AR093787A1 - Derivados de aminociclobutano, su metodo de preparacion y su uso como medicamentos - Google Patents
Derivados de aminociclobutano, su metodo de preparacion y su uso como medicamentosInfo
- Publication number
- AR093787A1 AR093787A1 ARP130104484A ARP130104484A AR093787A1 AR 093787 A1 AR093787 A1 AR 093787A1 AR P130104484 A ARP130104484 A AR P130104484A AR P130104484 A ARP130104484 A AR P130104484A AR 093787 A1 AR093787 A1 AR 093787A1
- Authority
- AR
- Argentina
- Prior art keywords
- trans
- amino
- diethyl
- cyclobutancarboxamide
- atom
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052731 fluorine Chemical group 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052801 chlorine Chemical group 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- KZZKOVLJUKWSKX-UHFFFAOYSA-N cyclobutanamine Chemical class NC1CCC1 KZZKOVLJUKWSKX-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a derivados de aminociclobutano particularmente como antagonistas de los receptores de NMDA, su aplicación en terapia para seres humanos y su método de preparación. Estos compuestos corresponden a la fórmula general (1), donde: X¹ representa un átomo de hidrógeno o átomo de flúor; X² es un átomo de hidrógeno o átomo de flúor o átomo de cloro; R¹ representa un átomo de hidrógeno o átomo de flúor o átomo de cloro o un grupo metilo o grupo metoxi o grupo ciano; R² representa independientemente o en forma conjunta un grupo metilo o un grupo etilo. Reivindicación 3: El compuesto de acuerdo con cualquiera de las reivindicaciones 1 ó 2, caracterizado porque se selecciona entre los siguientes compuestos: trans-3-amino-N,N-dietil-1-fenilciclobutancarboxamida, trans-3-amino-N,N-dimetil-1-fenilciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(2-fluorofenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(3-metoxifenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(3-fluorofenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(3-clorofenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(3-metilfenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(3-cianofenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(2-flúor-3-clorofenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(2,5-difluorofenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(3,5-difluorofenil)-ciclobutancarboxamida, trans-3-amino-N,N-dietil-1-(3,5-diclorofenil)-ciclobutancarboxamida.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1261621A FR2998892B1 (fr) | 2012-12-04 | 2012-12-04 | Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR093787A1 true AR093787A1 (es) | 2015-06-24 |
Family
ID=48128432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130104484A AR093787A1 (es) | 2012-12-04 | 2013-12-04 | Derivados de aminociclobutano, su metodo de preparacion y su uso como medicamentos |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US9469601B2 (es) |
| EP (1) | EP2928861B1 (es) |
| JP (1) | JP6391586B2 (es) |
| KR (1) | KR102221928B1 (es) |
| CN (2) | CN106957285B (es) |
| AR (1) | AR093787A1 (es) |
| AU (1) | AU2013354133B2 (es) |
| BR (1) | BR112015012752B1 (es) |
| CA (1) | CA2893216C (es) |
| CY (1) | CY1118841T1 (es) |
| DK (1) | DK2928861T3 (es) |
| ES (1) | ES2621896T3 (es) |
| FR (1) | FR2998892B1 (es) |
| HR (1) | HRP20170564T1 (es) |
| IL (1) | IL239146A (es) |
| LT (1) | LT2928861T (es) |
| MA (1) | MA38229B1 (es) |
| MX (1) | MX364556B (es) |
| MY (1) | MY179886A (es) |
| NZ (1) | NZ709572A (es) |
| PL (1) | PL2928861T3 (es) |
| PT (1) | PT2928861T (es) |
| RS (1) | RS55916B1 (es) |
| RU (1) | RU2655919C2 (es) |
| SA (1) | SA515360518B1 (es) |
| SI (1) | SI2928861T1 (es) |
| TN (1) | TN2015000240A1 (es) |
| TW (1) | TWI603947B (es) |
| UA (1) | UA114017C2 (es) |
| WO (1) | WO2014086825A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202003519A (zh) | 2018-03-28 | 2020-01-16 | 日商武田藥品工業股份有限公司 | 雜環化合物及其用途 |
| JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| WO2021098732A1 (zh) * | 2019-11-18 | 2021-05-27 | 江苏恩华药业股份有限公司 | 一种1',2'-二氢-3'h-螺[环丁烷1,4'-异喹啉]-3'-酮衍生物及其应用 |
| CN115353489A (zh) * | 2021-05-17 | 2022-11-18 | 苏州恩华生物医药科技有限公司 | 一种氘代酰胺类衍生物及其应用 |
| CN116425677A (zh) * | 2022-01-11 | 2023-07-14 | 苏州恩华生物医药科技有限公司 | 氨基环丁烷衍生物的盐、其晶型及其制备方法和应用 |
| CN116715632B (zh) * | 2022-03-07 | 2025-09-30 | 苏州恩华生物医药科技有限公司 | 螺[环丁烷1,4′-异喹啉]酮类衍生物顺反异构体的制备方法 |
| CN119143701B (zh) * | 2023-06-16 | 2025-11-18 | 北京大学 | 一种[2.1.1]桥环内酯单体和可回收聚酯及其制备方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133924A (en) * | 1960-05-31 | 1964-05-19 | Bristol Myers Co | Amino-substituted cyclobutane carboxamides |
| FR2581059B1 (fr) * | 1985-04-25 | 1988-04-22 | Pf Medicament | Procede de preparation du chlorhydrate de phenyl-1 diethyl amino carbonyl-1 aminomethyl-2 cyclopropane (z) |
| EP0747348A4 (en) * | 1994-02-22 | 1999-07-07 | Asahi Chemical Ind | AMINOALKYLCYCLOPROPAN DERIVATIVES |
| US6197830B1 (en) | 1995-09-22 | 2001-03-06 | Bruce M. Frome | Method for achieving relief from sympathetically mediated pain |
| ES2241055T3 (es) | 1996-08-23 | 2005-10-16 | Endo Pharmaceuticals Inc | Composicion que contiene un anticonvulsionante para tratar el dolor neuropatico. |
| BR9812162A (pt) | 1997-09-08 | 2000-07-18 | Warner Lambert Co | Composições analgésicas compreendendo compostos antiepiléticos e métodos para o uso das mesmas |
| US6118017A (en) * | 1998-04-14 | 2000-09-12 | Smithkline Beecham Corporation | Substituted-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylcyanocyclobutan-1-one |
| BR9912827A (pt) | 1998-07-16 | 2001-05-02 | Sloan Kettering Inst Cancer | Composições tópicas compreendendo um analgésico opióide e um antagonista de nmda |
| US6362201B1 (en) | 1999-03-02 | 2002-03-26 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
| US7820688B2 (en) | 2001-04-27 | 2010-10-26 | Memorial Sloan-Kettering Cancer Center | Topical anesthetic/opioid formulations and uses thereof |
| AU2003210486B2 (en) | 2002-01-16 | 2007-06-28 | Endo Pharmaceuticals Inc. | Pharmaceutical composition and method for treating disorders of the central nervous system |
| TW200307539A (en) * | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| US7687080B2 (en) | 2002-11-25 | 2010-03-30 | Taraxos Inc. | Treatment of neuropathy |
| US7709472B2 (en) | 2005-01-25 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
| US8212043B2 (en) | 2007-02-01 | 2012-07-03 | Janssen R&D Ireland | Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV |
| AU2008245662A1 (en) * | 2007-04-26 | 2008-11-06 | Auspex Pharmaceuticals, Inc. | Deuterium labelled ketamine |
| CA2697739A1 (en) | 2007-08-27 | 2009-03-05 | Wyeth Llc | Compositions and methods employing nmda antagonists for achieving an anesthetic-sparing effect |
| HRP20120944T1 (hr) | 2007-11-28 | 2012-12-31 | Astellas Pharma Inc. | Kondenzirani spoj indana |
| US8722714B2 (en) | 2008-01-16 | 2014-05-13 | The Honk Kong University of Science and Technology | Oxazolidine derivatives as NMDA antagonists |
| EP2334176A4 (en) | 2008-09-27 | 2012-05-02 | Taraxos Inc | TOPICAL FORMULATIONS FOR THE TREATMENT OF NERVE DISEASES |
| TW201026667A (en) | 2008-09-30 | 2010-07-16 | Merz Pharma Gmbh & Co Kgaa | Glycine b antagonists |
| FR2943666B1 (fr) | 2009-03-31 | 2011-04-15 | Commissariat Energie Atomique | Metallophore derive de nicotianamine et ses procedes de fabrication |
| FR2944011B1 (fr) * | 2009-04-03 | 2011-05-20 | Pf Medicament | Derives d'aminocyclobutane ou d'aminocyclobutene, leur procede de preparation et leur utilisation a titre de medicaments. |
| CA2759951C (en) * | 2009-05-07 | 2017-05-02 | Gruenenthal Gmbh | Substituted phenylureas and phenylamides as vanilloid receptor ligands |
| FR2946535B1 (fr) | 2009-06-10 | 2011-09-09 | Neureva | Composition comprenant une molecule favorisant l'interaction neurone-glie, notamment pour prevenir la formation de la cicatrice gliale et induire la regeneration neurale. |
| TWI544923B (zh) | 2009-12-29 | 2016-08-11 | 何應瑞 | 用於治療神經退化性疾病之醫藥組合物 |
-
2012
- 2012-12-04 FR FR1261621A patent/FR2998892B1/fr not_active Expired - Fee Related
-
2013
- 2013-12-03 TW TW102144198A patent/TWI603947B/zh not_active IP Right Cessation
- 2013-12-04 CN CN201710102368.2A patent/CN106957285B/zh not_active Expired - Fee Related
- 2013-12-04 MY MYPI2015701784A patent/MY179886A/en unknown
- 2013-12-04 AR ARP130104484A patent/AR093787A1/es not_active Application Discontinuation
- 2013-12-04 CN CN201380063117.8A patent/CN104854083B/zh not_active Expired - Fee Related
- 2013-12-04 RU RU2015126104A patent/RU2655919C2/ru active
- 2013-12-04 MA MA38229A patent/MA38229B1/fr unknown
- 2013-12-04 CA CA2893216A patent/CA2893216C/fr active Active
- 2013-12-04 NZ NZ709572A patent/NZ709572A/en not_active IP Right Cessation
- 2013-12-04 DK DK13811402.0T patent/DK2928861T3/en active
- 2013-12-04 JP JP2015545991A patent/JP6391586B2/ja active Active
- 2013-12-04 SI SI201330607A patent/SI2928861T1/sl unknown
- 2013-12-04 KR KR1020157017845A patent/KR102221928B1/ko not_active Expired - Fee Related
- 2013-12-04 MX MX2015006686A patent/MX364556B/es active IP Right Grant
- 2013-12-04 BR BR112015012752-5A patent/BR112015012752B1/pt not_active IP Right Cessation
- 2013-12-04 ES ES13811402.0T patent/ES2621896T3/es active Active
- 2013-12-04 WO PCT/EP2013/075481 patent/WO2014086825A1/fr not_active Ceased
- 2013-12-04 HR HRP20170564TT patent/HRP20170564T1/hr unknown
- 2013-12-04 LT LTEP13811402.0T patent/LT2928861T/lt unknown
- 2013-12-04 US US14/649,448 patent/US9469601B2/en active Active
- 2013-12-04 AU AU2013354133A patent/AU2013354133B2/en not_active Ceased
- 2013-12-04 EP EP13811402.0A patent/EP2928861B1/fr active Active
- 2013-12-04 RS RS20170379A patent/RS55916B1/sr unknown
- 2013-12-04 UA UAA201506431A patent/UA114017C2/uk unknown
- 2013-12-04 PL PL13811402T patent/PL2928861T3/pl unknown
- 2013-12-04 PT PT138114020T patent/PT2928861T/pt unknown
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2015
- 2015-06-02 IL IL239146A patent/IL239146A/en active IP Right Grant
- 2015-06-02 TN TNP2015000240A patent/TN2015000240A1/fr unknown
- 2015-06-03 SA SA515360518A patent/SA515360518B1/ar unknown
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2016
- 2016-09-12 US US15/262,885 patent/US9687459B2/en active Active
-
2017
- 2017-04-06 CY CY20171100409T patent/CY1118841T1/el unknown
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Legal Events
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| FC | Refusal |