[go: up one dir, main page]

MX2016002762A - Derivados de fenil-dihidropiridina como inhibidores de aldosterona sintasa. - Google Patents

Derivados de fenil-dihidropiridina como inhibidores de aldosterona sintasa.

Info

Publication number
MX2016002762A
MX2016002762A MX2016002762A MX2016002762A MX2016002762A MX 2016002762 A MX2016002762 A MX 2016002762A MX 2016002762 A MX2016002762 A MX 2016002762A MX 2016002762 A MX2016002762 A MX 2016002762A MX 2016002762 A MX2016002762 A MX 2016002762A
Authority
MX
Mexico
Prior art keywords
inhibitors
phenyl
aldosterone synthase
dihydropyridine derivatives
compounds
Prior art date
Application number
MX2016002762A
Other languages
English (en)
Inventor
Rainer E Martin
Johannes Aebi
Kurt Amrein
Benoit Hornsperger
Bernd Kuhn
Hans P Maerki
Alexander V Mayweg
Xuefei Tan
Robert Britton
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2016002762A publication Critical patent/MX2016002762A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a nuevos compuestos que tienen la fórmula general (I), en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1 y n, son como se describen en la presente, composiciones que incluyen los compuestos y métodos para usar los compuestos.
MX2016002762A 2013-10-17 2014-10-14 Derivados de fenil-dihidropiridina como inhibidores de aldosterona sintasa. MX2016002762A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013085412 2013-10-17
PCT/EP2014/071940 WO2015055602A1 (en) 2013-10-17 2014-10-14 Phenyl-dihydropyridine derivatives as inhibitors of aldosterone synthase

Publications (1)

Publication Number Publication Date
MX2016002762A true MX2016002762A (es) 2016-05-26

Family

ID=51691061

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016002762A MX2016002762A (es) 2013-10-17 2014-10-14 Derivados de fenil-dihidropiridina como inhibidores de aldosterona sintasa.

Country Status (8)

Country Link
US (1) US9636338B2 (es)
EP (1) EP3057940A1 (es)
JP (1) JP6484616B2 (es)
CN (1) CN105531263B (es)
CA (1) CA2918195A1 (es)
MX (1) MX2016002762A (es)
RU (1) RU2016116435A (es)
WO (1) WO2015055602A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109879755A (zh) * 2019-02-22 2019-06-14 江苏南大光电材料股份有限公司 1-乙基环己基（甲基）丙烯酸酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0511621A (pt) * 2004-05-28 2008-01-02 Speedel Experimenta Ag compostos orgánicos
US9353081B2 (en) * 2011-09-23 2016-05-31 Hoffmann-La Roche Inc. Bicyclic dihydroquinoline-2-one derivatives
SI2838883T1 (en) * 2012-04-17 2018-02-28 F. Hoffmann-La Roche Ag New derivatives of phenyl-tetrahydroisoquinoline
US9197429B1 (en) * 2013-05-22 2015-11-24 Google Inc. Reducing size of multicast retry transactions
CA2915788A1 (en) * 2013-10-17 2015-04-23 F. Hoffmann-La Roche Ag New phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors

Also Published As

Publication number Publication date
RU2016116435A (ru) 2017-11-22
WO2015055602A1 (en) 2015-04-23
EP3057940A1 (en) 2016-08-24
JP2016533355A (ja) 2016-10-27
JP6484616B2 (ja) 2019-03-13
CN105531263A (zh) 2016-04-27
CA2918195A1 (en) 2015-04-23
HK1217705A1 (zh) 2017-01-20
US9636338B2 (en) 2017-05-02
US20160221954A1 (en) 2016-08-04
CN105531263B (zh) 2019-08-23

Similar Documents

Publication Publication Date Title
PH12017500658B1 (en) Spirodiamine derivatives as aldosterone synthase inhibitors
PH12014500584A1 (en) New bicyclic dihydroquinoline-2-one derivatives
MY169043A (en) New dihydroquinoline-2-one derivatives
MX343225B (es) Nuevos derivados de aril-benzocicloalquil-amida.
MX2015001099A (es) Nuevos derivados biciclicos de piridina.
PH12017500408A1 (en) Heteroaryl compunds as btk inhibitors and uses thereof
IN2014DN09346A (es)
PH12017502090A1 (en) Heterocyclic amides as kinase inhibitors
PH12015500263A1 (en) New bicyclic derivatives
MX341456B (es) Amino-quinolinas como inhibidores de cinasa.
MY169267A (en) New aryl-quinoline derivatives
MX2014014531A (es) Derivados de aminoquinazolina y piridopirimidina.
MX2015007097A (es) Nuevas fenil-piridinas/pirazinas bi-anulares para el tratamiento de cancer.
PH12015500345A1 (en) Amino-quinolines as kinase inhibitors
PH12015501175A1 (en) Substituted pyridopyrazines as syk inhibitors
MX2015013365A (es) Derivados de urea y su uso como inhibidores de proteina de union de acidos grasos (puag).
MX2013005753A (es) Nuevos derivados de biaril amida.
MX366678B (es) Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona.
MX2015016332A (es) Inhibidores de alk biciclicos fusionados.
MX2015010611A (es) Nuevos derivados de dihidroquinolin-2-ona como inhibidores de la aldosterona-sintasa (citocromo p450, familia 11, subfamilia b, polipeptido 2 (cyp11b2) o citocromo p450, familia 11, subfamilia b, polipeptido 1 (cyp11b1)).
NZ712949A (en) Imidazo-triazine derivatives as pde10 inhibitors
MX2015013374A (es) Derivados de urea y su uso como inhibidores de proteina de uniuon a acidos grasos (puag).
MX2015011005A (es) Derivados de dihidorquinolin-2-ona para usarse como inhibidores de aldoesterona sintasa.
MX2015015058A (es) Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona.
MX2016002762A (es) Derivados de fenil-dihidropiridina como inhibidores de aldosterona sintasa.