AR099288A1 - Proteínas de fusión de interleucina-10 - Google Patents
Proteínas de fusión de interleucina-10Info
- Publication number
- AR099288A1 AR099288A1 ARP150100324A ARP150100324A AR099288A1 AR 099288 A1 AR099288 A1 AR 099288A1 AR P150100324 A ARP150100324 A AR P150100324A AR P150100324 A ARP150100324 A AR P150100324A AR 099288 A1 AR099288 A1 AR 099288A1
- Authority
- AR
- Argentina
- Prior art keywords
- mutant
- fusion proteins
- molecule
- refers
- treatment
- Prior art date
Links
- 230000004927 fusion Effects 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 abstract 5
- 108020001507 fusion proteins Proteins 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004551 Interleukin-10 Receptors Human genes 0.000 abstract 1
- 108010017550 Interleukin-10 Receptors Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Más particularmente, se refiere a proteínas de fusión de anticuerpos e IL-10 mutante que muestra propiedades mejoradas para su uso como agentes terapéuticos, por ejemplo, en el tratamiento de enfermedades inflamatorias. Además, la presente se refiere a polinucleótidos que codifican dichas proteínas de fusión, y a vectores y células hospedadoras que comprenden dichos polinucleótidos. Se refiere además a métodos para producir las proteínas de fusión de la presente, y a métodos de uso en el tratamiento de enfermedades. Reivindicación 1: Una proteína de fusión de un anticuerpo de clase IgG y una molécula de IL-10 mutante, en la que la proteína de fusión comprende dos polipéptidos de cadena pesada idénticos y dos polipéptidos de cadena ligera idénticos, y en la que la molécula de IL-10 mutante comprende una mutación de aminoácidos que reduce la afinidad de unión de la molécula de IL-10 mutante al receptor de IL-10, en comparación con una molécula de IL-10 de tipo silvestre.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461936642P | 2014-02-06 | 2014-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR099288A1 true AR099288A1 (es) | 2016-07-13 |
Family
ID=52440687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150100324A AR099288A1 (es) | 2014-02-06 | 2015-02-05 | Proteínas de fusión de interleucina-10 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20150218244A1 (es) |
| EP (1) | EP3102594A1 (es) |
| JP (3) | JP2017506075A (es) |
| KR (1) | KR20160117463A (es) |
| CN (1) | CN106061997A (es) |
| AR (1) | AR099288A1 (es) |
| BR (1) | BR112016016658A2 (es) |
| CA (1) | CA2935665A1 (es) |
| MX (1) | MX2016010174A (es) |
| RU (1) | RU2016135788A (es) |
| TW (1) | TW201613954A (es) |
| WO (1) | WO2015117930A1 (es) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013301656A1 (en) | 2012-08-08 | 2015-01-15 | Roche Glycart Ag | Interleukin-10 fusion proteins and uses thereof |
| PL3489256T3 (pl) | 2014-11-14 | 2021-08-23 | F. Hoffmann-La Roche Ag | Cząsteczki wiążące antygen zawierające trimer liganda z rodziny TNF |
| CA2966776C (en) | 2014-12-19 | 2021-05-04 | Alkermes, Inc. | Single chain fc fusion proteins |
| EP3973980A1 (en) | 2015-03-31 | 2022-03-30 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a trimeric tnf family ligand |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| CN115594765A (zh) | 2015-10-02 | 2023-01-13 | 豪夫迈·罗氏有限公司（Ch） | 对共刺激性tnf受体特异性的双特异性抗体 |
| BR112018010937A2 (pt) * | 2015-12-04 | 2018-12-04 | Novartis Ag | composições de anticorpos enxertados com citocina e métodos de uso para imunorregulação |
| CA3026393C (en) | 2016-06-22 | 2023-03-14 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
| IL266827B2 (en) | 2016-11-28 | 2025-04-01 | Chugai Pharmaceutical Co Ltd | Ligand binding molecule with tunable ligand binding activity, its fusion protein with a ligand, pharmaceutical compositions containing them, and method for their production |
