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AR071831A1 - Sistemas no invasivos y metodos para fotobiomodulacion in situ. composicion farmaceutica. kit. - Google Patents

Sistemas no invasivos y metodos para fotobiomodulacion in situ. composicion farmaceutica. kit.

Info

Publication number
AR071831A1
AR071831A1 ARP090101189A ARP090101189A AR071831A1 AR 071831 A1 AR071831 A1 AR 071831A1 AR P090101189 A ARP090101189 A AR P090101189A AR P090101189 A ARP090101189 A AR P090101189A AR 071831 A1 AR071831 A1 AR 071831A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
energy
activation
agent
active
Prior art date
Application number
ARP090101189A
Other languages
English (en)
Original Assignee
Univ Duke
Immunolight Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke, Immunolight Llc filed Critical Univ Duke
Publication of AR071831A1 publication Critical patent/AR071831A1/es

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    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
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Abstract

Productos, composiciones, sistemas y metodos para modificar una estructura blanco que media o est  asociada con una actividad biologica, incluyendo tratamiento de afecciones, trastornos, o enfermedades mediadas por o asociadas con una estructura blanco, tal como un virus, una celula, estructura celular o estructura extracelular. Kits que contienen los productos o las composiciones formuladas o configuradas y sistemas para usar en la puesta en pr ctica de estos metodos. Reivindicacion 1: Una composicion farmaceutica para modificar una estructura pretendida que media o est  asociada con una actividad biologica, que comprende: por lo menos un agente seleccionado del grupo que consiste en agentes de modulacion de energ¡a, agentes activosplasmonicos y combinaciones de los anteriores; y a veh¡culo aceptable desde el punto de vista farmaceutico. Reivindicacion 2: La composicion farmaceutica de la reivindicacion 1, comprende adem s una fuente de energ¡a qu¡mica. Reivindicacion 3: La composicion farmaceutica de la reivindicacion 2, en la cual la fuente de energ¡a qu¡mica es un elemento seleccionado del grupo que consiste en compuestos fluorescentes, compuestos quimioluminiscentes, compuestos bioluminiscentes y enzimas emisoras de luz. Reivindicacion 5: La composicion farmaceutica de la reivindicacion 1, que comprende adem s por lo menos un agente farmaceutico susceptible de activacion. Reivindicacion 9: La composicion farmaceutica de la reivindicacion 5, en la cual el por lo menos un agente farmaceutico susceptible de activacion es 8-MOP o AMT. Reivindicacion 10: La composicion farmaceutica de la reivindicacion 5, en la cual el por lo menos un agente farmaceutico susceptible de activacion es uno seleccionado de 7,8-dimetil-1 0-ribitilo, isoaloxazina, 7,8,10-trimetilisoaloxazina, 7,8-dimetilaloxazina, isoaloxazina-adenina dinucleotido, aloxazina mononucleotido, tetrasulfonato de aluminio (III) ftalocianina, hematoporfirina, y ftadocianina. Reivindicacion 12: La composicion farmaceutica de la reivindicacion 11, en la cual el veh¡culo es uno seleccionado de insulina, interleucina, timopoyetina o transferrina. Reivindicacion 31: La composicion farmaceutica de la reivindicacion 28, en la cual el agente activo-plasmonico es una sonda PEPST que comprende nano estructuras de metal activas con plasmonicos. Reivindicacion 61: La composicion farmaceutica de la reivindicacion 1, comprende adem s por lo menos un aditivo que tiene un efecto terapeutico o de diagnostico complementario, en la cual dicho aditivo es por lo menos un elemento seleccionado del grupo que consiste en antioxidantes, adyuvantes, fuentes de energ¡a qu¡micas, y combinaciones de los anteriores. Reivindicacion 105: Una composicion que comprende por lo menos un agente farmaceutico susceptible de activacion (PA) que es capaz de efectuar un cambio predeterminado en una estructura pretendida cuando se activa, y, en forma opcional, por lo menos un elemento seleccionado del grupo que consiste en agentes de modulacion de energ¡a, agentes activos-plasmonicos y combinaciones de los anteriores, para usar en la fabricacion de un medicamento para un tratamiento que modifica una estructura pretendida que media o est  asociada con una actividad biologica, en el cual el tratamiento comprende: (1) contactar dicha estructura pretendida con la composicion farmaceutica; y (2) aplicar una energ¡a de iniciacion proveniente de una fuente de energ¡a de iniciacion a dicha estructura pretendida, donde el agente de modulacion de energ¡a, si est  presente, eleva o disminuye la energ¡a de iniciacion a una energ¡a de activacion capaz de activar el por lo menos un agente farmaceutico susceptible de activacion; donde el agente activo-plasmonico, si est  presente, potencia o modifica la energ¡a de iniciacion aplicada o la energ¡a de activacion generada por el agente de modulacion de energ¡a, o ambos; y de este modo logrando que ocurra el cambio predeterminado a la estructura pretendida, en el cual dicho cambio predeterminado modifica la estructura pretendida y modula la actividad biologica de la estructura pretendida.
ARP090101189A 2008-04-04 2009-04-03 Sistemas no invasivos y metodos para fotobiomodulacion in situ. composicion farmaceutica. kit. AR071831A1 (es)

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US4256108P 2008-04-04 2008-04-04

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US (4) US20100016783A1 (es)
EP (2) EP3300744A1 (es)
JP (5) JP5967935B2 (es)
CN (3) CN102056625B (es)
AR (1) AR071831A1 (es)
CA (3) CA2720513C (es)
CL (1) CL2009000816A1 (es)
SA (1) SA109300207B1 (es)
TW (3) TWI615170B (es)
WO (1) WO2009124189A1 (es)

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