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AR096355A1 - Composición odontológica de papaína en gel para el tratamiento atraumático de caries y método para prepararla - Google Patents

Composición odontológica de papaína en gel para el tratamiento atraumático de caries y método para prepararla

Info

Publication number
AR096355A1
AR096355A1 ARP140101998A ARP140101998A AR096355A1 AR 096355 A1 AR096355 A1 AR 096355A1 AR P140101998 A ARP140101998 A AR P140101998A AR P140101998 A ARP140101998 A AR P140101998A AR 096355 A1 AR096355 A1 AR 096355A1
Authority
AR
Argentina
Prior art keywords
papain
caries
gel
dental composition
papaine
Prior art date
Application number
ARP140101998A
Other languages
English (en)
Inventor
Dobboletta Mauricio
Original Assignee
Brix S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brix S R L filed Critical Brix S R L
Priority to ARP140101998A priority Critical patent/AR096355A1/es
Priority to CN201410734129.5A priority patent/CN105078781B/zh
Priority to MX2015000884A priority patent/MX363200B/es
Priority to BR102015001449A priority patent/BR102015001449B8/pt
Priority to EP15796001.4A priority patent/EP3145484B1/en
Priority to US15/312,431 priority patent/US10137178B2/en
Priority to PCT/US2015/031669 priority patent/WO2015179463A1/en
Publication of AR096355A1 publication Critical patent/AR096355A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C5/00—Filling or capping teeth
    • A61C5/60—Devices specially adapted for pressing or mixing capping or filling materials, e.g. amalgam presses
    • A61C5/62—Applicators, e.g. syringes or guns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22002—Papain (3.4.22.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dentistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición odontológica de papaína en gel para el tratamiento atraumático de caries que comprende papaína con una actividad final de por lo menos 3.000 U/mg, en donde la papaína se encuentra bioencapsulada en una mezcla de buffer de pH = 7-poliol de C₁₋₄-pectina-alcanolamina de C₁₋₆-emulsionante no iónico, junto con colorantes, conservantes y solventes farmacéuticamente aceptables. Un método para preparar dicha composición de papaína. Reivindicación 16: La composición según la reivindicación 1, caracterizada porque comprende papaína (30.000 U/mg) 10,00% p/p, pectina cítrica 8,00% p/p, propilenglicol 8,00% p/p, trietanolamina (99%) 0,72% p/p, monoleato de polioxietileno sorbitano con 20 OE (TW 80) 0,50% p/p, KH₂PO₄ 0,0378% p/p, Na₂HPO₄ 0,1283% p/p, azul de toluidina (sol. ac. 1% p/p) 0,09% p/p, metilparabeno 0,10% p/p, propilparabeno 0,05 % p/p, y agua destilada 72,37 % p/p.
ARP140101998A 2014-05-20 2014-05-20 Composición odontológica de papaína en gel para el tratamiento atraumático de caries y método para prepararla AR096355A1 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ARP140101998A AR096355A1 (es) 2014-05-20 2014-05-20 Composición odontológica de papaína en gel para el tratamiento atraumático de caries y método para prepararla
CN201410734129.5A CN105078781B (zh) 2014-05-20 2014-12-04 龋齿的无创伤治疗用的木瓜蛋白酶牙科用凝胶组合物及其制备方法
MX2015000884A MX363200B (es) 2014-05-20 2015-01-20 Composición odontológica de papaína en gel para el tratamiento atraumático de caries y método para prepararla.
BR102015001449A BR102015001449B8 (pt) 2014-05-20 2015-01-22 composição de gel dental de papaína para tratamento não traumático de cáries e método para seu preparo
EP15796001.4A EP3145484B1 (en) 2014-05-20 2015-05-20 Dental gel composition of papain for the atraumatic treatment of caries and method of preparing same
US15/312,431 US10137178B2 (en) 2014-05-20 2015-05-20 Dental gel composition of papain for the atraumatic treatment of caries and method of preparing same
PCT/US2015/031669 WO2015179463A1 (en) 2014-05-20 2015-05-20 Dental gel composition of papain for the atraumatic treatment of caries and method of preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP140101998A AR096355A1 (es) 2014-05-20 2014-05-20 Composición odontológica de papaína en gel para el tratamiento atraumático de caries y método para prepararla

Publications (1)

Publication Number Publication Date
AR096355A1 true AR096355A1 (es) 2015-12-23

Family

ID=54554663

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140101998A AR096355A1 (es) 2014-05-20 2014-05-20 Composición odontológica de papaína en gel para el tratamiento atraumático de caries y método para prepararla

Country Status (7)

Country Link
US (1) US10137178B2 (es)
EP (1) EP3145484B1 (es)
CN (1) CN105078781B (es)
AR (1) AR096355A1 (es)
BR (1) BR102015001449B8 (es)
MX (1) MX363200B (es)
WO (1) WO2015179463A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10873938B2 (en) 2017-10-09 2020-12-22 Qualcomm Incorporated Rate matching for broadcast channels
US11571367B2 (en) * 2018-04-05 2023-02-07 Terrell F. Pannkuk Composition and method for endodontic debridement
US11147747B2 (en) * 2018-04-05 2021-10-19 Terrell F. Pannkuk Composition and method for endodontic debridement
CN109908000A (zh) * 2019-03-15 2019-06-21 朗力生物医药(武汉)有限公司 一种龋齿定向祛腐剂及其制备方法
RU2706010C1 (ru) * 2019-04-17 2019-11-13 Общество с ограниченной ответственностью "АЛЬФА-ДЕНТ" Гель стоматологический
CN113981025B (zh) * 2021-09-24 2023-05-23 闽南师范大学 一种氨基酸酰胺化果胶的制备方法

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
NL104948C (es) * 1952-02-15
US3228844A (en) * 1961-07-24 1966-01-11 Merck & Co Inc Method for reducing incidence of dental caries with vitamin b6
US4986981A (en) * 1986-07-07 1991-01-22 Den Mat Corporation Toothpaste having low abrasion
US6331291B1 (en) * 1996-05-30 2001-12-18 William R. Glace Dentifrice gel/paste compositions
AU773109B2 (en) * 1999-12-23 2004-05-20 Den Mat Corporation Starch thickened non-aqueous dentifrices
US20030003059A1 (en) * 2001-04-03 2003-01-02 Frederic Dana Dentifrice compositions
US6652841B1 (en) * 2002-08-28 2003-11-25 Colgate Palmolive Company Antiplaque enzyme containing dual component composition
WO2004089406A1 (es) * 2003-04-09 2004-10-21 Harold Armando Gomez Torres Composición tópica en forma de gel para el tratamiento de quemaduras de la piel
WO2005020946A1 (en) * 2003-08-28 2005-03-10 Marcia Boucas Chemical composition and process to obtaining of remover product of carious tissue and application of the product
EP1896027A4 (en) * 2005-06-10 2011-11-30 Donald E Scott TOPICAL COMPOSITIONS AND METHODS FOR TREATING OR INHIBITING SYMPTOMS RELATED TO CARPET TUNNEL SYNDROME, SURFACE FLUX, PSORIASIS, CANDLES, FIBROMYALGIA AND DIABETES
US20070275045A1 (en) * 2006-02-28 2007-11-29 Evans Robin D Composition for the treatment of warts and molluscum contagiosum
EP2337544A2 (en) 2007-04-30 2011-06-29 Living Proof, Inc. Use of matrix metalloproteinase inhibitors in skin care
AR085779A1 (es) * 2012-05-09 2013-10-30 Mario Alejandro Quaini Formulacion quimica odontologica removedora de tejido cariado, proceso de elaboracion y forma de aplicacion de la misma
WO2014016644A1 (en) * 2012-07-25 2014-01-30 Miziara Marcia Boucas "chemical composition to obtain a product to remove carious tissue and process to obtain a carious tissue removing product"

Also Published As

Publication number Publication date
MX2015000884A (es) 2015-11-19
BR102015001449B8 (pt) 2021-03-30
US20170100464A1 (en) 2017-04-13
BR102015001449A2 (pt) 2017-05-02
US10137178B2 (en) 2018-11-27
WO2015179463A1 (en) 2015-11-26
EP3145484A4 (en) 2018-01-24
EP3145484B1 (en) 2020-09-30
BR102015001449B1 (pt) 2021-02-17
MX363200B (es) 2019-03-14
EP3145484A1 (en) 2017-03-29
CN105078781A (zh) 2015-11-25
CN105078781B (zh) 2020-10-30

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