| BR112019008727A2 (pt) | 2016-11-28 | 2019-07-16 | Chugai Seiyaku Kabushiki Kaisha | domínio de ligação ao antígeno, e polipeptídeo incluindo seção de transporte |
| CN112142859A (zh) * | 2017-05-22 | 2020-12-29 | 杭州博虎生物科技有限公司 | 一种人白细胞介素10-Fc融合蛋白及其编码基因与应用 |
| EA201992765A1 (ru) | 2017-05-24 | 2020-03-25 | Новартис Аг | Белки на основе антител с привитым цитокином и способы их применения в лечении рака |
| PE20250757A1 (es) | 2017-08-03 | 2025-03-13 | Amgen Inc | Muteinas de interleucina 21 y metodos de tratamiento |
| EP3688023B1 (en) * | 2017-09-25 | 2025-08-27 | Shihuida Pharmaceutical Group (Jilin) Co., Ltd. | Methods and compositions for cancer treatment |
| CA3079844A1 (en) * | 2017-11-10 | 2019-05-16 | Armo Biosciences, Inc. | Compositions and methods of use of interleukin-10 in combination with immune checkpoint pathway inhibitors |
| TWI818934B (zh) | 2017-11-28 | 2023-10-21 | 日商中外製藥股份有限公司 | 可調整配體結合活性的配體結合分子 |
| SG11202004897XA (en) | 2017-11-28 | 2020-06-29 | Chugai Pharmaceutical Co Ltd | Polypeptide including antigen-binding domain and carrying section |
| KR20200110358A (ko) | 2018-01-12 | 2020-09-23 | 암젠 인크 | 항-pd-1 항체 및 치료 방법 |
| AU2019321449A1 (en) * | 2018-08-15 | 2021-04-01 | The Regents Of The University Of California | IL-10 inhibition for vaccines and immunotherapy |
| WO2020070035A1 (en) * | 2018-10-01 | 2020-04-09 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecules with trivalent binding to cd40 |
| US20220009986A1 (en) * | 2018-10-19 | 2022-01-13 | Ambrx, Inc. | Interleukin-10 polypeptide conjugates, dimers thereof, and their uses |
| CN111989340B (zh) * | 2018-11-18 | 2025-07-15 | 杭州博虎生物科技有限公司 | 一种重组人白细胞介素-10融合蛋白及其应用 |
| US12006345B2 (en) | 2019-02-21 | 2024-06-11 | Xencor, Inc. | Untargeted and targeted IL-10 Fc-fusion proteins |
| JP2022524018A (ja) * | 2019-03-06 | 2022-04-27 | デカ バイオサイエンシーズ， インコーポレイテッド | Ｉｌ－１０バリアント分子ならびに炎症性疾患および腫瘍を処置する方法 |
| EP3969907B1 (en) * | 2019-05-13 | 2025-09-24 | F. Hoffmann-La Roche AG | Interference-suppressed pharmacokinetic immunoassay |
| JP2022537515A (ja) * | 2019-06-10 | 2022-08-26 | アポロミクス インコーポレイテッド（ハンジョウ） | 抗体－インターロイキン融合タンパク質および使用方法 |
| EP3998282A4 (en) * | 2019-07-08 | 2023-08-09 | Progen Co., Ltd. | NEW FUSION PROTEIN AND ITS USE |
| CN112625137B (zh) * | 2019-10-08 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种人白细胞介素10-Fc融合蛋白及其医药用途 |
| CN112618698B (zh) * | 2019-10-08 | 2021-10-08 | 北京东方百泰生物科技股份有限公司 | 一种人白细胞介素10-Fc融合蛋白的注射制剂 |
| US11542276B2 (en) | 2019-11-25 | 2023-01-03 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| MX2022008500A (es) * | 2020-01-09 | 2023-03-03 | Deka Biosciences Inc | Método de uso de marcadores genéticos snp y/o indel para determinar capacidad de respuesta a tratamiento con il-10. |
| CN115943210A (zh) * | 2020-01-20 | 2023-04-07 | 中外制药株式会社 | 配体结合融合蛋白 |
| AU2021270563A1 (en) | 2020-05-12 | 2022-12-15 | Regeneron Pharmaceuticals, Inc. | Novel IL10 agonists and methods of use thereof |
| WO2021230460A1 (ko) * | 2020-05-14 | 2021-11-18 | 주식회사 제넥신 | Pd-l1 단백질 및 단량체성 il-10 변이체가 포함된 융합 단백질 및 이의 용도 |
| CA3180304A1 (en) * | 2020-05-28 | 2021-12-02 | Kenan Christopher GARCIA | Engineered interleukin-10 polypeptides and uses thereof |
| IL299149A (en) * | 2020-06-26 | 2023-02-01 | Amgen Inc | IL-10 mutants and their related proteins |
| MX2023000948A (es) | 2020-07-20 | 2023-04-14 | Deka Biosciences Inc | Proteínas de fusión de citocina doble que comprenden interleucina-10 (il-10). |
| CA3204723A1 (en) * | 2020-12-09 | 2022-06-16 | Asher Biotherapeutics, Inc. | Fusions of mutant interleukin-10 polypeptides with antigen binding molecules for modulating immune cell function |
| US20240043490A1 (en) * | 2020-12-09 | 2024-02-08 | Asher Biotherapeutics, Inc. | Targeted cytokine construct for engineered cell therapy |
| CA3201656A1 (en) * | 2020-12-10 | 2022-06-16 | Joint Stock Company "Biocad" | Immunocytokine for activating human il-10ra receptor and use thereof |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| CN116063570A (zh) * | 2021-11-02 | 2023-05-05 | 广东菲鹏制药股份有限公司 | Il10单体融合蛋白及其应用 |
| US20240190934A1 (en) * | 2022-11-28 | 2024-06-13 | Elixiron Immunotherapeutics (hong Kong) Limited | Engineered interleukin-10 and fusion proteins thereof |
| WO2024131600A1 (zh) * | 2022-12-24 | 2024-06-27 | 广东菲鹏制药股份有限公司 | Il10突变体、融合蛋白和药物 |
| WO2024146463A1 (zh) * | 2023-01-03 | 2024-07-11 | 深圳先进技术研究院 | 分泌白介素-10的细菌 |
| AU2024282178A1 (en) * | 2023-06-02 | 2025-11-27 | Synthekine, Inc. | Fused il10 polypeptides |
| WO2025113643A1 (en) * | 2023-12-01 | 2025-06-05 | Gilead Sciences Inc. | Anti-fap-light fusion protein and use thereof |
| TW202535949A (zh) | 2023-12-20 | 2025-09-16 | 美商必治妥美雅史谷比公司 | 靶向IL-18受體β(IL-18RB)之抗體及相關方法 |
| CN121343001A (zh) * | 2024-07-16 | 2026-01-16 | 广东菲鹏制药股份有限公司 | 一种融合蛋白及其用途 |
| CN119331091B (zh) * | 2024-11-06 | 2025-05-13 | 重庆探生科技有限公司 | 一种抗人白介素6的单克隆抗体及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6428985B1 (en) * | 1998-12-02 | 2002-08-06 | The Regents Of The University Of Michigan | Immunosuppressive structural definition of IL-10 |
| CN103172731A (zh) * | 2004-07-15 | 2013-06-26 | 赞科股份有限公司 | 优化的Fc变体 |
| CN101437847A (zh) * | 2006-05-08 | 2009-05-20 | 菲洛根有限公司 | 治疗用靶向细胞因子的抗体 |
| KR101836968B1 (ko) * | 2007-10-30 | 2018-03-12 | 필로겐 에스.피.에이. | 류마티스 관절염과 연관된 항원 |
| WO2010005389A1 (en) * | 2008-07-11 | 2010-01-14 | Forskarpatent I Syd Ab | Oxidized ldl specific antibody-fusion and conjugated proteins |
| CN102227447A (zh) * | 2008-10-02 | 2011-10-26 | 新兴产品开发西雅图有限公司 | Cd86拮抗物多靶点结合蛋白 |
| MA34519B1 (fr) * | 2010-08-13 | 2013-09-02 | Roche Glycart Ag | Anticorps anti-fap et procédés d'utilisation |
| BR112013024574B1 (pt) * | 2011-03-29 | 2022-08-09 | Roche Glycart Ag | Anticorpo e uso do anticorpo |
| EA201892619A1 (ru) * | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| AU2013301656A1 (en) * | 2012-08-08 | 2015-01-15 | Roche Glycart Ag | Interleukin-10 fusion proteins and uses thereof |
-
2015
- 2015-02-03 BR BR112016016658-2A patent/BR112016016658A2/pt not_active Application Discontinuation
- 2015-02-03 CN CN201580006766.3A patent/CN106061997A/zh active Pending
- 2015-02-03 MX MX2016010174A patent/MX2016010174A/es unknown
- 2015-02-03 EP EP15701991.0A patent/EP3102594A1/en not_active Withdrawn
- 2015-02-03 CA CA2935665A patent/CA2935665A1/en not_active Abandoned
- 2015-02-03 JP JP2016550540A patent/JP2017506075A/ja active Pending
- 2015-02-03 KR KR1020167021279A patent/KR20160117463A/ko not_active Withdrawn
- 2015-02-03 RU RU2016135788A patent/RU2016135788A/ru not_active Application Discontinuation
- 2015-02-03 WO PCT/EP2015/052119 patent/WO2015117930A1/en not_active Ceased
- 2015-02-04 US US14/613,987 patent/US20150218244A1/en not_active Abandoned
- 2015-02-05 TW TW104103942A patent/TW201613954A/zh unknown
- 2015-02-05 AR ARP150100324A patent/AR099288A1/es unknown
-
2020
- 2020-01-06 JP JP2020000462A patent/JP2020089371A/ja not_active Withdrawn
-
2022
- 2022-03-15 JP JP2022040084A patent/JP2022095643A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016016658A2 (pt) | 2018-01-23 |
| RU2016135788A3 (es) | 2018-10-12 |
| US20150218244A1 (en) | 2015-08-06 |
| JP2020089371A (ja) | 2020-06-11 |
| JP2022095643A (ja) | 2022-06-28 |
| MX2016010174A (es) | 2016-11-15 |
| JP2017506075A (ja) | 2017-03-02 |
| CN106061997A (zh) | 2016-10-26 |
| KR20160117463A (ko) | 2016-10-10 |
| WO2015117930A1 (en) | 2015-08-13 |
| TW201613954A (en) | 2016-04-16 |
| CA2935665A1 (en) | 2015-08-13 |
| RU2016135788A (ru) | 2018-03-07 |
| EP3102594A1 (en) | 2016-12-14 |
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