AR096165A1 - Síntesis de 3-(5-amino-2-metil-4-oxoquinazolin-3(4h)-il)piperidin-2,6-diona - Google Patents
Síntesis de 3-(5-amino-2-metil-4-oxoquinazolin-3(4h)-il)piperidin-2,6-dionaInfo
- Publication number
- AR096165A1 AR096165A1 ARP140101806A ARP140101806A AR096165A1 AR 096165 A1 AR096165 A1 AR 096165A1 AR P140101806 A ARP140101806 A AR P140101806A AR P140101806 A ARP140101806 A AR P140101806A AR 096165 A1 AR096165 A1 AR 096165A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxoquinazolin
- piperidin
- amino
- dione
- methyl
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- RSNPAKAFCAAMBH-UHFFFAOYSA-N 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione Chemical compound CC1=NC2=CC=CC(N)=C2C(=O)N1C1CCC(=O)NC1=O RSNPAKAFCAAMBH-UHFFFAOYSA-N 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- KHEXQYOPAOPUQQ-UHFFFAOYSA-N 3-(2-methyl-5-nitro-4-oxoquinazolin-3-yl)piperidine-2,6-dione Chemical compound CC1=NC2=CC=CC([N+]([O-])=O)=C2C(=O)N1C1CCC(=O)NC1=O KHEXQYOPAOPUQQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procedimientos para la preparación de 3-(5-amino-2-metil-4-oxoquinazolin-3(4H)-il)piperidin-2,6-diona, o su enantiómero o una mezcla de sus enantiómeros; o su sal, farmacéuticamente aceptable. Reivindicación 1: Un método para preparar 3-(5-amino-2-metil-4-oxoquinazolin-3(4H)-il)piperidin-2,6-diona o un enantiómero o una mezcla de sus enantiómeros; o una de sus sales, solvatos, hidratos o polimorfos farmacéuticamente aceptables; que comprende la etapa de reducir 3-(2-metil-5-nitro-4-oxoquinazolin-3(4H)-il)piperidin-2,6-diona por medio de hidrogenación por transferencia para formar 3-(5-amino-2-metil-4-oxoquinazolin-3(4H)-il)piperidin-2,6-diona o un enantiómero o una mezcla de sus enantiómeros; o una de sus sales, solvatos, hidratos o polimorfos farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361818254P | 2013-05-01 | 2013-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR096165A1 true AR096165A1 (es) | 2015-12-09 |
Family
ID=50885008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101806A AR096165A1 (es) | 2013-05-01 | 2014-04-30 | Síntesis de 3-(5-amino-2-metil-4-oxoquinazolin-3(4h)-il)piperidin-2,6-diona |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US9067912B2 (es) |
| EP (2) | EP2991976B1 (es) |
| JP (2) | JP6490055B2 (es) |
| KR (1) | KR20160003228A (es) |
| CN (2) | CN107935994A (es) |
| AR (1) | AR096165A1 (es) |
| AU (2) | AU2014260011A1 (es) |
| CA (1) | CA2910971A1 (es) |
| CY (1) | CY1119525T1 (es) |
| DK (1) | DK2991976T3 (es) |
| ES (1) | ES2645944T3 (es) |
| HR (1) | HRP20171535T1 (es) |
| HU (1) | HUE034770T2 (es) |
| LT (1) | LT2991976T (es) |
| MX (1) | MX363652B (es) |
| NZ (1) | NZ628322A (es) |
| PH (1) | PH12015502477A1 (es) |
| PL (1) | PL2991976T3 (es) |
| PT (1) | PT2991976T (es) |
| RS (1) | RS56565B1 (es) |
| RU (1) | RU2015151359A (es) |
| SG (1) | SG11201508836XA (es) |
| SI (1) | SI2991976T1 (es) |
| SM (1) | SMT201700513T1 (es) |
| TW (1) | TW201536766A (es) |
| WO (1) | WO2014179416A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102898416A (zh) | 2006-09-26 | 2013-01-30 | 细胞基因公司 | 作为抗肿瘤剂的5-取代的喹唑酮衍生物 |
| SG192946A1 (en) | 2011-03-11 | 2013-09-30 | Celgene Corp | Solid forms of 3-(5-amino-2methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
| CN104755472A (zh) | 2012-09-04 | 2015-07-01 | 细胞基因公司 | 3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4h)-基)哌啶-2,6-二酮的同位素体及其制备方法 |
| BR112017028530A2 (pt) | 2015-07-02 | 2018-08-28 | Celgene Corp | terapia combinada para tratamento de cânceres hematológicos e tumores sólidos |
| CN106083622B (zh) * | 2016-06-16 | 2018-06-19 | 常州齐晖药业有限公司 | 一种甲苯咪唑中间体3,4-二氨基二苯甲酮的制备方法 |
| US20180258064A1 (en) * | 2017-03-07 | 2018-09-13 | Celgene Corporation | Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
| CN113101295A (zh) * | 2020-03-20 | 2021-07-13 | 上海疆云医疗健康科技有限公司 | 二苯乙烯类似物在治疗糖尿病肾脏疾病中的用途 |
| KR20240055046A (ko) * | 2021-09-02 | 2024-04-26 | 신톤 비.브이. | 오시머티닙을 제조하는 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007146824A2 (en) * | 2006-06-08 | 2007-12-21 | Array Biopharma Inc. | Quinoline compounds and methods of use |
| CN102898416A (zh) * | 2006-09-26 | 2013-01-30 | 细胞基因公司 | 作为抗肿瘤剂的5-取代的喹唑酮衍生物 |
| EP3025715A1 (en) * | 2011-03-11 | 2016-06-01 | Celgene Corporation | Methods of treating cancer using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione |
| SG192946A1 (en) * | 2011-03-11 | 2013-09-30 | Celgene Corp | Solid forms of 3-(5-amino-2methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
| CN104755472A (zh) | 2012-09-04 | 2015-07-01 | 细胞基因公司 | 3-(5-氨基-2-甲基-4-氧代喹唑啉-3(4h)-基)哌啶-2,6-二酮的同位素体及其制备方法 |
| US9540340B2 (en) * | 2013-01-14 | 2017-01-10 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same |
-
2014
- 2014-04-30 AU AU2014260011A patent/AU2014260011A1/en not_active Abandoned
- 2014-04-30 NZ NZ628322A patent/NZ628322A/en not_active IP Right Cessation
- 2014-04-30 EP EP14728381.6A patent/EP2991976B1/en active Active
- 2014-04-30 CA CA2910971A patent/CA2910971A1/en not_active Abandoned
- 2014-04-30 DK DK14728381.6T patent/DK2991976T3/da active
- 2014-04-30 PT PT147283816T patent/PT2991976T/pt unknown
- 2014-04-30 US US14/266,448 patent/US9067912B2/en not_active Expired - Fee Related
- 2014-04-30 KR KR1020157034184A patent/KR20160003228A/ko not_active Withdrawn
- 2014-04-30 SG SG11201508836XA patent/SG11201508836XA/en unknown
- 2014-04-30 CN CN201810004591.8A patent/CN107935994A/zh active Pending
- 2014-04-30 AR ARP140101806A patent/AR096165A1/es unknown
- 2014-04-30 HR HRP20171535TT patent/HRP20171535T1/hr unknown
- 2014-04-30 RS RS20171105A patent/RS56565B1/sr unknown
- 2014-04-30 JP JP2016511825A patent/JP6490055B2/ja not_active Expired - Fee Related
- 2014-04-30 LT LTEP14728381.6T patent/LT2991976T/lt unknown
- 2014-04-30 HU HUE14728381A patent/HUE034770T2/hu unknown
- 2014-04-30 PL PL14728381T patent/PL2991976T3/pl unknown
- 2014-04-30 RU RU2015151359A patent/RU2015151359A/ru unknown
- 2014-04-30 WO PCT/US2014/036083 patent/WO2014179416A1/en not_active Ceased
- 2014-04-30 MX MX2015015073A patent/MX363652B/es unknown
- 2014-04-30 CN CN201480038438.7A patent/CN105377831B/zh not_active Expired - Fee Related
- 2014-04-30 EP EP17161076.9A patent/EP3199532A1/en not_active Withdrawn
- 2014-04-30 SM SM20170513T patent/SMT201700513T1/it unknown
- 2014-04-30 SI SI201430431T patent/SI2991976T1/sl unknown
- 2014-04-30 TW TW103115643A patent/TW201536766A/zh unknown
- 2014-04-30 ES ES14728381.6T patent/ES2645944T3/es active Active
-
2015
- 2015-06-10 US US14/736,146 patent/US9266858B2/en not_active Expired - Fee Related
- 2015-09-24 US US14/864,614 patent/US9303014B2/en not_active Expired - Fee Related
- 2015-10-27 PH PH12015502477A patent/PH12015502477A1/en unknown
-
2017
- 2017-02-13 AU AU2017200965A patent/AU2017200965A1/en not_active Abandoned
- 2017-10-26 CY CY20171101119T patent/CY1119525T1/el unknown
-
2018
- 2018-12-06 JP JP2018229189A patent/JP2019069958A/ja active Pending
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