AR094496A1 - Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas - Google Patents
Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricasInfo
- Publication number
- AR094496A1 AR094496A1 ARP140100153A ARP140100153A AR094496A1 AR 094496 A1 AR094496 A1 AR 094496A1 AR P140100153 A ARP140100153 A AR P140100153A AR P140100153 A ARP140100153 A AR P140100153A AR 094496 A1 AR094496 A1 AR 094496A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- cycloalkyl
- haloalkyl
- halo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 17
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 14
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 10
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000001475 halogen functional group Chemical group 0.000 abstract 9
- 229910052799 carbon Inorganic materials 0.000 abstract 7
- 125000006578 monocyclic heterocycloalkyl group Chemical group 0.000 abstract 7
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000002950 monocyclic group Chemical group 0.000 abstract 4
- -1 heterocyclic substituted heterocyclic compound Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 3
- 125000000335 thiazolyl group Chemical group 0.000 abstract 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente también se refiere a composiciones que comprenden al menos un compuesto tetracíclico sustituido con heterociclo, y métodos de uso para tratar o prevenir la infección por el VHC en un paciente. Reivindicación 1: Un compuesto que tiene la fórmula (1), o una sal farmacéuticamente aceptable del mismo, en la que: A es un compuesto de fórmula (2); A es un compuesto de la fórmula (3); cada aparición de R¹ está seleccionada independientemente entre H, alquilo C₁₋₆, haloalquilo C₁₋₆ y halo; cada aparición de R¹A está seleccionada independientemente entre H, alquilo C₁₋₆, haloalquilo C₁₋₆ y halo, o un grupo R¹ y un grupo R¹ que están unidos al mismo anillo, junto con los átomos de carbono en el anillo a los que están unidos, se pueden combinar para formar un grupo cicloalquilo C₃₋₇ condensado, o dos grupos R¹A que están unidos al mismo átomo de carbono, y el átomo de carbono común al que están unidos, se pueden combinar para formar un grupo cicloalquilo C₃₋₇ espirocíclico; cada aparición de R¹B es independientemente H, alquilo C₁₋₆, haloalquilo C₁₋₆ o halo, o un grupo R¹B y un grupo R¹A que están unidos al mismo anillo, junto con los átomos de carbono a los que están unidos, se pueden combinar para formar un grupo cicloalquilo C₃₋₇ condensado, o un grupo R¹B y un grupo R¹ que están unidos al mismo anillo, se pueden combinar para formar un grupo puente que tiene la fórmula -CH₂- o -CH₂CH₂-; R² es H, alquilo C₁₋₆, cicloalquilo C₃₋₇, fenilo o halo; R³ es tiazolilo o tiadiazolilo en el que dicho grupo tiazolilo y dicho grupo tiadiazolilo pueden estar opcionalmente sustituido en uno o más átomos de carbono en el anillo con R⁶, y en el que dicho grupo tiazolilo y dicho grupo tiadiazolilo pueden estar opcionalmente condensado con un grupo cicloalquilo C₃₋₇; cada aparición de R⁴ está seleccionada independientemente entre -C(O)-C(R⁷)₂NHC(O)O-R⁸; R⁵ representa hasta 3 sustituyentes, cada uno seleccionado independientemente entre H, halo, -CN, alquilo C₁₋₆, haloalquilo C₁₋₆, cicloalquilo C₃₋₇, heterocicloalquilo monocíclico de 4 a 6 miembros, heteroarilo monocíclico de 5 ó 6 miembros, arilo C₆₋₁₀, bencilo y -O-(alquilo C₁₋₆), en el que dicho grupo cicloalquilo C₃₋₇, dicho grupo heterocicloalquilo monocíclico de 4 ó 6 miembros, dicho grupo heteroarilo monocíclico de 5 ó 6 miembros, dicho grupo arilo C₆₋₁₀, o el resto fenilo de dicho grupo bencilo puede estar opcionalmente sustituido con hasta 3 grupos, que pueden ser iguales o diferentes, y están seleccionados entre halo, -CN, alquilo C₁₋₆, haloalquilo C₁₋₆, -O-alquilo C₁₋₆, -(alquileno C₁₋₆)-O-alquilo C₁₋₆ y -O-(haloalquilo C₁₋₆); R⁶ representa hasta 2 sustituyentes cada uno seleccionado independientemente entre halo, -CN, alquilo C₁₋₆, haloalquilo C₁₋₆, -O-(haloalquilo C₁₋₆), alquinilo C₂₋₆, hidroxialquilo C₁₋₆, -(alquileno C₁₋₆)ₘ-O-alquilo C₁₋₆, -N(R⁶)₂, arilo C₆₋₁₀, -(alquileno C₁₋₆)ₘ-(cicloalquilo C₃₋₇), -O-(arilo C₆₋₁₀), heterocicloalquilo monocíclico de 4 a 7 miembros, heteroarilo monocíclico de 5 ó 6 miembros, -O-(heteroarilo monocíclico de 5 ó 6 miembros), heteroarilo bicíclico de 8 a 10 miembros y -O-(heteroarilo bicíclico de 8 a 10 miembros), en el que dicho grupo arilo C₆₋₁₀, dicho grupo cicloalquilo C₃₋₇, dicho grupo heterocicloalquilo monocíclico de 4 a 7 miembros, dicho grupo heteroarilo monocíclico de 5 ó 6 miembros y dicho grupo heteroarilo bicíclico de 8 a 10 miembros, puede estar opcionalmente sustituido con hasta 3 grupos, cada uno seleccionado independientemente entre halo, hidroxi, alquilo C₁₋₆, haloalquilo C₁₋₆, y -O-alquilo C₁₋₆, y en el que dicho grupo arilo C₆₋₁₀, dicho grupo heteroarilo monocíclico de 5 ó 6 miembros y dicho grupo heteroarilo bicíclico de 8 a 10 miembros, puede estar opcionalmente condensado con un grupo cicloalquilo de 3 a 6 miembros; cada aparición de R⁷ está seleccionada independientemente entre H, alquilo C₁₋₆, haloalquilo C₁₋₆, fenilo, heterocicloalquilo monocíclico de 4 a 8 miembros, heterocicloalquilo bicíclico de 6 a 10 miembros y cicloalquilo C₃₋₇, en el que dicho grupo heterocicloalquilo monocíclico de 4 a 8 miembros, dicho de grupo heterocicloalquilo bicíclico de 6 a 10 miembros y dicho grupo cicloalquilo C₃₋₇ puede estar opcionalmente sustituido con hasta 5 grupos, cada uno seleccionado independientemente entre halo, -CN, alquilo C₁₋₆, haloalquilo C₁₋₆, cicloalquilo C₃₋₇, -O-alquilo C₁₋₆, -N(R⁶)₂ y -O-(haloalquilo C₁₋₆), y en el que dicho grupo cicloalquilo C₃₋₇ puede estar opcionalmente condensado con un grupo heterocicloalquilo monocíclico de 4 a 6 miembros, en el que dicho grupo heterocicloalquilo monocíclico de 4 a 8 miembros y dicho grupo cicloalquilo C₃₋₇ pueden estar sustituidos en un átomo de carbono del anillo con un grupo cicloalquilo C₃₋₆ espirocíclico; y en el que dicho grupo cicloalquilo C₃₋₇ puede estar sustituido en un átomo de carbono del anillo con un grupo heterocicloalquilo monocíclico de 3 a 6 miembros espirocíclico, y en el que dos grupos R⁷, que están unidos a un átomo de carbono común, junto con átomo de carbono común a los que están unidos, se unen para formar un grupo cicloalquilo C₃₋₇; cada aparición de R⁸ está seleccionada independientemente entre alquilo C₁₋₆, cicloalquilo C₃₋₇ y arilo C₆₋₁₀; y cada aparición de m es independientemente 0 ó 1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2013/000038 WO2014110687A1 (en) | 2013-01-16 | 2013-01-16 | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094496A1 true AR094496A1 (es) | 2015-08-05 |
Family
ID=51208906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100153A AR094496A1 (es) | 2013-01-16 | 2014-01-16 | Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9555038B2 (es) |
| EP (1) | EP2945952B1 (es) |
| JP (3) | JP6093451B2 (es) |
| KR (1) | KR101748974B1 (es) |
| CN (1) | CN105073755B (es) |
| AP (1) | AP2015008625A0 (es) |
| AR (1) | AR094496A1 (es) |
| AU (1) | AU2013374112B2 (es) |
| BR (1) | BR112015016325A2 (es) |
| CA (1) | CA2898049C (es) |
| CL (1) | CL2015001971A1 (es) |
| CR (1) | CR20150378A (es) |
| DO (1) | DOP2015000169A (es) |
| EA (1) | EA030554B1 (es) |
| EC (1) | ECSP15035530A (es) |
| HK (1) | HK1211290A1 (es) |
| IL (1) | IL239832A0 (es) |
| MA (1) | MA38315B1 (es) |
| MD (1) | MD20150075A2 (es) |
| MX (1) | MX356203B (es) |
| PE (1) | PE20151892A1 (es) |
| PH (1) | PH12015501560A1 (es) |
| SG (1) | SG11201505536RA (es) |
| TN (1) | TN2015000293A1 (es) |
| TW (1) | TW201441231A (es) |
| WO (2) | WO2014110687A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014110687A1 (en) | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
| US10457690B2 (en) | 2015-06-04 | 2019-10-29 | Merck Sharp & Dohme Corp. | Process for preparing substituted tetracyclic heterocycle compounds |
| WO2017023714A1 (en) * | 2015-08-04 | 2017-02-09 | Merck Sharp & Dohme Corp. | Fixed-dose combinations of antiviral compounds |
| US20180228828A1 (en) * | 2015-08-04 | 2018-08-16 | Merck Sharp & Dohme Corp. | Fixed-dose combinations of antiviral compounds |
| EP3393585A4 (en) * | 2015-12-21 | 2019-05-08 | Merck Sharp & Dohme Corp. | SILANOUS HETEROCYCLIC COMPOUNDS AND METHOD FOR USE THEREOF FOR THE TREATMENT OF VIRUS DISEASES |
| WO2017181383A1 (en) | 2016-04-21 | 2017-10-26 | Merck Sharp & Dohme Corp. | Hepatitis c virus inhibitors |
| CN107522716B (zh) * | 2016-06-21 | 2021-02-02 | 浙江柏拉阿图医药科技有限公司 | 丙型肝炎病毒抑制剂及应用 |
| WO2018032468A1 (en) * | 2016-08-18 | 2018-02-22 | Merck Sharp & Dohme Corp. | Heterocycle-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
| WO2018032467A1 (en) * | 2016-08-18 | 2018-02-22 | Merck Sharp & Dohme Corp. | Chromane-substitued tetracyclic compounds and uses thereof for treatment of viral diseases |
| CN109206396B (zh) * | 2017-07-05 | 2023-03-28 | 上海迪赛诺化学制药有限公司 | 2-c-甲基-4,5-o-(1-甲基乙烯基)-d-阿拉伯糖酸乙酯的制备方法 |
| CN109232612A (zh) * | 2017-07-11 | 2019-01-18 | 周龙兴 | 抑制丙肝病毒的化合物、药物组合物及其用途 |
| WO2020086414A1 (en) * | 2018-10-26 | 2020-04-30 | Merck Sharp & Dohme Corp. | Formulations of antiviral compounds |
| TW202317145A (zh) * | 2021-06-17 | 2023-05-01 | 美商亞堤製藥公司 | 有利之抗hcv組合療法 |
| IL308921A (en) * | 2021-06-17 | 2024-01-01 | Atea Pharmaceuticals Inc | Combination anti-HCV therapy is beneficial |
| WO2024259085A2 (en) * | 2023-06-14 | 2024-12-19 | Alexion Pharmaceuticals, Inc. | Methods for the synthesis of complement factor d inhibitors and intermediates thereof |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3927630B2 (ja) | 1996-09-27 | 2007-06-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ウイルス感染症の予防・治療剤 |
| BR0114020A (pt) | 2000-09-20 | 2003-07-22 | Merck Patent Gmbh | 4-amino-quinazolinas |
| EP1644385B1 (en) | 2003-07-10 | 2007-08-29 | Takeda Cambridge Limited | Silicon compounds and their use |
| ES2322602T3 (es) | 2004-02-24 | 2009-06-23 | Japan Tobacco, Inc. | Compuestos heterotetraciclicos condensados y su uso como inhibidor de polimerasa del vhc. |
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| WO2007084413A2 (en) | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7662809B2 (en) | 2004-10-26 | 2010-02-16 | Istituto Di Richerche Di Biologia Molecolare P Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
| WO2006093867A1 (en) | 2005-02-28 | 2006-09-08 | The Rockefeller University | Structure of the hepatitits c virus ns5a protein |
| US7994360B2 (en) | 2005-05-16 | 2011-08-09 | Xtl Biopharmaceuticals Ltd. | Benzofuran compounds |
| US20110104109A1 (en) | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| WO2007009120A2 (en) | 2005-07-14 | 2007-01-18 | Irm Llc | Heterotetracyclic compounds as tpo mimetics |
| US7473784B2 (en) | 2005-08-01 | 2009-01-06 | Bristol-Myers Squibb Company | Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors |
| FR2894963A1 (fr) | 2005-12-16 | 2007-06-22 | Inst Nat Sante Rech Med | Nouveaux composes interagissant avec pea-15 |
| US7745636B2 (en) | 2006-08-11 | 2010-06-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7642251B2 (en) | 2007-08-09 | 2010-01-05 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| EP2185554A1 (en) | 2007-08-09 | 2010-05-19 | Merck Sharp & Dohme Corp. | Silicon derivatives as histone deacetylase inhibitors |
| BRPI0814939A2 (pt) | 2007-08-10 | 2015-01-27 | Glaxosmithkline Llc | Entidade química, composição farmacêutica, e, método para tratar uma infecção viral em um mamífero. |
| EA018088B1 (ru) | 2008-02-13 | 2013-05-30 | Бристол-Маерс Сквибб Компани | Имидазолилбифенильные имидазолы в качестве ингибиторов вируса гепатита с |
| US7704992B2 (en) | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2540350B1 (en) | 2008-07-22 | 2014-05-21 | Merck Sharp & Dohme Corp. | Combinations of a macrocyclic quinoxaline compound which is an hcv ns3 protease inhibitor with other hcv agents |
| WO2010041687A1 (ja) | 2008-10-09 | 2010-04-15 | コニカミノルタホールディングス株式会社 | 有機光電変換素子、太陽電池及び光センサアレイ |
| WO2010062821A1 (en) | 2008-11-28 | 2010-06-03 | Glaxosmithkline Llc | Anti-viral compounds, compositions, and methods of use |
| CA2746004C (en) | 2008-12-03 | 2017-06-06 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| US8563513B2 (en) | 2009-03-27 | 2013-10-22 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| MX2011010132A (es) | 2009-03-27 | 2011-10-14 | Presidio Pharmaceuticals Inc | Inhibidores de anillo fusionado de hepatitis c. |
| MA33209B1 (fr) | 2009-03-27 | 2012-04-02 | Merck Sharp & Dohme | Inhibiteurs de la replication du virus de l'hepatite c |
| JP2012528194A (ja) | 2009-05-29 | 2012-11-12 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃ型肝炎などの疾患を処置するための３つの整列型アリール部分で構成された抗菌性化合物 |
| US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US20130156731A1 (en) | 2009-12-22 | 2013-06-20 | Kevin X. Chen | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas |
| ES2558554T3 (es) | 2010-03-09 | 2016-02-05 | Merck Sharp & Dohme Corp. | Compuestos de sililo tricíclicos condensados y métodos de uso de los mismos para el tratamiento de enfermedades víricas |
| WO2012040923A1 (en) * | 2010-09-29 | 2012-04-05 | Merck Sharp & Dohme Corp. | Tetracyclic indole derivatives and methods of use thereof for the treatment of viral diseases |
| MX2013003631A (es) * | 2010-09-29 | 2013-10-01 | Merck Sharp & Dohme | Derivados de indol tetraciclicos y sus métodos para el tratamiento de enfermedades virales. |
| US20130280214A1 (en) * | 2010-09-29 | 2013-10-24 | Merck Sharp & Dohme Corp. | Polycyclic heterocycle derivatives and methods of use thereof for the treatment of viral diseases |
| WO2014110687A1 (en) | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
| WO2014110688A1 (en) * | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiophene- sub stitued tetracyclic compounds and methods of use thereof for the treatment of viral diseases |
-
2013
- 2013-01-16 WO PCT/CN2013/000038 patent/WO2014110687A1/en not_active Ceased
- 2013-12-31 MA MA38315A patent/MA38315B1/fr unknown
- 2013-12-31 EA EA201591328A patent/EA030554B1/ru not_active IP Right Cessation
- 2013-12-31 AU AU2013374112A patent/AU2013374112B2/en not_active Ceased
- 2013-12-31 PE PE2015001352A patent/PE20151892A1/es not_active Application Discontinuation
- 2013-12-31 CA CA2898049A patent/CA2898049C/en not_active Expired - Fee Related
- 2013-12-31 HK HK15112117.6A patent/HK1211290A1/xx unknown
- 2013-12-31 AP AP2015008625A patent/AP2015008625A0/xx unknown
- 2013-12-31 US US14/761,256 patent/US9555038B2/en active Active
- 2013-12-31 WO PCT/CN2013/001676 patent/WO2014110705A1/en not_active Ceased
- 2013-12-31 JP JP2015551946A patent/JP6093451B2/ja not_active Expired - Fee Related
- 2013-12-31 CN CN201380074735.2A patent/CN105073755B/zh not_active Expired - Fee Related
- 2013-12-31 MD MDA20150075A patent/MD20150075A2/ro not_active Application Discontinuation
- 2013-12-31 EP EP13871363.1A patent/EP2945952B1/en active Active
- 2013-12-31 BR BR112015016325A patent/BR112015016325A2/pt not_active Application Discontinuation
- 2013-12-31 MX MX2015009225A patent/MX356203B/es active IP Right Grant
- 2013-12-31 KR KR1020157021818A patent/KR101748974B1/ko not_active Expired - Fee Related
- 2013-12-31 SG SG11201505536RA patent/SG11201505536RA/en unknown
-
2014
- 2014-01-16 AR ARP140100153A patent/AR094496A1/es unknown
- 2014-01-16 TW TW103101674A patent/TW201441231A/zh unknown
-
2015
- 2015-06-29 TN TNP2015000293A patent/TN2015000293A1/fr unknown
- 2015-07-08 IL IL239832A patent/IL239832A0/en unknown
- 2015-07-13 CL CL2015001971A patent/CL2015001971A1/es unknown
- 2015-07-13 PH PH12015501560A patent/PH12015501560A1/en unknown
- 2015-07-16 DO DO2015000169A patent/DOP2015000169A/es unknown
- 2015-07-16 CR CR20150378A patent/CR20150378A/es unknown
- 2015-08-17 EC ECIEPI201535530A patent/ECSP15035530A/es unknown
-
2016
- 2016-11-07 JP JP2016217169A patent/JP6148779B2/ja not_active Expired - Fee Related
- 2016-11-18 JP JP2016225137A patent/JP6417380B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR094496A1 (es) | Compuestos tetracíclicos sustituidos con heterociclo y métodos de uso de los mismos para el tratamiento de enfermedades víricas | |
| AR099379A1 (es) | Compuestos tricíclicos como agentes antineoplásicos | |
| AR111407A1 (es) | Compuestos inhibidores de ask1 y usos de los mismos | |
| AR105845A1 (es) | Compuestos de heteroarilo bicíclicos fusionados como moduladores de la función irak4 | |
| AR105648A1 (es) | Métodos para la preparación de ácidos biliares y derivados de los mismos | |
| AR110298A1 (es) | Compuestos de heterociclo tetracíclicos útiles como inhibidores de la integrasa del vih | |
| AR107170A1 (es) | Compuestos heterocíclicos tricíclicos condesados como inhibidores de integrasa del vih | |
| AR094452A1 (es) | COMPUESTOS HETEROCÍCLICOS SUSTITUIDOS CON AMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O INFa | |
| AR096332A1 (es) | Compuestos heterocíclicos tricíclicos condensados como inhibidores de la integrasa del vih | |
| AR106472A1 (es) | Inhibidores de acc y usos de los mismos | |
| AR095426A1 (es) | Inhibidores tripeptídicos de la epoxicetona proteasa | |
| AR095312A1 (es) | Compuestos de biarilamida como inhibidores de cinasa | |
| AR087791A1 (es) | Derivados de benzofurano con sustitucion heterociclica y metodos para el uso de los mismos en el tratamiento de enfermedades virales | |
| AR094537A1 (es) | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa | |
| AR102177A1 (es) | Compuestos de heteroarilo como inhibidores de btk y usos de los mismos | |
| AR094762A1 (es) | Compuestos de hexahidropirano[3,4-d][1,3]tiazin-2-amina sustituida con heteroarilo | |
| AR088828A1 (es) | DERIVADOS DE CICLOHEXILAMINA QUE TIENEN ACTIVIDAD COMO AGONISTAS ADRENERGICOS b2 Y COMO ANTAGONISTAS MUSCARINICOS M3 | |
| AR111494A1 (es) | Compuestos de anilinoquinazolina c₅ y su uso en el tratamiento del cáncer | |
| AR087792A1 (es) | Compuestos heterociclicos tetraciclicos y metodos para el uso de los mismos en el tratamiento de enfermedades virales | |
| AR095359A1 (es) | Compuestos heteroaromáticos y su uso como ligandos d1 de dopamina | |
| AR112831A1 (es) | Terapia de combinación usando un antagonista del receptor 2 de quimiocina (ccr2) y un inhibidor de pd-1 / pd-l1 | |
| AR109650A1 (es) | Compuestos de heteroarilcarboxamida como inhibidores de ripk2 | |
| AR094497A1 (es) | Compuestos tetracíclicos sustituidos con tiofeno y métodos de uso de los mismos para el tratamiento de enfermedades víricas | |
| AR110282A1 (es) | Compuestos de amida bicíclica y uso de éstos en el tratamiento de enfermedades mediadas por rip1 | |
| AR110440A1 (es) | Compuestos para el tratamiento de la enfermedad respiratoria bovina o porcina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |