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MX2018007415A - Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida. - Google Patents

Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida.

Info

Publication number
MX2018007415A
MX2018007415A MX2018007415A MX2018007415A MX2018007415A MX 2018007415 A MX2018007415 A MX 2018007415A MX 2018007415 A MX2018007415 A MX 2018007415A MX 2018007415 A MX2018007415 A MX 2018007415A MX 2018007415 A MX2018007415 A MX 2018007415A
Authority
MX
Mexico
Prior art keywords
methods
dihidro
phenylbenzo
isoquinolin
ami
Prior art date
Application number
MX2018007415A
Other languages
English (en)
Other versions
MX385672B (es
Inventor
P Reed David
Bates Craig
Mao Jianmin
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of MX2018007415A publication Critical patent/MX2018007415A/es
Publication of MX385672B publication Critical patent/MX385672B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a métodos para preparar el Compuesto A: o una sal del mismo, y una sal diclorhidrato del Compuesto A polimórfica.
MX2018007415A 2015-12-17 2016-12-16 Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituida. MX385672B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562268758P 2015-12-17 2015-12-17
PCT/US2016/067161 WO2017106639A1 (en) 2015-12-17 2016-12-16 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

Publications (2)

Publication Number Publication Date
MX2018007415A true MX2018007415A (es) 2018-11-09
MX385672B MX385672B (es) 2025-03-18

Family

ID=59057623

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020012771A MX2020012771A (es) 2015-12-17 2016-12-16 Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida.
MX2018007415A MX385672B (es) 2015-12-17 2016-12-16 Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituida.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020012771A MX2020012771A (es) 2015-12-17 2016-12-16 Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida.

Country Status (16)

Country Link
US (4) US9834519B2 (es)
EP (2) EP3390368A4 (es)
JP (2) JP6940504B2 (es)
KR (1) KR20180085814A (es)
CN (2) CN114874149A (es)
AU (2) AU2016369520B2 (es)
BR (1) BR112018012325A2 (es)
CA (1) CA3006077A1 (es)
EA (1) EA201891431A1 (es)
HK (1) HK1255014A1 (es)
IL (1) IL259557A (es)
MX (2) MX2020012771A (es)
NZ (1) NZ742785A (es)
SG (1) SG11201804601TA (es)
TW (1) TWI748972B (es)
WO (1) WO2017106639A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201804601TA (en) 2015-12-17 2018-07-30 Arqule Inc Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
US9981921B2 (en) * 2015-12-17 2018-05-29 Arqule, Inc. Solid forms of substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds
CN110669015A (zh) * 2018-07-03 2020-01-10 上海喀露蓝科技有限公司 一种fgfr抑制剂的制备方法
US10878412B2 (en) * 2019-05-13 2020-12-29 Truist Bank In-line verification of transactions
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US6057329A (en) * 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
JP4932735B2 (ja) 2004-12-17 2012-05-16 アムジエン・インコーポレーテツド アミノピリミジン化合物および使用方法
ES2656496T3 (es) 2006-12-29 2018-02-27 Rigel Pharmaceuticals, Inc. Triazoles sustituidos útiles como inhibidores de AXL
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
DK2379506T3 (en) * 2008-12-30 2015-12-14 Arqule Inc Substituted 5,6-dihydro-6-phenylbenzo [f] isoquinolin-2-amine compounds
EP2643314B1 (en) 2010-11-25 2016-07-13 ratiopharm GmbH Novel salts and polymorphic forms of afatinib
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
US10703798B2 (en) * 2014-03-31 2020-07-07 Debiopharm International Sa Methods of cancer therapy by inhibiting fusion polypeptides comprising fibroblast growth factor receptor 2 (FGFR2) and vinculin (VCL)
SG11201804601TA (en) 2015-12-17 2018-07-30 Arqule Inc Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
US9981921B2 (en) 2015-12-17 2018-05-29 Arqule, Inc. Solid forms of substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds

Also Published As

Publication number Publication date
JP6940504B2 (ja) 2021-09-29
US10093632B2 (en) 2018-10-09
SG11201804601TA (en) 2018-07-30
US20170174637A1 (en) 2017-06-22
MX2020012771A (es) 2022-10-04
US20190241527A1 (en) 2019-08-08
US10766868B2 (en) 2020-09-08
MX385672B (es) 2025-03-18
WO2017106639A1 (en) 2017-06-22
AU2021202610A1 (en) 2021-05-27
HK1255014A1 (zh) 2019-08-02
US11279679B2 (en) 2022-03-22
US20200102276A1 (en) 2020-04-02
AU2016369520A1 (en) 2018-06-07
KR20180085814A (ko) 2018-07-27
EP4015508A1 (en) 2022-06-22
AU2016369520B2 (en) 2021-02-18
AU2021202610B2 (en) 2022-06-02
CN114874149A (zh) 2022-08-09
CN108602779A (zh) 2018-09-28
TWI748972B (zh) 2021-12-11
US20180065937A1 (en) 2018-03-08
JP2021191782A (ja) 2021-12-16
EP3390368A4 (en) 2019-07-03
IL259557A (en) 2018-07-31
EA201891431A1 (ru) 2018-11-30
NZ742785A (en) 2023-06-30
US9834519B2 (en) 2017-12-05
TW201733992A (zh) 2017-10-01
BR112018012325A2 (pt) 2018-12-04
JP2018537495A (ja) 2018-12-20
CA3006077A1 (en) 2017-06-22
EP3390368A1 (en) 2018-10-24

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