AR071790A1 - Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales. - Google Patents
Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales.Info
- Publication number
- AR071790A1 AR071790A1 ARP090101736A ARP090101736A AR071790A1 AR 071790 A1 AR071790 A1 AR 071790A1 AR P090101736 A ARP090101736 A AR P090101736A AR P090101736 A ARP090101736 A AR P090101736A AR 071790 A1 AR071790 A1 AR 071790A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- compounds
- lower alkyl
- unsubstituted
- Prior art date
Links
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical class NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procesos para la obtencion de dichos compuestos as¡ como a los medicamentos que contienen dichos compuestos. Los compuestos de esta solicitud poseen actividad anti-proliferante e inductora de la diferenciacion y por ello son utiles para el tratamiento de enfermedades tales como el c ncer en seres humanos y en animales. Reivindicacion 1: Compuestos de la formula (1) en la que R1 es hidrogeno; alquilo inferior; cicloalquilo; heterociclilo; arilo o heteroarilo; y todos los grupos recien mencionados pueden estar sin sustituir o sustituidos una o varias veces por halogeno; alquilo inferior, que est sin sustituir o sustituido una o varias veces por halogeno; alcoxi inferior; cicloalquilo; ciano; -NRaRb; -OCF3; o -S(O)2-alquilo inferior; en los que Ra/Rb con independencia entre s¡ son alquilo inferior o cicloalquilo, o junto con el tomo de nitrogeno al que est n unidos pueden formar un heterociclilo de 4-6 eslabones; R2, R3, R4 se eligen con independencia entre hidrogeno; halogeno; alquilo interior, que est sin sustituir o sustituido una vez por hidroxi; alcoxi inferior; hidroxi; heterociclilo; un grupo de formula (2), o -NRR', en el que R/R' con independencia entre s¡ son hidrogeno; alquilo inferior sustituido por hidroxi; -C(O)-alquilo inferior; o el mismo alquilo inferior u otro diferente; y n es el numero 0, 1 o 2; o R2 y R3 junto con los tomos de carbono a los que est n unidos pueden formar un cicloalquilo de 4-6 eslabones, en el que uno de los tomos de carbono puede haberse reemplazado por nitrogeno, ox¡geno o azufre; y sus sales farmaceuticamente activas, mezclas racemicas, enantiomeros, isomeros opticos o formas tautomeras.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08156365 | 2008-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071790A1 true AR071790A1 (es) | 2010-07-14 |
Family
ID=40756614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101736A AR071790A1 (es) | 2008-05-16 | 2009-05-14 | Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7999000B2 (es) |
| EP (1) | EP2280940A1 (es) |
| JP (1) | JP2011519966A (es) |
| KR (1) | KR20100132553A (es) |
| CN (1) | CN102026969A (es) |
| AR (1) | AR071790A1 (es) |
| AU (1) | AU2009248231A1 (es) |
| BR (1) | BRPI0912399A2 (es) |
| CA (1) | CA2724003A1 (es) |
| CL (1) | CL2009001150A1 (es) |
| IL (1) | IL208873A0 (es) |
| MX (1) | MX2010012297A (es) |
| PE (1) | PE20100139A1 (es) |
| TW (1) | TW200951110A (es) |
| WO (1) | WO2009138338A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8202866B2 (en) * | 2008-09-17 | 2012-06-19 | Hoffmann-La Roche Inc. | Ortho-aminoanilides for the treatment of cancer |
| KR20110117194A (ko) * | 2009-02-23 | 2011-10-26 | 에프. 호프만-라 로슈 아게 | 암 치료를 위한 신규한 오르토-아미노아미드 |
| US9212132B2 (en) | 2011-12-05 | 2015-12-15 | Ricoh Company Ltd. | (Meth)acrylic acid ester, activation energy ray curing composition, and inkjet recording ink |
| WO2014142255A1 (ja) | 2013-03-14 | 2014-09-18 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3018123B1 (en) | 2013-07-03 | 2023-05-10 | Takeda Pharmaceutical Company Limited | Amide compound |
| EP3018126A4 (en) | 2013-07-03 | 2016-12-07 | Takeda Pharmaceuticals Co | HETEROCYCLIC CONNECTION |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1033046B (it) | 1970-10-31 | 1979-07-10 | Finotto Martino | Procedimento di fabbricazione di benzimidazoli sostituiti |
| DE2201062A1 (de) * | 1972-01-11 | 1973-07-26 | Bayer Ag | N-alkoxycarbonyl- bzw. n-alkylthiocarbonyl-2-(2'-thienyl)-benzimidazole, ein verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| EP1233958B1 (en) | 1999-11-23 | 2011-06-29 | MethylGene Inc. | Inhibitors of histone deacetylase |
| KR20100107509A (ko) * | 2001-09-14 | 2010-10-05 | 9222-9129 퀘벡 인코포레이티드 | 히스톤 데아세틸라아제의 억제제 |
| US7253204B2 (en) * | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US7834034B2 (en) * | 2005-04-20 | 2010-11-16 | Merck Sharp & Dohme Corp. | Benzothiophene derivatives |
| EP1973405A4 (en) | 2006-01-12 | 2011-06-01 | Merck Sharp & Dohme | HYDROXYALKYLARYLAMID DERIVATIVES |
| EP1991226B1 (en) * | 2006-02-28 | 2013-03-20 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
| JP2011510917A (ja) * | 2008-01-29 | 2011-04-07 | エフ．ホフマン−ラ ロシュ アーゲー | 新規ｎ−（２−アミノ−フェニル）−アミド誘導体 |
-
2009
- 2009-05-06 WO PCT/EP2009/055441 patent/WO2009138338A1/en not_active Ceased
- 2009-05-06 KR KR1020107025623A patent/KR20100132553A/ko not_active Abandoned
- 2009-05-06 MX MX2010012297A patent/MX2010012297A/es active IP Right Grant
- 2009-05-06 JP JP2011508865A patent/JP2011519966A/ja active Pending
- 2009-05-06 CN CN2009801175566A patent/CN102026969A/zh active Pending
- 2009-05-06 EP EP09745671A patent/EP2280940A1/en not_active Withdrawn
- 2009-05-06 CA CA2724003A patent/CA2724003A1/en not_active Abandoned
- 2009-05-06 AU AU2009248231A patent/AU2009248231A1/en not_active Abandoned
- 2009-05-06 BR BRPI0912399A patent/BRPI0912399A2/pt not_active IP Right Cessation
- 2009-05-11 US US12/463,452 patent/US7999000B2/en not_active Expired - Fee Related
- 2009-05-12 CL CL2009001150A patent/CL2009001150A1/es unknown
- 2009-05-12 PE PE2009000647A patent/PE20100139A1/es not_active Application Discontinuation
- 2009-05-14 TW TW098116054A patent/TW200951110A/zh unknown
- 2009-05-14 AR ARP090101736A patent/AR071790A1/es unknown
-
2010
- 2010-10-21 IL IL208873A patent/IL208873A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2280940A1 (en) | 2011-02-09 |
| KR20100132553A (ko) | 2010-12-17 |
| TW200951110A (en) | 2009-12-16 |
| AU2009248231A1 (en) | 2009-11-19 |
| MX2010012297A (es) | 2010-12-06 |
| CL2009001150A1 (es) | 2010-06-11 |
| PE20100139A1 (es) | 2010-03-05 |
| US20090286848A1 (en) | 2009-11-19 |
| CN102026969A (zh) | 2011-04-20 |
| US7999000B2 (en) | 2011-08-16 |
| BRPI0912399A2 (pt) | 2016-01-12 |
| IL208873A0 (en) | 2011-01-31 |
| CA2724003A1 (en) | 2009-11-19 |
| WO2009138338A1 (en) | 2009-11-19 |
| JP2011519966A (ja) | 2011-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR079327A1 (es) | Derivados de 2-amino-5,5-difluor -5,6-dihidro-4h-(1,3) oxazin-4-il) fenil)-amida | |
| GT200600429A (es) | Compuestos organicos | |
| AR067663A1 (es) | Derivados heterociclicos de etiloxi amidas, composiciones que los comprenden y usos de los mismos en agricultura u horticultura, como agentes antifungicos. | |
| AR071790A1 (es) | Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales. | |
| CO6361937A2 (es) | Derivados de heteroaril amidas y sus usos como activadores de glucoquinasa | |
| PE20071094A1 (es) | Derivados 1-ortoflurofenil sustituidos 1,2,5-tiadiazolidindionas como inhibidores de ptpasa | |
| UY29656A1 (es) | Grupos de compuestos de amino benzoilos heterociclilos, composiciones farmacéuticas que los contienen, procesos de prepación y aplicaciones | |
| AR066583A1 (es) | Derivados de 3,3-espiroindolinona | |
| AR096979A1 (es) | Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| PE20141191A1 (es) | Compuestos como inhibidores de bace | |
| UY29457A1 (es) | Compuestos novedosos de derivados de aminosulfonilo | |
| GT200300296A (es) | Derivados de pirimidina para el tratamiento del crecimiento celular anormal | |
| ECSP10010654A (es) | Derivados de tienopiridonas como activadores de proteína quinasa activados por amp (ampk) | |
| CO6612267A2 (es) | Nuevos derivados de 1,1 dióxido- 5 fenil- 2,3,4-5tetrahidro- 1,4-benzotiazepina y composiciones farmaceúticas que los comprenden | |
| CU20090184A7 (es) | Compuestos amino-heterocíclicos | |
| UY33458A (es) | Derivados de metoxifenilo heterocíclicamente sustituidos con un grupo oxo, procedimientos para su preparación y uso de los mismos como medicamentos | |
| AR085960A1 (es) | 1,3-oxazinas como inhibidores de la bace1 y/o de la bace2 | |
| PE20120031A1 (es) | Compuestos aril metil benzoquinazolinona como moduladores alostericos positivos del receptor m1 | |
| CU23824A3 (es) | Compuestos tricíclicos y sus composiciones | |
| PA8614301A1 (es) | Derivados de tropano | |
| AR072793A1 (es) | Compuestos de aril isoxazol con actividades antitumorales | |
| GT200800096A (es) | (1-aza-biciclo-(3.3.1)-non-4-il)-(5-(1h-indol-5-il)-heteroaril)-aminas como ligandos colinergicos del n-achr para el tratamiento de trastornos psicoticos y neurodegenerativos. | |
| NI200800015A (es) | Derivados de n-(heteroaril)-1-heteroarilalquil - 1h - indol - 2 - carboxamidas, su preparación y su aplicación en terapéutica. | |
| UY30835A1 (es) | 8-alquinilxantinas y derivados | |
| AR068376A1 (es) | Amidas heterociclicas utiles para inhibir la via hedgehog. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |