SMT201500191B - Derivati di benzopirazina sostituiti come inibitori delle chinasi fgfr per il trattamento di malattie tumorali - Google Patents
Derivati di benzopirazina sostituiti come inibitori delle chinasi fgfr per il trattamento di malattie tumoraliInfo
- Publication number
- SMT201500191B SMT201500191B SM201500191T SM201500191T SMT201500191B SM T201500191 B SMT201500191 B SM T201500191B SM 201500191 T SM201500191 T SM 201500191T SM 201500191 T SM201500191 T SM 201500191T SM T201500191 B SMT201500191 B SM T201500191B
- Authority
- SM
- San Marino
- Prior art keywords
- benzopyrazine
- treatment
- kinase inhibitors
- tumor diseases
- derivatives substituted
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41774410P | 2010-11-29 | 2010-11-29 | |
| GBGB1020179.6A GB201020179D0 (en) | 2010-11-29 | 2010-11-29 | New compounds |
| PCT/GB2011/052356 WO2012073017A1 (en) | 2010-11-29 | 2011-11-29 | Substituted benzopyrazin derivatives as fgfr kinase inhibitors for the treatment of cancer diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201500191B true SMT201500191B (it) | 2015-09-07 |
Family
ID=43500774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201500191T SMT201500191B (it) | 2010-11-29 | 2015-08-06 | Derivati di benzopirazina sostituiti come inibitori delle chinasi fgfr per il trattamento di malattie tumorali |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9290478B2 (it) |
| EP (1) | EP2646432B1 (it) |
| JP (1) | JP5868992B2 (it) |
| KR (1) | KR101914720B1 (it) |
| CN (1) | CN103370314B (it) |
| AU (1) | AU2011334624B2 (it) |
| BR (1) | BR112013013435B1 (it) |
| CA (1) | CA2819009C (it) |
| DK (1) | DK2646432T3 (it) |
| ES (1) | ES2541493T3 (it) |
| GB (1) | GB201020179D0 (it) |
| HR (1) | HRP20150692T8 (it) |
| HU (1) | HUE025091T2 (it) |
| MX (1) | MX2013005897A (it) |
| RU (1) | RU2602233C2 (it) |
| SI (1) | SI2646432T1 (it) |
| SM (1) | SMT201500191B (it) |
| WO (1) | WO2012073017A1 (it) |
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| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
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| EP2757885B1 (en) | 2011-09-21 | 2017-03-15 | Neupharma, Inc. | Certain chemical entites, compositions, and methods |
| WO2013049701A1 (en) | 2011-09-30 | 2013-04-04 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| US9670180B2 (en) | 2012-01-25 | 2017-06-06 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
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- 2011-11-29 AU AU2011334624A patent/AU2011334624B2/en active Active
- 2011-11-29 US US13/990,193 patent/US9290478B2/en active Active
- 2011-11-29 KR KR1020137016924A patent/KR101914720B1/ko active Active
- 2011-11-29 DK DK11805567.2T patent/DK2646432T3/en active
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| ES2541493T3 (es) | 2015-07-21 |
| AU2011334624A1 (en) | 2013-06-13 |
| BR112013013435A2 (pt) | 2016-10-11 |
| HRP20150692T1 (hr) | 2015-08-14 |
| DK2646432T3 (en) | 2015-07-13 |
| EP2646432A1 (en) | 2013-10-09 |
| WO2012073017A1 (en) | 2012-06-07 |
| US9290478B2 (en) | 2016-03-22 |
| CA2819009C (en) | 2020-02-25 |
| GB201020179D0 (en) | 2011-01-12 |
| KR20130132509A (ko) | 2013-12-04 |
| RU2602233C2 (ru) | 2016-11-10 |
| AU2011334624B2 (en) | 2016-09-15 |
| RU2013129820A (ru) | 2015-01-10 |
| EP2646432B1 (en) | 2015-04-08 |
| US20130267525A1 (en) | 2013-10-10 |
| KR101914720B1 (ko) | 2018-11-05 |
| JP5868992B2 (ja) | 2016-02-24 |
| HK1187916A1 (en) | 2014-04-17 |
| CN103370314B (zh) | 2015-10-21 |
| CA2819009A1 (en) | 2012-06-07 |
| US9856236B2 (en) | 2018-01-02 |
| MX2013005897A (es) | 2013-10-25 |
| JP2013543883A (ja) | 2013-12-09 |
| CN103370314A (zh) | 2013-10-23 |
| HUE025091T2 (en) | 2016-01-28 |
| US20160031856A1 (en) | 2016-02-04 |
| BR112013013435B1 (pt) | 2020-10-20 |
| HRP20150692T8 (en) | 2015-09-25 |
| SI2646432T1 (sl) | 2015-08-31 |
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