AR086586A1 - Forma cristalina de ciclosporina a, metodos de preparacion y metodos para utilizar la misma - Google Patents
Forma cristalina de ciclosporina a, metodos de preparacion y metodos para utilizar la mismaInfo
- Publication number
- AR086586A1 AR086586A1 ARP120101878A ARP120101878A AR086586A1 AR 086586 A1 AR086586 A1 AR 086586A1 AR P120101878 A ARP120101878 A AR P120101878A AR P120101878 A ARP120101878 A AR P120101878A AR 086586 A1 AR086586 A1 AR 086586A1
- Authority
- AR
- Argentina
- Prior art keywords
- methods
- cyclosporin
- crystalline form
- same
- preparation
- Prior art date
Links
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 4
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
- 108010036949 Cyclosporine Proteins 0.000 title abstract 4
- 229960001265 ciclosporin Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 208000022873 Ocular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente se refiere en general a las formas cristalinas de ciclosporina A y particularmente a una forma recientemente identificada de ciclosporina A. Se refiere además a métodos para su preparación y métodos para tratar ciertos desórdenes oculares.Reivindicación 1: Una ciclosporina A que posee la estructura de fórmula (1) en Forma 2 cristalina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490887P | 2011-05-27 | 2011-05-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086586A1 true AR086586A1 (es) | 2014-01-08 |
Family
ID=46178866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101878A AR086586A1 (es) | 2011-05-27 | 2012-05-28 | Forma cristalina de ciclosporina a, metodos de preparacion y metodos para utilizar la misma |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US8772245B2 (es) |
| EP (2) | EP3521302A1 (es) |
| JP (1) | JP6163482B2 (es) |
| KR (1) | KR102079402B1 (es) |
| CN (1) | CN103649108B (es) |
| AR (1) | AR086586A1 (es) |
| AU (4) | AU2012262513B2 (es) |
| BR (1) | BR112013030554B1 (es) |
| CA (1) | CA2836946C (es) |
| CL (1) | CL2013003400A1 (es) |
| IL (2) | IL229475A0 (es) |
| MX (1) | MX362271B (es) |
| MY (1) | MY180581A (es) |
| RU (1) | RU2602062C2 (es) |
| SG (1) | SG10201607344UA (es) |
| TW (1) | TWI554522B (es) |
| UA (1) | UA113627C2 (es) |
| WO (1) | WO2012166610A1 (es) |
| ZA (1) | ZA201308665B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102015151B1 (ko) | 2011-11-15 | 2019-08-27 | 알러간, 인코포레이티드 | 사이클로스포린 a 제2형의 고압멸균처리 가능한 현탁액 |
| EP2780358B1 (en) * | 2011-11-15 | 2016-03-23 | Allergan, Inc. | Cyclosporine a form 2 and method of making same |
| EP3381443A1 (en) | 2011-11-15 | 2018-10-03 | Allergan, Inc. | Sustained action formulation of cyclosporin form 2 |
| DK2779994T3 (da) * | 2011-11-15 | 2020-05-18 | Allergan Inc | Suspensioner af cyclosporin a form 2 |
| CA2874548A1 (en) | 2012-06-01 | 2013-12-05 | Allergan, Inc. | Cyclosporin a analogs |
| GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
| US10524661B2 (en) * | 2013-06-12 | 2020-01-07 | Proactive Live, Inc. | Sleep monitoring and stimulation |
| BR112017001017A2 (pt) | 2014-07-18 | 2018-01-23 | Allergan Inc | composições em suspensão de ciclosporina a para injeção subconjuntival e periocular |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| US10443292B2 (en) * | 2016-04-25 | 2019-10-15 | Magna Closures, Inc. | Non-contact obstacle detection system for motor vehicles |
| JP7680824B2 (ja) * | 2017-05-17 | 2025-05-21 | ユーユー ファーマ，インコーポレーテッド | 新規ペプチド及びその新規ペプチドを活性成分として含む眼疾患の治療のための医薬組成物 |
| US11613558B2 (en) | 2018-11-14 | 2023-03-28 | Yuyu Pharma, Inc. | Peptides and pharmaceutical compositions for treating eye diseases |
| AU2021267217A1 (en) * | 2021-08-20 | 2024-02-29 | Sun Pharmaceutical Industries Limited | Stable cyclosporine ophthalmic formulation and manufacturing process thereof |
| EP4585605A1 (en) | 2022-10-20 | 2025-07-16 | Chugai Seiyaku Kabushiki Kaisha | Method for producing cyclic peptide crystals |
| CN120731215A (zh) | 2023-03-20 | 2025-09-30 | 中外制药株式会社 | 用于产生环肽的共晶的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU203564B (en) * | 1987-12-21 | 1991-08-28 | Sandoz Ag | Process for producing new orthorombos cyclosporin without solvatation |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5474979A (en) * | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| US6656504B1 (en) * | 1999-09-09 | 2003-12-02 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
| CA2686234A1 (en) * | 2007-05-04 | 2008-11-13 | Allergan, Inc. | Use of cyclosporines in the treatment of patients with intraocular lenses |
| BRPI0822221A2 (pt) * | 2008-01-04 | 2015-06-23 | Alcon Pharmaceuticals Ltd | Composições aquosas e estáveis de ciclosporina |
-
2012
