AR085038A1 - COMPUESTOS UTILES EN LA INHIBICION DE LA IL-17 Y DEL IFN-g PARA EL TRATAMIENTO DE LAS INFLAMACIONES AUTOINMUNES - Google Patents
COMPUESTOS UTILES EN LA INHIBICION DE LA IL-17 Y DEL IFN-g PARA EL TRATAMIENTO DE LAS INFLAMACIONES AUTOINMUNESInfo
- Publication number
- AR085038A1 AR085038A1 ARP120100295A ARP120100295A AR085038A1 AR 085038 A1 AR085038 A1 AR 085038A1 AR P120100295 A ARP120100295 A AR P120100295A AR P120100295 A ARP120100295 A AR P120100295A AR 085038 A1 AR085038 A1 AR 085038A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heterocyclyl
- haloalkyl
- heteroaryl
- cycloalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000001363 autoimmune Effects 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003106 haloaryl group Chemical group 0.000 abstract 2
- 125000002034 haloarylalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuestos de la formula general (1) y sales o solvatos farmacéuticamente aceptables de éstos que pueden usarse como agentes antiinflamatorios e inmunomoduladores.Reivindicación 1: Un compuesto caracterizado porque es de la fórmula general (1) y sales aceptables farmacéuticamente o solvatos del mismo, donde R1 es arilo, heteroarilo, cicloalquilo, heterociclilo o alquilo, que puede estar sustituido con uno o más sustituyentes R’; Ar es arilo, cicloalquilo, heterociclilo o heteroarilo, que puede estar sustituido con uno o más sustituyentes R’; Z es arilo, heteroarilo, cicloalquilo o heterociclilo, que puede estar sustituido con uno o más sustituyentes R’; Y es H, halógeno, haloalquilo, alquilo o un alquiléster, que puede estar sustituido con uno o más sustituyentes R’; R’ representa en forma independiente H, -CO2R’’, - CONHR’’, -CR’’O, -SO2N(R’’)2, -SO2NHR’’, -NR’’-CO-haloalquilo, -NO2, -NR’’-SO2-haloalquilo, -NR’’SO2-alquilo, -SO2-alquilo, -NR’’-CO-alquilo, -CN, alquilo, cicloalquilo, aminoalquilo, alquilamino, alcoxi, -OH, -SH, alquiltio, hidroxialquilo, hidroxialquilamino, halógeno, haloalquilo, haloalcoxi, amino, heterociclilo, arilo, haloarilo, haloarilalquilo, arilalquilo o heteroarilo; R’’ representa en forma independiente H, haloalquilo, hidroxialquilo, amino, alcoxi, -N=C(R’)2, -NR’-CO-R’, -CR’O, -CO2R’, alquilo, cicloalquilo, arilo, haloarilo, haloarilalquilo, heteroarilo, heterociclilo, arilalquilo o aminoalquilo, que están opcionalmente sustituidos con uno o más sustituyentes R’.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437080P | 2011-01-28 | 2011-01-28 | |
| EP11152512 | 2011-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR085038A1 true AR085038A1 (es) | 2013-08-07 |
Family
ID=46577836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100295A AR085038A1 (es) | 2011-01-28 | 2012-01-30 | COMPUESTOS UTILES EN LA INHIBICION DE LA IL-17 Y DEL IFN-g PARA EL TRATAMIENTO DE LAS INFLAMACIONES AUTOINMUNES |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8354436B2 (es) |
| EP (1) | EP2668183B1 (es) |
| JP (1) | JP5883034B2 (es) |
| KR (1) | KR101865437B1 (es) |
| CN (1) | CN103459385B (es) |
| AR (1) | AR085038A1 (es) |
| AU (1) | AU2012210491B2 (es) |
| BR (1) | BR112013019256B1 (es) |
| CA (1) | CA2825779C (es) |
| DK (1) | DK2668183T3 (es) |
| EA (1) | EA026361B1 (es) |
| ES (1) | ES2664219T3 (es) |
| HU (1) | HUE036027T2 (es) |
| IL (1) | IL227682A0 (es) |
| MX (1) | MX348726B (es) |
| MY (1) | MY183974A (es) |
| PH (1) | PH12013501591A1 (es) |
| PL (1) | PL2668183T3 (es) |
| PT (1) | PT2668183T (es) |
| RU (1) | RU2013139662A (es) |
| SG (1) | SG192198A1 (es) |
| TW (1) | TWI533867B (es) |
| UA (1) | UA110048C2 (es) |
| UY (1) | UY33885A (es) |
| WO (1) | WO2012101263A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101875248B1 (ko) * | 2011-01-28 | 2018-08-02 | 4에스체 디스코베리 게엠베하 | 자가면역 염증의 치료를 위한 il17 및 ifn-감마 억제 |
| US9156837B2 (en) | 2011-07-29 | 2015-10-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP2809660B1 (en) | 2012-02-02 | 2016-01-20 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating il-17 |
| JP6225178B2 (ja) | 2012-05-31 | 2017-11-01 | フェネックス ファーマシューティカルス アーゲー | オーファン核内受容体ＲＯＲγの調整剤としてのカルボキサミドまたはスルホンアミド置換されたチアゾールおよび関連する誘導体 |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| US9707154B2 (en) | 2013-04-24 | 2017-07-18 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| WO2017221174A1 (en) * | 2016-06-22 | 2017-12-28 | Novartis Ag | Methods of treating vitiligo using interleukin-17 (il-17) antibodies |
| JP7406990B2 (ja) * | 2016-11-11 | 2023-12-28 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ヒト血漿様培地 |
| KR20200069299A (ko) * | 2017-09-06 | 2020-06-16 | 이뮤닉 아게 | 자가면역 질환 및 만성 염증을 치료하기 위한 il-17 및 ifn-감마 억제제로서의 1-(4-(이속사졸-5-일)-1h-피라졸-1-일)-2-메틸프로판-2-올 유도체 및 관련 화합물 |
| US20200392223A1 (en) * | 2018-02-22 | 2020-12-17 | Tokai University Educational System | Il-17a activity inhibitor and use thereof |
| RU2704967C1 (ru) * | 2018-06-19 | 2019-11-01 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный педагогический университет им. К.Д. Ушинского (ЯГПУ им. К.Д. Ушинского) | Карбоксамидные производные изоксазолина, способ их получения и применения для лечения воспалительных заболеваний |
| WO2021027721A1 (zh) * | 2019-08-09 | 2021-02-18 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN112341440B (zh) * | 2019-08-09 | 2022-05-31 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN112341439B (zh) * | 2019-08-09 | 2022-02-15 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| WO2023281097A1 (en) | 2021-07-09 | 2023-01-12 | Immunic Ag | Methods for treating cancer |
| WO2023198873A1 (en) | 2022-04-14 | 2023-10-19 | Immunic Ag | Deuterated rorgamma/rorgammat inverse agonists |
| WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514977B1 (en) * | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| DE602005014621D1 (de) * | 2004-03-09 | 2009-07-09 | Boehringer Ingelheim Pharma | 3-ä4-heterocyclyl-1,2,3-triazol-1-ylü-n-arylbenzamide als inhibitoren der cytokinenproduktion für die behandlung von chronischen entzündlichen erkrankungen |
| WO2007071598A1 (en) * | 2005-12-23 | 2007-06-28 | F. Hoffmann-La Roche Ag | Aryl-isoxazolo-4-yl-oxadiazole derivatives |
| EP2382212B1 (en) * | 2009-01-23 | 2014-07-16 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
| KR101875248B1 (ko) * | 2011-01-28 | 2018-08-02 | 4에스체 디스코베리 게엠베하 | 자가면역 염증의 치료를 위한 il17 및 ifn-감마 억제 |
-
2012
- 2012-01-27 PL PL12703014T patent/PL2668183T3/pl unknown
- 2012-01-27 KR KR1020137022373A patent/KR101865437B1/ko not_active Expired - Fee Related
- 2012-01-27 AU AU2012210491A patent/AU2012210491B2/en not_active Ceased
- 2012-01-27 EP EP12703014.6A patent/EP2668183B1/en active Active
- 2012-01-27 MY MYPI2013002824A patent/MY183974A/en unknown
- 2012-01-27 PT PT127030146T patent/PT2668183T/pt unknown
- 2012-01-27 HU HUE12703014A patent/HUE036027T2/hu unknown
- 2012-01-27 DK DK12703014.6T patent/DK2668183T3/da active
- 2012-01-27 US US13/360,063 patent/US8354436B2/en active Active
- 2012-01-27 CA CA2825779A patent/CA2825779C/en active Active
- 2012-01-27 ES ES12703014.6T patent/ES2664219T3/es active Active
- 2012-01-27 SG SG2013057583A patent/SG192198A1/en unknown
- 2012-01-27 JP JP2013550894A patent/JP5883034B2/ja not_active Expired - Fee Related
- 2012-01-27 BR BR112013019256-9A patent/BR112013019256B1/pt not_active IP Right Cessation
- 2012-01-27 EA EA201300863A patent/EA026361B1/ru not_active IP Right Cessation
- 2012-01-27 UA UAA201310355A patent/UA110048C2/ru unknown
- 2012-01-27 RU RU2013139662/04A patent/RU2013139662A/ru not_active Application Discontinuation
- 2012-01-27 WO PCT/EP2012/051360 patent/WO2012101263A1/en not_active Ceased
- 2012-01-27 MX MX2013008722A patent/MX348726B/es active IP Right Grant
- 2012-01-27 PH PH1/2013/501591A patent/PH12013501591A1/en unknown
- 2012-01-27 CN CN201280010976.6A patent/CN103459385B/zh not_active Expired - Fee Related
- 2012-01-30 UY UY0001033885A patent/UY33885A/es not_active Application Discontinuation
- 2012-01-30 AR ARP120100295A patent/AR085038A1/es active IP Right Grant
- 2012-01-30 TW TW101102963A patent/TWI533867B/zh not_active IP Right Cessation
-
2013
- 2013-07-28 IL IL227682A patent/IL227682A0/en active IP Right Grant
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