AR098508A1 - Soluciones para incrementar la estabilidad y la vida útil de un órgano, y solución de conservación de tejido - Google Patents
Soluciones para incrementar la estabilidad y la vida útil de un órgano, y solución de conservación de tejidoInfo
- Publication number
- AR098508A1 AR098508A1 ARP140104385A ARP140104385A AR098508A1 AR 098508 A1 AR098508 A1 AR 098508A1 AR P140104385 A ARP140104385 A AR P140104385A AR P140104385 A ARP140104385 A AR P140104385A AR 098508 A1 AR098508 A1 AR 098508A1
- Authority
- AR
- Argentina
- Prior art keywords
- solution
- preparation
- arginine
- tissue
- water
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 6
- 238000002360 preparation method Methods 0.000 abstract 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- 108010024636 Glutathione Proteins 0.000 abstract 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 3
- 229930064664 L-arginine Natural products 0.000 abstract 3
- 235000014852 L-arginine Nutrition 0.000 abstract 3
- 229960005070 ascorbic acid Drugs 0.000 abstract 3
- 235000010323 ascorbic acid Nutrition 0.000 abstract 3
- 239000011668 ascorbic acid Substances 0.000 abstract 3
- 239000000162 organ preservation solution Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000003855 balanced salt solution Substances 0.000 abstract 2
- 229960003180 glutathione Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- FADLIXHQWBEYBF-RELJEZBFSA-N (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid Chemical compound N[C@H](C(=O)O)CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O.N[C@@H](CCCNC(N)=N)C(=O)O FADLIXHQWBEYBF-RELJEZBFSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 239000000082 organ preservation Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Reivindicación 1: Un equipo de conservación de órganos compuesto por una primera solución acuosa contenida en un primer recipiente, y una segunda solución contenida en un segundo recipiente, donde la primera solución acuosa está compuesta por una solución salina balanceada, y dicha primera solución tiene un pH de por lo menos 7,0; y donde la segunda solución está compuesta por agua, glutationa reducida, ácido ascórbico, un azúcar, L-Arginina, y dicha segunda solución tiene un pH de alrededor de 5,0 o inferior. Reivindicación 2: El equipo de la reivindicación 1, donde el primer y segundo recipientes son primera y segunda cámaras dentro de un solo recipiente, y la primera y segunda cámaras están divididas entre si por una división, donde, con la eliminación de la división, la primera solución se mezcla con la segunda solución para formar la solución de conservación de tejido y órganos completa. Reivindicación 6: Un método para la preparación de una solución de conservación de tejido u órganos, que comprende: la preparación de una primera solución que comprende la formación de una solución salina balanceada que tiene un pH de 7,6 a alrededor de 8,0; la preparación de una segunda solución compuesta por agua, D-Glucosa, L-Arginina; glutationa y ácido ascórbico, a un pH de alrededor de 3 - 5; y en el punto de uso, la mezcla de la primera solución junto con la segunda solución para formar una solución combinada que tiene un pH de 7,3 ± 0,4. Reivindicación 12: Un método para la preparación de una solución de conservación de tejido u órganos, que comprende: la preparación de una primera solución compuesta por una solución salina balanceada acuosa y un azúcar con un pH de alrededor de 7,6 a 8,0; la preparación de una segunda solución compuesta por agua, L-Arginina glutationa y ácido ascórbico a un pH de alrededor de 3 - 5; y la mezcla de la primera solución junto con la segunda solución. Reivindicación 17: Una solución que consiste en agua, L-Arginina, glutationa, un azúcar, un agente reductor y un agente regulador.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361963093P | 2013-11-22 | 2013-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR098508A1 true AR098508A1 (es) | 2016-06-01 |
Family
ID=52023642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140104385A AR098508A1 (es) | 2013-11-22 | 2014-11-21 | Soluciones para incrementar la estabilidad y la vida útil de un órgano, y solución de conservación de tejido |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11291201B2 (es) |
| EP (1) | EP3027016B1 (es) |
| JP (1) | JP2016537333A (es) |
| KR (2) | KR102428676B1 (es) |
| CN (1) | CN105916374B (es) |
| AR (1) | AR098508A1 (es) |
| AU (1) | AU2014353199B2 (es) |
| BR (1) | BR112016006512B1 (es) |
| CA (1) | CA2923441C (es) |
| CL (1) | CL2016001003A1 (es) |
| CR (1) | CR20160188A (es) |
| DK (1) | DK3027016T3 (es) |
| EA (1) | EA201691066A1 (es) |
| ES (1) | ES2744637T3 (es) |
| IL (1) | IL244834B (es) |
| MX (1) | MX378411B (es) |
| MY (1) | MY181282A (es) |
| PE (1) | PE20160861A1 (es) |
| PH (1) | PH12016500909B1 (es) |
| SG (1) | SG10201709595WA (es) |
| TW (1) | TW201605342A (es) |
| WO (1) | WO2015077199A1 (es) |
| ZA (2) | ZA201602253B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11291201B2 (en) * | 2013-11-22 | 2022-04-05 | Marizyme, Inc. | Solutions for increasing the stability and shelf life of an organ and tissue preservation solution |
| AU2017350817B2 (en) * | 2016-10-25 | 2022-07-21 | Marquette University | Storage media and powder formulations for avulsed teeth and explanted tissues comprising fibroblasts |
| WO2018165327A1 (en) | 2017-03-08 | 2018-09-13 | Alafair Biosciences, Inc. | Hydrogel medium for the storage and preservation of tissue |
| EP4507493A1 (en) | 2022-04-15 | 2025-02-19 | Marizyme, Inc. | Powder formulations and use thereof in medical and/or surgical procedures |
| US20250270515A1 (en) * | 2022-05-16 | 2025-08-28 | Marizyme, Inc. | Use of cytoprotectant formulations in cell or tissue transport and/or storage |
| WO2024076634A1 (en) | 2022-10-04 | 2024-04-11 | Marizyme, Inc. | Kits and use thereof in surgical procedures for endoscopic harvesting of vessels |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4550022A (en) | 1981-10-05 | 1985-10-29 | Alcon Laboratories, Inc. | Tissue irrigating solution |
| US4443432A (en) | 1981-10-05 | 1984-04-17 | Alcon Laboratories, Inc. | Ophthmalic irrigating solution |
| US5409904A (en) | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
| US4879283A (en) | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US4837021A (en) | 1986-12-31 | 1989-06-06 | Laboratoires P.O.S. | Two part tissue irrigating solution |
| US5304724A (en) | 1988-09-09 | 1994-04-19 | Entravision, Inc. | Tissue irrigating solution |
| US4938961A (en) | 1989-04-28 | 1990-07-03 | Geoffrey Collins | Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia |
| US5257985A (en) | 1989-12-04 | 1993-11-02 | Richard Puhl | Multi-chamber intravenous bag apparatus |
| US5066578A (en) * | 1989-12-21 | 1991-11-19 | The Regents Of The University Of California | Long-term preservation of organs for transplantation |
| EP0510185B1 (en) | 1990-11-07 | 1996-12-11 | Baxter International Inc. | Blood platelet storage medium |
| CA2071833C (en) * | 1990-11-07 | 1998-11-03 | Jean-Marc Payrat | Red blood cell storage solution |
| US5498427A (en) | 1990-11-20 | 1996-03-12 | Pasteur Merieux Serums Et Vaccines | Solutions for the perfusion, preservation and reperfusion of organs |
| JP3326177B2 (ja) * | 1992-06-26 | 2002-09-17 | 鳥居薬品株式会社 | 臓器保存液 |
| BE1007500A3 (fr) | 1992-09-18 | 1995-07-18 | Pasteur Merieux Serums Vacc | Solution de perfusion, de conservation et de reperfusion d'organes. |
| ITPD940054A1 (it) | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | Polisaccaridi solfatati |
| JP3623294B2 (ja) | 1995-11-28 | 2005-02-23 | 株式会社新素材総合研究所 | 電解質液が収容された医療用容器及びその製造方法 |
| US8409846B2 (en) * | 1997-09-23 | 2013-04-02 | The United States Of America As Represented By The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
| US6153582A (en) | 1998-11-05 | 2000-11-28 | Bausch & Lomb Surgical, Inc. | Defined serumfree medical solution for ophthalmology |
| US7611830B2 (en) * | 2000-04-10 | 2009-11-03 | The United States Of America As Represented By The Department Of Veteran's Affairs | Device to lavage a blood vessel |
| US6569615B1 (en) | 2000-04-10 | 2003-05-27 | The United States Of America As Represented By The Department Of Veteran's Affairs | Composition and methods for tissue preservation |
| SI21704A (en) | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
| US20060093765A1 (en) | 2004-10-29 | 2006-05-04 | Sealed Air Corporation (Us) | Multi-compartment pouch having a frangible seal |
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| CN105746492A (zh) * | 2007-02-17 | 2016-07-13 | 哈佛学院董事会 | 用于进行组织保存的组合物以及方法 |
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| BRPI0908181A2 (pt) | 2008-02-15 | 2015-08-18 | Harvard College | Solução de cardioplegia para cirurgia cardíaca |
| US8608922B2 (en) | 2008-11-07 | 2013-12-17 | The University Of Connecticut | Biosensor for continuous monitoring of metabolites and proteins and methods of manufacture thereof |
| EP2355806A2 (en) | 2008-11-14 | 2011-08-17 | Profimed s.r.o. | Non-aqueous colloidal formulation |
| US8288084B2 (en) | 2009-07-12 | 2012-10-16 | Revive Organtech, Inc. | Composition and method for flushing and cold/cryo preserving organs, tissues, and cells |
| WO2011026498A1 (en) * | 2009-09-01 | 2011-03-10 | Medovent Gmbh | Chitosan tissue dressing |
| FR2963965B1 (fr) | 2010-08-20 | 2013-02-15 | Vallourec Mannesmann Oil & Gas | Procede et dispositif de controle d'un filetage de joint tubulaire utilise dans l'industrie du petrole |
| MX2015008528A (es) * | 2012-12-31 | 2016-02-10 | Somahlution Llc | Formulaciones para conservacion de organos y tejidos con estabilidad y vida util aumentadas. |
| WO2014109083A1 (ja) * | 2013-01-09 | 2014-07-17 | 三菱マテリアル株式会社 | 電子・電気機器用銅合金、電子・電気機器用銅合金薄板、電子・電気機器用銅合金の製造方法、電子・電気機器用導電部品および端子 |
| WO2014176224A1 (en) | 2013-04-24 | 2014-10-30 | Somahlution, Llc | Organ and tissue preservation solutions having increased oxygen-content, stability and shelf life |
| EP2991481A1 (en) * | 2013-04-29 | 2016-03-09 | Somahlution, LLC | Formulations containing poly (0-2-hydroxyethyl) starch for increasing the oxygen-content, stability and shelf life of an organ and tissue preservation solution |
| US11291201B2 (en) * | 2013-11-22 | 2022-04-05 | Marizyme, Inc. | Solutions for increasing the stability and shelf life of an organ and tissue preservation solution |
-
2014
- 2014-11-18 US US14/906,582 patent/US11291201B2/en active Active
- 2014-11-18 JP JP2016525916A patent/JP2016537333A/ja active Pending
- 2014-11-18 DK DK14812052.0T patent/DK3027016T3/da active
- 2014-11-18 CA CA2923441A patent/CA2923441C/en active Active
- 2014-11-18 CN CN201480061943.3A patent/CN105916374B/zh not_active Expired - Fee Related
- 2014-11-18 ES ES14812052T patent/ES2744637T3/es active Active
- 2014-11-18 EP EP14812052.0A patent/EP3027016B1/en active Active
- 2014-11-18 MX MX2016006651A patent/MX378411B/es unknown
- 2014-11-18 KR KR1020167015581A patent/KR102428676B1/ko active Active
- 2014-11-18 WO PCT/US2014/066054 patent/WO2015077199A1/en not_active Ceased
- 2014-11-18 EA EA201691066A patent/EA201691066A1/ru unknown
- 2014-11-18 KR KR1020227026130A patent/KR102570322B1/ko active Active
- 2014-11-18 MY MYPI2016701801A patent/MY181282A/en unknown
- 2014-11-18 PE PE2016000488A patent/PE20160861A1/es not_active Application Discontinuation
- 2014-11-18 AU AU2014353199A patent/AU2014353199B2/en active Active
- 2014-11-18 SG SG10201709595WA patent/SG10201709595WA/en unknown
- 2014-11-18 BR BR112016006512-3A patent/BR112016006512B1/pt not_active IP Right Cessation
- 2014-11-21 TW TW103140510A patent/TW201605342A/zh unknown
- 2014-11-21 AR ARP140104385A patent/AR098508A1/es active IP Right Grant
-
2016
- 2016-03-30 IL IL244834A patent/IL244834B/en active IP Right Grant
- 2016-04-05 ZA ZA2016/02253A patent/ZA201602253B/en unknown
- 2016-04-22 CR CR20160188A patent/CR20160188A/es unknown
- 2016-04-27 CL CL2016001003A patent/CL2016001003A1/es unknown
- 2016-05-17 PH PH12016500909A patent/PH12016500909B1/en unknown
-
2022
- 2022-03-02 US US17/684,495 patent/US20220232822A1/en active Pending
- 2022-10-04 ZA ZA2022/10899A patent/ZA202210899B/en unknown
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |