[go: up one dir, main page]

AR073516A1 - Terapia combinada para tratar infeccion por hcv y kit - Google Patents

Terapia combinada para tratar infeccion por hcv y kit

Info

Publication number
AR073516A1
AR073516A1 ARP090103556A ARP090103556A AR073516A1 AR 073516 A1 AR073516 A1 AR 073516A1 AR P090103556 A ARP090103556 A AR P090103556A AR P090103556 A ARP090103556 A AR P090103556A AR 073516 A1 AR073516 A1 AR 073516A1
Authority
AR
Argentina
Prior art keywords
kit
hcv infection
combined therapy
hcv
patient
Prior art date
Application number
ARP090103556A
Other languages
English (en)
Inventor
Gerhard G Steinmann
David Huang
Jerry O Stern
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41571875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR073516(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR073516A1 publication Critical patent/AR073516A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El compuesto (1) es un inhibidor selectivo y potente de la proteasa de serina NS3 de HCV. Métodos para emplear tales combinaciones terapéuticas para el tratamiento de infeccion por HCV o para aliviar uno o más síntomas de la misma en un paciente. Reivindicacion 1: Un método para tratar infeccion por virus de hepatitis C (HCV) o aliviar uno o más síntomas de la misma en un paciente caracterizado porque comprende el paso de administrar al paciente una combinacion terapéutica que comprende: (a) un compuesto de la formula (1) siguiente o una sal farmacéuticamente aceptable del mismo; b) interferon alfa; y c) ribavirina
ARP090103556A 2008-09-17 2009-09-16 Terapia combinada para tratar infeccion por hcv y kit AR073516A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9775308P 2008-09-17 2008-09-17
US10903308P 2008-10-28 2008-10-28
US17193509P 2009-04-23 2009-04-23

Publications (1)

Publication Number Publication Date
AR073516A1 true AR073516A1 (es) 2010-11-10

Family

ID=41571875

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103556A AR073516A1 (es) 2008-09-17 2009-09-16 Terapia combinada para tratar infeccion por hcv y kit

Country Status (24)

