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AR114159A2 - Pirrolidina-2-carboxamidas sustituidas - Google Patents

Pirrolidina-2-carboxamidas sustituidas

Info

Publication number
AR114159A2
AR114159A2 ARP180103640A ARP180103640A AR114159A2 AR 114159 A2 AR114159 A2 AR 114159A2 AR P180103640 A ARP180103640 A AR P180103640A AR P180103640 A ARP180103640 A AR P180103640A AR 114159 A2 AR114159 A2 AR 114159A2
Authority
AR
Argentina
Prior art keywords
ch2ch2o
substituted
unsubstituted
so2r
cor
Prior art date
Application number
ARP180103640A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR114159A2 publication Critical patent/AR114159A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Se proporcionan compuestos de la fórmula (1) en la que X, Y, R¹, R², R³, R⁴, R⁵, R⁶ y R⁷ tienen los significados aquí descritos y los enantiómeros y sales y ésteres farmacéuticamente aceptables de los mismos. Estos compuestos son útiles como agentes anticancerosos. Reivindicación 1: Los compuestos de la fórmula (1) en la que X se elige entre el grupo formado por H, F, Cl, Br, I, ciano, nitro, etinilo, ciclopropilo, metilo, etilo, isopropilo, vinilo y metoxi; Y es de uno a cuatro restos elegidos con independencia entre el grupo formado por H, F, Cl, Br, I, CN, OH, nitro, alquilo inferior, cicloalquilo, alcoxi inferior, alquenilo inferior, cicloalquenilo, alquinilo inferior, arilo, heteroarilo, heterociclo, COOR’, OCOR’, CONR’R’’, NR’COR’’, NR’’SO₂R’, SO₂NR’R’’ y NR’R’’, en los que R’ y R’’ se eligen con independencia entre H, alquilo inferior sustituido o sin sustituir, cicloalquilo inferior sustituido o sin sustituir, alquenilo inferior sustituido o sin sustituir, cicloalquenilo inferior sustituido o sin sustituir, arilo sustituido o sin sustituir, heteroarilo sustituido o sin sustituir y heterociclo sustituido o sin sustituir; y en el caso de que R’ y R’’ puedan unirse de modo independiente para formar una estructura cíclica elegida entre cicloalquilo sustituido o sin sustituir, cicloalquenilo sustituido o sin sustituir, heteroarilo sustituido o sin sustituir y heterociclo sustituido o sin sustituir, uno de R¹ y R² se elige entre el grupo formado por alquilo inferior, alquilo inferior sustituido, alquenilo inferior, alquenilo inferior sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo, heterociclo sustituido, cicloalquilo, cicloalquilo sustituido, cicloalquenilo y cicloalquenilo sustituido y el otro es hidrógeno o alquilo inferior; R³ es H o alquilo inferior; uno de R⁴ y R⁵ se elige entre el grupo formado por alquilo inferior, alquilo inferior sustituido, alquenilo inferior, alquenilo inferior sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo, heterociclo sustituido, cicloalquilo, cicloalquilo sustituido, cicloalquenilo y cicloalquenilo sustituido y el otro es hidrógeno; R⁶ y R⁷ se eligen entre el grupo formado por (CH₂)ₙ-R’, (CH₂)ₙ-NR’R’’, (CH₂)ₙ-NR’COR’’, (CH₂)ₙ-NR’SO₂R’’, (CH₂)ₙ-COOH, (CH₂)ₙ-COOR’, (CH₂)ₙ-CONR’R’’, (CH₂)ₙ-OR’, (CH₂)ₙ-SR’, (CH₂)ₙ-SOR’, (CH₂)ₙ-SO₂R’, (CH₂)ₙ-COR’, (CH₂)ₙ-SO₃H, (CH₂)ₙ-SONR’R’’, (CH₂)ₙ-SO₂NR’R’’, (CH₂CH₂O)ₘ-(CH₂)ₙ-R’, (CH₂CH₂O)ₘ-(CH₂)ₙ-OH, (CH₂CH₂O)ₘ-(CH₂)ₙ-OR’, (CH₂CH₂O)ₘ-(CH₂)ₙ-NR’R’’, (CH₂CH₂O)ₘ-(CH₂)ₙ-NR’COR’’, (CH₂CH₂O)ₘ-(CH₂)ₙ-NR’SO₂R’’, (CH₂CH₂O)ₘ-(CH₂)ₙ-COOH, (CH₂CH₂O)ₘ-(CH₂)ₙ-COOR’, (CH₂CH₂O)ₘ-(CH₂)ₙ-CONR’R’’, (CH₂CH₂O)ₘ-(CH₂)ₙ-SO₂R’, (CH₂CH₂O)ₘ(CH₂)ₙ-COR’, (CH₂CH₂O)ₘ-(CH₂)ₙ-SONR’R’’, (CH₂CH₂O)ₘ-(CH₂)ₙ-SO₂NR’R’’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-R’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-OH, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-OR’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-NR’R’’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-NR’COR’’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-NR’SO₂R’’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-COOH, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-COOR’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-CONR’R’’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-SO₂R’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-COR’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-SONR’R’’, (CH₂)ₚ-(CH₂CH₂O)ₘ-(CH₂)ₙ-SO₂NR’R’’, -COR’, -SOR’ y SO₂R’, en los que R’ y R’’ tienen los significados definidos anteriormente; m, n y p son con independencia un número de 0 a 6; y las sales y ésteres farmacéuticamente aceptables de los mismos.
ARP180103640A 2010-02-09 2018-12-13 Pirrolidina-2-carboxamidas sustituidas AR114159A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/702,402 US8354444B2 (en) 2008-09-18 2010-02-09 Substituted pyrrolidine-2-carboxamides

Publications (1)

Publication Number Publication Date
AR114159A2 true AR114159A2 (es) 2020-07-29

Family

ID=43608850

Family Applications (2)

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ARP110100393A AR080143A1 (es) 2010-02-09 2011-02-07 Pirrolidina-2-carboxamidas sustituidas, composicion farmaceutica que las contiene y su uso en el tratamiento de tastornos oncologicos
ARP180103640A AR114159A2 (es) 2010-02-09 2018-12-13 Pirrolidina-2-carboxamidas sustituidas

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ARP110100393A AR080143A1 (es) 2010-02-09 2011-02-07 Pirrolidina-2-carboxamidas sustituidas, composicion farmaceutica que las contiene y su uso en el tratamiento de tastornos oncologicos

Country Status (33)

Country Link
US (1) US8354444B2 (es)
EP (1) EP2534132B1 (es)
JP (1) JP5612710B2 (es)
KR (1) KR101461298B1 (es)
CN (1) CN102753522B (es)
AR (2) AR080143A1 (es)
AU (1) AU2011214506C1 (es)
BR (1) BR112012019672B1 (es)
CA (1) CA2788236C (es)
CL (1) CL2012002189A1 (es)
CR (1) CR20120410A (es)
CY (1) CY1119049T1 (es)
DK (1) DK2534132T3 (es)
EC (1) ECSP12012083A (es)
ES (1) ES2629439T3 (es)
HR (1) HRP20170903T1 (es)
HU (1) HUE034816T2 (es)
LT (1) LT2534132T (es)
MX (1) MX2012009186A (es)
MY (1) MY165238A (es)
NZ (1) NZ601422A (es)
PE (1) PE20121532A1 (es)
PH (1) PH12012501546A1 (es)
PL (1) PL2534132T3 (es)
PT (1) PT2534132T (es)
RS (1) RS56163B1 (es)
RU (1) RU2564022C2 (es)
SG (1) SG182763A1 (es)
SI (1) SI2534132T1 (es)
SM (1) SMT201700319T1 (es)
TW (1) TWI401243B (es)
UA (1) UA107954C2 (es)
WO (1) WO2011098398A1 (es)

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