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AR080564A1 - Metodos para el tratamiento o prevencion de enfermedades asociadas al receptor del factor de crecimiento epidermico humano-3 (her-3) - Google Patents

Metodos para el tratamiento o prevencion de enfermedades asociadas al receptor del factor de crecimiento epidermico humano-3 (her-3)

Info

Publication number
AR080564A1
AR080564A1 ARP100104211A AR080564A1 AR 080564 A1 AR080564 A1 AR 080564A1 AR P100104211 A ARP100104211 A AR P100104211A AR 080564 A1 AR080564 A1 AR 080564A1
Authority
AR
Argentina
Prior art keywords
agent
prevention
receiver
treatment
methods
Prior art date
Application number
Other languages
English (en)
Inventor
Robert Radinsky
Thore Hettmann
Daniel J Freeman
Original Assignee
U3 Pharma Gmbh
Amgen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by U3 Pharma Gmbh, Amgen filed Critical U3 Pharma Gmbh
Publication of AR080564A1 publication Critical patent/AR080564A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07—ORGANIC CHEMISTRY
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    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

El primer y el segundo agente pueden ser un producto biologico, tales como una proteína de union al antígeno, o un pequeno inhibidor molecular de la tirosina de quinasa por ejemplo. Reivindicacion 1: Un método para tratar o prevenir una enfermedad asociada con HER-3 en un sujeto, que comprende la administracion al sujeto de un primer agente y un segundo agente, en donde el primer agente se une a HER-3 y el segundo agente se une al y/o inhiben el actividad de otro miembro de la familia HER. Reivindicacion 29: El método de cualquiera de las reivindicaciones 1-15, en donde el segundo agente es un compuesto de moléculas pequenas o de una proteína de union al antígeno. Reivindicacion 30: El método de la reivindicacion 29, en donde el trastuzumab segundo agente. Reivindicacion 31: El método de la reivindicacion 29, en donde el segundo agente se selecciona entre el grupo de lapatinib y neratinib. Reivindicacion 32: El método de la reivindicacion 29, en donde el segundo agente es panitumumab. Reivindicacion 33: El método de la reivindicacion 29, en donde el segundo agente es Erlotinib. Reivindicacion 34: El método de la reivindicacion 29, en donde el segundo agente es Cetuximab Reivindicacion 35: El método de la reivindicacion 29, en donde el segundo agente es pertuzumab. Reivindicacion 36: El método de la reivindicacion 2, en el segundo agente es Erbitux, Reivindicacion 37: El método de la reivindicacion 29, en donde el segundo agente es T-DM1.
ARP100104211 2009-11-13 2010-11-15 Metodos para el tratamiento o prevencion de enfermedades asociadas al receptor del factor de crecimiento epidermico humano-3 (her-3) AR080564A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26114909P 2009-11-13 2009-11-13

Publications (1)

Publication Number Publication Date
AR080564A1 true AR080564A1 (es) 2012-04-18

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ARP100104211 AR080564A1 (es) 2009-11-13 2010-11-15 Metodos para el tratamiento o prevencion de enfermedades asociadas al receptor del factor de crecimiento epidermico humano-3 (her-3)

Country Status (26)

Country Link
US (4) US9101760B2 (es)
EP (5) EP2719708B1 (es)
JP (5) JP5931736B2 (es)
KR (1) KR101806323B1 (es)
CN (2) CN105999263B (es)
AR (1) AR080564A1 (es)
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HK1207651A1 (en) 2016-02-05
UY33034A (es) 2011-05-31
US20140017166A1 (en) 2014-01-16
SMT201800167T1 (it) 2018-05-02
JP7317650B2 (ja) 2023-07-31
US20110229406A1 (en) 2011-09-22
BR112012012160A2 (pt) 2017-01-10
MX2012005589A (es) 2012-11-30
DK3351558T3 (da) 2020-06-02
JP2013510868A (ja) 2013-03-28
US12139549B2 (en) 2024-11-12
WO2011060206A2 (en) 2011-05-19
EP2896632B1 (en) 2017-10-25
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LT2719708T (lt) 2018-02-12
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JP2020011980A (ja) 2020-01-23
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EP2896632A3 (en) 2015-08-19
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US20160222126A1 (en) 2016-08-04
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EP2719708B1 (en) 2017-10-25
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US20180134805A1 (en) 2018-05-17
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SI3351558T1 (sl) 2020-07-31
PT3351558T (pt) 2020-04-09
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