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AR064561A1 - Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina. - Google Patents

Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina.

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Publication number
AR064561A1
AR064561A1 ARP070105930A ARP070105930A AR064561A1 AR 064561 A1 AR064561 A1 AR 064561A1 AR P070105930 A ARP070105930 A AR P070105930A AR P070105930 A ARP070105930 A AR P070105930A AR 064561 A1 AR064561 A1 AR 064561A1
Authority
AR
Argentina
Prior art keywords
alkyl
group
heterocyclyl
aryl
substituents
Prior art date
Application number
ARP070105930A
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English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR064561A1 publication Critical patent/AR064561A1/es

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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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Abstract

Derivados 2-aza-biciclo[3.1.0]hexano de formula (1). Uso de dichos compuestos, o de sales farmacéuticamente aceptables de dichos compuestos, como medicamentos, especialmente como antagonistas del receptor orexina. Reivindicacion 1: Un compuesto de formula (1) donde A representa arilo o heterociclilo, donde el arilo o heterociclilo es no sustituido o independientemente mono- o di-sustituido, donde los sustituyentes están independientemente seleccionados del grupo que consiste en alquilo C1-4, cicloalquilo C3-6, alquinilo C2-6, alcoxi C1-4, NR2R3, halogeno y fenilo o piridilo no sustituido o independientemente mono- o di-sustituido, donde los sustituyentes están independientemente seleccionados del grupo que consiste en alquilo C1-4, alcoxi C1-4, trifluormetilo, trifluormetoxi, fluor y cloro; B representa un grupo arilo- o heterociclilo, donde el arilo o heterociclilo es no sustituido o independientemente mono-, di-, o tri-sustituido, donde los sustituyentes están independientemente seleccionados del grupo que consiste en alquilo C1-4, alcoxi C1-4, trifluormetilo, -NR2R3, -NHSO2-alquilo C1-4, -N(R2)C(O)R3 y halogeno; n representa el numero entero 0 o 1; R1 representa arilo o heterociclilo, donde el arilo o heterociclilo es no sustituido o independientemente mono-, di-, o tri-sustituido, donde los sustituyentes están seleccionados independientemente del grupo que consiste en alquilo C1-4, alcoxi C1-4, halogeno, trifluormetilo, ciano, alquiltio C1-4, alquinilo C2-6 y -NR2R3; o R1 representa un grupo 2,3-dihidro-benzofuranilo, benzo[1,3]dioxolilo, 2,3-dihidro-benzo[1,4]dioxinilo, 4H-benzo[1,3]dioxinilo, 2H-cromenilo, cromanilo, 2,3-dihidro-tieno[3,4-b][1,4]dioxinilo, un 34-dihidro-2H- benzo[1,4]oxazinilo, o un grupo 4-morfolino-fenilo, donde dichos grupos están no sustituidos o mono- o di-sustituidos, donde los sustituyentes están seleccionados independientemente del grupo que consiste en alquilo C1-4, alcoxi C1-4 y halogeno; R2 representa hidrogeno o alquilo C1-4 y R3 representa hidrogeno o alquilo C1-4 o una sal de dicho compuesto farmacéuticamente aceptable.
ARP070105930A 2006-12-28 2007-12-27 Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina. AR064561A1 (es)

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IB2006055042 2006-12-28

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AR064561A1 true AR064561A1 (es) 2009-04-08

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ARP070105930A AR064561A1 (es) 2006-12-28 2007-12-27 Derivados de 2-aza-biciclo[3.1.0]hexano y su uso en la preparacion de un medicamento para el tratamiento de enfermedades relacionadas con disfunciones generales del sistema de la orexina.

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EP (1) EP2094690B1 (es)
JP (1) JP2010514751A (es)
KR (1) KR20090094168A (es)
CN (1) CN101568536B (es)
AR (1) AR064561A1 (es)
AT (1) ATE505467T1 (es)
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RU (1) RU2460732C2 (es)
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Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008038251A2 (en) * 2006-09-29 2008-04-03 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives
ATE496043T1 (de) 2006-12-01 2011-02-15 Actelion Pharmaceuticals Ltd 3-heteroaryl (amino bzw. amido)-1- (biphenyl bzw. phenylthiazolyl) carbonylpiperdinderivate als orexinrezeptor-inhibitoren
CL2008000836A1 (es) * 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras.
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