Country Link
US (1) US8399484B2 (es)
EP (1) EP2337583A1 (es)
JP (1) JP5539363B2 (es)
KR (1) KR20110054003A (es)
CN (1) CN102159245B (es)
AR (1) AR073516A1 (es)
AU (1) AU2009293493B2 (es)
BR (1) BRPI0918653A2 (es)
CA (1) CA2737376A1 (es)
CL (1) CL2011000571A1 (es)
CO (1) CO6351753A2 (es)
EA (1) EA019965B1 (es)
EC (1) ECSP11010877A (es)
IL (1) IL210152A0 (es)
MA (1) MA32634B1 (es)
MX (1) MX2011002602A (es)
MY (1) MY152824A (es)
NZ (1) NZ591030A (es)
PE (1) PE20110343A1 (es)
TW (1) TWI454263B (es)
UA (1) UA103496C2 (es)
UY (1) UY32124A (es)
WO (1) WO2010033443A1 (es)
ZA (1) ZA201009151B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
AU2009293493B2 (en) 2008-09-17 2014-09-18 Boehringer Ingelheim International Gmbh Combination of HCV NS3 protease inhibitor with interferon and ribavirin
AR075584A1 (es) * 2009-02-27 2011-04-20 Intermune Inc COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
JP2013505952A (ja) * 2009-09-28 2013-02-21 インターミューン・インコーポレーテッド Ｃ型肝炎ウイルス複製の新しい大環状阻害剤
CA2779244A1 (en) * 2009-10-30 2011-05-05 Boehringer Ingelheim International Gmbh Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
CA2813093A1 (en) * 2010-09-30 2012-04-05 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection
CA2822556A1 (en) 2010-12-30 2012-07-05 Enanta Pharmaceuticals, Inc Macrocyclic hepatitis c serine protease inhibitors
CN103380132B (zh) 2010-12-30 2016-08-31 益安药业 菲啶大环丙型肝炎丝氨酸蛋白酶抑制剂
CA2824376C (en) * 2011-01-10 2016-02-23 Proteus Digital Health, Inc. System, method, and article to prompt behavior change
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
AU2013201532B2 (en) 2011-10-21 2014-10-02 Abbvie Ireland Unlimited Company Methods for treating HCV
EA201490837A1 (ru) 2011-10-21 2014-11-28 Эббви Инк. Способы лечения hcv, включающие по меньшей мере два противовирусных агента прямого действия, рибавирин, но не интерферон
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
WO2013137869A1 (en) * 2012-03-14 2013-09-19 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection in an hcv-hiv coinfected patient population
US20140242029A1 (en) * 2013-02-27 2014-08-28 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection in an hcv-hiv coinfected patient population
WO2013147750A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
WO2013147749A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient subgenotype populations
JP2015512900A (ja) * 2012-03-28 2015-04-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 特別な患者の遺伝子亜型分集団のｈｃｖ感染症を治療するための併用療法
WO2014138374A1 (en) 2013-03-08 2014-09-12 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247479A (en) * 1976-12-03 1981-01-27 Hoechst Aktiengesellschaft Process for the manufacture of aromatic amines from α, β-unsaturated cycloaliphatic ketoximes
US6387365B1 (en) * 1995-05-19 2002-05-14 Schering Corporation Combination therapy for chronic hepatitis C infection
DE69632062T2 (de) * 1995-11-02 2004-11-18 Schering Corp. Kontinuierliche, niedrigdosierte zytokine-infusionstherapie
US5908621A (en) * 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US6172046B1 (en) * 1997-09-21 2001-01-09 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection
US6472373B1 (en) * 1997-09-21 2002-10-29 Schering Corporation Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
RS50144B (sr) * 1998-06-08 2009-03-25 F. Hoffmann-La Roche Ag., Primena peg-inf-alfa 2a i ribavirina za proizvodnju leka za lečenje hroničnog hepatitisa c
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
US6824768B2 (en) * 1998-12-18 2004-11-30 Schering Corporation Ribavirin-pegylated interferon alfa induction HCV combination therapy
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
US6849254B1 (en) * 1999-04-19 2005-02-01 Schering Corporation HCV combination therapy
DE60129445T2 (de) * 2000-08-09 2008-04-24 F. Hoffmann-La Roche Ag Quinolin-derivate als antientzündungsmittel
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US6867185B2 (en) 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7119072B2 (en) * 2002-01-30 2006-10-10 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis C virus
US20050075279A1 (en) * 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
US7601709B2 (en) * 2003-02-07 2009-10-13 Enanta Pharmaceuticals, Inc. Macrocyclic hepatitis C serine protease inhibitors
CN1771257A (zh) * 2003-04-10 2006-05-10 贝林格尔·英格海姆国际有限公司 通过钌络合物催化的易位反应制备大环化合物的方法
JP4231524B2 (ja) * 2003-04-10 2009-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 大環状化合物の製造方法
ATE422895T1 (de) * 2003-04-16 2009-03-15 Bristol Myers Squibb Co Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus
EA009295B1 (ru) * 2003-05-21 2007-12-28 Бёрингер Ингельхайм Интернациональ Гмбх Соединения в качестве ингибиторов вируса гепатита с
RU2371195C2 (ru) * 2003-08-13 2009-10-27 Говард Дж. Смит Энд Эссошиэйтс Пти Лтд Способ лечения вирусных инфекций
RS20060197A (sr) * 2003-09-22 2008-09-29 Boehringer Ingelheim International Gmbh., Makrociklični peptidi koji su aktivni protiv hepatitisa c virusa
AR045870A1 (es) * 2003-10-11 2005-11-16 Vertex Pharma Terapia de combinacion para la infeccion de virus de hepatitis c
US7491794B2 (en) * 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
US7410979B2 (en) * 2003-11-19 2008-08-12 Rigel Pharmaceuticals, Inc. Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
CN103319464A (zh) * 2004-02-20 2013-09-25 贝林格尔.英格海姆国际有限公司 病毒聚合酶抑制剂
BRPI0508867A (pt) * 2004-03-15 2007-09-04 Boehringer Ingelheim Int processo para a preparação de compostos macrocìclicos
BRPI0509467A (pt) 2004-03-30 2007-09-11 Intermune Inc compostos macrocìclicos como inibidores de replicação viral
EP1753775B1 (en) 2004-05-25 2012-12-26 Boehringer Ingelheim International GmbH Process for preparing acyclic hcv protease inhibitors
DE102004033312A1 (de) * 2004-07-08 2006-01-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kontinuierliches Metatheseverfahren mit Ruthenium-Katalysatoren
DE602005026294D1 (de) * 2004-07-14 2011-03-24 Novartis Ag Verwendung einer kombination von cyclosporin und pegylierten interferonen zur behandlung von hepatitis c (hcv)
WO2006033851A1 (en) * 2004-09-17 2006-03-30 Boehringer Ingelheim International, Gmbh Ring-closing metathesis process in supercritical fluid
JP2008513454A (ja) * 2004-09-17 2008-05-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 大環状ｈｃｖプロテアーゼインヒビターの調製方法
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
US20070274951A1 (en) * 2006-02-09 2007-11-29 Xiao Tong Combinations comprising HCV protease inhibitor(s) and HCV polymerase inhibitor(s), and methods of treatment related thereto
WO2008070358A2 (en) * 2006-11-16 2008-06-12 Phenomix Corporation N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain
JP5465666B2 (ja) 2007-06-29 2014-04-09 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス化合物
KR20100038417A (ko) 2007-06-29 2010-04-14 길리애드 사이언시즈, 인코포레이티드 항바이러스 화합물
WO2009014730A1 (en) 2007-07-26 2009-01-29 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
WO2009021121A2 (en) 2007-08-08 2009-02-12 Wyeth Identification and characterization of hcv replicon variants with reduced susceptibility to a combination of polymerase and protease inhibitors, and methods related thereto
WO2009099596A2 (en) 2008-02-04 2009-08-13 Idenix Pharamaceuticals, Inc. Macrocyclic serine protease inhibitors
AU2009293494B2 (en) 2008-09-16 2014-04-24 Boehringer Ingelheim International Gmbh Crystalline forms of a 2-thiazolyl- 4-quinolinyl-oxy derivative, a potent HCV inhibitor
AU2009293493B2 (en) 2008-09-17 2014-09-18 Boehringer Ingelheim International Gmbh Combination of HCV NS3 protease inhibitor with interferon and ribavirin
AR073603A1 (es) 2008-09-18 2010-11-17 Ortho Mcneil Janssen Pharm Combinaciones sinergicas de un inhibidor macrociclico del vhc y un nucleosido
UA104195C2 (ru) * 2009-07-07 2014-01-10 Берингер Ингельхайм Интернациональ Гмбх Фармацевтическая композиция ингибитора протеазы вируса гепатита c
CA2779244A1 (en) 2009-10-30 2011-05-05 Boehringer Ingelheim International Gmbh Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
US8530497B2 (en) 2010-03-11 2013-09-10 Boehringer Ingelheim International Gmbh Crystalline salts of a potent HCV inhibitor
CA2813093A1 (en) * 2010-09-30 2012-04-05 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection

Also Published As

Publication number Publication date
JP2012502999A (ja) 2012-02-02
US20100068182A1 (en) 2010-03-18
UY32124A (es) 2010-04-30
EA019965B1 (ru) 2014-07-30
PE20110343A1 (es) 2011-06-25
ECSP11010877A (es) 2011-04-29
BRPI0918653A2 (pt) 2015-12-01
TW201016218A (en) 2010-05-01
AU2009293493B2 (en) 2014-09-18
CA2737376A1 (en) 2010-03-25
HK1156865A1 (en) 2012-06-22
EP2337583A1 (en) 2011-06-29
JP5539363B2 (ja) 2014-07-02
US8399484B2 (en) 2013-03-19
CO6351753A2 (es) 2011-12-20
NZ591030A (en) 2012-10-26
WO2010033443A1 (en) 2010-03-25
AU2009293493A1 (en) 2010-03-25
CN102159245B (zh) 2013-07-24
UA103496C2 (uk) 2013-10-25
EA201100506A1 (ru) 2011-10-31
TWI454263B (zh) 2014-10-01
MA32634B1 (fr) 2011-09-01
MY152824A (en) 2014-11-28
IL210152A0 (en) 2011-03-31
ZA201009151B (en) 2011-09-28
MX2011002602A (es) 2011-04-07
KR20110054003A (ko) 2011-05-24
CN102159245A (zh) 2011-08-17
CL2011000571A1 (es) 2011-07-29

Similar Documents

Publication Publication Date Title
AR073516A1 (es) Terapia combinada para tratar infeccion por hcv y kit
PH12012500827A1 (en) Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
EA201490837A1 (ru) Способы лечения hcv, включающие по меньшей мере два противовирусных агента прямого действия, рибавирин, но не интерферон
NO20062428L (no) Kombinasjoner for HCV-behandling
ECSP13012551A (es) Terapia de combinación para tratar infección por hcv.
PH12014502847A1 (en) Combination treatment (eg with abt-072-333) of daas for use in treating hcv
ECSP077217A (es) Inhibidores de proteasa peptidomimeticos
RU2015114543A (ru) Способы лечения гепатита с
PA8744101A1 (es) Metodo de terapia combinada para el tratamiento de la infeccion por el virus de la hepatitis c y composiciones farmaceuticas para usar en dicha terapia
ATE548044T1 (de) Kombinationstherapie zur behandlung von hiv- infektionen
RU2015114566A (ru) Способы лечения гепатита с
EA201170484A1 (ru) Терапевтический режим лечения гепатита, включающий пэг-интерферон, рибавирин и vx-950
RU2010153688A (ru) Режим дозирования телапревира
WO2009067225A3 (en) Boceprevir derivatives for the treatment of hcv infections
UY34020A (es) Terapia combinada para tratar la infección por vhc en una población de pacientes co-infectados por vhc-vih
RU2013148539A (ru) Алиспоривир для лечения инфекции вируса гепатита с
TN2011000134A1 (en) Polytherapie destinee a traiter une infection par le vhc
AR086185A1 (es) Terapia combinada oral para tratar infeccion por hcv en una subpoblacion de pacientes especificos
TH139548A (th) การบำบัดรักษาแบบผสมผสาน สำหรับการรักษาการติดเชื้อ hcv
UY28555A1 (es) Terapia de combinación para la infección de hcv
AR086186A1 (es) Terapia combinada oral para tratar infeccion por hcv en una poblacion de subgenotipos de pacientes especificos, kit y compuesto
TN2013000134A1 (en) Combination therapy for treating hcv infection
AR085928A1 (es) Terapia combinada para tratar infecciones por hcv (virus de la hepatitis c) en una subpoblacion de subgenotipos de pacientes especificos
BR112015021692A2 (pt) formulação de dosagem oral sólida de inibidor de hcv no estado amorfo

Legal Events

Date Code Title Description
FB Suspension of granting procedure