AR070051A2 - Una preparacion farmaceutica para la cura del sindrome de xeroftalmia - Google Patents
Una preparacion farmaceutica para la cura del sindrome de xeroftalmiaInfo
- Publication number
- AR070051A2 AR070051A2 ARP080105747A ARP080105747A AR070051A2 AR 070051 A2 AR070051 A2 AR 070051A2 AR P080105747 A ARP080105747 A AR P080105747A AR P080105747 A ARP080105747 A AR P080105747A AR 070051 A2 AR070051 A2 AR 070051A2
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical preparation
- cure
- syndrome
- xeroftalmia
- carbestiryl
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 4
- 208000011580 syndromic disease Diseases 0.000 title abstract 3
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 2
- 206010013774 Dry eye Diseases 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000005494 xerophthalmia Diseases 0.000 abstract 2
- -1 4-chlorobenzoylamino Chemical group 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229960003194 meglumine Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una preparacion farmacéutica para la cura de del síndrome de xeroftalmia (ojo seco), que contiene como un ingrediente activo, del 0,01 al 3% en peso de un derivado de carboestirilo o sal del mismo representado por la formula (1); (donde R es un átomo de halogeno, la posicion substituida de la cadena lateral de la formula (2); es la posicion 3- o 4- en la estructura de carboestirilo, y el enlace carbono-carbono entre las posiciones 3- y 4- en la estructura de carboestirilo es un enlace simple o un enlace doble) y, como agente diluyente, agua. Reivindicacion 5: La preparacion farmacéutica para la cura del síndrome de xeroftalmia (ojo seco) de acuerdo con alguna de las reivindicaciones 1 a 4, caracterizada porque el ingrediente activo es el ácido 2-(4-clorobenzoilamino)-3-(2-quinolon-4-il)propionico o una sal del mismo. Reivindicacion 6: La preparacion farmacéutica de acuerdo con alguna de las reivindicaciones 1 a 5, caracterizada porque además contiene Meglumina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26389695 | 1995-10-12 | ||
| JP5733796 | 1996-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070051A2 true AR070051A2 (es) | 2010-03-10 |
Family
ID=26398366
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104658A AR004214A1 (es) | 1995-10-12 | 1996-09-10 | Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas |
| ARP060103704A AR055393A2 (es) | 1995-10-12 | 2006-08-25 | Uso de un derivado de carboestirilo para la preparcion de una composicion farmaceutica para tratar enfermedades oftalmologicas |
| ARP080105747A AR070051A2 (es) | 1995-10-12 | 2008-12-29 | Una preparacion farmaceutica para la cura del sindrome de xeroftalmia |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104658A AR004214A1 (es) | 1995-10-12 | 1996-09-10 | Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas |
| ARP060103704A AR055393A2 (es) | 1995-10-12 | 2006-08-25 | Uso de un derivado de carboestirilo para la preparcion de una composicion farmaceutica para tratar enfermedades oftalmologicas |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6060486A (es) |
| EP (1) | EP0859615B1 (es) |
| KR (1) | KR100281865B1 (es) |
| CN (1) | CN1132580C (es) |
| AR (3) | AR004214A1 (es) |
| AT (1) | ATE201992T1 (es) |
| AU (1) | AU709734B2 (es) |
| CA (1) | CA2234247C (es) |
| DE (1) | DE69613386T2 (es) |
| DK (1) | DK0859615T3 (es) |
| ES (1) | ES2159043T3 (es) |
| GR (1) | GR3036457T3 (es) |
| MX (1) | MX9802817A (es) |
| PT (1) | PT859615E (es) |
| TW (1) | TW446702B (es) |
| WO (1) | WO1997013515A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3093661B2 (ja) | 1995-10-12 | 2000-10-03 | 大塚製薬株式会社 | 眼疾患治療剤 |
| US6506412B2 (en) | 2000-11-29 | 2003-01-14 | Sciencebased Health | Treatment of dry eye syndrome |
| US6623754B2 (en) * | 2001-05-21 | 2003-09-23 | Noveon Ip Holdings Corp. | Dosage form of N-acetyl cysteine |
| DE10133870A1 (de) * | 2001-07-12 | 2003-02-06 | Chris P Lohmann | Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge |
| KR100907407B1 (ko) * | 2002-09-28 | 2009-07-10 | 주식회사 케이티 | 대량 메시지 동보 전송을 위한 메시지 예약 및 전송 방법 |
| EP1648563B1 (en) * | 2003-07-30 | 2007-09-19 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives for accelerating salivation |
| WO2005046700A1 (ja) * | 2003-11-14 | 2005-05-26 | Senju Pharmaceutical Co., Ltd. | アミノグリコシド系抗生物質およびブロムフェナクを含有する水溶液製剤 |
| TWI340650B (en) * | 2004-01-21 | 2011-04-21 | Otsuka Pharma Co Ltd | Amine saly of carbostyril derivative |
| WO2006022291A1 (ja) | 2004-08-27 | 2006-03-02 | Senju Pharmaceutical Co, .Ltd. | ドライアイ治療用点眼液 |
| TWI363626B (en) * | 2004-11-15 | 2012-05-11 | Otsuka Pharma Co Ltd | Aqueous ophthalmic suspension of crystalline rebamipide |
| TW200808375A (en) * | 2006-05-12 | 2008-02-16 | Otsuka Pharma Co Ltd | Hydrogel suspension and manufacturing process thereof |
| TWI415629B (zh) * | 2006-10-26 | 2013-11-21 | Otsuka Pharma Co Ltd | 含有瑞巴匹特之水性醫藥懸浮物及其製造方法 |
| RU2331408C1 (ru) * | 2007-05-31 | 2008-08-20 | Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) | Глазная мазь |
| TWI495634B (zh) * | 2008-06-19 | 2015-08-11 | Otsuka Pharma Co Ltd | 醫藥組成物 |
| WO2012114317A1 (en) | 2011-02-25 | 2012-08-30 | Nuformix Limited | Novel rebamipide complexes and cocrystals |
| TW201322982A (zh) * | 2011-11-01 | 2013-06-16 | Otsuka Pharma Co Ltd | 用於治療前眼疾病之藥劑，該藥劑包含瑞巴派特及眼淚保持劑 |
| KR101692578B1 (ko) * | 2013-04-18 | 2017-01-03 | 삼진제약주식회사 | 레바미피드 또는 이의 전구체를 포함하는 안구건조증의 예방 또는 치료를 위한 경구용 약제학적 조성물 |
| CN106535740B (zh) * | 2014-05-02 | 2019-10-15 | 马萨诸塞眼科耳科诊所 | 用于确定表示角膜染色量的分数的方法和系统 |
| KR20170039347A (ko) | 2015-10-01 | 2017-04-11 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
| KR102307958B1 (ko) | 2015-10-01 | 2021-10-05 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
| CN110891555B (zh) | 2017-03-05 | 2023-12-26 | 雷斯德沃克研究及发展有限公司 | 用于治疗非因感染引起的刺激的滴眼剂 |
| KR102615076B1 (ko) | 2021-07-14 | 2023-12-19 | 대우제약 주식회사 | 안정한 레바미피드 점안제의 대용량 제조 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI80022C (fi) * | 1982-07-05 | 1990-04-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat. |
| JPH0713138B2 (ja) * | 1986-07-30 | 1995-02-15 | 保土谷化学工業株式会社 | ポリテトラメチレンエ−テルグリコ−ルの製法 |
| KR0180248B1 (ko) * | 1991-06-07 | 1999-03-20 | 오오쓰까 아끼히꼬 | 항당뇨병약품 |
| TW227558B (es) * | 1992-05-14 | 1994-08-01 | Otsuka Pharma Co Ltd | |
| CN1105799A (zh) * | 1993-03-18 | 1995-07-26 | 大制药株式会社 | 作为基质金属蛋白酶抑制剂的喹诺酮衍生物 |
| DK0674515T3 (da) * | 1993-10-21 | 1999-12-20 | Otsuka Pharma Co Ltd | Anvendelse af carbostyrilderivater til fremstilling af et medikament til inhibering af interleukin-8 |
| WO1996004911A1 (en) * | 1994-08-10 | 1996-02-22 | Otsuka Pharmaceutical Co., Ltd. | Method of preventing and treating ophthalmic inflammation and/or wound |
-
1996
- 1996-09-10 AR ARP960104658A patent/AR004214A1/es not_active Application Discontinuation
- 1996-10-01 ES ES96932058T patent/ES2159043T3/es not_active Expired - Lifetime
- 1996-10-01 AU AU70975/96A patent/AU709734B2/en not_active Expired
- 1996-10-01 PT PT96932058T patent/PT859615E/pt unknown
- 1996-10-01 EP EP96932058A patent/EP0859615B1/en not_active Expired - Lifetime
- 1996-10-01 DK DK96932058T patent/DK0859615T3/da active
- 1996-10-01 CA CA002234247A patent/CA2234247C/en not_active Expired - Lifetime
- 1996-10-01 KR KR1019980702671A patent/KR100281865B1/ko not_active Expired - Lifetime
- 1996-10-01 WO PCT/JP1996/002850 patent/WO1997013515A1/en not_active Ceased
- 1996-10-01 US US09/051,194 patent/US6060486A/en not_active Expired - Lifetime
- 1996-10-01 DE DE69613386T patent/DE69613386T2/de not_active Expired - Lifetime
- 1996-10-01 CN CN96198194A patent/CN1132580C/zh not_active Expired - Lifetime
- 1996-10-01 AT AT96932058T patent/ATE201992T1/de active
- 1996-10-02 TW TW085112022A patent/TW446702B/zh not_active IP Right Cessation
-
1998
- 1998-04-08 MX MX9802817A patent/MX9802817A/es unknown
-
2001
- 2001-08-27 GR GR20010401307T patent/GR3036457T3/el unknown
-
2006
- 2006-08-25 AR ARP060103704A patent/AR055393A2/es not_active Application Discontinuation
-
2008
- 2008-12-29 AR ARP080105747A patent/AR070051A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9802817A (es) | 1998-09-30 |
| ATE201992T1 (de) | 2001-06-15 |
| WO1997013515A1 (en) | 1997-04-17 |
| GR3036457T3 (en) | 2001-11-30 |
| AR004214A1 (es) | 1998-11-04 |
| CN1202108A (zh) | 1998-12-16 |
| AR055393A2 (es) | 2007-08-22 |
| KR100281865B1 (ko) | 2001-02-15 |
| EP0859615B1 (en) | 2001-06-13 |
| AU7097596A (en) | 1997-04-30 |
| DE69613386T2 (de) | 2002-05-23 |
| US6060486A (en) | 2000-05-09 |
| CA2234247C (en) | 2005-05-10 |
| CN1132580C (zh) | 2003-12-31 |
| DK0859615T3 (da) | 2001-09-03 |
| AU709734B2 (en) | 1999-09-02 |
| KR19990064187A (ko) | 1999-07-26 |
| PT859615E (pt) | 2001-09-28 |
| EP0859615A1 (en) | 1998-08-26 |
| TW446702B (en) | 2001-07-21 |
| CA2234247A1 (en) | 1997-04-17 |
| DE69613386D1 (de) | 2001-07-19 |
| ES2159043T3 (es) | 2001-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |