AR088669A1 - Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos - Google Patents
Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitosInfo
- Publication number
- AR088669A1 AR088669A1 ARP120104167A ARP120104167A AR088669A1 AR 088669 A1 AR088669 A1 AR 088669A1 AR P120104167 A ARP120104167 A AR P120104167A AR P120104167 A ARP120104167 A AR P120104167A AR 088669 A1 AR088669 A1 AR 088669A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- hydrogen
- oxaborol
- dihydrodibenzo
- dihydroisoxazol
- Prior art date
Links
- 244000078703 ectoparasite Species 0.000 title 1
- OHENQANLQNOMAO-UHFFFAOYSA-N oxaborole Chemical compound O1B=CC=C1 OHENQANLQNOMAO-UHFFFAOYSA-N 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 238000006467 substitution reaction Methods 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003652 trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Reivindicación 1: Un compuesto que tienen una estructura de fórmula (1) ó (2), caracterizado porque A es un compuesto del grupo de fórmulas (3), donde * se enlaza al carbonilo; Y es hidrógeno, fluoro, cloro o bromo; R¹ es fenilo sustituido 2 - 4 veces, las sustituciones comprenden i) 1 - 4 sustituciones con el mismo o diferente de halo, y 0 - 1 sustituciones con metilo, difluorometilo, trifluorometilo, metoxi, trifluorometoxi, o trifluoroetoxi, o ii) 2 grupos trifluorometilo; R² es metilo, fluorometilo, trifluorometilo, o perfluoroetilo; R³ᵃ y R³ᵇ se seleccionan independientemente de hidrógeno, metilo, etilo, fluorometilo, o R³ᵃ y R³ᵇ se combinan con el carbono al cual se unen para formar un anillo ciclopentilo o un anillo ciclohexilo; Z es -CH₂-, -CH₂-CH₂-, -CH(CH₃)-, o -C(CH₃)₂-; y R⁶ es hidrógeno o metilo; o una sal del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161562383P | 2011-11-21 | 2011-11-21 | |
| US201161562428P | 2011-11-21 | 2011-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088669A1 true AR088669A1 (es) | 2014-06-25 |
Family
ID=47279084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104167A AR088669A1 (es) | 2011-11-21 | 2012-11-06 | Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8546357B2 (es) |
| EP (1) | EP2782449B1 (es) |
| JP (1) | JP6118812B2 (es) |
| CN (2) | CN104066330B (es) |
| AR (1) | AR088669A1 (es) |
| AU (2) | AU2012327171B2 (es) |
| CA (1) | CA2891530A1 (es) |
| DK (1) | DK2782449T3 (es) |
| ES (1) | ES2599728T3 (es) |
| TW (1) | TW201333022A (es) |
| WO (1) | WO2013078071A1 (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3424932T (pt) * | 2005-02-16 | 2021-05-19 | Anacor Pharmaceuticals Inc | Boronoftalidas para utilização terapêutica |
| JP2009526751A (ja) | 2005-12-30 | 2009-07-23 | アナコール ファーマシューティカルズ，インコーポレイテッド | ホウ素含有小分子 |
| US8716478B2 (en) | 2010-01-27 | 2014-05-06 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| NZ710723A (en) | 2013-01-30 | 2019-12-20 | Agrofresh Inc | Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts |
| WO2014121124A1 (en) | 2013-02-01 | 2014-08-07 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
| US11446241B2 (en) | 2013-07-29 | 2022-09-20 | Attillaps Holdings Inc. | Treatment of ophthalmological conditions with acetylcholinesterase inhibitors |
| AU2014296454B2 (en) | 2013-07-29 | 2018-06-21 | Attillaps Holdings | Organophosphates for treating afflictions of the skin |
| EP4512471A3 (en) | 2014-06-19 | 2025-05-07 | Attillaps Holdings | Acetylcholinesterase inhibitors for treatment of dermatological conditions |
| RU2595831C2 (ru) * | 2014-11-06 | 2016-08-27 | Федеральное государственное бюджетное научное учреждение Якутский научно-исследовательский институт сельского хозяйства | Способ защиты домашних северных оленей от нападения гнуса |
| EP3280413A1 (en) * | 2015-04-08 | 2018-02-14 | Merial, Inc. | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| TW201735792A (zh) | 2016-03-07 | 2017-10-16 | 農業保鮮股份有限公司 | 使用苯并氧雜硼雜環戊烯化合物和防腐氣體作為作物的抗微生物劑之協同方法 |
| SG11201809237RA (en) | 2016-05-12 | 2018-11-29 | Anacor Pharmaceuticals Inc | Oxaborole esters and uses thereof |
| BR112019002284A2 (pt) * | 2016-08-03 | 2019-06-18 | Centre Nat Rech Scient | glicosaminoglicanos reticulados, método para reticulação de um primeiro glicosaminoglicano com uma função diol de cadeia principal e um segundo glicosaminoglicano sendo enxertado com um hemiéster boronato, uso de um hemiéster boronato, e, composição de polímero |
| BR112019002290A2 (pt) * | 2016-08-03 | 2019-06-18 | Centre Nat Rech Scient | um novo hidrogel feito de glicosaminoglicanos reticulados duplos, particularmente ácido hialurônico reticulado, condroitina ou sulfato de condroitina, com ligações reversíveis usando ácido borônico ou derivados de boroxol levando a novos benefícios. glicosaminoglicanos reticulados duplos, uma ligação por meio de duas uniões de éter com um grupo hidroxila de cada dos dois glicosaminoglicanos e outra ligação por meio de um ânion de éster alcoxiboronato formado entre um hemiéster de boronato enxertado a um dos glicosaminoglicanos e uma função diol de ao outro glicosaminoglicano. a função diol pode ser uma função diol de cadeia principal ou uma porção diol de uma fração funcional diol enxertada ao outro glicosaminoglicano. |
| ES2901326T3 (es) * | 2016-08-03 | 2022-03-22 | Galderma Res & Dev | Procedimiento de reticulación de glicosaminoglicanos |
| US10961261B2 (en) | 2017-03-01 | 2021-03-30 | Anacor Pharmaceuticals, Inc. | Oxaborole analogs and uses thereof |
| JP7569781B2 (ja) | 2018-07-27 | 2024-10-18 | アペルタ バイオサイエンシズ，エルエルシー | デモデックスにより誘発される眼の異常および顔面の異常を治療するためのスピノシン配合 |
| CN109879826B (zh) * | 2019-03-18 | 2021-04-13 | 丽珠集团新北江制药股份有限公司 | 一种异噁唑啉类杀虫剂的制备方法 |
| CN110028462B (zh) * | 2019-04-12 | 2021-03-23 | 丽珠集团新北江制药股份有限公司 | 一种制备异噁唑啉类中间体及异噁唑啉的方法 |
| CN110684000B (zh) * | 2019-10-18 | 2021-08-31 | 上海皓元医药股份有限公司 | 苯并呋喃衍生物的制备方法 |
| US12497370B2 (en) | 2019-12-18 | 2025-12-16 | Elanco Tiergesundheit Ag | Isoxazoline derivatives |
| CN111909143B (zh) * | 2020-07-30 | 2021-10-29 | 山东省联合农药工业有限公司 | 一种异噁唑啉取代的苯甲酰胺类衍生物及其制备方法与用途 |
| US20230340530A1 (en) | 2020-08-31 | 2023-10-26 | Pfizer Inc. | Methods of Protecting RNA |
| CN112552252B (zh) * | 2020-09-30 | 2024-01-02 | 浙江美诺华药物化学有限公司 | 一种氟雷拉纳中间体的制备方法 |
| WO2022192623A1 (en) * | 2021-03-11 | 2022-09-15 | In The Bowl Animal Health, Inc. | Oral canine feed and methods for controlling flea infestations in a canine |
| WO2022192614A1 (en) * | 2021-03-11 | 2022-09-15 | In The Bowl Animal Health, Inc. | Oral canine feed and methods for controlling flea infestations in a canine |
| KR20230162001A (ko) * | 2021-03-11 | 2023-11-28 | 인 더 보울 애니멀 헬스, 인크. | 갯과에서 진드기 감염을 방제하기 위한 경구용 갯과 사료 및 방법 |
