AR083451A2 - Metodo para preparar una suspension farmaceutica acuosa de nevirapina, dicha suspension farmaceutica y uso de nevirapina para preparar dicha suspension farmaceutica - Google Patents
Metodo para preparar una suspension farmaceutica acuosa de nevirapina, dicha suspension farmaceutica y uso de nevirapina para preparar dicha suspension farmaceuticaInfo
- Publication number
- AR083451A2 AR083451A2 ARP110103815A ARP110103815A AR083451A2 AR 083451 A2 AR083451 A2 AR 083451A2 AR P110103815 A ARP110103815 A AR P110103815A AR P110103815 A ARP110103815 A AR P110103815A AR 083451 A2 AR083451 A2 AR 083451A2
- Authority
- AR
- Argentina
- Prior art keywords
- nevirapine
- hemihydrate
- pharmaceutical suspension
- prepare
- suspension
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Método para preparar una suspensión farmacéutica acuosa de nevirapina que comprende mezclar hemihidrato de nevirapina que tiene un tamaño de partículas entre aproximadamente 1 y 150 mm, con agua y, discrecionalmente, aditivos farmacéuticos convencionales. Suspensión farmacéutica que consta esencialmente de hemihidrato de nevirapina que tiene un tamaño de partículas entre aproximadamente 1 y 150 mm, agua y, discrecionalmente, aditivos farmacéuticos convencionales. Uso de nevirapina para preparar una suspensión farmacéutica, la cual contiene hemihidrato de nevirapina y está destinada al tratamiento de la infección VIH-1.Reivindicación 1: Un proceso para la preparación de hemihidrato de nevirapina, caracterizado porque comprende a) tratar una suspensión acuosa de nevirapina anhidra con un ácido fuerte, para obtener una solución de sal de adición de ácido; b) tratar la solución de la sal de adición de ácido producida en el paso previo con una base fuerte, para obtener la base libre de nevirapina como un precipitado, en forma de hemihidrato; y c) separar el precipitado de hemihidrato de nevirapina del medio acuoso por medio de filtración; d) lavar con agua el precipitado de hemihidrato de nevirapina producido en el paso previo; y e) secar el hemihidrato de nevirapina producido en el paso d) hasta que el contenido de agua esté dentro 3,1 y 3,9 % en peso.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5680397P | 1997-08-25 | 1997-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR083451A2 true AR083451A2 (es) | 2013-02-27 |
Family
ID=22006658
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104200A AR016869A1 (es) | 1997-08-25 | 1998-08-25 | Metodo para preparar una suspension farmaceutica acuosa de nevirapina, dicha suspension farmaceutica y uso de nevirapina para preparar dicha suspensionfarmaceutica |
| ARP110103815A AR083451A2 (es) | 1997-08-25 | 2011-10-14 | Metodo para preparar una suspension farmaceutica acuosa de nevirapina, dicha suspension farmaceutica y uso de nevirapina para preparar dicha suspension farmaceutica |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104200A AR016869A1 (es) | 1997-08-25 | 1998-08-25 | Metodo para preparar una suspension farmaceutica acuosa de nevirapina, dicha suspension farmaceutica y uso de nevirapina para preparar dicha suspensionfarmaceutica |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US6172059B1 (es) |
| EP (1) | EP1019058B1 (es) |
| JP (1) | JP3472261B2 (es) |
| KR (1) | KR100426516B1 (es) |
| CN (1) | CN1197578C (es) |
| AR (2) | AR016869A1 (es) |
| AT (1) | ATE326971T1 (es) |
| AU (1) | AU742761B2 (es) |
| BG (1) | BG64337B1 (es) |
| BR (1) | BR9811994B1 (es) |
| CA (1) | CA2301646C (es) |
| CL (1) | CL2008003111A1 (es) |
| CO (1) | CO4970742A1 (es) |
| CY (1) | CY1105228T1 (es) |
| CZ (1) | CZ290667B6 (es) |
| DE (1) | DE69834655T2 (es) |
| DK (1) | DK1019058T3 (es) |
| EG (1) | EG24075A (es) |
| ES (1) | ES2265666T3 (es) |
| HR (1) | HRP980461B1 (es) |
| HU (1) | HU226063B1 (es) |
| ID (1) | ID21650A (es) |
| IL (1) | IL134185A (es) |
| MY (1) | MY122272A (es) |
| NO (1) | NO326226B1 (es) |
| NZ (1) | NZ503414A (es) |
| PE (1) | PE105799A1 (es) |
| PL (1) | PL192361B1 (es) |
| PT (1) | PT1019058E (es) |
| RS (1) | RS49808B (es) |
| RU (1) | RU2196584C2 (es) |
| SA (1) | SA98190680B1 (es) |
| TR (1) | TR200000490T2 (es) |
| TW (1) | TW450812B (es) |
| UA (1) | UA44370C2 (es) |
| WO (1) | WO1999009990A1 (es) |
| ZA (1) | ZA987623B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002092095A1 (en) * | 2001-05-11 | 2002-11-21 | Boehringer Ingelheim International Gmbh | Use of nevirapine to treat or prevent lipid pathology in patients with hiv that is resistant to nevirapine |
