AR096046A1 - Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso - Google Patents
Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de usoInfo
- Publication number
- AR096046A1 AR096046A1 ARP140101652A ARP140101652A AR096046A1 AR 096046 A1 AR096046 A1 AR 096046A1 AR P140101652 A ARP140101652 A AR P140101652A AR P140101652 A ARP140101652 A AR P140101652A AR 096046 A1 AR096046 A1 AR 096046A1
- Authority
- AR
- Argentina
- Prior art keywords
- difluoropropanamide
- methods
- forms
- polymodic
- derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- XJGBNZRVGOENRN-UHFFFAOYSA-N 2,2-difluoropropanamide Chemical class CC(F)(F)C(N)=O XJGBNZRVGOENRN-UHFFFAOYSA-N 0.000 title 1
- TXGZJQLMVSIZEI-UQMAOPSPSA-N Bardoxolone Chemical compound C1=C(C#N)C(=O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5[C@H]4C(=O)C=C3[C@]21C TXGZJQLMVSIZEI-UQMAOPSPSA-N 0.000 title 1
- 229950002483 bardoxolone Drugs 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910016523 CuKa Inorganic materials 0.000 abstract 2
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
La presente se relaciona en general con el compuesto: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-ciano-2,2,6a,6b,9,9,12a-heptametil-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahidropiren-4a-il)-2,2-difluoropropanamida, formas polimórficas del mismo, métodos para su preparación y uso, composiciones farmacéuticas del mismo y conjuntos de elementos y artículos para elaborarlo. Reivindicación 1: Una forma polimórfica de un compuesto, caracterizada porque es de la fórmula (1) en donde la forma polimórfica es cristalina, con un patrón de difracción de rayos X en polvo (CuKa) que comprende picos a aproximadamente 10,601, 11,638, 12,121, 13,021, 13,435, 15,418, 15,760, 17,830, 18,753 y 19,671 º2q. Reivindicación 5: Una forma polimórfica de un compuesto, caracterizada porque es de la fórmula (1) en donde la forma polimórfica es cristalina, con un patrón de difracción de rayos X en polvo (CuKa) que comprende picos a aproximadamente 7,552, 10,339, 11,159, 12,107, 14,729, 15,329, 15,857, 16,824, 17,994, 18,344, 19,444, 19,764, 20,801 y 22,414 º2q.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361815502P | 2013-04-24 | 2013-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR096046A1 true AR096046A1 (es) | 2015-12-02 |
Family
ID=50842351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101652A AR096046A1 (es) | 2013-04-24 | 2014-04-21 | Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso |
Country Status (35)
| Country | Link |
|---|---|
| US (5) | US9856286B2 (es) |
| EP (2) | EP2989114B1 (es) |
| JP (2) | JP6409050B2 (es) |
| KR (2) | KR20150144807A (es) |
| CN (1) | CN105324389B (es) |
| AR (1) | AR096046A1 (es) |
| AU (2) | AU2014257072C1 (es) |
| BR (1) | BR112015027012B1 (es) |
| CA (1) | CA2909066C (es) |
| CL (1) | CL2015003135A1 (es) |
| CR (1) | CR20150620A (es) |
| CY (1) | CY1120570T1 (es) |
| DK (1) | DK2989114T3 (es) |
| DO (1) | DOP2015000263A (es) |
| EC (1) | ECSP23088864A (es) |
| ES (1) | ES2683626T3 (es) |
| HR (1) | HRP20181321T1 (es) |
| HU (1) | HUE039899T2 (es) |
| IL (1) | IL242183B (es) |
| LT (1) | LT2989114T (es) |
| MX (1) | MX372760B (es) |
| MY (1) | MY182677A (es) |
| PE (1) | PE20160006A1 (es) |
| PH (1) | PH12015502459B1 (es) |
| PL (1) | PL2989114T3 (es) |
| PT (1) | PT2989114T (es) |
| RS (1) | RS57571B1 (es) |
| RU (2) | RU2019120236A (es) |
| SG (2) | SG11201508752WA (es) |
| SI (1) | SI2989114T1 (es) |
| TW (2) | TW201936625A (es) |
| UA (1) | UA118348C2 (es) |
| UY (2) | UY39092A (es) |
| WO (1) | WO2014176415A1 (es) |
| ZA (1) | ZA201507481B (es) |
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| PT3444261T (pt) | 2012-04-27 | 2021-03-12 | Reata Pharmaceuticals Inc | Derivados de 2,2-difluoropropionamida de metil bardoxolona, formas polimorfas e métodos de uso dos mesmos |
| US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| TWI630212B (zh) | 2012-09-10 | 2018-07-21 | 瑞塔醫藥有限責任公司 | 丁香油素（ｏｌｅａｎｏｌｉｃ ａｃｉｄ）之ｃ１７－烷二基與烯二基衍生物及其使用方法 |
| UY39092A (es) | 2013-04-24 | 2021-03-26 | Abbvie Inc | Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso |
| EP3310786B1 (en) | 2015-06-16 | 2021-03-03 | Nanophagix LLC | Drug delivery and imaging chemical conjugate, formulations and methods of use thereof |
| CN106279344A (zh) * | 2016-08-14 | 2017-01-04 | 吴芊葭 | 一种从防风中分离的天然化合物及其制备方法、医药应用 |
| CN106309451A (zh) * | 2016-08-14 | 2017-01-11 | 吴芊葭 | 一种头孢呋辛酯的药物组合物及其医药用途 |
| BR112019009256A2 (pt) | 2016-11-08 | 2019-07-16 | Reata Pharmaceuticals Inc | métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo |
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| KR102590310B1 (ko) | 2018-08-20 | 2023-10-17 | 얀센 파마슈티카 엔브이 | KEAP1-Nrf2 단백질간 상호작용 억제제 |
| WO2020190733A1 (en) * | 2019-03-15 | 2020-09-24 | University Of Rhode Island Board Of Trustees | pHLIP®-MEDIATED TARGETING OF CORTICOSTEROIDS TO DISEASED TISSUE |
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