AR086571A1 - METHOD FOR THE IDENTIFICATION OF THE ORIGIN OF A CANCER OF UNKNOWN PRIMARY ORIGIN - Google Patents
METHOD FOR THE IDENTIFICATION OF THE ORIGIN OF A CANCER OF UNKNOWN PRIMARY ORIGINInfo
- Publication number
- AR086571A1 AR086571A1 ARP120101861A AR086571A1 AR 086571 A1 AR086571 A1 AR 086571A1 AR P120101861 A ARP120101861 A AR P120101861A AR 086571 A1 AR086571 A1 AR 086571A1
- Authority
- AR
- Argentina
- Prior art keywords
- cpd
- origin
- methylation profile
- methods
- primary tumor
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000011987 methylation Effects 0.000 abstract 6
- 238000007069 methylation reaction Methods 0.000 abstract 6
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 206010073059 Malignant neoplasm of unknown primary site Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Se refiere a métodos y reactivos para la identificación del origen de un carcinoma de origen primario desconocido (CPD) basada en la determinación del perfil de metilación en el genoma del CPD. Se refiere también a métodos para seleccionar una terapia adecuada para un paciente que padece un CPD así como a métodos para la medicina personalizada de pacientes que padecen un CPD basándose en el uso de un tratamiento que sea adecuado para el tumor primario del que deriva el CPD. También se refiere a kits que comprenden reactivos adecuados para realizar los métodos anteriores así como a sistemas y programas informáticos que se pueden usar para implementar los métodos.Reivindicación 1: Un método para identificar el origen de un cáncer de origen primario desconocido (CPD) que comprende los pasos de: (i) determinar el perfil de metilación en una región seleccionada de un ADN aislado de dicho CPD y (ii) comparar el perfil de metilación de dicha región seleccionada con el perfil de metilación de la misma región en una muestra de ADN aislada de al menos un tumor primario en donde una identidad sustancial entre el perfil de metilación obtenido en el paso (i) y el perfil de metilación del tumor primario es indicativo de que el CPD deriva de dicho tumor primario.It refers to methods and reagents for the identification of the origin of a carcinoma of unknown primary origin (CPD) based on the determination of the methylation profile in the genome of the CPD. It also refers to methods for selecting a suitable therapy for a patient suffering from a CPD as well as methods for personalized medicine of patients suffering from a CPD based on the use of a treatment that is suitable for the primary tumor from which the CPD is derived. . It also refers to kits comprising suitable reagents for performing the above methods as well as systems and software that can be used to implement the methods. Claim 1: A method for identifying the origin of a cancer of unknown primary origin (CPD) that It comprises the steps of: (i) determining the methylation profile in a selected region of a DNA isolated from said CPD and (ii) comparing the methylation profile of said selected region with the methylation profile of the same region in a sample of DNA isolated from at least one primary tumor where a substantial identity between the methylation profile obtained in step (i) and the methylation profile of the primary tumor is indicative that the CPD derives from said primary tumor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP120101861 AR086571A1 (en) | 2012-05-24 | 2012-05-24 | METHOD FOR THE IDENTIFICATION OF THE ORIGIN OF A CANCER OF UNKNOWN PRIMARY ORIGIN |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP120101861 AR086571A1 (en) | 2012-05-24 | 2012-05-24 | METHOD FOR THE IDENTIFICATION OF THE ORIGIN OF A CANCER OF UNKNOWN PRIMARY ORIGIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086571A1 true AR086571A1 (en) | 2014-01-08 |
Family
ID=50190871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101861 AR086571A1 (en) | 2012-05-24 | 2012-05-24 | METHOD FOR THE IDENTIFICATION OF THE ORIGIN OF A CANCER OF UNKNOWN PRIMARY ORIGIN |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR086571A1 (en) |
-
2012
- 2012-05-24 AR ARP120101861 patent/AR086571A1/en unknown
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|---|---|---|---|
| FB | Suspension of granting procedure |