2 (en) * 2019-10-21 2023-04-18 Celgene Corporation Methods of treating chronic lymphocytic leukemia using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione
IL317218A (en) 2022-06-06 2025-01-01 Treeline Biosciences Inc BCL6 tricyclic quinolone bifunctional compounds
KR20250023481A (ko) 2022-06-13 2025-02-18 트리라인 바이오사이언시스, 인크. 1,8-나프티리딘-2-온 이종이작용성 bcl6 분해제
CA3258325A1 (en) 2022-06-13 2023-12-21 Treeline Biosciences, Inc. BIFUNCTIONAL QUINOLONE DEGRADING AGENTS BCL6
CN115261469B (zh) * 2022-06-23 2023-03-31 山东第一医科大学附属省立医院(山东省立医院) Brd9在慢性淋巴细胞白血病诊治中的应用
CN121041446A (zh) * 2025-11-05 2025-12-02 哈尔滨医科大学 Bahd1作为靶点在制备白血病治疗药物中的应用

Family Cites Families (13)

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EP2272513A1 (en) * 2002-05-17 2011-01-12 Celgene Corporation Pharmaceutical compositions for treating cancer
US8404716B2 (en) * 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
DK2076260T3 (da) * 2006-09-15 2011-06-27 Celgene Corp N-methylaminomethyl-isoindol-forbindelser og sammensætninger, der indeholder disse, samt fremgangsmåder til deres anvendelse
JP6016892B2 (ja) * 2011-04-29 2016-10-26 セルジーン コーポレイション セレブロンを予測因子として使用する癌及び炎症性疾患の治療方法
ES3013301T3 (en) * 2012-06-29 2025-04-11 Celgene Corp Methods for determining drug efficacy using ikzf3 (aiolos)
AU2014235453A1 (en) * 2013-03-15 2015-10-08 Genentech, Inc. Biomarkers and methods of treating PD-1 and PD-L1 related conditions
AU2014360316A1 (en) * 2013-12-06 2016-06-16 Celgene Corporation Methods of treating hematological cancers and predicting clinical sensitivity to leanlidomide using biomarkers
US10759808B2 (en) * 2016-04-06 2020-09-01 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
WO2018081830A1 (en) * 2016-10-31 2018-05-03 Oregon Health & Science University Combinations of agents to treat hematological malignancies
SI3784663T1 (sl) * 2018-04-23 2023-11-30 Celgene Corporation Spojine substituiranega 4-aminoizoindolin-1,3-diona in njihova uporaba za zdravljenje limfoma
AR119715A1 (es) * 2019-04-12 2022-01-05 Celgene Corp Métodos para tratar linfoma no hodgkin con el uso de 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona
CA3154908A1 (en) * 2019-10-21 2021-04-29 Sreenivas S. Bhat Pharmaceutical compositions comprising (s)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione and methods of using the sam
US11628172B2 (en) * 2019-10-21 2023-04-18 Celgene Corporation Methods of treating chronic lymphocytic leukemia using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione

Also Published As

Publication number Publication date
US20210116454A1 (en) 2021-04-22
AU2020372333A1 (en) 2022-04-28
EP4048668A4 (en) 2024-03-13
IL292305A (en) 2022-06-01
EP4048668A1 (en) 2022-08-31
CN115175903A (zh) 2022-10-11
JP7662625B2 (ja) 2025-04-15
CA3154890A1 (en) 2021-04-29
JP2022552883A (ja) 2022-12-20
KR20220103949A (ko) 2022-07-25
WO2021080950A1 (en) 2021-04-29
BR112022007386A2 (pt) 2022-07-05

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