| MX2023014965A (es) | 2021-06-16 | 2024-02-13 | Elanco Tiergesundheit Ag | Plaguicidas de (thi)oxazolina. |
| MX2023015272A (es) | 2021-06-16 | 2024-03-19 | Elanco Tiergesundheit Ag | Derivados de isoxazolina. |
| CN113735681B (zh) * | 2021-10-11 | 2023-12-12 | 丽珠集团新北江制药股份有限公司 | 一种氟雷拉纳中间体及其制备氟雷拉纳的方法 |
| WO2023118434A1 (en) * | 2021-12-22 | 2023-06-29 | Globachem Nv | Pesticidally active amide compounds |
| CN116102511A (zh) * | 2023-02-10 | 2023-05-12 | 河北圣雪大成制药有限责任公司 | 一种高纯度氟雷拉纳中间体的制备方法 |
| WO2026006412A1 (en) | 2024-06-25 | 2026-01-02 | Elanco Us Inc. | Isooxazoline compounds as antiparasitic agents |
| WO2026006414A1 (en) | 2024-06-25 | 2026-01-02 | Elanco Us Inc. | Isoxazol-benzamide compounds as antiparasitic compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102558082B (zh) * | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| PT3424932T (pt) | 2005-02-16 | 2021-05-19 | Anacor Pharmaceuticals Inc | Boronoftalidas para utilização terapêutica |
| CN101351450A (zh) * | 2005-12-15 | 2009-01-21 | 学校法人中央大学 | 金属配位化合物以及应用该化合物的有机电致发光元件 |
| TWI412322B (zh) * | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| JP2009526751A (ja) * | 2005-12-30 | 2009-07-23 | アナコール ファーマシューティカルズ，インコーポレイテッド | ホウ素含有小分子 |
| RU2508113C2 (ru) | 2006-02-16 | 2014-02-27 | Анакор Фармасьютикалз, Инк. | Борсодержащие малые молекулы в качестве противовоспалительных средств |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| TWI556741B (zh) * | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| US9493489B2 (en) * | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
| WO2011019618A1 (en) * | 2009-08-14 | 2011-02-17 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
-
2012
- 2012-11-06 AR ARP120104167A patent/AR088669A1/es unknown
- 2012-11-09 TW TW101141930A patent/TW201333022A/zh unknown
- 2012-11-16 EP EP12795228.1A patent/EP2782449B1/en not_active Not-in-force
- 2012-11-16 ES ES12795228.1T patent/ES2599728T3/es active Active
- 2012-11-16 JP JP2014543503A patent/JP6118812B2/ja active Active
- 2012-11-16 CN CN201280066186.XA patent/CN104066330B/zh not_active Expired - Fee Related
- 2012-11-16 AU AU2012327171A patent/AU2012327171B2/en not_active Ceased
- 2012-11-16 US US13/678,578 patent/US8546357B2/en not_active Expired - Fee Related
- 2012-11-16 WO PCT/US2012/065397 patent/WO2013078071A1/en not_active Ceased
- 2012-11-16 DK DK12795228.1T patent/DK2782449T3/en active
- 2012-11-16 CA CA2891530A patent/CA2891530A1/en not_active Abandoned
- 2012-11-16 CN CN201610243119.0A patent/CN105906655A/zh active Pending
-
2016
- 2016-06-22 AU AU2016204248A patent/AU2016204248A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012327171B2 (en) | 2016-03-31 |
| CA2891530A1 (en) | 2013-05-30 |
| TW201333022A (zh) | 2013-08-16 |
| JP6118812B2 (ja) | 2017-04-19 |
| ES2599728T3 (es) | 2017-02-02 |
| DK2782449T3 (en) | 2016-11-14 |
| AU2012327171A1 (en) | 2013-06-06 |
| EP2782449A1 (en) | 2014-10-01 |
| AU2016204248A1 (en) | 2016-07-14 |
| HK1202774A1 (en) | 2015-10-09 |
| CN104066330B (zh) | 2016-05-18 |
| JP2014534260A (ja) | 2014-12-18 |
| EP2782449B1 (en) | 2016-08-03 |
| US20130131017A1 (en) | 2013-05-23 |
| CN104066330A (zh) | 2014-09-24 |
| WO2013078071A1 (en) | 2013-05-30 |
| US8546357B2 (en) | 2013-10-01 |
| CN105906655A (zh) | 2016-08-31 |
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