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AR082006A1 - Proceso para la obtencion de dronedarone - Google Patents

Proceso para la obtencion de dronedarone

Info

Publication number
AR082006A1
AR082006A1 ARP110102110A ARP110102110A AR082006A1 AR 082006 A1 AR082006 A1 AR 082006A1 AR P110102110 A ARP110102110 A AR P110102110A AR P110102110 A ARP110102110 A AR P110102110A AR 082006 A1 AR082006 A1 AR 082006A1
Authority
AR
Argentina
Prior art keywords
formula
benzofuran
propoxy
benzoyl
butyl
Prior art date
Application number
ARP110102110A
Other languages
English (en)
Inventor
Antal Friesz
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR082006A1 publication Critical patent/AR082006A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicación 1: Un proceso para la preparación de N-[2-n-butil-3-{4-[(3-dibutilamino)-propoxi]-benzoil}-1-benzofuran-5-il]-metano-sulfonamida, que tiene la fórmula (1) y sus sales farmacéuticamente aceptables, caracterizado porque uno de los grupos metilsulfonilo del 2-n-butil-3-[(di-n-butilamino-3-propoxi)-benzoil]-5-bis-(metilsulfonamido)-benzofurano que tiene la fórmula (2) se segmenta de manera selectiva y -si así se lo desea- el compuesto resultante que tiene la fórmula (1), se transforma en su sal.
ARP110102110A 2010-06-18 2011-06-17 Proceso para la obtencion de dronedarone AR082006A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1000330A HUP1000330A2 (en) 2010-06-18 2010-06-18 Process for the preparation of dronedarone and the novel intermediates

Publications (1)

Publication Number Publication Date
AR082006A1 true AR082006A1 (es) 2012-11-07

Family

ID=89989791

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110102110A AR082006A1 (es) 2010-06-18 2011-06-17 Proceso para la obtencion de dronedarone

Country Status (15)

Country Link
US (1) US9174958B2 (es)
EP (1) EP2582685A1 (es)
JP (1) JP2013528641A (es)
KR (1) KR20130036282A (es)
CN (1) CN103068810A (es)
AR (1) AR082006A1 (es)
AU (1) AU2011266805A1 (es)
BR (1) BR112012032358A2 (es)
CA (1) CA2802918A1 (es)
HU (1) HUP1000330A2 (es)
MX (1) MX2012014675A (es)
RU (1) RU2013102259A (es)
SG (1) SG186260A1 (es)
TW (1) TW201200506A (es)
WO (1) WO2011158050A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
CN102725279A (zh) * 2010-11-08 2012-10-10 山东邹平大展新材料有限公司 一种盐酸决奈达隆的制备方法
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
WO2012171135A1 (zh) * 2011-06-13 2012-12-20 山东邹平大展新材料有限公司 一种苯并呋喃化合物、其制备方法及用途
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) * 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
TW201536763A (zh) * 2013-08-27 2015-10-01 Gilead Sciences Inc 製備決奈達隆或其鹽類之製程

Family Cites Families (62)

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DE2337396A1 (de) 1973-07-23 1975-02-13 Hoechst Ag Verfahren zur herstellung aromatischer 1,3-diketone
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JPS62155269A (ja) 1984-12-29 1987-07-10 Kaken Pharmaceut Co Ltd ベンゾフラン誘導体
US5066803A (en) 1989-12-07 1991-11-19 Sterling Drug Inc. 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
GB9416219D0 (en) 1994-08-11 1994-10-05 Karobio Ab Receptor ligands
IT1275997B1 (it) 1995-03-31 1997-10-24 Great Lakes Chemical Italia Enammine come accelleranti di vulcanizzazione per gomme naturali o sintetiche
EP1222181B1 (fr) 1999-10-21 2003-12-10 Rhodia Chimie Procede de preparation d'un compose de type benzofurane ou benzothiophene
FR2800067B1 (fr) 1999-10-21 2004-12-17 Rhodia Chimie Sa Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations
FR2813306B1 (fr) 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2813308B1 (fr) 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
FR2817864B1 (fr) 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817865B1 (fr) * 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
IL146389A0 (en) 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
FR2833262A1 (fr) 2001-12-06 2003-06-13 Rhodia Chimie Sa Procede de monosulfonylation d'un compose de type aminobenzofuranne ou aminobenzothiophene
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CN101993427B (zh) 2009-08-26 2012-10-10 成都伊诺达博医药科技有限公司 一种制备决奈达隆的方法
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
BR112012020058A2 (pt) * 2010-02-10 2016-11-01 Mapi Pharma Ltd preparação de benzofuranos e uso dos mesmos como intermediários sintéticos.
IT1398317B1 (it) 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
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FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958289B1 (fr) 2010-03-30 2012-06-15 Sanofi Aventis Procede de preparation de derives de 3-ceto-benzofurane
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HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
WO2012004658A2 (en) 2010-07-09 2012-01-12 Frichem Private Limited Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
WO2012032545A1 (en) 2010-09-08 2012-03-15 Cadila Healthcare Limited Processes for preparing dronedarone and its intermediates
FR2973027A1 (fr) 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100166A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
WO2013014480A1 (en) 2011-07-26 2013-01-31 Sanofi Process for preparation of dronedarone using amide intermediary compound
WO2013014478A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive amination process for preparation of dronedarone using carboxyl intermediary compound
WO2013014479A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive animation process for preparation of dronedarone using aldehyde intermediary compound
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group

Also Published As

Publication number Publication date
AU2011266805A1 (en) 2013-01-10
TW201200506A (en) 2012-01-01
BR112012032358A2 (pt) 2016-11-08
HUP1000330A2 (en) 2011-12-28
RU2013102259A (ru) 2014-07-27
CA2802918A1 (en) 2011-12-22
KR20130036282A (ko) 2013-04-11
EP2582685A1 (en) 2013-04-24
CN103068810A (zh) 2013-04-24
JP2013528641A (ja) 2013-07-11
HU1000330D0 (en) 2010-08-30
US9174958B2 (en) 2015-11-03
US20130109868A1 (en) 2013-05-02
WO2011158050A1 (en) 2011-12-22
MX2012014675A (es) 2013-01-22
SG186260A1 (en) 2013-01-30

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