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MX2019011789A - 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. - Google Patents

2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.

Info

Publication number
MX2019011789A
MX2019011789A MX2019011789A MX2019011789A MX2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A
Authority
MX
Mexico
Prior art keywords
difluorophenyl
difluoro
pyridin
substituted
ols
Prior art date
Application number
MX2019011789A
Other languages
English (en)
Other versions
MX382905B (es
Inventor
Deamicis Carl
Zhu Yuanming
Knueppel Daniel
Whiteker Greg
Choy Nakyen
Renga Jim
J Hoekstra William
T Sullenberger Michael
D Gustafson Gary
Original Assignee
Viamet Pharmaceuticals Nc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Nc Inc filed Critical Viamet Pharmaceuticals Nc Inc
Publication of MX2019011789A publication Critical patent/MX2019011789A/es
Publication of MX382905B publication Critical patent/MX382905B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se proporcionan 2-(2,4-difluorofenil)-1,1-difluoro- 1-(5-sustituido-piridin-2-iI)-3-(1H-tetrazol-1-il)propan-2-oles y 1-(2,4-difluorofenil)-2,2-difluoro-2-(5-sustituido-piridin-2-il)e tanonas y procesos para su preparación.
MX2019011789A 2014-03-19 2015-03-19 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. MX382905B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461955680P 2014-03-19 2014-03-19
PCT/US2015/021527 WO2015143192A1 (en) 2014-03-19 2015-03-19 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation

Publications (2)

Publication Number Publication Date
MX2019011789A true MX2019011789A (es) 2019-11-18
MX382905B MX382905B (es) 2025-03-13

Family

ID=54145334

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016012060A MX2016012060A (es) 2014-03-19 2015-03-19 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.
MX2019011789A MX382905B (es) 2014-03-19 2015-03-19 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016012060A MX2016012060A (es) 2014-03-19 2015-03-19 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.

Country Status (11)

Country Link
US (2) US9988365B2 (es)
EP (1) EP3119756B9 (es)
JP (1) JP6633539B2 (es)
KR (1) KR102441243B1 (es)
CN (2) CN109678791B (es)
BR (1) BR112016021260B1 (es)
CA (1) CA2942982C (es)
IL (1) IL247832B (es)
MX (2) MX2016012060A (es)
WO (1) WO2015143192A1 (es)
ZA (1) ZA201606386B (es)

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Publication number Publication date
KR102441243B1 (ko) 2022-09-07
CN106132947A (zh) 2016-11-16
IL247832A0 (en) 2016-11-30
EP3119756A4 (en) 2017-09-20
EP3119756B1 (en) 2021-04-21
EP3119756B9 (en) 2021-08-25
JP2017507982A (ja) 2017-03-23
MX2016012060A (es) 2017-01-19
ZA201606386B (en) 2020-01-29
CN109678791B (zh) 2022-07-01
MX382905B (es) 2025-03-13
CN109678791A (zh) 2019-04-26
CA2942982C (en) 2023-09-19
US9988365B2 (en) 2018-06-05
US10301283B2 (en) 2019-05-28
JP6633539B2 (ja) 2020-01-22
US20180155324A1 (en) 2018-06-07
CA2942982A1 (en) 2015-09-24
CN106132947B (zh) 2019-08-09
KR20160133446A (ko) 2016-11-22
WO2015143192A1 (en) 2015-09-24
US20170158667A1 (en) 2017-06-08
BR112016021260B1 (pt) 2020-05-26
EP3119756A1 (en) 2017-01-25
IL247832B (en) 2019-10-31

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