AR102521A1 - Variantes de región fc con unión de fcrn modificada y métodos de utilización - Google Patents
Variantes de región fc con unión de fcrn modificada y métodos de utilizaciónInfo
- Publication number
- AR102521A1 AR102521A1 ARP150103563A ARP150103563A AR102521A1 AR 102521 A1 AR102521 A1 AR 102521A1 AR P150103563 A ARP150103563 A AR P150103563A AR P150103563 A ARP150103563 A AR P150103563A AR 102521 A1 AR102521 A1 AR 102521A1
- Authority
- AR
- Argentina
- Prior art keywords
- region
- region polypeptide
- igg class
- polypeptide
- variant
- Prior art date
Links
- 101150050927 Fcgrt gene Proteins 0.000 title 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 19
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 19
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 19
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000009109 Fc receptors Human genes 0.000 abstract 1
- 108010087819 Fc receptors Proteins 0.000 abstract 1
- 208000014245 Ocular vascular disease Diseases 0.000 abstract 1
- 239000001825 Polyoxyethene (8) stearate Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/528—CH4 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Compression Or Coding Systems Of Tv Signals (AREA)
Abstract
En la presente memoria se informa de una región Fc de clase IgG que comprende un primer polipéptido de región Fc variante y un segundo polipéptido de región Fc variante, en el que: a) el primer polipéptido de región Fc variante se deriva de un primer polipéptido de región Fc de clase IgG parental y el segundo polipéptido de región Fc se deriva de un segundo polipéptido de región Fc de clase IgG parental, de manera que el primer polipéptido de región Fc de clase IgG parental es idéntico o diferente del segundo polipéptido de región Fc de clase IgG parental, y b) el primer polipéptido de región Fc variante difiere del segundo polipéptido de región Fc variante en uno o más residuos aminoácidos diferentes de los residuos aminoácidos en los que el primer polipéptido de región Fc de clase IgG parental difiere del segundo polipéptido de región Fc de clase IgG parental, y c) la región Fc de clase IgG que comprende el primer polipéptido de región Fc variante y el segundo polipéptido de región Fc variante presentan una afinidad para un receptor Fc humano que es diferente de la de una región Fc de clase IgG que comprende el primer polipéptido de clase IgG parental de a) y el segundo polipéptido de región Fc de clase IgG parental de a), en el que el primer polipéptido de región Fc o el segundo polipéptido de región Fc o ambos polipéptidos de región Fc comprenden independientemente uno de otro una de las mutaciones o combinaciones de mutaciones siguientes: T307H, o Q311H, o E430 H, o N434H, o T307H y Q311H, o T307H y E430H, o T307H y N434A, o T307H y N434H, o T307Q y Q311H, o T307Q y E430H, o T307Q y N434H, o T307H y Q311H y E430H y N434A, o T307H y Q311H y E430H y N434H, o T307H y Q311H y E430H y N434Y, o T307Q y Q311H y E430H y N434A, o T307Q y Q311H y E430H y N434H, o T307Q y Q311H y E430H y N434Y, o T307Q y V308P y N434Y y Y436H, o T307H y M252Y y S254T y T256E, o T307Q y M252Y y S254T y T256E, o Q311H y M252Y y S254T y T256E, o E430 H y M252Y y S254T y T256E, o N434H y M252Y y S254T y T256E, o T307H y Q311H y M252Y y S254T y T256E, o T307H y E430H y M252Y y S254T y T256E, o T307H y N434A y M252Y y S254T y T256E, o T307H y N434H y M252Y y S254T y T256E, o T307Q y Q311H y M252Y y S254T y T256E, o T307Q y E430H y M252Y y S254T y T256E, o T307Q y N434H y M252Y y S254T y T256E, o T307H y Q311H y E430H y N434A y M252Y y S254T y T256E, o T307H y Q311H y E430H y N434H y M252Y y S254T y T256E, o T307H y Q311H y E430H y N434Y y M252Y y S254T y T256E, o T307Q y Q311H y E430H y N434A y M252Y y S254T y T256E, o T307Q y Q311H y E430H y N434H y M252Y y S254T y T256E, o T307Q y Q311H y E430H y N434Y y M252Y y S254T y T256E, o T307Q y V308P y N434Y y Y436H y M252Y y S254T y T256E. Reivindicación 12: Formulación farmacéutica según la reivindicación 11, en la que la formulación farmacéutica está destinada a la utilización en el tratamiento de enfermedades vasculares oculares.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14192052 | 2014-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR102521A1 true AR102521A1 (es) | 2017-03-08 |
Family
ID=51947132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150103563A AR102521A1 (es) | 2014-11-06 | 2015-11-04 | Variantes de región fc con unión de fcrn modificada y métodos de utilización |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10683368B2 (es) |
| EP (2) | EP3215528B1 (es) |
| JP (2) | JP6707090B2 (es) |
| KR (1) | KR20170078677A (es) |
| CN (1) | CN107108720A (es) |
| AR (1) | AR102521A1 (es) |
| BR (1) | BR112017006178A2 (es) |
| CA (1) | CA2960797A1 (es) |
| DK (1) | DK3215528T3 (es) |
| ES (1) | ES2749383T3 (es) |
| HR (1) | HRP20191766T1 (es) |
| HU (1) | HUE045466T2 (es) |
| LT (1) | LT3215528T (es) |
| MX (2) | MX378451B (es) |
| PL (1) | PL3215528T3 (es) |
| PT (1) | PT3215528T (es) |
| RS (1) | RS59340B1 (es) |
| RU (1) | RU2714116C2 (es) |
| SI (1) | SI3215528T1 (es) |
| WO (1) | WO2016071376A2 (es) |
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- 2015-11-04 PT PT157909227T patent/PT3215528T/pt unknown
- 2015-11-04 LT LT15790922T patent/LT3215528T/lt unknown
- 2015-11-04 CN CN201580060466.3A patent/CN107108720A/zh active Pending
- 2015-11-04 SI SI201530912T patent/SI3215528T1/sl unknown
- 2015-11-04 KR KR1020177012250A patent/KR20170078677A/ko not_active Ceased
- 2015-11-04 CA CA2960797A patent/CA2960797A1/en not_active Abandoned
-
2017
- 2017-04-20 MX MX2020010061A patent/MX2020010061A/es unknown
- 2017-05-04 US US15/586,679 patent/US10683368B2/en active Active
-
2020
- 2020-03-17 JP JP2020045925A patent/JP7023306B2/ja active Active
- 2020-05-07 US US16/868,972 patent/US11440971B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3215528B1 (en) | 2019-08-07 |
| RU2017117856A3 (es) | 2019-08-08 |
| PL3215528T3 (pl) | 2020-01-31 |
| US10683368B2 (en) | 2020-06-16 |
| JP2018502143A (ja) | 2018-01-25 |
| US20170342167A1 (en) | 2017-11-30 |
| CN107108720A (zh) | 2017-08-29 |
| EP3611188A1 (en) | 2020-02-19 |
| MX2020010061A (es) | 2020-10-15 |
| RS59340B1 (sr) | 2019-10-31 |
| JP2020111588A (ja) | 2020-07-27 |
| WO2016071376A2 (en) | 2016-05-12 |
| CA2960797A1 (en) | 2016-05-12 |
| US20200270367A1 (en) | 2020-08-27 |
| PT3215528T (pt) | 2019-10-11 |
| MX2017005148A (es) | 2017-08-08 |
| RU2017117856A (ru) | 2018-12-06 |
| MX378451B (es) | 2025-03-11 |
| RU2714116C2 (ru) | 2020-02-11 |
| DK3215528T3 (da) | 2019-10-07 |
| EP3611188B1 (en) | 2022-05-04 |
| EP3215528A2 (en) | 2017-09-13 |
| ES2749383T3 (es) | 2020-03-20 |
| SI3215528T1 (sl) | 2019-11-29 |
| WO2016071376A3 (en) | 2016-06-30 |
| HRP20191766T1 (hr) | 2019-12-27 |
| KR20170078677A (ko) | 2017-07-07 |
| LT3215528T (lt) | 2019-10-25 |
| US11440971B2 (en) | 2022-09-13 |
| HUE045466T2 (hu) | 2019-12-30 |
| JP7023306B2 (ja) | 2022-02-21 |
| JP6707090B2 (ja) | 2020-06-10 |
| BR112017006178A2 (pt) | 2018-05-02 |
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