- 2012-05-25 EP EP18211911.5A patent/EP3521302A1/en not_active Withdrawn
- 2012-05-25 WO PCT/US2012/039611 patent/WO2012166610A1/en not_active Ceased
- 2012-05-25 UA UAA201314231A patent/UA113627C2/uk unknown
- 2012-05-25 RU RU2013155033/04A patent/RU2602062C2/ru active
- 2012-05-25 JP JP2014512145A patent/JP6163482B2/ja active Active
- 2012-05-25 BR BR112013030554-1A patent/BR112013030554B1/pt active IP Right Grant
- 2012-05-25 US US13/480,710 patent/US8772245B2/en active Active
- 2012-05-25 EP EP12724525.6A patent/EP2714720B1/en active Active
- 2012-05-25 MX MX2013013855A patent/MX362271B/es active IP Right Grant
- 2012-05-25 CN CN201280033382.7A patent/CN103649108B/zh active Active
- 2012-05-25 KR KR1020137034444A patent/KR102079402B1/ko not_active Expired - Fee Related
- 2012-05-25 SG SG10201607344UA patent/SG10201607344UA/en unknown
- 2012-05-25 AU AU2012262513A patent/AU2012262513B2/en not_active Ceased
- 2012-05-25 MY MYPI2013004226A patent/MY180581A/en unknown
- 2012-05-25 CA CA2836946A patent/CA2836946C/en active Active
- 2012-05-28 TW TW101119051A patent/TWI554522B/zh not_active IP Right Cessation
- 2012-05-28 AR ARP120101878A patent/AR086586A1/es not_active Application Discontinuation
-
2013
- 2013-11-17 IL IL229475A patent/IL229475A0/en unknown
- 2013-11-19 ZA ZA2013/08665A patent/ZA201308665B/en unknown
- 2013-11-26 CL CL2013003400A patent/CL2013003400A1/es unknown
-
2014
- 2014-07-02 US US14/322,475 patent/US9206228B2/en active Active
-
2015
- 2015-12-07 US US14/961,132 patent/US20160083432A1/en not_active Abandoned
-
2016
- 2016-06-15 AU AU2016203990A patent/AU2016203990A1/en not_active Abandoned
-
2017
- 2017-11-21 AU AU2017265008A patent/AU2017265008A1/en not_active Abandoned
-
2019
- 2019-06-14 AU AU2019204192A patent/AU2019204192B2/en not_active Ceased
-
2021
- 2021-01-13 US US17/148,315 patent/US20210269484A1/en not_active Abandoned
-
2022
- 2022-01-27 IL IL290158A patent/IL290158A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR086586A1 (es) | Forma cristalina de ciclosporina a, metodos de preparacion y metodos para utilizar la misma | |
| GT201400033A (es) | Pirimidinas anilladas sustituidas y uso de las mismas | |
| HRP20200197T1 (hr) | 5-((halofenil)-3-halo-piridin-2-il)-nitrilni derivati kao posrednici u pripremi [(5-(halofenila)-3-hidroksipiridin-2-karbonil)-amino]derivata alkanske kiseline | |
| MX373291B (es) | Composiciones y metodos para el uso de ésteres de forbol | |
| MX391043B (es) | Formulaciones de anticuerpo y metodos. | |
| CO6940374A2 (es) | Composiciones, usos y métodos para tratamiento de trastornos y enfermedades metabólicas | |
| GT201200161A (es) | Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa | |
| UY34545A (es) | Novedosas dihidropirimidinoisoquinolinonas y composiciones farmacéuticas de las mismas para el tratamiento de trastornos inflamatorios. | |
| UY34278A (es) | Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades | |
| BR112013020767A2 (pt) | composições compreendendo ácido peróxi alfa-cetocarboxílico e métodos para a produção e o uso do mesmo | |
| MX383715B (es) | Formas sólidas de acido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y usos de las mismas. | |
| ECSP12012125A (es) | Ariltriazolonas ligadas a bisarilo y su uso | |
| MX2016003823A (es) | Inhibidor selectivo de fosfatidil-inositol 3-cinasa-gamma. | |
| CR20130464A (es) | Inhibidores sustituidos de acetil-coa carboxilasa | |
| WO2012129341A3 (en) | Disease detection in plants | |
| DOP2009000287A (es) | Oxazolidinonas sustituidas y su uso | |
| PL2717692T3 (pl) | Kwasy tetrahydrokannabinol-11-owe do stosowania w leczeniu chorób zwłóknieniowych | |
| BR112013022052A2 (pt) | ligantes antagonísticos de dr3 | |
| CL2012002540A1 (es) | Hidrato de hidrocloruro de agomelatina; forma cristalina; metodo de preparacion; composicion farmaceutica ; y su uso para el tratamiento de trastornos del sueño, estrés, ansiedad, depresion mayor, enfermedades cardiovasculares, entre otras. | |
| CO6970598A2 (es) | Derivados de 4-pregenen-11ss-17-21-triol-3,20-diona para el tratamiento de afecciones oculares | |
| CO6660435A2 (es) | Una forma cristalina de clorhidrato de (r) -7- cloro-n- (quinuclidin -3-il)benzo[b] tiofeno-2- carboxamida monohodratado | |
| PL2718434T3 (pl) | Kompozycje i sposoby leczenia choroby trzewnej | |
| DOP2009000285A (es) | (oxazolidinon-5-il-metil)-2-tiofen-carboxamidas sustituidas y su uso en el campo de la coagulacion sanguinea. | |
| BR112014000634A2 (pt) | métodos para tratamento de incontinência associada com atividade sexual | |
| BR112015003957A2 (pt) | alfa-1-microglobulina para uso no tratamento de doenças relacionadas com a mitocôndria |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |