AR070017A1 - Una composiciones de liberacion prolongada que comprende micofenolato sodico,el metodo de utilizar dicha composicion y el uso de dicha composicion - Google Patents
Una composiciones de liberacion prolongada que comprende micofenolato sodico,el metodo de utilizar dicha composicion y el uso de dicha composicionInfo
- Publication number
- AR070017A1 AR070017A1 ARP080103537A ARP080103537A AR070017A1 AR 070017 A1 AR070017 A1 AR 070017A1 AR P080103537 A ARP080103537 A AR P080103537A AR P080103537 A ARP080103537 A AR P080103537A AR 070017 A1 AR070017 A1 AR 070017A1
- Authority
- AR
- Argentina
- Prior art keywords
- agent
- composition
- active
- mycophenolate
- coating
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 12
- 229960000951 mycophenolic acid Drugs 0.000 title abstract 5
- 230000002035 prolonged effect Effects 0.000 title abstract 2
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 9
- -1 anesthetic Substances 0.000 abstract 5
- 239000013543 active substance Substances 0.000 abstract 4
- DOZYTHNHLLSNIK-JOKMOOFLSA-M mycophenolate sodium Chemical compound [Na+].OC1=C(C\C=C(/C)CCC([O-])=O)C(OC)=C(C)C2=C1C(=O)OC2 DOZYTHNHLLSNIK-JOKMOOFLSA-M 0.000 abstract 4
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000003018 immunosuppressive agent Substances 0.000 abstract 3
- 239000003472 antidiabetic agent Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- 239000000150 Sympathomimetic Substances 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000048 adrenergic agonist Substances 0.000 abstract 1
- 239000000674 adrenergic antagonist Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000004004 anti-anginal agent Substances 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 230000000151 anti-reflux effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 229940124345 antianginal agent Drugs 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 229940124346 antiarthritic agent Drugs 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127090 anticoagulant agent Drugs 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- 239000000504 antifibrinolytic agent Substances 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000003524 antilipemic agent Substances 0.000 abstract 1
- 239000000939 antiparkinson agent Substances 0.000 abstract 1
- 229940127218 antiplatelet drug Drugs 0.000 abstract 1
- 239000003908 antipruritic agent Substances 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 229960001265 ciclosporin Drugs 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000002702 enteric coating Substances 0.000 abstract 1
- 238000009505 enteric coating Methods 0.000 abstract 1
- 230000010437 erythropoiesis Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000013265 extended release Methods 0.000 abstract 1
- 239000003527 fibrinolytic agent Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 229940126904 hypoglycaemic agent Drugs 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 229940127230 sympathomimetic drug Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960000103 thrombolytic agent Drugs 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composiciones farmacéuticas de liberacion prolongada que comprenden micofenolato sodico como agente activo, en las que la composicion muestra un perfil de liberacion característico cuando se la somete un estudio de disolucion in vitro, y en la que dicho micofenolato sodico se libera de manera sostenida in vivo durante un período prolongado de tiempo, en cantidades tales que alivian substancialmente o al menos reducen las posibilidades de causar cualquier efecto secundario gastrointestinal sin comprometer la biodisponibilidad de dicho agente activo. Un proceso para preparar tales composiciones con forma de dosificacion y métodos profilácticos y/o terapéuticos para utilizar tal forma de dosificacion. La composicion de la presente es segura, eficaz y bien tolerada, y es de utilidad en el manejo, por ejemplo, la profilaxis, mejora y/o tratamiento de enfermedades/trastornos en los que están indicados inmunosupresores, especialmente para el tratamiento o prevencion del rechazo de xenoinjertos o aloinjertos de organos, tejidos o células, por ejemplo, después de un trasplante, o el manejo de enfermedades de mediacion inmunologica (enfermedades autoinmunes). Reivindicacion 9: La composicion tal como se reivindica en las reivindicaciones 1 a 8, caracterizada porque la composicion comprende además al menos otros agentes activos seleccionados de un grupo que incluye fármacos cardiovasculares, fármacos respiratorios, fármacos simpatomiméticos, fármacos colonomiméticos, agonista adrenérgico, antagonista adrenérgico, analgésico/antipirético, anestésico, antiasmático, antibiotico, antidepresivo, antidiabético, agente antifungal, agente antihipertensivo, agente antiinflamatorio, antineoplásico, agente antiansiedad, antipsicotico, agente inmunosupresor, agente antimigrana, sedantes/hipnoticos, agente antianginoso, agente antipsicotico, agente antimaníaco, antiarrítmico, agente antiartrítico, agente antigotoso, agente anticoagulante, agente trombolítico, agente antifibrinolítico, agente hemoreologico, agente antiplaquetario, agente anticonvulsivo, agente antiparkinsoniano, agente antihistamínico/antiprurítico, agente de utilidad para la regulacion del calcio, agente antibacteriano, agente antiviral, antimicrobiano, antiinfeccioso, broncodilatador, hormona, agente hipoglicémico, agente hipolipidémico, proteína, ácido nucleico, agente de utilidad para la estimulacion de la eritropoiesis, agente antiulcerosos/antireflujo, antinauseoso/antiemético, vitaminas solubles en aceite y sus sales farmacéuticamente aceptables, ésteres, amidas, polimorfos, solvatos, hidratos, análogos, enantiomeros, formas tautoméricas o sus mezclas, utilizadas solas o en combinacion con las mismas. Reivindicacion 10: La composicion tal como se reivindica en la reivindicacion 9, caracterizada porque el otro agente activo de utilidad en la presente solicitud junto con el micofenolato sodico es un inmunosupresor tal como ciclosporina o un corticoesteroide. Reivindicacion 25: La composicion tal como se reivindica en cualquiera de las reivindicaciones precedentes, caracterizada porque la composicion comprende un nucleo y al menos un recubrimiento tal que el agente activo micofenolato sodico está presente en el nucleo o el recubrimiento, o en ambos, y en donde el recubrimiento no es un recubrimiento entérico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1714DE2007 IN2007DE01714A (es) | 2004-09-08 | 2007-08-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070017A1 true AR070017A1 (es) | 2010-03-10 |
Family
ID=40350431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080103537A AR070017A1 (es) | 2007-08-13 | 2008-08-13 | Una composiciones de liberacion prolongada que comprende micofenolato sodico,el metodo de utilizar dicha composicion y el uso de dicha composicion |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9642808B2 (es) |
| EP (1) | EP2187872A4 (es) |
| KR (1) | KR20100063059A (es) |
| AR (1) | AR070017A1 (es) |
| AU (1) | AU2008288106B2 (es) |
| BR (1) | BRPI0816231A2 (es) |
| CL (1) | CL2008002380A1 (es) |
| MX (1) | MX2010001711A (es) |
| RU (1) | RU2010109408A (es) |
| WO (1) | WO2009022355A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985994B (zh) * | 2005-12-19 | 2011-01-12 | 康泰乐(北京)医药科技发展有限公司 | 改进的包含霉酚酸盐的包有肠溶衣的药物组合物 |
| PT2049123E (pt) | 2006-08-03 | 2013-03-06 | Horizon Pharma Ag | Tratamento de doença reumatóide com glucocorticóide de libertação retardada |
| WO2011046546A1 (en) * | 2009-10-13 | 2011-04-21 | Teva Pharmaceutical Industries Ltd. | Delayed release compositions |
| US8841476B2 (en) | 2010-06-07 | 2014-09-23 | Telik, Inc. | Preparation of crystalline ezatiostat hydrochloride ansolvate form D |
| WO2011156045A2 (en) | 2010-06-07 | 2011-12-15 | Telik, Inc. | Tablet formulation of ezatiostat |
| US8759303B2 (en) | 2010-06-07 | 2014-06-24 | Telik, Inc. | Compositions and methods for treating myelodysplastic syndrome |
| GB201100786D0 (en) | 2011-01-18 | 2011-03-02 | Ems Sa | Pharmaceutical compositions of immunosuppressants |
| JP2015537029A (ja) | 2012-11-14 | 2015-12-24 | ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ | 生物学的に活性な物質及び不規則性無機酸化物を含有する組成物 |
| WO2018170022A2 (en) * | 2017-03-13 | 2018-09-20 | Okava Pharmaceuticals, Inc. | Methods and compositions for delivering mycophenolic acid active agents to non-human mammals |
| US10835489B2 (en) | 2018-03-09 | 2020-11-17 | University Of Saskatchewan | Modified release formulations of mycophenolate mofetil |
| CN112730680B (zh) * | 2020-12-24 | 2024-02-13 | 浙江长典药物技术开发有限公司 | 吗替麦考酚酯的溶出曲线测定方法 |
| CN116196286A (zh) * | 2023-02-17 | 2023-06-02 | 卓和药业集团股份有限公司 | 一种麦考酚钠胃漂浮片 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991010432A1 (en) * | 1990-01-13 | 1991-07-25 | Yamasa Shoyu Kabushiki Kaisha | Ataractic |
| ID18663A (id) | 1996-04-12 | 1998-04-30 | Novartis Ag | Komposisi farmasi berlapis enterik |
| GB0124953D0 (en) * | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
| AR045957A1 (es) * | 2003-10-03 | 2005-11-16 | Novartis Ag | Composicion farmaceutica y combinacion |
| GB0419355D0 (en) * | 2004-08-31 | 2004-09-29 | Novartis Ag | Organic compounds |
| CN1994295A (zh) * | 2006-01-06 | 2007-07-11 | 华北制药集团新药研究开发有限责任公司 | 霉酚酸盐的包有肠溶衣的药物组合物 |
-
2008
- 2008-08-11 RU RU2010109408/15A patent/RU2010109408A/ru unknown
- 2008-08-11 EP EP08789927.4A patent/EP2187872A4/en not_active Withdrawn
- 2008-08-11 WO PCT/IN2008/000505 patent/WO2009022355A1/en not_active Ceased
- 2008-08-11 BR BRPI0816231-0A patent/BRPI0816231A2/pt not_active IP Right Cessation
- 2008-08-11 MX MX2010001711A patent/MX2010001711A/es not_active Application Discontinuation
- 2008-08-11 AU AU2008288106A patent/AU2008288106B2/en not_active Ceased
- 2008-08-11 KR KR1020107005378A patent/KR20100063059A/ko not_active Withdrawn
- 2008-08-11 US US12/672,180 patent/US9642808B2/en active Active
- 2008-08-13 CL CL2008002380A patent/CL2008002380A1/es unknown
- 2008-08-13 AR ARP080103537A patent/AR070017A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0816231A2 (pt) | 2015-06-16 |
| KR20100063059A (ko) | 2010-06-10 |
| US9642808B2 (en) | 2017-05-09 |
| RU2010109408A (ru) | 2011-09-20 |
| AU2008288106A1 (en) | 2009-02-19 |
| EP2187872A1 (en) | 2010-05-26 |
| US20110223249A1 (en) | 2011-09-15 |
| MX2010001711A (es) | 2010-03-11 |
| AU2008288106B2 (en) | 2012-03-15 |
| WO2009022355A1 (en) | 2009-02-19 |
| EP2187872A4 (en) | 2013-09-18 |
| CL2008002380A1 (es) | 2009-01-09 |
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