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AR106728A1 - 4-((6-(2-(2,4difluorofenil)-1,1-difluoro-2-hidroxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación - Google Patents

4-((6-(2-(2,4difluorofenil)-1,1-difluoro-2-hidroxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación

Info

Publication number
AR106728A1
AR106728A1 ARP160103514A ARP160103514A AR106728A1 AR 106728 A1 AR106728 A1 AR 106728A1 AR P160103514 A ARP160103514 A AR P160103514A AR P160103514 A ARP160103514 A AR P160103514A AR 106728 A1 AR106728 A1 AR 106728A1
Authority
AR
Argentina
Prior art keywords
propil
hidroxi
piridin
oxi
triazol
Prior art date
Application number
ARP160103514A
Other languages
English (en)
Inventor
Whiteker Gregory
Ryan Sarah
Hao Yan
Yang Qiang
Original Assignee
Viamet Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Inc filed Critical Viamet Pharmaceuticals Inc
Publication of AR106728A1 publication Critical patent/AR106728A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un método para preparar un compuesto de fórmula (1) que comprende el paso de poner en contacto un compuesto de fórmula (2) con un haluro de trialquilsulfoxonio, una base, y 1H-1,2,4-triazol.
ARP160103514A 2015-11-17 2016-11-17 4-((6-(2-(2,4difluorofenil)-1,1-difluoro-2-hidroxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación AR106728A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562256531P 2015-11-17 2015-11-17

Publications (1)

Publication Number Publication Date
AR106728A1 true AR106728A1 (es) 2018-02-14

Family

ID=58717854

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103514A AR106728A1 (es) 2015-11-17 2016-11-17 4-((6-(2-(2,4difluorofenil)-1,1-difluoro-2-hidroxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación

Country Status (12)

Country Link
US (2) US20180370946A1 (es)
EP (1) EP3377475A4 (es)
JP (1) JP6898340B2 (es)
KR (1) KR20180101342A (es)
CN (1) CN108473443A (es)
AR (1) AR106728A1 (es)
BR (1) BR112018009931A8 (es)
CA (1) CA3005862A1 (es)
IL (1) IL259440B (es)
TW (1) TWI636049B (es)
WO (1) WO2017087643A1 (es)
ZA (1) ZA201803747B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016021282A8 (pt) 2014-03-19 2021-07-20 The Us Secretary Department Of Health & Human Services processos para a preparação de compostos antifúngicos e os referidos compostos
AU2015231234B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119745B1 (en) 2014-03-19 2020-08-05 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP6633539B2 (ja) 2014-03-19 2020-01-22 ダウ アグロサイエンシィズ エルエルシー ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換−ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程
AU2015231216B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP6518683B2 (ja) 2014-03-19 2019-05-22 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 抗真菌化合物の調製方法
US9914726B2 (en) 2014-03-19 2018-03-13 Vps-3, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
AU2015231220B2 (en) 2014-03-19 2019-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Antifungal compound process
JP2017514790A (ja) 2014-03-19 2017-06-08 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
AU2016323782B2 (en) 2015-09-18 2020-11-26 Nqp 1598, Ltd. Antifungal compound process
KR20180100114A (ko) * 2015-11-17 2018-09-07 다우 아그로사이언시즈 엘엘씨 4-((6-(2-(2,4-디플루오로페닐)-1,1-디플루오로-2-히드록시-3-(1h-1,2,4-트리아졸-1-일)프로필)피리딘-3-일)옥시)벤조니트릴 및 제조방법
CN108473463A (zh) * 2015-11-17 2018-08-31 美国陶氏益农公司 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-羟基-3-(1h-1,2,4-三唑-1-基)丙基)吡啶-3-基)氧基)苄腈以及制备方法
BR112021017650A2 (pt) * 2019-03-06 2021-11-16 Corteva Agriscience Llc Composto de difluoro-(2-hidroxipropil) piridina como um fungicida para sigatoka negra

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3839170A1 (de) * 1988-11-19 1990-05-31 Bayer Ag Cyclopropyl-substituierte azolylmethylcarbinole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4987144A (en) * 1989-05-02 1991-01-22 Ss Pharmaceutical Co., Ltd. 1,3-bis(1,2,4-triazol-1-yl)2-(4-trifluoromethylphenyl)propan-2-ol useful for the prevention and/or treatment of deep-seated mycosis
JP2630877B2 (ja) * 1990-08-24 1997-07-16 持田製薬株式会社 光学活性なトリアゾール誘導体および組成物
TW211006B (es) * 1990-08-24 1993-08-11 Mochida Pharm Co Ltd
US5710280A (en) * 1996-07-09 1998-01-20 Development Center For Biotechnology Preparation of fluconazole and pharmaceutically acceptable salts thereof
JP3622882B2 (ja) * 1996-10-04 2005-02-23 三共株式会社 トリアゾール誘導体を含有する医薬
KR100194945B1 (ko) * 1997-01-29 1999-06-15 서치영 플루코나졸의 제조방법
KR20030029878A (ko) * 2000-08-30 2003-04-16 다우 아그로사이언시즈 엘엘씨 살충제로서 유용한 화합물, 살비제로서 유용한 화합물 및,이들의 사용방법 및 제조방법
CZ20022642A3 (cs) * 2001-08-27 2003-09-17 Pfizer Products Inc. Způsob výroby dialkylpyridylboranů
US6884892B2 (en) * 2002-06-20 2005-04-26 Sumitomo Chemical Company, Limited Production methods of epoxytriazole derivative and intermediate therefor
CN101094847B (zh) * 2004-11-02 2011-06-15 Msdk.K.公司 芳氧基取代的苯并咪唑衍生物
US7994331B2 (en) * 2005-07-13 2011-08-09 Msd K.K. Heterocycle-substituted benzimidazole derivative
JP4990783B2 (ja) * 2005-09-30 2012-08-01 Ｍｓｄ株式会社 ２−ヘテロアリール置換インドール誘導体
EA201490038A1 (ru) 2011-06-19 2014-04-30 Вайамет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
KR20180095108A (ko) 2011-06-19 2018-08-24 비아멧 파마슈티컬즈(엔씨), 인코포레이티드 금속효소 억제제 화합물
JP6223329B2 (ja) 2011-06-23 2017-11-01 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素化合物
JP6387401B2 (ja) * 2013-05-28 2018-09-05 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 殺真菌組成物
JP6633539B2 (ja) * 2014-03-19 2020-01-22 ダウ アグロサイエンシィズ エルエルシー ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換−ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程
US9914726B2 (en) * 2014-03-19 2018-03-13 Vps-3, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
WO2015150947A1 (en) * 2014-03-29 2015-10-08 Wockhardt Limited A process for the preparation of isavuconazole and its intermediates
US9719857B2 (en) * 2014-12-31 2017-08-01 Thermo Scientific Portable Analytical Instruments Inc. Laser induced breakdown spectroscopy sample chamber
JP6908533B2 (ja) * 2015-05-18 2021-07-28 マイコヴィア ファーマシューティカルズ，インコーポレイテッド 抗真菌性化合物
CN108473463A (zh) * 2015-11-17 2018-08-31 美国陶氏益农公司 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-羟基-3-(1h-1,2,4-三唑-1-基)丙基)吡啶-3-基)氧基)苄腈以及制备方法
KR20180100114A (ko) * 2015-11-17 2018-09-07 다우 아그로사이언시즈 엘엘씨 4-((6-(2-(2,4-디플루오로페닐)-1,1-디플루오로-2-히드록시-3-(1h-1,2,4-트리아졸-1-일)프로필)피리딘-3-일)옥시)벤조니트릴 및 제조방법
US20190276430A1 (en) * 2016-11-18 2019-09-12 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
US20190276429A1 (en) * 2016-11-18 2019-09-12 Dow Agrosciencesllc 4-(6-(2-(2,4-difluorophenyl)-1.1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation

Also Published As

Publication number Publication date
US20190382369A1 (en) 2019-12-19
US20180370946A1 (en) 2018-12-27
CN108473443A (zh) 2018-08-31
JP6898340B2 (ja) 2021-07-07
JP2018538366A (ja) 2018-12-27
IL259440B (en) 2021-07-29
IL259440A (en) 2018-07-31
CA3005862A1 (en) 2017-05-26
WO2017087643A1 (en) 2017-05-26
ZA201803747B (en) 2019-03-27
BR112018009931A2 (pt) 2018-11-06
EP3377475A1 (en) 2018-09-26
KR20180101342A (ko) 2018-09-12
BR112018009931A8 (pt) 2019-02-26
EP3377475A4 (en) 2019-04-10
TWI636049B (zh) 2018-09-21
TW201726649A (zh) 2017-08-01

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