AR104934A1 - Moduladores de receptores nucleares - Google Patents
Moduladores de receptores nuclearesInfo
- Publication number
- AR104934A1 AR104934A1 ARP160101700A ARP160101700A AR104934A1 AR 104934 A1 AR104934 A1 AR 104934A1 AR P160101700 A ARP160101700 A AR P160101700A AR P160101700 A ARP160101700 A AR P160101700A AR 104934 A1 AR104934 A1 AR 104934A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- independently
- cycloalkyl
- cra
- Prior art date
Links
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 11
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente solicitud se refiere a compuestos y sales farmacéuticamente aceptables de los mismos útiles para tratar trastornos inmunológicos. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), una sal farmacéuticamente aceptable, o un estereoisómero del mismo, donde W es C o CRᵃ, L¹ está conectado a W o Y; y A y E son en forma independiente C o N con la condición de que no son ambos N; V es CR³ o N; X es CRᵃ, NRᵃ, N, ó O; Y es C, CRᵃ, NRᵃ, N, O ó S; Z es CR³ o N; o W es N o NRᵃ, L¹ está conectado a W o Y; y A y E son en forma independiente C o N con la condición de que no son ambos N; V es CR³ o N; X es CRᵃ, NRᵃ, o N; Y es C, CRᵃ, o N; Z es CR³ o N; o Cy es un anillo aromático, heteroaromático o parcialmente saturado de seis miembros sustituido con R¹ y R²; L¹ es -CH(Rᵇ)-, -C(Rᵇ)(Rᵈ)-, -C(O)- o -N(Rᶜ)-; L² es -C(O)-, -O-, -C(Rᵇ)(Rᵈ)-, -S-, -S(O)-, -S(O)₂-; R¹ y R² son en forma independiente halo, -O-C₁₋₃ alquilo, -O-C₃₋₆ cicloalquilo, C₃₋₆ cicloalquilo opcionalmente sustituido, o -C₁₋₃ alquilo; cada R³ es en forma independiente H, CF₃, CN, halo, -C(=O)C₁₋₃ alquilo, -C(O)N(Rᵉ)₂, -NRᵉCORᵉ, -OCHF₂, OCF₃, -O-C₁₋₃ alquilo, -O-C₃₋₆ cicloalquilo, -S-C₁₋₃ alquilo, C₁₋₆ alquilo opcionalmente sustituido, C₃₋₆ cicloalquilo opcionalmente sustituido, heteroarilo opcionalmente sustituido o heterociclo opcionalmente sustituido; R⁴ es H, -OH, C₁₋₆ alquilo opcionalmente sustituido, -NR⁵R⁶, C₃₋₆ cicloalquilo opcionalmente sustituido o -(CH₂)ₘ-heterociclo opcionalmente sustituido; donde R⁵ es H o -C₁₋₃ alquilo, y R⁶ es C₁₋₄ alquilo opcionalmente sustituido, C₃₋₆ cicloalquilo opcionalmente sustituido o -(CH₂)ₘ-heterociclo opcionalmente sustituido; o R⁵ y R⁶, junto con el átomo de nitrógeno al que están unidos, forman un heterociclo opcionalmente sustituido; cada Rᵃ es en forma independiente H, -C(O)CH₃, C₁₋₆ alquilo opcionalmente sustituido, C₃₋₆ cicloalquilo opcionalmente sustituido o -S(O)₂-fenilo; cada Rᵇ es en forma independiente H, F, OH, -O-C₁₋₃ alquilo, o C₁₋₃ alquilo; Rᶜ es en forma independiente H o -C₁₋₃ alquilo; cada Rᵈ es en forma independiente H, F, o C₁₋₃ alquilo; o Rᵈ y Rᵇ forman un C₃₋₅ espirociclo; Rᵉ es en forma independiente H o -C₁₋₃ alquilo; y m es en forma independiente 0 ó 1; con la condición de que no más que dos de A, E, W, X e Y son N.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2015/001693 WO2016198908A1 (en) | 2015-06-09 | 2015-06-09 | Ror nuclear receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104934A1 true AR104934A1 (es) | 2017-08-23 |
Family
ID=54293273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101700A AR104934A1 (es) | 2015-06-09 | 2016-06-08 | Moduladores de receptores nucleares |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR104934A1 (es) |
| PE (1) | PE20181020A1 (es) |
| WO (1) | WO2016198908A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108689942B (zh) * | 2017-04-11 | 2023-06-09 | 广东东阳光药业有限公司 | 含氮双环化合物及其制备方法和用途 |
| US11427596B2 (en) * | 2019-07-19 | 2022-08-30 | Indian Institute of Technology Indore | Metal-free solvent-free synthesis of fused-pyrido heterocycles and biomedical applications |
| UA130303C2 (uk) | 2019-12-06 | 2026-01-14 | Вертекс Фармасьютикалз Інкорпорейтед | Заміщені тетрагідрофурани як модулятори натрієвих каналів |
| AU2021251335A1 (en) | 2020-04-06 | 2022-10-27 | Basf Se | Imidazo-pyrimidone compounds as pesticides |
| MX2023014378A (es) | 2021-06-04 | 2023-12-15 | Vertex Pharma | N-(hidroxialquil(hetero)aril)tetrahidrofurano carboxamidas como moduladores de canales de sodio. |
| EP4578856A1 (en) | 2022-09-30 | 2025-07-02 | Ubience Inc. | Heterocyclic compound |
| CN116283753A (zh) * | 2023-03-20 | 2023-06-23 | 武汉朗克环境科技有限公司 | 一种三氟甲基吡啶酰胺衍生物及其制备方法和应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070129334A1 (en) | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
| ATE521599T1 (de) | 2001-12-21 | 2011-09-15 | X Ceptor Therapeutics Inc | Heterocyclische modulatoren von nukleären rezeptoren |
| CA2509565A1 (en) | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds |
| US7312215B2 (en) | 2003-07-29 | 2007-12-25 | Bristol-Myers Squibb Company | Benzimidazole C-2 heterocycles as kinase inhibitors |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| EP1761521A1 (en) | 2004-06-24 | 2007-03-14 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
| WO2006050076A1 (en) | 2004-10-29 | 2006-05-11 | Janssen Pharmaceutica, N.V. | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
| PL1807072T3 (pl) | 2004-10-29 | 2009-06-30 | Lilly Co Eli | Cykloalkilowe pochodne laktamów jako inhibitory 11-ß-HSD1 |
| US8026257B2 (en) | 2007-07-11 | 2011-09-27 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in CNS disorders |
| SG10201407409WA (en) | 2009-02-06 | 2015-01-29 | Elan Pharm Inc | Inhibitors of jun n-terminal kinase |
| NZ598269A (en) | 2009-09-18 | 2014-12-24 | Zalicus Pharmaceuticals Ltd | Aryl sulphone derivatives as calcium channel blockers |
| US8466186B2 (en) * | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| EP2487159A1 (en) * | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| US8513419B2 (en) | 2011-07-25 | 2013-08-20 | Allergan, Inc. | N-(imidazolidin-2-ylidene)-heterocyclopenta[b]pyridine derivatives as modulators of alpha 2 adrenergic receptors |
| WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
| US9957271B2 (en) | 2011-10-20 | 2018-05-01 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
| EP2647628A1 (en) | 2012-04-02 | 2013-10-09 | Almirall, S.A. | Substituted tricyclic compounds with activity towards ep1 receptors |
| WO2014026328A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof |
| CN105531274A (zh) * | 2013-09-11 | 2016-04-27 | 豪夫迈·罗氏有限公司 | 作为RORc调节剂的酮-咪唑并吡啶衍生物 |
-
2015
- 2015-06-09 WO PCT/IB2015/001693 patent/WO2016198908A1/en not_active Ceased
-
2016
- 2016-06-08 AR ARP160101700A patent/AR104934A1/es unknown
- 2016-06-08 PE PE2017002535A patent/PE20181020A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016198908A1 (en) | 2016-12-15 |
| PE20181020A1 (es) | 2018-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |