AR082696A1 - Derivados heterociclicos nitrogenados de 1,2,4-oxadiazol, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades cardiovasculares e inflamatorias, entre otras - Google Patents
Derivados heterociclicos nitrogenados de 1,2,4-oxadiazol, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades cardiovasculares e inflamatorias, entre otrasInfo
- Publication number
- AR082696A1 AR082696A1 ARP110102966A ARP110102966A AR082696A1 AR 082696 A1 AR082696 A1 AR 082696A1 AR P110102966 A ARP110102966 A AR P110102966A AR P110102966 A ARP110102966 A AR P110102966A AR 082696 A1 AR082696 A1 AR 082696A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally
- substituted
- membered
- independently
- Prior art date
Links
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical class [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- -1 -O-benzyl Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en la que cada uno de R1 y R2 es independientemente hidrógeno, alquilo C1-7 o carbociclo C3-10, con la condición de que R1 y R2 no sean los dos hidrógeno; R3 es un anillo de heteroarilo de 5 - 11 miembros que contiene de uno a tres heteroátomos seleccionados entre nitrógeno, oxígeno y azufre, donde el anillo de heteroarilo está opcionalmente sustituido independientemente con uno a tres grupos seleccionados entre alquilo C1-5 opcionalmente sustituido con uno a tres átomos de halógeno, alcoxi C1-5, hidroxi C1-3, halógeno, hidroxi, -O-bencilo, oxo, ciano, amino, -NH-carbociclo C3-6, alquilamino C1-6 y dialquilamino C1-3; R4 es hidrógeno, alquilo C1-3, halógeno o nitrilo; R5 es alquilo C1-6, carbociclo C3-10, heterociclo de 3 - 11 miembros, arilo, heteroarilo de 5 - 11 miembros, -C(O)-R6, hidroxi o -NR7R8, donde cada R5 está opcionalmente sustituido independientemente con uno a tres grupos seleccionados entre R9, R10 y R11; R6 es heterociclo C3-8 o -NH-heterociclo de 5 - 6 miembros, cada uno opcionalmente sustituido independientemente con uno a tres grupos seleccionados entre R9, R10 y R11; cada uno de R7 y R8 es independientemente hidrógeno, heterociclo de 5 - 6 miembros opcionalmente sustituido con alquilo C1-6, carbociclo C3-10 opcionalmente sustituido con hidroxi o alquilo C1-6; R9, R10 y R11 se seleccionan independientemente entre (a) -H, (b) -OH, (c) halógeno, (d) -CN, (e) -CF3, (f) alquilo C1-6 opcionalmente sustituido con uno a tres -OH, -N(R12)(R13), heterociclo de 3 - 6 miembros, alcoxi C1-6, alcoxi C1-6-O-alquilo C1-6, -CO2R12, -C(O)N(R12)(R13) o -S(O)n-alquilo C1-6, (g) alcoxi C1-6, (h) -N(R12)(R13), (i) -S(O)n-alquilo C1-6, (j) -CO2R12, (k) -C(O)N(R12)(R13), (l) -S(O)2N(R12)(R13), (m) un grupo heterocíclico de 3 - 10 miembros opcionalmente sustituido con uno a tres grupos alquilo C1-6, (n) oxo, (o) -C(O)-alquilo C1-3; cada uno de R12 y R13 se selecciona independientemente entre -H, -alquilo C1-6, -C(O)alquilo C1-6, y un grupo heterocíclico de 3 - 6 miembros, cada uno de los cuales está opcionalmente sustituido independientemente con uno a tres grupos alquilo C1-6, -OH, alcoxi C1-6, -C(O)N(R14)(R15), -S(O)n-alquilo C1-6, CN, un grupo heterocíclico de 3 - 6 miembros, -O-alquilo C1-6, CF3; o R12 y R13 tomados junto con el anillo de nitrógeno al que están unidos forman un anillo de heterociclilo opcionalmente sustituido con uno a tres -OH, CN, -O-alquilo C1-6 u oxo; cada uno de R14 y R15 se selecciona independientemente entre -H y -alquilo C1-6; n es 0, 1 ó 2; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37392510P | 2010-08-16 | 2010-08-16 | |
| US201161492176P | 2011-06-01 | 2011-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082696A1 true AR082696A1 (es) | 2012-12-26 |
Family
ID=44511591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102966A AR082696A1 (es) | 2010-08-16 | 2011-08-15 | Derivados heterociclicos nitrogenados de 1,2,4-oxadiazol, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades cardiovasculares e inflamatorias, entre otras |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8658661B2 (es) |
| EP (1) | EP2606045B1 (es) |
| JP (1) | JP5619284B2 (es) |
| KR (1) | KR20130100105A (es) |
| CN (1) | CN103180314A (es) |
| AP (1) | AP2013006678A0 (es) |
| AR (1) | AR082696A1 (es) |
| AU (1) | AU2011292285A1 (es) |
| BR (1) | BR112013003439A2 (es) |
| CA (1) | CA2807364A1 (es) |
| CL (1) | CL2013000455A1 (es) |
| CO (1) | CO6680645A2 (es) |
| EA (1) | EA201300250A1 (es) |
| EC (1) | ECSP13012494A (es) |
| MX (1) | MX2013001872A (es) |
| NZ (1) | NZ605690A (es) |
| PE (1) | PE20130751A1 (es) |
| PH (1) | PH12013500301A1 (es) |
| SG (1) | SG187549A1 (es) |
| TW (1) | TW201238947A (es) |
| UY (1) | UY33557A (es) |
| WO (1) | WO2012024150A1 (es) |
| ZA (1) | ZA201300238B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2013006678A0 (en) | 2010-08-16 | 2013-01-31 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
| WO2012027322A1 (en) * | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| US8580825B2 (en) * | 2010-09-23 | 2013-11-12 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| PH12013500545A1 (en) * | 2010-09-23 | 2013-05-06 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
| US9073895B2 (en) * | 2010-12-16 | 2015-07-07 | Boehringer Ingelheim International Gmbh | Biarylamide inhibitors of leukotriene production |
| WO2012129037A1 (en) | 2011-03-18 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Process for preparing carboxylic acids |
| US9174980B2 (en) * | 2012-01-31 | 2015-11-03 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as inhibitors of leukotriene production |
| AR089853A1 (es) * | 2012-02-01 | 2014-09-24 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso |
| US9029592B2 (en) * | 2012-02-09 | 2015-05-12 | Boehringer Ingelheim International Gmbh | Process for preparing carboxamidine compounds |
| EP2746256A1 (en) | 2012-12-19 | 2014-06-25 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| WO2014095381A1 (en) | 2012-12-19 | 2014-06-26 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| EP2746279A1 (en) | 2012-12-19 | 2014-06-25 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| EP2746277A1 (en) | 2012-12-19 | 2014-06-25 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| WO2014095249A1 (en) | 2012-12-19 | 2014-06-26 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| CN103724279B (zh) * | 2014-01-20 | 2016-04-06 | 新发药业有限公司 | 一步成环制备2-甲基-4-氨基-5-氨基甲基嘧啶的便捷合成方法 |
| EP3119774A1 (en) | 2014-03-17 | 2017-01-25 | reMynd NV | Oxadiazole compounds |
| IL291418B2 (en) | 2022-03-16 | 2024-05-01 | Anima Biotech Inc | Substances that function as modulators of cMYC-mRNA translation and their uses for cancer treatment |
| JP7805983B2 (ja) | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3141019A (en) * | 1964-07-14 | Chaohj | ||
| GB1053825A (es) * | 1963-03-22 | |||
| JP2719742B2 (ja) * | 1991-04-30 | 1998-02-25 | 株式会社大塚製薬工場 | フェニルチアゾール誘導体 |
| IL133916A0 (en) * | 1997-07-10 | 2001-04-30 | Janssen Pharmaceutica Nv | Il-5 inhibiting 6-azauracil derivatives |
| EP0987265A1 (en) * | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
| HRP20020096A2 (en) | 1999-08-06 | 2005-10-31 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
| US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
| DE602005013272D1 (de) * | 2004-10-18 | 2009-04-23 | Merck & Co Inc | Diphenyl-substituierte alkane als flap-inhibitoren |
| PE20070405A1 (es) * | 2005-08-10 | 2007-05-06 | Smithkline Beecham Corp | Compuestos derivados de xantina como agonistas del receptor de acido nicotinico hm74a |
| GB0516464D0 (en) * | 2005-08-10 | 2005-09-14 | Smithkline Beecham Corp | Novel compounds |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US20070219206A1 (en) * | 2005-11-04 | 2007-09-20 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| AU2007238878A1 (en) | 2006-04-11 | 2007-10-25 | Merck Sharp & Dohme Corp. | Diaryl substituted alkanes |
| WO2007130499A2 (en) * | 2006-05-01 | 2007-11-15 | Virobay, Inc. | Antiviral agents |
| AU2007265475B2 (en) * | 2006-06-26 | 2010-08-19 | Amgen Inc. | Methods for treating atherosclerosis |
| WO2008030369A1 (en) * | 2006-09-01 | 2008-03-13 | Merck & Co., Inc. | Inhibitors of 5 -lipoxygenase activating protein ( flap) |
| FR2906866A1 (fr) * | 2006-10-10 | 2008-04-11 | Felix Ifrah | Luminaire comprenant au moins un moyen d'eclairage dont l'activation s'effectue par l'emission d'un rayonnement lumineux |
| WO2008050200A1 (en) * | 2006-10-24 | 2008-05-02 | Pfizer Products Inc. | Oxadiazole compounds as calcium channel antagonists |
| EP2148878A4 (en) | 2007-04-20 | 2011-08-10 | Merck Canada Inc | NEW HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME-A-DELTA-9-DESATURASE |
| EP2170065A4 (en) | 2007-06-20 | 2011-11-23 | Merck Sharp & Dohme | DIPHENYL SUBSTITUTED ALKANES |
| EP2209761A4 (en) | 2007-10-10 | 2012-01-04 | Merck Sharp & Dohme | DIPHENYL-SUBSTITUTED CYCLOAL CANS |
| WO2010089686A1 (en) * | 2009-02-04 | 2010-08-12 | Pfizer Inc. | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives |
| WO2011143466A1 (en) | 2010-05-12 | 2011-11-17 | Vanderbilt University | Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| AP2013006678A0 (en) | 2010-08-16 | 2013-01-31 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
| WO2012027322A1 (en) | 2010-08-26 | 2012-03-01 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| US8580825B2 (en) | 2010-09-23 | 2013-11-12 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
-
2011
- 2011-08-11 AP AP2013006678A patent/AP2013006678A0/xx unknown
- 2011-08-11 CA CA2807364A patent/CA2807364A1/en not_active Abandoned
- 2011-08-11 NZ NZ605690A patent/NZ605690A/en not_active IP Right Cessation
- 2011-08-11 MX MX2013001872A patent/MX2013001872A/es not_active Application Discontinuation
- 2011-08-11 KR KR1020137003938A patent/KR20130100105A/ko not_active Withdrawn
- 2011-08-11 PE PE2013000279A patent/PE20130751A1/es not_active Application Discontinuation
- 2011-08-11 SG SG2013003694A patent/SG187549A1/en unknown
- 2011-08-11 PH PH1/2013/500301A patent/PH12013500301A1/en unknown
- 2011-08-11 EA EA201300250A patent/EA201300250A1/ru unknown
- 2011-08-11 AU AU2011292285A patent/AU2011292285A1/en not_active Abandoned
- 2011-08-11 WO PCT/US2011/047356 patent/WO2012024150A1/en not_active Ceased
- 2011-08-11 JP JP2013524874A patent/JP5619284B2/ja active Active
- 2011-08-11 EP EP11748842.9A patent/EP2606045B1/en active Active
- 2011-08-11 BR BR112013003439A patent/BR112013003439A2/pt not_active IP Right Cessation
- 2011-08-11 CN CN2011800500399A patent/CN103180314A/zh active Pending
- 2011-08-12 US US13/208,582 patent/US8658661B2/en active Active
- 2011-08-15 TW TW100129127A patent/TW201238947A/zh unknown
- 2011-08-15 UY UY0001033557A patent/UY33557A/es not_active Application Discontinuation
- 2011-08-15 AR ARP110102966A patent/AR082696A1/es unknown
-
2013
- 2013-01-10 ZA ZA2013/00238A patent/ZA201300238B/en unknown
- 2013-02-14 CL CL2013000455A patent/CL2013000455A1/es unknown
- 2013-02-15 CO CO13031460A patent/CO6680645A2/es not_active Application Discontinuation
- 2013-03-15 EC ECSP13012494 patent/ECSP13012494A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2807364A1 (en) | 2012-02-23 |
| JP5619284B2 (ja) | 2014-11-05 |
| NZ605690A (en) | 2014-06-27 |
| EP2606045A1 (en) | 2013-06-26 |
| EP2606045B1 (en) | 2016-01-06 |
| PE20130751A1 (es) | 2013-06-21 |
| PH12013500301A1 (en) | 2013-03-25 |
| TW201238947A (en) | 2012-10-01 |
| SG187549A1 (en) | 2013-03-28 |
| CO6680645A2 (es) | 2013-05-31 |
| ECSP13012494A (es) | 2013-04-30 |
| US20120220561A1 (en) | 2012-08-30 |
| MX2013001872A (es) | 2013-09-02 |
| ZA201300238B (en) | 2014-06-25 |
| CN103180314A (zh) | 2013-06-26 |
| US8658661B2 (en) | 2014-02-25 |
| CL2013000455A1 (es) | 2013-05-03 |
| AU2011292285A1 (en) | 2013-01-31 |
| UY33557A (es) | 2012-03-30 |
| BR112013003439A2 (pt) | 2019-09-24 |
| JP2013534245A (ja) | 2013-09-02 |
| AP2013006678A0 (en) | 2013-01-31 |
| WO2012024150A1 (en) | 2012-02-23 |
| KR20130100105A (ko) | 2013-09-09 |
| EA201300250A1 (ru) | 2013-08-30 |
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