| WO2003091290A1 (en) * | 2002-04-23 | 2003-11-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for reduction of residual organic solvent in carbomer |
| AU2006286314A1 (en) * | 2005-08-31 | 2007-03-08 | Cipla Limited | Pharmaceutical combinations containing lamivudine, stavudine and nevirapine |
| EP2306980A2 (en) * | 2008-06-30 | 2011-04-13 | Tibotec Pharmaceuticals | Powders for reconstitution |
| DE112010004065T5 (de) * | 2009-11-10 | 2012-10-25 | North West University | Verfahren zur Erhöhung der Löslichkeit einer Transkriptaseinhibitor-Zusammensetzung |
| BR112012014762A2 (pt) * | 2009-12-17 | 2016-03-29 | Univ Northwest | forma polimorfa de nevirapina e sua preparação |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5366972A (en) * | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
| EP0410148B1 (en) * | 1989-06-28 | 1994-04-06 | Boehringer Ingelheim Pharmaceuticals Inc. | Novel 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-ones and thiones and their use in the prevention or treatment of AIDS |
| CA2030056C (en) * | 1989-11-17 | 1995-10-17 | Karl D. Hargrave | 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection |
| US5571912A (en) * | 1990-10-19 | 1996-11-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the preparation of 5,11-dihydro-6h-dipyrido [3,2-b:2',3'-e][1,4]diazepines |
| GB9215178D0 (en) * | 1992-07-16 | 1992-08-26 | Glaxo Group Ltd | Antiviral combinations |
| JP3000564B2 (ja) * | 1993-12-15 | 2000-01-17 | メルク エンド カンパニー インコーポレーテッド | Ｈｉｖプロテアーゼ阻害剤 |
| DE4403311C1 (de) * | 1994-02-03 | 1995-04-20 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on) |
-
1998
- 1998-08-11 NZ NZ503414A patent/NZ503414A/xx not_active IP Right Cessation
- 1998-08-11 CZ CZ2000694A patent/CZ290667B6/cs not_active IP Right Cessation
- 1998-08-11 DE DE69834655T patent/DE69834655T2/de not_active Expired - Lifetime
- 1998-08-11 UA UA2000031668A patent/UA44370C2/uk unknown
- 1998-08-11 CN CNB988084899A patent/CN1197578C/zh not_active Expired - Fee Related
- 1998-08-11 JP JP2000507380A patent/JP3472261B2/ja not_active Expired - Fee Related
- 1998-08-11 IL IL13418598A patent/IL134185A/xx not_active IP Right Cessation
- 1998-08-11 BR BRPI9811994-0B1A patent/BR9811994B1/pt not_active IP Right Cessation
- 1998-08-11 RS YUP-98/00A patent/RS49808B/sr unknown
- 1998-08-11 CA CA002301646A patent/CA2301646C/en not_active Expired - Fee Related
- 1998-08-11 US US09/131,829 patent/US6172059B1/en not_active Expired - Lifetime
- 1998-08-11 PT PT98939312T patent/PT1019058E/pt unknown
- 1998-08-11 WO PCT/US1998/016581 patent/WO1999009990A1/en not_active Ceased
- 1998-08-11 HU HU0003093A patent/HU226063B1/hu not_active IP Right Cessation
- 1998-08-11 DK DK98939312T patent/DK1019058T3/da active
- 1998-08-11 ES ES98939312T patent/ES2265666T3/es not_active Expired - Lifetime
- 1998-08-11 RU RU2000107825/14A patent/RU2196584C2/ru not_active IP Right Cessation
- 1998-08-11 EP EP98939312A patent/EP1019058B1/en not_active Expired - Lifetime
- 1998-08-11 TR TR2000/00490T patent/TR200000490T2/xx unknown
- 1998-08-11 PE PE1998000718A patent/PE105799A1/es not_active Application Discontinuation
- 1998-08-11 KR KR10-2000-7001889A patent/KR100426516B1/ko not_active Expired - Fee Related
- 1998-08-11 PL PL338828A patent/PL192361B1/pl unknown
- 1998-08-11 AU AU87771/98A patent/AU742761B2/en not_active Ceased
- 1998-08-11 AT AT98939312T patent/ATE326971T1/de active
- 1998-08-21 MY MYPI98003819A patent/MY122272A/en unknown
- 1998-08-23 EG EG98398A patent/EG24075A/xx active
- 1998-08-24 ZA ZA9807623A patent/ZA987623B/xx unknown
- 1998-08-24 CO CO98048247A patent/CO4970742A1/es unknown
- 1998-08-24 HR HR980461A patent/HRP980461B1/xx not_active IP Right Cessation
- 1998-08-24 ID IDP981156A patent/ID21650A/id unknown
- 1998-08-24 TW TW087113878A patent/TW450812B/zh not_active IP Right Cessation
- 1998-08-25 AR ARP980104200A patent/AR016869A1/es not_active Application Discontinuation
- 1998-11-01 SA SA98190680A patent/SA98190680B1/ar unknown
-
2000
- 2000-02-07 BG BG104133A patent/BG64337B1/bg unknown
- 2000-02-24 NO NO20000906A patent/NO326226B1/no not_active IP Right Cessation
- 2000-03-02 US US09/517,564 patent/US6255481B1/en not_active Expired - Lifetime
-
2006
- 2006-08-11 CY CY20061101147T patent/CY1105228T1/el unknown
-
2008
- 2008-10-21 CL CL2008003111A patent/CL2008003111A1/es unknown
-
2011
- 2011-10-14 AR ARP110103815A patent/AR083451A2/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |