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AR104176A1 - Inhibidores de ido (indolamina-2,3-dioxigenasa) - Google Patents

Inhibidores de ido (indolamina-2,3-dioxigenasa)

Info

Publication number
AR104176A1
AR104176A1 ARP160100897A ARP160100897A AR104176A1 AR 104176 A1 AR104176 A1 AR 104176A1 AR P160100897 A ARP160100897 A AR P160100897A AR P160100897 A ARP160100897 A AR P160100897A AR 104176 A1 AR104176 A1 AR 104176A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
cycloalkyl
alkyl
heteroaryl
heterocyclyl
Prior art date
Application number
ARP160100897A
Other languages
English (en)
Inventor
Pulicharla Nagalakshmi
Kanyaboina Yadagiri
Thangathirupathy Srinivasan
Cheruku Srinivas
Kumar Sistla Ramesh
Thangavel Soodamani
Roy Saumya
Jethanand Nara Susheel
Murugesan Natesan
K Williams David
Shan Weifang
P Seitz Steven
A Markwalder Jay
Huang Audris
Guo Weiwei
Charlotte Cherney Emily
Aaron Balog James
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR104176A1 publication Critical patent/AR104176A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en donde: Y es N, CH o CF; V es N, CH o CF; R¹ es -COOH, -COOC₁₋₆ alquilo, -CONH₂, -CN, heterociclilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, -NHCONHR¹³, -CONHSO₂R¹⁴, -CONHCOR¹³, -SO₂NHCOR¹³, -CONR¹³, -CONHSO₂NR¹³R¹⁴, -SO₂NHR¹³, -NHCONHSO₂R¹³, -CHCF₃OH, -COCF₃, -CR²R³OH o -NHSO₂R¹³; R¹³ es H, C₁₋₁₀ alquilo opcionalmente sustituido, C₃₋₈ cicloalquilo opcionalmente sustituido, C₂₋₁₀ alquenilo opcionalmente sustituido, C₂₋₁₀ alquinilo opcionalmente sustituido, heterociclilo opcionalmente sustituido, fenilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; R¹⁴ es H, C₁₋₁₀ alquilo opcionalmente sustituido; fenilo o C₃₋₈ cicloalquilo; R² y R³ son independientemente -hidrógeno, C₁₋₁₀ alquilo opcionalmente sustituido, C₃₋₈ cicloalquilo opcionalmente sustituido o fenilo opcionalmente sustituido; o R² y R³ se toman junto con el carbono al cual están unidos para formar un anillo carbocíclico o heterocíclico de 3 a 6 miembros opcionalmente sustituido; R⁴ y R⁵ son independientemente H, C₁₋₁₀ alquilo opcionalmente sustituido, C₁₋₁₀ alcoxi-C₁₋₁₀ alquilo opcionalmente sustituido, C₁₋₁₀ alcoxi opcionalmente sustituido, arilo opcionalmente sustituido, aril-C₁₋₁₀ alquilo opcionalmente sustituido, heteroarilo de 5 a 8 miembros opcionalmente sustituido, C₃₋₈ cicloalquilo opcionalmente sustituido o heterociclilo opcionalmente sustituido; o R⁴ y R⁵ se toman junto con el nitrógeno al cual están unidos para formar un anillo heterocíclico de 4 a 8 miembros opcionalmente sustituido que contiene 0 - 3 heteroátomos adicionales seleccionados de -N-, -S- y -O-; o R⁴ y R⁵ se toman junto con el nitrógeno al cual están unidos para formar un anillo heterobicíclico de 6 a 10 miembros opcionalmente sustituido que contiene 0 - 3 heteroátomos adicionales seleccionados de -N-, -S- y -O-; R⁶ es arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, C₃₋₈ cicloalquilo opcionalmente sustituido, heterociclilo opcionalmente sustituido o -COR⁷; R⁷ es -CR²R³-arilo opcionalmente sustituido, -CR²R³-heteroarilo opcionalmente sustituido, -CR²R³-heterociclilo, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, C₃₋₈ cicloalquilo opcionalmente sustituido o heterociclilo opcionalmente sustituido; y Rˣ y Rʸ son, cada uno independientemente, H, C₁₋₁₀ alquilo opcionalmente sustituido, C₁₋₁₀ alcoxi opcionalmente sustituido o C₃₋₈ cicloalquilo opcionalmente sustituido; o Rˣ y Rʸ se toman junto con el carbono al cual están unidos para formar un anillo heterocíclico de 3 a 7 miembros que contiene 0 - 3 heteroátomos adicionales seleccionados de -N-, -S- y -O-; y/o un estereoisómero, un tautómero o una sal de aquel aceptable desde el punto de vista farmacéutico. Reivindicación 21: Uso de un compuesto de acuerdo con cualquiera de las reivindicaciones anteriores en un medicamento para tratar el cáncer. Reivindicación 23: El uso de acuerdo con la reivindicación 22, que también comprende un agente antineoplásico adicional.
ARP160100897A 2015-04-03 2016-04-01 Inhibidores de ido (indolamina-2,3-dioxigenasa) AR104176A1 (es)

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Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE046273T2 (hu) 2014-02-13 2020-02-28 Incyte Corp Ciklopropilaminok mint LSD1 inhibitorok
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
SMT201900620T1 (it) 2014-02-13 2020-01-14 Incyte Corp Ciclopropilammine come inibitori di lsd1
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
CN107660205B (zh) 2015-04-03 2021-08-27 因赛特公司 作为lsd1抑制剂的杂环化合物
SG11201708097SA (en) * 2015-04-03 2017-10-30 Bristol Myers Squibb Co Inhibitors of indoleamine 2,3-dioxygenase for the treatment of cancer
HUE070538T2 (hu) 2015-08-12 2025-06-28 Incyte Holdings Corp Egy LSD1 inhibitor sói
AU2016327168A1 (en) * 2015-09-24 2018-04-12 Glaxosmithkline Intellectual Property (No.2) Limited Modulators of indoleamine 2,3-dioxygenase
US10787442B2 (en) 2016-12-20 2020-09-29 Glaxosmithkline Intellectual Property Development Limited Modulators of indoleamine 2,3-dioxygenase
US10899754B2 (en) * 2016-12-20 2021-01-26 Glaxosmithkline Intellectual Property Development Limited Modulators of indoleamine 2,3-dioxygenase
SG10201911243WA (en) 2016-12-22 2020-02-27 Calithera Biosciences Inc Compositions and methods for inhibiting arginase activity
EP3570832A4 (en) 2017-01-17 2020-06-10 Board Of Regents, The University Of Texas System COMPOUNDS AS INHIBITORS OF INDOLAMINE-2,3-DIOXYGENASE AND / OR TRYPTOPHANE-DIOXYGENASE
US20200188482A1 (en) * 2017-04-28 2020-06-18 The Brigham And Women`S Hospital, Inc. Targeting gamma-delta t cells in obesity and cachexia
WO2018204532A1 (en) 2017-05-03 2018-11-08 Vivace Therapeutics, Inc. Non-fused tricyclic compounds
CN108976139B (zh) * 2017-06-02 2021-03-16 沈阳化工研究院有限公司 一种芳乙烯衍生物及其应用
CN110785408A (zh) * 2017-06-28 2020-02-11 葛兰素史克知识产权开发有限公司 吲哚胺2,3-双加氧酶的调节剂
CN107325019B (zh) * 2017-08-11 2019-11-22 石河子大学 芳胺基苯甲酰胺类化合物及n-芳基-芳胺基苯甲酰胺类化合物的制备方法
CN111542315B (zh) 2017-08-21 2023-05-12 维瓦斯治疗公司 苯并磺酰基化合物
US11180497B2 (en) * 2017-10-18 2021-11-23 Angex Pharmaceutical, Inc. Cyclic compounds as immunomodulating agents
CN109836356B (zh) * 2017-11-24 2022-03-08 沈阳化工研究院有限公司 一种芳甲醚衍生物及其应用
WO2019113236A1 (en) 2017-12-06 2019-06-13 Vivace Therapeutics, Inc. Benzocarbonyl compounds
EP3697423A4 (en) 2018-01-05 2021-08-11 Dicerna Pharmaceuticals, Inc. REDUCED EXPRESSION OF BETA-CATENIN AND IDO TO POTENTIALIZE IMMUNOTHERAPY
US11447449B2 (en) 2018-01-05 2022-09-20 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
EP3793551A4 (en) 2018-05-16 2022-01-26 Vivace Therapeutics, Inc. OXADIAZOLE COMPOUNDS
AU2019297428C1 (en) * 2018-07-06 2023-03-23 Gilead Sciences, Inc. Therapeutic heterocyclic compounds
WO2020018670A1 (en) 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
WO2020023355A1 (en) * 2018-07-23 2020-01-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
CN109608334B (zh) * 2019-01-11 2021-07-13 盐城通海生物科技有限公司 一种合成4-甲氧基巴豆酸甲酯的方法
BR112021014911A2 (pt) * 2019-02-01 2021-11-23 Glaxosmithkline Ip Dev Ltd Belantamabe mafodotina em combinação com pembrolizumabe para tratamento de câncer
KR102386849B1 (ko) * 2019-10-14 2022-04-13 포항공과대학교 산학협력단 면역치료를 위한 환경 반응형 접착성 항체전달체 및 이의 제조방법
WO2021102618A1 (en) 2019-11-25 2021-06-03 InventisBio Co., Ltd. Novel salts of indoleamine 2,3-dioxygenase inhibitors
CN113214138A (zh) * 2020-02-04 2021-08-06 中国医学科学院药物研究所 苯丙酸类衍生物、及其制法和药物组合物与用途
US11839659B2 (en) 2020-07-02 2023-12-12 Northwestern University Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein
CN112174891B (zh) * 2020-11-02 2022-02-01 浙江省农业科学院 一种氟唑菌苯胺代谢物的制备方法
JP2024016314A (ja) * 2020-12-24 2024-02-07 小野薬品工業株式会社 一般式（ｉ－ａ）で示される化合物、その薬学的に許容される塩、またはそれらの水和物と免疫チェックポイント阻害薬および／またはｅｐ４受容体拮抗薬との組み合わせ
BR112023017582A2 (pt) 2021-03-05 2023-12-05 Univ Basel Composições para o tratamento de doenças ou condições associadas ao ebv
EP4052705A1 (en) 2021-03-05 2022-09-07 Universität Basel Vizerektorat Forschung Compositions for the treatment of ebv associated diseases or conditions

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622337A (en) * 1968-08-02 1971-11-23 Gaf Corp Cyan color formers for color photography
US4252894A (en) * 1975-10-22 1981-02-24 Gaf Corporation Hydrophilic color coupler composition containing diepoxide
EP1505966A4 (en) 2002-05-10 2006-08-30 Bristol Myers Squibb Co 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA HEMMER
WO2005030704A1 (en) 2003-09-24 2005-04-07 Methylgene, Inc. Inhibitors of histone deacetylase
CN101445469B (zh) * 2003-09-24 2013-02-13 梅特希尔基因公司 组蛋白脱乙酰基酶抑制剂
TWI380996B (zh) 2004-09-17 2013-01-01 Hoffmann La Roche 抗ｏｘ４０ｌ抗體
AU2006230099B2 (en) 2005-03-25 2012-04-19 Gitr, Inc. GITR binding molecules and uses therefor
PL1879573T3 (pl) 2005-05-10 2013-05-31 Incyte Holdings Corp Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
CN101248089A (zh) 2005-07-01 2008-08-20 米德列斯公司 抗程序性死亡配体1（pd-l1）的人单克隆抗体
ES2540561T3 (es) 2005-12-20 2015-07-10 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa
CA2649043C (en) 2006-04-19 2013-09-17 Astellas Pharma Inc. Azolecarboxamide derivative
US20080125470A1 (en) 2006-09-19 2008-05-29 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
CN101801413A (zh) 2007-07-12 2010-08-11 托勒克斯股份有限公司 采用gitr结合分子的联合疗法
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
WO2009073620A2 (en) 2007-11-30 2009-06-11 Newlink Genetics Ido inhibitors
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
HUE034832T2 (hu) 2008-12-09 2021-12-28 Hoffmann La Roche Anti-PD-L1 antitestek és alkalmazásuk T-sejt-funkció fokozására
AU2010289677B2 (en) 2009-09-03 2014-07-31 Merck Sharp & Dohme Llc Anti-GITR antibodies
WO2011056652A1 (en) 2009-10-28 2011-05-12 Newlink Genetics Imidazole derivatives as ido inhibitors
RU2565541C2 (ru) 2009-12-10 2015-10-20 Ф.Хоффманн-Ля Рош Аг Антитела, связывающиеся преимущественно с внеклеточным доменом 4 человеческого csf-1r, и их применение
HUE045487T2 (hu) 2010-03-04 2019-12-30 Macrogenics Inc B7-H3-ra reaktív antitestek, immunológiailag aktív fragmenseik és alkalmazásaik
CA2789076C (en) 2010-03-05 2017-11-21 F. Hoffmann-La Roche Ag Antibodies against human colony stimulating factor-1 receptor and uses thereof
US9221910B2 (en) 2010-03-05 2015-12-29 Hoffmann-La Roche Inc. Antibodies against human CSF-1R
CN107011438B (zh) 2010-05-04 2020-11-20 戊瑞治疗有限公司 结合csf1r的抗体
JP6105470B2 (ja) 2010-09-09 2017-03-29 ファイザー・インク ４−１ｂｂ結合分子
NO2694640T3 (es) 2011-04-15 2018-03-17
PL2699264T3 (pl) 2011-04-20 2018-08-31 Medimmune, Llc Przeciwciała i inne cząsteczki wiążące B7-H1 i PD-1
BR112014012819B1 (pt) 2011-11-28 2022-08-16 Merck Patent Gmbh Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição
CN104159921B (zh) 2011-12-15 2018-05-04 霍夫曼-拉罗奇有限公司 针对人csf-1r的抗体及其用途
EP2812355A4 (en) 2012-02-06 2016-03-02 Hoffmann La Roche COMPOSITIONS AND METHODS OF USE OF CSF1R INHIBITORS
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
EP3539984A1 (en) 2012-05-11 2019-09-18 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
TWI713436B (zh) 2012-08-31 2020-12-21 美商戊瑞治療有限公司 用結合群落刺激因子１受體（ｃｓｆ１ｒ）之抗體治療病狀之方法
AU2014235816B2 (en) 2013-03-15 2018-05-17 Bristol-Myers Squibb Company IDO inhibitors
SI2970155T1 (en) * 2013-03-15 2018-06-29 Bristol-Myers Squibb Company INHIBITORS INDOLEAMIN 2,3-DIOXYGENESIS (IDO)
JP6371851B2 (ja) * 2013-08-27 2018-08-08 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｉｄｏ阻害剤
SG11201708097SA (en) * 2015-04-03 2017-10-30 Bristol Myers Squibb Co Inhibitors of indoleamine 2,3-dioxygenase for the treatment of cancer

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