AR079409A1 - Preparaciones antihelminticas granuladas y sistemas de suninistros - Google Patents
Preparaciones antihelminticas granuladas y sistemas de suninistrosInfo
- Publication number
- AR079409A1 AR079409A1 ARP100103280A ARP100103280A AR079409A1 AR 079409 A1 AR079409 A1 AR 079409A1 AR P100103280 A ARP100103280 A AR P100103280A AR P100103280 A ARP100103280 A AR P100103280A AR 079409 A1 AR079409 A1 AR 079409A1
- Authority
- AR
- Argentina
- Prior art keywords
- anthelmintic
- active agents
- granule
- composition
- stable
- Prior art date
Links
- 230000000507 anthelmentic effect Effects 0.000 title abstract 9
- 238000002360 preparation method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 6
- 239000013543 active substance Substances 0.000 abstract 5
- 239000008187 granular material Substances 0.000 abstract 5
- 229940124339 anthelmintic agent Drugs 0.000 abstract 3
- 239000000921 anthelmintic agent Substances 0.000 abstract 3
- 150000002596 lactones Chemical class 0.000 abstract 3
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 2
- FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 abstract 2
- 239000005660 Abamectin Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229960002957 praziquantel Drugs 0.000 abstract 2
- 239000000375 suspending agent Substances 0.000 abstract 2
- 239000000080 wetting agent Substances 0.000 abstract 2
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 abstract 1
- UMZCLZPXPCNKML-UHFFFAOYSA-N 2h-imidazo[4,5-d][1,3]thiazole Chemical class C1=NC2=NCSC2=N1 UMZCLZPXPCNKML-UHFFFAOYSA-N 0.000 abstract 1
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 abstract 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 abstract 1
- 229950008167 abamectin Drugs 0.000 abstract 1
- 229960002669 albendazole Drugs 0.000 abstract 1
- HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 abstract 1
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical group C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract 1
- 150000001556 benzimidazoles Chemical class 0.000 abstract 1
- HDDSHPAODJUKPD-UHFFFAOYSA-N fenbendazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1SC1=CC=CC=C1 HDDSHPAODJUKPD-UHFFFAOYSA-N 0.000 abstract 1
- 229960005473 fenbendazole Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000008240 homogeneous mixture Substances 0.000 abstract 1
- 229960002418 ivermectin Drugs 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229960004454 oxfendazole Drugs 0.000 abstract 1
- BEZZFPOZAYTVHN-UHFFFAOYSA-N oxfendazole Chemical group C=1C=C2NC(NC(=O)OC)=NC2=CC=1S(=O)C1=CC=CC=C1 BEZZFPOZAYTVHN-UHFFFAOYSA-N 0.000 abstract 1
- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 abstract 1
- 229950000975 salicylanilide Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una composicion antihelmíntica en forma de gránulo estable que comprende dos o más agentes activos antihelmínticos seleccionados entre uno o más imidazotiazoles, uno o más benzimidazoles, una o más lactonas macrocíclicas, una o más salicilanilidas, praziquantel, en la cual el gránulo estable es fácilmente dispersable en agua para proveer una mezcla homogénea de los agentes activos antihelmínticos para la administracion a un mamífero no humano, en donde el gránulo comprende, además, un agente de suspension si los agentes activos antihelmínticos comprenden un benzimidazol, un agente de humedecimiento si los agentes activos antihelmínticos comprenden una lactona macrocíclica, un agente de humedecimiento si los agentes activos antihelmínticos comprenden una salicilanilida y un agente de suspension si los agentes activos antihelmínticos comprenden praziquantel. Sistema de dosificacion para dosificar los animales en forma oral con un agente antihelmíntico. Método para preparar una formulacion de suministro líquida estable para tratar un animal a partir de la composicion antihelmíntica en forma de gránulo estable y método para obtener una composicion antihelmíntica en forma de gránulo. Reivindicacion 7: Una composicion de acuerdo con una cualquiera de las reivindicaciones 1 a 6, caracterizada porque la lactona macrocíclica se selecciona entre avermectina, ivermectina y abamectina. Reivindicacion 8: Una composicion de acuerdo con una cualquiera de las reivindicaciones 1 a 6, caracterizada porque el benzimidazol se selecciona entre oxfendazol, albendazol o fenbendazol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ57954409 | 2009-09-07 | ||
| NZ57954609 | 2009-09-07 | ||
| NZ57954509 | 2009-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079409A1 true AR079409A1 (es) | 2012-01-25 |
Family
ID=43648938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103280A AR079409A1 (es) | 2009-09-07 | 2010-09-07 | Preparaciones antihelminticas granuladas y sistemas de suninistros |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11253593B2 (es) |
| EP (1) | EP2475430B1 (es) |
| AR (1) | AR079409A1 (es) |
| AU (8) | AU2010290829A1 (es) |
| BR (1) | BR112012005127B1 (es) |
| CA (2) | CA3040719C (es) |
| CL (1) | CL2012000595A1 (es) |
| ES (1) | ES2667026T3 (es) |
| WO (1) | WO2011027333A1 (es) |
| ZA (1) | ZA201207975B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2482526A (en) * | 2010-08-05 | 2012-02-08 | Fiona Anne Macdonald | Praziquantel suspendable powder as an immersion fish treatment for parasites |
| WO2015118468A1 (en) * | 2014-02-04 | 2015-08-13 | Douglas Robert Cleverly | Ectoparasite formulation |
| RU2669377C2 (ru) * | 2015-03-18 | 2018-10-11 | Федеральное государственное бюджетное научное учреждение Якутский научно-исследовательский институт сельского хозяйства | Способ комплексного лечения паразитарных болезней домашних северных оленей |
| CA3033065A1 (en) | 2016-08-11 | 2018-02-15 | Adamis Pharmaceuticals Corporation | Drug compositions |
| UY37780A (es) | 2017-06-26 | 2019-01-31 | Merial Inc | Composiciones de gránulos parasiticidas con doble principio activo, sus métodos y usos |
| EP3720844A4 (en) | 2017-12-08 | 2021-08-11 | Adamis Pharmaceuticals Corporation | MEDICINAL COMPOSITIONS |
| IT202000022126A1 (it) * | 2020-09-18 | 2022-03-18 | Nutrilinea S R L | Procedimento per preparare formulazioni solide comprendenti un composto idrofobico disperdibili in un liquido a freddo e relative formulazioni solide |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3626070A (en) * | 1968-03-20 | 1971-12-07 | Du Pont | Substituted 2-aminobenzimidazoles as anthelmintics |
| DE19654079A1 (de) * | 1996-12-23 | 1998-06-25 | Bayer Ag | Endo-ekto-parasitizide Mittel |
| DE60025198D1 (de) * | 1999-06-04 | 2006-02-02 | Nufarm Ltd | Stabile biozidale zusammensetzung |
| US20040151759A1 (en) * | 2002-08-16 | 2004-08-05 | Douglas Cleverly | Non-animal product containing veterinary formulations |
| NZ523128A (en) * | 2002-12-12 | 2006-01-27 | Ashmont Holdings Ltd | Anthelmintic formulations containing avermectins and or milbemycins |
| AU2003900505A0 (en) * | 2003-02-05 | 2003-02-20 | Jurox Pty Ltd | Anthelmintic composition |
| GB2403407B (en) * | 2003-07-03 | 2006-12-13 | Michael Hilary Burke | Palatable oral anthelmintic composition |
| WO2005016356A1 (en) * | 2003-08-08 | 2005-02-24 | The Hartz Mountain Corporation | Improved anthelmintic formulations |
| BRPI0509673A (pt) * | 2004-04-07 | 2007-10-09 | Intervet Int Bv | composição para o tratamento de parasitas, forma de dosagem farmacêutica, método para tratar um organismo, e, processos para introduzir pelo menos um aditivo em um organismo, para fabricar uma composição, para liberar um aditivo em um organismo, e, para conformar um produto macio mastigável |
| NZ552040A (en) * | 2006-12-13 | 2009-04-30 | Bomac Research Ltd | Veterinary formulation comprising an anthelmintic compound and glyceryl acetate |
| HUE039193T2 (hu) * | 2007-11-07 | 2018-12-28 | Rigel Pharmaceuticals Inc | Nedves granulálás egy vízlágyító szerrel |
| MX2010004852A (es) * | 2007-11-09 | 2010-06-02 | Intervet Int Bv | Combinacion antihelmintica. |
| AU2010330844B2 (en) * | 2009-12-17 | 2014-11-27 | Boehringer Ingelheim Animal Health USA Inc. | Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles |
-
2010
- 2010-09-07 CA CA3040719A patent/CA3040719C/en active Active
- 2010-09-07 AR ARP100103280A patent/AR079409A1/es not_active Application Discontinuation
- 2010-09-07 ES ES10813424.8T patent/ES2667026T3/es active Active
- 2010-09-07 BR BR112012005127-0A patent/BR112012005127B1/pt active IP Right Grant
- 2010-09-07 WO PCT/IB2010/054005 patent/WO2011027333A1/en not_active Ceased
- 2010-09-07 CA CA2777225A patent/CA2777225C/en active Active
- 2010-09-07 AU AU2010290829A patent/AU2010290829A1/en not_active Abandoned
- 2010-09-07 EP EP10813424.8A patent/EP2475430B1/en active Active
-
2012
- 2012-03-06 CL CL2012000595A patent/CL2012000595A1/es unknown
- 2012-03-07 US US13/414,495 patent/US11253593B2/en active Active
- 2012-10-23 ZA ZA2012/07975A patent/ZA201207975B/en unknown
-
2016
- 2016-10-07 AU AU2016238922A patent/AU2016238922A1/en not_active Abandoned
-
2018
- 2018-09-05 AU AU2018226427A patent/AU2018226427A1/en not_active Abandoned
-
2020
- 2020-04-27 AU AU2020202781A patent/AU2020202781B2/en active Active
-
2021
- 2021-02-12 AU AU2021200921A patent/AU2021200921A1/en not_active Abandoned
- 2021-02-12 AU AU2021200922A patent/AU2021200922A1/en not_active Abandoned
-
2022
- 2022-01-07 US US17/571,084 patent/US20220125924A1/en not_active Abandoned
- 2022-01-11 AU AU2022200149A patent/AU2022200149B2/en active Active
- 2022-11-11 AU AU2022268388A patent/AU2022268388A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA3040719C (en) | 2022-06-14 |
| CA3040719A1 (en) | 2011-03-10 |
| AU2021200922A1 (en) | 2021-03-04 |
| BR112012005127A2 (pt) | 2016-05-03 |
| US20120238516A1 (en) | 2012-09-20 |
| EP2475430B1 (en) | 2018-01-24 |
| EP2475430A1 (en) | 2012-07-18 |
| AU2022200149B2 (en) | 2023-06-15 |
| BR112012005127B1 (pt) | 2020-10-27 |
| CA2777225A1 (en) | 2011-03-10 |
| AU2022200149A1 (en) | 2022-02-10 |
| AU2010290829A1 (en) | 2012-04-26 |
| CA2777225C (en) | 2019-06-11 |
| ZA201207975B (en) | 2013-06-26 |
| AU2018226427A1 (en) | 2018-09-27 |
| US20220125924A1 (en) | 2022-04-28 |
| ES2667026T3 (es) | 2018-05-09 |
| CL2012000595A1 (es) | 2012-12-14 |
| AU2016238922A1 (en) | 2016-12-15 |
| EP2475430A4 (en) | 2013-05-15 |
| AU2021200921A1 (en) | 2021-03-04 |
| US11253593B2 (en) | 2022-02-22 |
| AU2020202781B2 (en) | 2021-05-13 |
| AU2020202781A1 (en) | 2020-05-14 |
| AU2022268388A1 (en) | 2022-12-15 |
| WO2011027333A1 (en) | 2011-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |