AR107474A2 - Proceso para la preparación de un ácido de 1,2,4-oxadiazol benzoico - Google Patents
Proceso para la preparación de un ácido de 1,2,4-oxadiazol benzoicoInfo
- Publication number
- AR107474A2 AR107474A2 ARP170100223A ARP170100223A AR107474A2 AR 107474 A2 AR107474 A2 AR 107474A2 AR P170100223 A ARP170100223 A AR P170100223A AR P170100223 A ARP170100223 A AR P170100223A AR 107474 A2 AR107474 A2 AR 107474A2
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- oxadiazol
- benzoic
- preparation
- acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- RAAGZOYMEQDCTD-UHFFFAOYSA-N 2-fluorobenzoyl chloride Chemical compound FC1=CC=CC=C1C(Cl)=O RAAGZOYMEQDCTD-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- RAMPDACRJWTXEV-UHFFFAOYSA-N methyl 2-cyanobenzoate Chemical compound COC(=O)C1=CC=CC=C1C#N RAMPDACRJWTXEV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Reivindicación 1: Un proceso para preparar un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable de éste, caracterizado porque comprende realizar las siguientes etapas sin el aislamiento de un intermediario: (i) hacer reaccionar el metil éster de ácido cianobenzoico de fórmula (2), con hidroxilamina, para producir el compuesto de fórmula (3), seguido por (ii) acilación con cloruro de 2-fluorobenzoilo, para producir el compuesto de fórmula (4) seguido por (iii) condensación.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84359506P | 2006-09-08 | 2006-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR107474A2 true AR107474A2 (es) | 2018-05-02 |
Family
ID=38935880
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103975A AR062715A1 (es) | 2006-09-08 | 2007-09-07 | Procesos para la preparacion de acidos de 1,2,4- oxadiazol benzoico |
| ARP170100223A AR107474A2 (es) | 2006-09-08 | 2017-01-27 | Proceso para la preparación de un ácido de 1,2,4-oxadiazol benzoico |
| ARP200101362A AR118922A2 (es) | 2006-09-08 | 2020-05-12 | Procesos para la preparación de ácidos de 1,2,4-oxadiazol benzoico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103975A AR062715A1 (es) | 2006-09-08 | 2007-09-07 | Procesos para la preparacion de acidos de 1,2,4- oxadiazol benzoico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200101362A AR118922A2 (es) | 2006-09-08 | 2020-05-12 | Procesos para la preparación de ácidos de 1,2,4-oxadiazol benzoico |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7678922B2 (es) |
| EP (1) | EP2059513B1 (es) |
| JP (2) | JP5955494B2 (es) |
| KR (1) | KR101466368B1 (es) |
| CN (1) | CN101535284B (es) |
| AR (3) | AR062715A1 (es) |
| AU (1) | AU2007292915B2 (es) |
| BR (1) | BRPI0716996B8 (es) |
| CA (2) | CA2842625C (es) |
| CL (1) | CL2007002606A1 (es) |
| DK (1) | DK2059513T3 (es) |
| ES (1) | ES2404348T3 (es) |
| IL (1) | IL197445A (es) |
| MX (1) | MX2009002439A (es) |
| MY (1) | MY148598A (es) |
| NZ (2) | NZ598012A (es) |
| PE (2) | PE20080771A1 (es) |
| PL (1) | PL2059513T3 (es) |
| PT (1) | PT2059513E (es) |
| RU (1) | RU2495030C2 (es) |
| TW (1) | TWI482761B (es) |
| UA (1) | UA99265C2 (es) |
| WO (1) | WO2008030570A1 (es) |
| ZA (1) | ZA200901782B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2887054T3 (es) | 2003-04-11 | 2021-12-21 | Ptc Therapeutics Inc | Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades |
| DK1874306T3 (da) | 2005-04-08 | 2012-10-01 | Ptc Therapeutics Inc | Sammensætninger af en oralt aktiv 1,2,4-oxadiazol til nonsens-mutationssuppressionsterapi |
| IN2014CN04406A (es) * | 2006-03-30 | 2015-09-04 | Ptc Therapeutics Inc | |
| BRPI0716996B8 (pt) * | 2006-09-08 | 2021-05-25 | Ptc Therapeutics Inc | processo para preparar um composto |
| WO2008130370A1 (en) | 2006-09-25 | 2008-10-30 | Ptc Therapeutics, Inc. | Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression |
| US7863456B2 (en) * | 2006-09-25 | 2011-01-04 | Ptc Therapeutics, Inc. | Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-YL]-benzoic acid |
| RU2462247C2 (ru) | 2006-10-12 | 2012-09-27 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы дозирования перорально активного 1,2,4-оксадиазола для терапии, подавляющей нонсенс-мутацию |
| CN101714009A (zh) * | 2009-05-14 | 2010-05-26 | 翁印嵩 | 集成通用电话功能的计算机 |
| EP2668951B9 (en) | 2011-01-25 | 2017-03-15 | Viviabiotech, S.L. | 1,2,4-oxadiazole derivatives as drugs modulating the glp-1 peptide receptor |
| ES2782509T3 (es) | 2012-07-02 | 2020-09-15 | Monsanto Technology Llc | Procedimiento para la preparación de 1,2,4-oxadiazoles 3,5-disustituidos |
| WO2015134711A1 (en) | 2014-03-06 | 2015-09-11 | Ptc Therapeutics, Inc. | Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid |
| CN105461650B (zh) * | 2014-09-12 | 2018-04-13 | 杭州普晒医药科技有限公司 | 一种噁二唑化合物的溶剂化物及其制备方法 |
| CN106316885B (zh) * | 2015-07-03 | 2019-02-12 | 普济生物科技（台州）有限公司 | 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法 |
| CN108348527A (zh) | 2015-10-30 | 2018-07-31 | Ptc医疗公司 | 用于治疗癫痫的方法 |
| TW201808922A (zh) | 2016-06-20 | 2018-03-16 | 台灣神隆股份有限公司 | 製備阿塔魯仁及其中間體的方法 |
| WO2020128816A2 (en) | 2018-12-20 | 2020-06-25 | Pfizer Inc. | Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent |
| KR20210151131A (ko) | 2019-04-10 | 2021-12-13 | 피티씨 테라퓨틱스, 인크. | 소아 환자에서 넌센스 돌연변이 매개된 뒤센 근이영양증의 치료 방법 |
| WO2022112919A1 (en) | 2020-11-25 | 2022-06-02 | Pfizer Inc. | (aza)benzothiazolyl substituted pyrazole compounds |
| CN113045510B (zh) * | 2021-03-31 | 2022-05-27 | 北京大学生命科学华东产业研究院 | 一种阿塔鲁伦的制备方法 |
| CN114920667B (zh) * | 2022-06-30 | 2024-06-21 | 湖南大学 | 一种阿塔鲁伦酯的电化学制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2801509A1 (de) * | 1978-01-12 | 1979-07-19 | Schering Ag | 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel |
| DE3905242A1 (de) * | 1989-02-21 | 1990-08-23 | Basf Ag | Verfahren zur herstellung von phenyloxdiazolylanilinen |
| NZ234760A (en) * | 1989-08-18 | 1991-09-25 | Sterling Drug Inc | Antiviral oxazole compounds and compositions |
| DE4425794A1 (de) * | 1994-07-21 | 1996-01-25 | Basf Ag | Nitrofarbstoffe |
| US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| AU2002313633B2 (en) | 2001-06-08 | 2007-03-01 | Cytovia, Inc. | Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs |
| MY151199A (en) | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| JP2006506340A (ja) | 2002-08-09 | 2006-02-23 | アストラゼネカ アクチボラグ | 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール |
| GB0303503D0 (en) | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| ES2887054T3 (es) * | 2003-04-11 | 2021-12-21 | Ptc Therapeutics Inc | Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades |
| WO2004110351A2 (en) | 2003-05-14 | 2004-12-23 | Anadys Pharmaceuticals, Inc. | Heterocyclic compounds for treating hepatitis c virus |
| DK1874306T3 (da) | 2005-04-08 | 2012-10-01 | Ptc Therapeutics Inc | Sammensætninger af en oralt aktiv 1,2,4-oxadiazol til nonsens-mutationssuppressionsterapi |
| BRPI0716996B8 (pt) * | 2006-09-08 | 2021-05-25 | Ptc Therapeutics Inc | processo para preparar um composto |
-
2007
- 2007-09-06 BR BRPI0716996A patent/BRPI0716996B8/pt active IP Right Grant
- 2007-09-06 CN CN200780041169.XA patent/CN101535284B/zh active Active
- 2007-09-06 RU RU2009113019/04A patent/RU2495030C2/ru active
- 2007-09-06 MY MYPI20090941A patent/MY148598A/en unknown
- 2007-09-06 EP EP07837899A patent/EP2059513B1/en active Active
- 2007-09-06 JP JP2009527430A patent/JP5955494B2/ja active Active
- 2007-09-06 WO PCT/US2007/019561 patent/WO2008030570A1/en not_active Ceased
- 2007-09-06 ZA ZA200901782A patent/ZA200901782B/xx unknown
- 2007-09-06 PL PL07837899T patent/PL2059513T3/pl unknown
- 2007-09-06 ES ES07837899T patent/ES2404348T3/es active Active
- 2007-09-06 MX MX2009002439A patent/MX2009002439A/es active IP Right Grant
- 2007-09-06 DK DK07837899.9T patent/DK2059513T3/da active
- 2007-09-06 NZ NZ598012A patent/NZ598012A/xx unknown
- 2007-09-06 UA UAA200903350A patent/UA99265C2/ru unknown
- 2007-09-06 KR KR1020097007202A patent/KR101466368B1/ko not_active Expired - Fee Related
- 2007-09-06 US US11/899,813 patent/US7678922B2/en active Active - Reinstated
- 2007-09-06 PT PT78378999T patent/PT2059513E/pt unknown
- 2007-09-06 CA CA2842625A patent/CA2842625C/en active Active
- 2007-09-06 CA CA2662749A patent/CA2662749C/en active Active
- 2007-09-06 NZ NZ575511A patent/NZ575511A/en unknown
- 2007-09-06 AU AU2007292915A patent/AU2007292915B2/en active Active
- 2007-09-07 PE PE2007001203A patent/PE20080771A1/es active IP Right Grant
- 2007-09-07 PE PE2011001405A patent/PE20120669A1/es active IP Right Grant
- 2007-09-07 AR ARP070103975A patent/AR062715A1/es not_active Application Discontinuation
- 2007-09-07 TW TW096133607A patent/TWI482761B/zh active
- 2007-09-07 CL CL200702606A patent/CL2007002606A1/es unknown
-
2009
- 2009-03-05 IL IL197445A patent/IL197445A/en active IP Right Grant
- 2009-11-13 US US12/617,757 patent/US8367841B2/en active Active
-
2014
- 2014-05-20 JP JP2014103966A patent/JP2014193896A/ja active Pending
-
2017
- 2017-01-27 AR ARP170100223A patent/AR107474A2/es not_active Application Discontinuation
-
2020
- 2020-05-12 AR ARP200101362A patent/AR118922A2/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |