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AR099138A1 - Piridinas fusionadas como inhibidores del complejo p97 - Google Patents

Piridinas fusionadas como inhibidores del complejo p97

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Publication number
AR099138A1
AR099138A1 ARP150100150A ARP150100150A AR099138A1 AR 099138 A1 AR099138 A1 AR 099138A1 AR P150100150 A ARP150100150 A AR P150100150A AR P150100150 A ARP150100150 A AR P150100150A AR 099138 A1 AR099138 A1 AR 099138A1
Authority
AR
Argentina
Prior art keywords
independently
group
hydrogen
optionally substituted
ring
Prior art date
Application number
ARP150100150A
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English (en)
Original Assignee
Cleave Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52478057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR099138(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cleave Biosciences Inc filed Critical Cleave Biosciences Inc
Publication of AR099138A1 publication Critical patent/AR099138A1/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

La presente se refiere a ciertas pirimidinas fusionadas que tienen un anillo homo- o hetero-ciclopentilo, ciclohexilo o cicloheptilo como par de fusión de la pirimidina; que tienen un grupo aminobencilo o aminobencilo sustituido en la posición 4 del anillo pirimidina; y un anillo heterobiciclo 5:6 con al menos un N, O ó S en la posición 2 del anillo pirimidina. Estos compuestos son útiles para el tratamiento del cáncer por inhibición del complejo p97. Reivindicación 1: Un compuesto de pirimidina fusionada de fórmula (1), en donde: Y es CR⁴, NH, NR⁵, O ó S y C cuando CR⁴ es un átomo sp³; m y n son cada uno independientemente un número entero de 0 a 4, y la suma de m y n es un número entero de 2, 3 ó 4; Ar es un grupo arilo opcionalmente sustituido; A, D y E son cada uno independientemente C o N, en donde C es un carbono sp² sustituido por hidrógeno o alquilo de 1 a 4 carbonos cuando una de las valencias de C no está designada de otro modo; Z y B son cada uno independientemente CR⁶, N, NR⁷, O ó S, en donde C como CR⁶ es un carbono sp²; R¹, R², R³, R⁴, R⁵, R⁶ y R⁷ se seleccionan cada uno independientemente del grupo que consiste en hidrógeno, un grupo alifático opcionalmente sustituido, un grupo aromático opcionalmente sustituido y un grupo funcional opcionalmente sustituido; con la condición de que; a) al menos uno de D y E sea C; b) al menos uno de A, D, E, Z y B sea distinto de C; c) Z y B no pueden ser ambos simultáneamente cualquiera de NR⁷, O ó S; d) cuando uno de D y E es N y A es C, entonces Z y B son cada uno independientemente CR⁶, N o NR⁷; e) cuando ambos D y E son C y A es N, Z y B son cada uno independientemente CR⁶ o N, pero cuando Y es carbono y R³ es hidrógeno, entonces Z y B no pueden ser ambos CR⁶ y B no puede ser N; f) cuando ambos D y E son C y A es N, Z y B son cada uno independientemente CR⁶ o N, pero cuando ni m ni n es cero y R³ es hidrógeno, entonces Z y B no pueden ser ambos CR⁶ y B no puede ser N; g) cuando D, E y A son todos C, entonces Z y B son cada uno independientemente CR⁶, N, NR⁷, O ó S; h) cuando uno de Z y B es O ó S, entonces el otro es CR⁶ o N, y A, D y E son todos C; i) cuando uno de Z y B es NR⁷, entonces el otro es N o CR⁶, A, D y E son todos C.
ARP150100150A 2014-01-20 2015-01-20 Piridinas fusionadas como inhibidores del complejo p97 AR099138A1 (es)

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US201461929382P 2014-01-20 2014-01-20

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AR099138A1 true AR099138A1 (es) 2016-06-29

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US (2) US9828363B2 (es)
EP (1) EP3097092B1 (es)
JP (1) JP6387111B2 (es)
KR (1) KR101922317B1 (es)
CN (1) CN106458996B (es)
AR (1) AR099138A1 (es)
AU (1) AU2015206292B2 (es)
BR (1) BR112016016421B1 (es)
CA (1) CA2936559C (es)
CL (1) CL2016001840A1 (es)
EA (1) EA031317B1 (es)
ES (1) ES2819867T3 (es)
IL (1) IL246692B (es)
MX (1) MX374379B (es)
NZ (1) NZ722624A (es)
SG (1) SG11201605699QA (es)
TW (1) TWI640516B (es)
WO (1) WO2015109285A1 (es)
ZA (1) ZA201605107B (es)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
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