AR093903A1 - Coagonistas de glucagon y glp-1 para el tratamiento de la obesidad - Google Patents
Coagonistas de glucagon y glp-1 para el tratamiento de la obesidadInfo
- Publication number
- AR093903A1 AR093903A1 ARP130104612A ARP130104612A AR093903A1 AR 093903 A1 AR093903 A1 AR 093903A1 AR P130104612 A ARP130104612 A AR P130104612A AR P130104612 A ARP130104612 A AR P130104612A AR 093903 A1 AR093903 A1 AR 093903A1
- Authority
- AR
- Argentina
- Prior art keywords
- glucagon
- glp
- obesity
- treatment
- coagonists
- Prior art date
Links
- 108060003199 Glucagon Proteins 0.000 title abstract 2
- 208000008589 Obesity Diseases 0.000 title abstract 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 2
- 229960004666 glucagon Drugs 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 title 1
- 102000051325 Glucagon Human genes 0.000 title 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title 1
- 102100040918 Pro-glucagon Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102400000321 Glucagon Human genes 0.000 abstract 1
- 108010088406 Glucagon-Like Peptides Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Child & Adolescent Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Péptidos agonistas de GLP-1 (péptido similar a glucagón) / glucagón para el tratamiento de enfermedades metabólicas, por ejemplo, obesidad. Reivindicación 1: Un péptido aislado caracterizado porque comprende la secuencia de aminoácidos: HX²QGTFTSDX¹⁰SX¹²X¹³LX¹⁵X¹⁶X¹⁷X¹⁸AX²⁰X²¹FX²³X²⁴WLX²⁷X²⁸GX³⁰ en donde X² es G o S, X¹⁰ es Y o K, X¹² es K, E, R, o S, X¹³ es K o Y, X¹⁵ es D o E, X¹⁶ es S o G, X¹⁷ es E, R, Q, o K, X¹⁸ es R, S, o A, X²⁰ es R, K, o Q, X²¹ es D o E, X²³ es V o I, X²⁴ es A o Q, X²⁷ es E o V, X²⁸ es A o K, y X³⁰ es G o R (SEQ ID Nº 4).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261735823P | 2012-12-11 | 2012-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR093903A1 true AR093903A1 (es) | 2015-06-24 |
Family
ID=50588751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130104612A AR093903A1 (es) | 2012-12-11 | 2013-12-10 | Coagonistas de glucagon y glp-1 para el tratamiento de la obesidad |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US9765130B2 (es) |
| EP (2) | EP3495380B1 (es) |
| JP (1) | JP6490011B2 (es) |
| KR (1) | KR102080366B1 (es) |
| CN (2) | CN104822699B (es) |
| AR (1) | AR093903A1 (es) |
| AU (3) | AU2013356934C1 (es) |
| BR (1) | BR112015012238B1 (es) |
| CA (1) | CA2893445C (es) |
| CY (2) | CY1121114T1 (es) |
| DK (2) | DK3495380T3 (es) |
| ES (2) | ES2698329T3 (es) |
| HR (2) | HRP20181678T1 (es) |
| HU (1) | HUE039952T2 (es) |
| LT (2) | LT3495380T (es) |
| MX (2) | MX388904B (es) |
| PL (2) | PL2931745T3 (es) |
| PT (2) | PT2931745T (es) |
| RS (2) | RS63305B1 (es) |
| RU (2) | RU2671088C2 (es) |
| SG (2) | SG10201801159WA (es) |
| SI (2) | SI2931745T1 (es) |
| SM (2) | SMT201800611T1 (es) |
| TR (1) | TR201815172T4 (es) |
| TW (2) | TWI674270B (es) |
| WO (1) | WO2014091316A2 (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| TWI674270B (zh) * | 2012-12-11 | 2019-10-11 | 英商梅迪繆思有限公司 | 用於治療肥胖之升糖素與glp-1共促效劑 |
| MX2015008114A (es) | 2012-12-21 | 2015-11-06 | Sanofi Sa | Derivados de exendina-4. |
| EP3238734A1 (en) * | 2013-03-14 | 2017-11-01 | Medimmune Limited | Pegylated glucagon and glp-1 co-agonists for the treatment of obesity |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／升糖素受體促效劑 |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| CN106519015B (zh) * | 2014-09-23 | 2020-04-17 | 深圳市图微安创科技开发有限公司 | 胃泌酸调节素类似物 |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| WO2016198628A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| TWI622596B (zh) * | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| CN113546159B (zh) * | 2015-12-29 | 2023-09-08 | 派格生物医药(苏州)股份有限公司 | 包含glp-1受体激动剂和胰高血糖素受体激动剂的组合物及其用途 |
| TWI793069B (zh) | 2016-03-10 | 2023-02-21 | 英商梅迪繆思有限公司 | 升糖素及ｇｌｐ－１共促效劑於治療肥胖之用途 |
| WO2017210099A1 (en) * | 2016-06-02 | 2017-12-07 | Indiana University Research And Technology Corporation | Glucagon-t3 conjugates |
| CN107281471A (zh) * | 2017-06-26 | 2017-10-24 | 中国药科大学 | 一种改构的胰高血糖素样肽－1及其修饰物的应用 |
| WO2019085772A1 (zh) * | 2017-11-06 | 2019-05-09 | 深圳市图微安创科技开发有限公司 | 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗胆汁性肝硬化 |
| TWI770085B (zh) * | 2017-11-21 | 2022-07-11 | 日商武田藥品工業股份有限公司 | 胜肽化合物 |
| WO2019193576A1 (en) | 2018-04-05 | 2019-10-10 | Sun Pharmaceutical Industries Limited | Novel glp-1 analogues |
| EP3882263A4 (en) * | 2018-11-12 | 2022-08-31 | Tianjin Institute Of Pharmaceutical Research Co., Ltd. | GLUCAGON DERIVED PEPTIDE AND USE THEREOF |
| EA202193102A1 (ru) | 2019-05-21 | 2022-02-17 | Медиммун Лимитед | Инъекционные совместные составы на основе циклодекстрина, содержащие ингибиторы sglt2 и инкретиновые пептиды |
| CR20220046A (es) | 2019-07-01 | 2022-03-24 | Medimmune Ltd | Composiciones farmacéuticas para péptidos co-agonistas de glucagón y glp-1 |
| CN110845601B (zh) * | 2019-10-12 | 2021-01-19 | 广东药科大学 | 不同构型的glp-1类似肽修饰二聚体及其制备方法在治疗ii型糖尿病中的应用 |
| EP4069720A4 (en) * | 2019-12-03 | 2023-12-27 | MedImmune, LLC | COMBINATION THERAPY WITH GLUCAGON AND GLP-1 CO-AGONISTS FOR THE TREATMENT OF OBESITY |
| TW202140061A (zh) | 2020-01-10 | 2021-11-01 | 英商梅迪繆思有限公司 | 用於治療２型糖尿病中的慢性腎病和糖尿病性腎病的升糖素及ｇｌｐ－１協同促效劑 |
| CN113493503B (zh) * | 2020-04-08 | 2022-08-05 | 浙江道尔生物科技有限公司 | 一种肠促胰岛素类似物及其制备方法和用途 |
| MX2022013230A (es) | 2020-04-24 | 2022-11-14 | Boehringer Ingelheim Int | Analogos de glucagon como agonistas de accion prolongada del receptor de glp-1/glucagon para usarse en el tratamiento de enfermedad del higado graso y esteatohepatitis. |
| TW202313974A (zh) | 2021-06-08 | 2023-04-01 | 瑞典商阿斯特捷利康公司 | 用於治療肝病之組合療法 |
| KR20240043778A (ko) | 2021-07-30 | 2024-04-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 장시간-작용하는 glp1/글루카곤 수용체 작용제를 위한 용량 용법 |
| TW202346323A (zh) | 2022-02-07 | 2023-12-01 | 英商梅迪繆思有限公司 | 具有改善的生物穩定性的ｇｌｐ—１及升糖素雙重激動肽 |
| JP2025537202A (ja) * | 2022-11-03 | 2025-11-14 | イーフィル バイオサイエンス インコーポレーテッド | Ｇｌｐ－１受容体作動薬とａｃａｔ阻害剤とを含む組成物（関連出願との相互参照） 本出願は、２０２２年１１月３日に出願され、参照により本明細書に組み込まれる、米国仮出願第６３／３８２，２８７号の優先権を主張するものである。 |
| WO2024123812A1 (en) * | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| CN115975057B (zh) * | 2023-03-16 | 2023-05-16 | 杭州信海医药科技有限公司 | 一种可妥度肽的固相合成方法 |
| WO2024252366A1 (en) | 2023-06-09 | 2024-12-12 | Sun Pharmaceutical Industries Limited | Glp-1/gip dual, glp-1/gcg dual and glp-1/gip/gcg triple receptor agonists |
| WO2025024788A1 (en) * | 2023-07-27 | 2025-01-30 | Biomedit, Llc | Stabilized glp-1 peptides and dual agonist peptides against glp-1r and gipr and methods of use thereof |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
| WO2025242620A1 (en) | 2024-05-20 | 2025-11-27 | Medimmune Limited | Polypeptide combinations and uses thereof |
| CN118787658B (zh) * | 2024-06-14 | 2025-01-21 | 中国农业大学 | 一种胰高血糖素样肽-1受体特异性核酸适配体在代谢疾病干预中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US30326A (en) * | 1860-10-09 | Steam-g-eneratob | ||
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
| WO2004022004A2 (en) * | 2002-09-06 | 2004-03-18 | Bayer Pharmaceuticals Corporation | Modified glp-1 receptor agonists and their pharmacological methods of use |
| CN1938334A (zh) * | 2004-01-30 | 2007-03-28 | 瓦拉塔药品公司 | Glp－1激动剂和胃泌素化合物的联合使用 |
| DE102004043153B4 (de) * | 2004-09-03 | 2013-11-21 | Philipps-Universität Marburg | Erfindung betreffend GLP-1 und Exendin |
| JP2009504681A (ja) * | 2005-08-11 | 2009-02-05 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 選択可能な特性を有するハイブリッドポリペプチド |
| CN1935846A (zh) * | 2005-09-14 | 2007-03-28 | 王庆华 | 一种用于治疗糖尿病的融合蛋白及其制备方法和应用 |
| AU2008266448B2 (en) | 2007-06-21 | 2013-06-13 | Technische Universitat Munchen | Biological active proteins having increased in vivo and/or vitro stability |
| ES2558155T3 (es) * | 2007-10-30 | 2016-02-02 | Indiana University Research And Technology Corporation | Compuestos que muestran actividad antagonista de glucacón y agonista de GLP-1 |
| PE20120914A1 (es) | 2009-06-16 | 2012-08-22 | Univ Indiana Res & Tech Corp | Compuestos glucagon activo de receptor de gip |
| CN103079587B (zh) * | 2010-05-13 | 2016-05-11 | 印第安纳大学研究及科技有限公司 | 呈现核激素受体活性的胰高血糖素超家族肽 |
| TWI674270B (zh) * | 2012-12-11 | 2019-10-11 | 英商梅迪繆思有限公司 | 用於治療肥胖之升糖素與glp-1共促效劑 |
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2013
- 2013-12-05 TW TW107102837A patent/TWI674270B/zh active
- 2013-12-05 TW TW102144692A patent/TWI617574B/zh active
- 2013-12-10 PT PT13849992T patent/PT2931745T/pt unknown
- 2013-12-10 SM SM20180611T patent/SMT201800611T1/it unknown
- 2013-12-10 RU RU2015127780A patent/RU2671088C2/ru active
- 2013-12-10 BR BR112015012238-8A patent/BR112015012238B1/pt active IP Right Grant
- 2013-12-10 PT PT181822743T patent/PT3495380T/pt unknown
- 2013-12-10 PL PL13849992T patent/PL2931745T3/pl unknown
- 2013-12-10 MX MX2019006260A patent/MX388904B/es unknown
- 2013-12-10 HR HRP20181678TT patent/HRP20181678T1/hr unknown
- 2013-12-10 US US14/650,469 patent/US9765130B2/en active Active
- 2013-12-10 HU HUE13849992A patent/HUE039952T2/hu unknown
- 2013-12-10 RS RS20220574A patent/RS63305B1/sr unknown
- 2013-12-10 DK DK18182274.3T patent/DK3495380T3/da active
- 2013-12-10 EP EP18182274.3A patent/EP3495380B1/en active Active
- 2013-12-10 RS RS20181267A patent/RS57899B1/sr unknown
- 2013-12-10 LT LTEP18182274.3T patent/LT3495380T/lt unknown
- 2013-12-10 HR HRP20220734TT patent/HRP20220734T1/hr unknown
- 2013-12-10 ES ES13849992T patent/ES2698329T3/es active Active
- 2013-12-10 JP JP2015546105A patent/JP6490011B2/ja active Active
- 2013-12-10 RU RU2018137842A patent/RU2018137842A/ru unknown
- 2013-12-10 KR KR1020157015139A patent/KR102080366B1/ko active Active
- 2013-12-10 LT LTEP13849992.6T patent/LT2931745T/lt unknown
- 2013-12-10 AU AU2013356934A patent/AU2013356934C1/en not_active Ceased
- 2013-12-10 MX MX2015006568A patent/MX365458B/es active IP Right Grant
- 2013-12-10 WO PCT/IB2013/003191 patent/WO2014091316A2/en not_active Ceased
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