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AR100131A1 - Proceso de purificación de gonadotropina - Google Patents

Proceso de purificación de gonadotropina

Info

Publication number
AR100131A1
AR100131A1 ARP150101169A ARP150101169A AR100131A1 AR 100131 A1 AR100131 A1 AR 100131A1 AR P150101169 A ARP150101169 A AR P150101169A AR P150101169 A ARP150101169 A AR P150101169A AR 100131 A1 AR100131 A1 AR 100131A1
Authority
AR
Argentina
Prior art keywords
steps
chromatography
gonadotropin
purification process
column chromatography
Prior art date
Application number
ARP150101169A
Other languages
English (en)
Inventor
K Singh Avanish
S Reddy Mirtha
Bandyopadhyay Sanjay
Kumar Mendiratta Sanjeev
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of AR100131A1 publication Critical patent/AR100131A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

Reivindicación 1: Un proceso de purificación de gonadotropina caracterizado porque comprende los siguientes pasos esenciales: (a) cromatografía de afinidad; (b) cromatografía de intercambio aniónico, seguido de otros pasos de purificación adecuados. Reivindicación 9: El proceso de purificación de gonadotropina de acuerdo con cualquiera de las reivindicaciones anteriores, a partir de una mezcla cruda, caracterizado porque comprende los siguientes pasos: (a) separación de células y reacondicionamiento; (b) cromatografía en columna de afinidad; (c) ultrafiltración-diafiltración y reacondicionamiento; (d) inactivación viral; (e) cromatografía en columna de intercambio aniónico (AEX); (f) reacondicionamiento; (g) cromatografía en columna de interacción hidrofóbica (HIC); (h) ultrafiltración-diafiltración; (i) nanofiltración; (j) microfiltración en donde los pasos de cromatografía de intercambio aniónico e hidrofóbica se pueden llevar a cabo en cualquier orden después del paso de cromatografía de afinidad; y los pasos (c) a (j) se pueden llevar a cabo en cualquier orden. Reivindicación 14: El proceso de acuerdo con cualquier reivindicación anterior, caracterizado porque la gonadotropina se selecciona entre r-hFSH, u-FSH, r-hLH, u-LH, r-hHCG y u-HCG.
ARP150101169A 2014-04-18 2015-04-17 Proceso de purificación de gonadotropina AR100131A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1398MU2014 2014-04-18

Publications (1)

Publication Number Publication Date
AR100131A1 true AR100131A1 (es) 2016-09-14

Family

ID=53773477

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150101169A AR100131A1 (es) 2014-04-18 2015-04-17 Proceso de purificación de gonadotropina

Country Status (15)

Country Link
US (1) US20170029482A1 (es)
EP (1) EP3131924A1 (es)
JP (1) JP2017514803A (es)
KR (1) KR20160131113A (es)
CN (1) CN106170493A (es)
AR (1) AR100131A1 (es)
AU (1) AU2015248461B2 (es)
BR (1) BR112016023680A2 (es)
CA (1) CA2945591A1 (es)
EA (1) EA201691834A1 (es)
IL (1) IL248293A (es)
MX (1) MX2016013416A (es)
MY (1) MY183011A (es)
SG (1) SG11201608513WA (es)
WO (1) WO2015159309A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108503705A (zh) * 2018-07-10 2018-09-07 北京伟杰信生物科技有限公司 一种重组绒促性素（rhCG）的纯化方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105968185A (zh) * 2016-07-20 2016-09-28 宁波人健药业集团股份有限公司 一种绒促性素纯化方法
KR102752765B1 (ko) * 2019-12-26 2025-01-14 주식회사 엘지화학 여포 자극 호르몬의 정제 방법
CN111303274B (zh) * 2020-03-21 2024-01-30 上海浦东明炎生物技术有限公司 一种人绒毛膜促性腺激素纯化方法
CN114591414A (zh) * 2022-03-24 2022-06-07 江西浩然生物制药有限公司 一种人绒毛膜促性腺激素的制备方法
CN116143901B (zh) * 2022-11-28 2024-08-02 景泽生物医药(合肥)股份有限公司 一种促卵泡激素的纯化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050071683A (ko) 2003-07-15 2005-07-07 마쯔시다덴기산교 가부시키가이샤 플라즈마 디스플레이 패널의 제조방법
BRPI0417992B8 (pt) * 2003-12-22 2021-05-25 Ares Trading Sa métodos para purificar fsh humano recombinante ou uma variante de fsh
CN101087805B (zh) 2004-11-09 2012-05-23 阿雷斯贸易股份有限公司 Fsh的纯化方法
US8604175B2 (en) 2005-12-09 2013-12-10 Ares Trading S.A. Method for purifying FSH or a FSH mutant
CA2755927A1 (en) * 2009-04-01 2010-10-14 Biogenerix Ag Method for purifying recombinant fsh
EP2325194A1 (en) * 2009-11-24 2011-05-25 Glycotope GmbH Process for the purification of glycoproteins
CN102464713A (zh) * 2010-12-21 2012-05-23 上海丽珠制药有限公司 一种卵泡刺激素的制备方法
CN103059125B (zh) * 2012-12-27 2015-08-12 浙江海正药业股份有限公司 重组人促卵泡激素的纯化方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108503705A (zh) * 2018-07-10 2018-09-07 北京伟杰信生物科技有限公司 一种重组绒促性素（rhCG）的纯化方法

Also Published As

Publication number Publication date
CA2945591A1 (en) 2015-10-22
SG11201608513WA (en) 2016-11-29
EP3131924A1 (en) 2017-02-22
BR112016023680A2 (pt) 2017-08-15
MY183011A (en) 2021-02-05
AU2015248461A1 (en) 2016-11-03
MX2016013416A (es) 2017-01-18
WO2015159309A1 (en) 2015-10-22
US20170029482A1 (en) 2017-02-02
EA201691834A1 (ru) 2017-02-28
JP2017514803A (ja) 2017-06-08
IL248293A (en) 2017-04-30
AU2015248461B2 (en) 2017-05-04
CN106170493A (zh) 2016-11-30
KR20160131113A (ko) 2016-11-15

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