AR072810A1 - Compuesto de 3-( 4 fenilsulfonil-1-piperazinil) carbonil) pirazolo(1,5 -a) pirimidina , composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento del dolor. - Google Patents
Compuesto de 3-( 4 fenilsulfonil-1-piperazinil) carbonil) pirazolo(1,5 -a) pirimidina , composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento del dolor.Info
- Publication number
- AR072810A1 AR072810A1 ARP090102693A ARP090102693A AR072810A1 AR 072810 A1 AR072810 A1 AR 072810A1 AR P090102693 A ARP090102693 A AR P090102693A AR P090102693 A ARP090102693 A AR P090102693A AR 072810 A1 AR072810 A1 AR 072810A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- pyrimidine
- manufacture
- pharmaceutical composition
- piperazinil
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 239000002131 composite material Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 101000935123 Homo sapiens Voltage-dependent N-type calcium channel subunit alpha-1B Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102100025342 Voltage-dependent N-type calcium channel subunit alpha-1B Human genes 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical compound N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un Compuesto de 3-[4-fenilsulfonil-1-piperazinil)carbonil]pirazolo[1,5-a]pirimidina que es de la formula (1), o una sal del mismo: R1 es alquilo C1-4, halogeno o ciano; m y n se seleccionan de 0, 1 y 2; R2 es alquilo C1-4 R3 es hidrogeno, ciano, haloalquilo C1-4, haloalcoxi C1-4 o halogeno; R4 es hidrogeno o alquilo C1-4; R5 es hidrogeno, ciano, haloalquilo C1-4, haloalcoxi C1-4 o halogeno; R6 es hidrogeno, ciano, haloalquilo C1-4, haloalcoxi C1-4 o halogeno; de modo que al menos 1 de R3, R4, R5 y R6 es un grupo diferente de hidrogeno; R7 es hidrogeno o alquilo C1-4; de manera que cuando R7 es alquilo C1-4, n es 0. Composicion farmacéutica que lo contienen y uso del mismo para la fabricacion de un medicamento para tratar enfermedades en las que es beneficioso el bloqueo de los canales de calcio Cav2.2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0813144.3A GB0813144D0 (en) | 2008-07-17 | 2008-07-17 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072810A1 true AR072810A1 (es) | 2010-09-22 |
Family
ID=39737241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090102693A AR072810A1 (es) | 2008-07-17 | 2009-07-15 | Compuesto de 3-( 4 fenilsulfonil-1-piperazinil) carbonil) pirazolo(1,5 -a) pirimidina , composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento del dolor. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8093249B2 (es) |
| EP (1) | EP2313413B1 (es) |
| JP (1) | JP5611201B2 (es) |
| AR (1) | AR072810A1 (es) |
| ES (1) | ES2387733T3 (es) |
| GB (1) | GB0813144D0 (es) |
| TW (1) | TW201016699A (es) |
| UY (1) | UY31989A (es) |
| WO (1) | WO2010007074A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201000685D0 (en) | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
| EP3156405A1 (en) | 2015-10-13 | 2017-04-19 | Boehringer Ingelheim International GmbH | Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| KR20230017828A (ko) * | 2020-05-27 | 2023-02-06 | 에스테베 파마슈티칼스 에스에이 | 통증에 대한 다중모드 활성을 갖는 피라졸로[1,5-a]피리미딘 유도체 |
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| CA2680842C (en) | 2007-05-31 | 2015-11-24 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | N-acetyl mannosamine or derivatives thereof for use in treating a kidney disorder in a mammal |
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-
2008
- 2008-07-17 GB GBGB0813144.3A patent/GB0813144D0/en not_active Ceased
-
2009
- 2009-07-15 AR ARP090102693A patent/AR072810A1/es not_active Application Discontinuation
- 2009-07-15 US US12/503,135 patent/US8093249B2/en not_active Expired - Fee Related
- 2009-07-15 ES ES09780588T patent/ES2387733T3/es active Active
- 2009-07-15 JP JP2011517912A patent/JP5611201B2/ja not_active Expired - Fee Related
- 2009-07-15 WO PCT/EP2009/059013 patent/WO2010007074A1/en not_active Ceased
- 2009-07-15 UY UY0001031989A patent/UY31989A/es unknown
- 2009-07-15 TW TW098123841A patent/TW201016699A/zh unknown
- 2009-07-15 EP EP09780588A patent/EP2313413B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010007074A1 (en) | 2010-01-21 |
| TW201016699A (en) | 2010-05-01 |
| EP2313413A1 (en) | 2011-04-27 |
| JP5611201B2 (ja) | 2014-10-22 |
| JP2011528021A (ja) | 2011-11-10 |
| ES2387733T3 (es) | 2012-10-01 |
| US8093249B2 (en) | 2012-01-10 |
| UY31989A (es) | 2010-01-05 |
| EP2313413B1 (en) | 2012-05-16 |
| US20100016330A1 (en) | 2010-01-21 |
| GB0813144D0 (en) | 2008-08-27 |
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