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AR091726A1 - Metodo para la preparacion de 2,4-dihidroxibutirato - Google Patents

Metodo para la preparacion de 2,4-dihidroxibutirato

Info

Publication number
AR091726A1
AR091726A1 ARP130102456A AR091726A1 AR 091726 A1 AR091726 A1 AR 091726A1 AR P130102456 A ARP130102456 A AR P130102456A AR 091726 A1 AR091726 A1 AR 091726A1
Authority
AR
Argentina
Prior art keywords
homoserine
dehydrogenase
dhb
ohb
hydroxybutyrate
Prior art date
Application number
Other languages
English (en)
Inventor
Marie Francois Jean
Huet Robert
Dressaire Clementine
Cordier Helene
Walther Thomas
Original Assignee
Adisseo France Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adisseo France Sas filed Critical Adisseo France Sas
Publication of AR091726A1 publication Critical patent/AR091726A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01028—D-Lactate dehydrogenase (1.1.1.28)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01037—Malate dehydrogenase (1.1.1.37)
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01082—Malate dehydrogenase (NADP+) (1.1.1.82)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01272—(R)-2-Hydroxyacid dehydrogenase (1.1.1.272)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01299—Malate dehydrogenase (NAD(P)+)(1.1.1.299)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01001—Aspartate transaminase (2.6.1.1), i.e. aspartate-aminotransferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01042—Branched-chain-amino-acid transaminase (2.6.1.42)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01057—Aromatic-amino-acid transaminase (2.6.1.57)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente se refiere a un método para la preparación de ácido 2,4-dihidroxibutírico a partir de homoserina, que comprende una primera etapa de conversión del grupo amino primario de homoserina en un grupo carbonilo para obtener 2-oxo-4-hidroxibutirato y una segunda etapa de reducción del 2-oxo-4-hidroxibutirato (OHB) obtenido a 2,4-dihidroxibutirato. Reivindicación 3: El método de acuerdo con la reivindicación 1 ó 2, caracterizado porque la primera etapa es catalizada por una enzima que tiene actividad de homoserina transaminasa, homoserina deshidrogenasa u homoserina oxidasa, respectivamente. Reivindicación 19: Un método de producción de 2,4-DHB que comprende las etapas de: cultivar el microorganismo modificado de acuerdo con cualquiera de las reivindicaciones 11 a 18 en un medio de cultivo apropiado, recuperar 2,4-DHB del medio de cultivo. Reivindicación 22: Uso de cualquiera de las enzimas que tiene actividad de (L)-lactato deshidrogenasa, (L)-malato deshidrogenasa o 2-hidroxiácido deshidrogenasa para transformar el OHB en 2,4-DHB.
ARP130102456 2012-07-11 2013-07-11 Metodo para la preparacion de 2,4-dihidroxibutirato AR091726A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261670405P 2012-07-11 2012-07-11

Publications (1)

Publication Number Publication Date
AR091726A1 true AR091726A1 (es) 2015-02-25

Family

ID=48748274

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130102456 AR091726A1 (es) 2012-07-11 2013-07-11 Metodo para la preparacion de 2,4-dihidroxibutirato

Country Status (11)

Country Link
US (2) US10570422B2 (es)
EP (1) EP2872640B1 (es)
JP (1) JP6293746B2 (es)
KR (1) KR102093172B1 (es)
CN (1) CN104471069B (es)
AR (1) AR091726A1 (es)
BR (1) BR112015000534B1 (es)
ES (1) ES2800341T3 (es)
IN (1) IN2014DN10637A (es)
RU (1) RU2645260C2 (es)
WO (1) WO2014009435A1 (es)

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EP3155111A1 (en) * 2014-06-16 2017-04-19 Invista Technologies S.à r.l. Process for producing glutarate and glutaric acid methyl ester
US10385322B2 (en) 2014-10-03 2019-08-20 Metabolic Explorer Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
WO2016162442A1 (en) 2015-04-07 2016-10-13 Metabolic Explorer A modified microorganism for the optimized production of 2,4-dihydroxyburyrate with enhanced 2,4-dihydroxybutyrate efflux
WO2016162712A1 (en) 2015-04-07 2016-10-13 Metabolic Explorer Modified microorganism for the optimized production of 2,4-dihydroxyburyrate
MX389370B (es) 2015-06-04 2025-03-20 Basf Se Microorganismo recombinante para la produccion mejorada de quimicos finos.
WO2016198529A1 (en) * 2015-06-12 2016-12-15 Basf Se Recombinant microorganism for improved production of alanine
EP3313808A4 (en) 2015-06-25 2019-02-13 Dynamic Food Ingredients Corporation PROCESS FOR PREPARING 2,4-DIHYDROXYBUTYLIC ACID
WO2019013573A2 (ko) * 2017-07-12 2019-01-17 울산과학기술원 2-히드록시 감마 부티로락톤 또는 2, 4-디히드록시 -부티레이트 의 제조 방법
CN107312737A (zh) * 2017-07-25 2017-11-03 北京理工大学 一种重组大肠杆菌、制备方法及合成3,4‑二羟基丁酸的方法
EP3470512A1 (en) 2017-10-10 2019-04-17 Metabolic Explorer Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
CN108866017B (zh) * 2018-08-24 2020-07-03 浙江华睿生物技术有限公司 一种酶法制备β-羟基-β-甲基丁酸的方法
KR20220012847A (ko) 2019-04-25 2022-02-04 자이모켐 인코포레이티드 재생가능한 공급원으로부터 화학물질의 생산
CN110577961B (zh) * 2019-09-23 2021-05-04 安徽师范大学 一种热稳定性苹果酸脱氢酶基因的构建方法、编码蛋白及其应用
DE102021101004B3 (de) 2021-01-19 2022-03-10 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges
CN113106029A (zh) * 2021-04-20 2021-07-13 南京工业大学 一种过表达aro8基因的酿酒酵母工程菌及其构建方法与应用
CN119256092A (zh) * 2022-05-23 2025-01-03 加利福尼亚大学董事会 新的碳固定途径
CN115948482B (zh) * 2023-02-07 2024-02-09 中国科学院天津工业生物技术研究所 一种2，4-二羟基丁酸生物合成途径的构建方法及应用
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CN118894912B (zh) * 2023-05-04 2025-06-27 安徽华恒生物科技股份有限公司 一种RthB蛋白突变体及其在异亮氨酸生产中的应用

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Also Published As

Publication number Publication date
EP2872640B1 (en) 2020-03-25
KR20150035726A (ko) 2015-04-07
JP2015524253A (ja) 2015-08-24
RU2645260C2 (ru) 2018-02-19
BR112015000534A2 (pt) 2017-12-19
JP6293746B2 (ja) 2018-03-14
RU2014153354A (ru) 2016-08-27
BR112015000534B1 (pt) 2023-02-28
US10570422B2 (en) 2020-02-25
ES2800341T3 (es) 2020-12-29
US11505811B2 (en) 2022-11-22
US20150147793A1 (en) 2015-05-28
WO2014009435A1 (en) 2014-01-16
EP2872640A1 (en) 2015-05-20
IN2014DN10637A (es) 2015-09-11
US20200131542A1 (en) 2020-04-30
CN104471069B (zh) 2018-06-01
KR102093172B1 (ko) 2020-03-25
CN104471069A (zh) 2015-03-25
BR112015000534A8 (pt) 2023-01-03

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