AR078797A1 - Inhibidores de la caseina quinasa, composiciones farmaceuticas y sus usos para tratar trastornos del snc - Google Patents
Inhibidores de la caseina quinasa, composiciones farmaceuticas y sus usos para tratar trastornos del sncInfo
- Publication number
- AR078797A1 AR078797A1 ARP100103948A ARP100103948A AR078797A1 AR 078797 A1 AR078797 A1 AR 078797A1 AR P100103948 A ARP100103948 A AR P100103948A AR P100103948 A ARP100103948 A AR P100103948A AR 078797 A1 AR078797 A1 AR 078797A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- pharmaceutical compositions
- caseina
- quinasa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se dan a conocer también las composiciones farmacéuticas, los procedimientos de tratamiento, los procedimientos de síntesis y los productos intermedios correspondiente Reivindicacion 1: Un compuesto de formula (1): o sus sales farmacéuticamente aceptables caracterizado porque: A es un heterocicloalquilo de 4 a 7 miembros que contiene nitrogeno o, alternativamente, A se puede condensar directamente con el anillo al cual está unido mediante R1; L es alquilo C1-3; R1 es hidrogeno, alquilo C1-3 o cicloalquilo C3-4; cada R2 es independientemente alquilo C1-3, fluor, hidroxilo, alcoxi C1-3 o ciano; R3 es hidrogeno, alquilo C1-3 o cicloalquilo C3-4; R4 es un heteroarilo de 5 a 10 miembros con de 1 a 3 heteroátomos, sustituido opcionalmente con de uno a tres sustituyentes R7; R5 es hidrogeno o -N(R8)2; R6 es hidrogeno, halogeno o alquilo C1-3; cada R7 es independientemente halogeno, (CH2)t-Fq, alquilo C1-3, -CF3, -(CH2)t-cicloalquilo C3-4, -(CH2)t-O-alquilo C1-3, -(CH2)t-ciano o -(CH2)t-hidroxi; Z es N o CR9; cada R8 es independientemente hidrogeno o alquilo C1-3; R9 es hidrogeno, alquilo C1-3 o halogeno; m es 0, 1 o 2; n es 0, 1 o 2; q es 1, 2 o 3; t es 0, 1 o 2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25550609P | 2009-10-28 | 2009-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078797A1 true AR078797A1 (es) | 2011-12-07 |
Family
ID=43301770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103948A AR078797A1 (es) | 2009-10-28 | 2010-10-28 | Inhibidores de la caseina quinasa, composiciones farmaceuticas y sus usos para tratar trastornos del snc |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8518944B2 (es) |
| EP (1) | EP2493876B1 (es) |
| JP (1) | JP5784620B2 (es) |
| KR (1) | KR101421852B1 (es) |
| CN (1) | CN102686580B (es) |
| AR (1) | AR078797A1 (es) |
| AU (1) | AU2010311035B2 (es) |
| CA (1) | CA2777632C (es) |
| DK (1) | DK2493876T3 (es) |
| ES (1) | ES2460065T3 (es) |
| HR (1) | HRP20140252T1 (es) |
| IL (1) | IL219190A0 (es) |
| IN (1) | IN2012DN03182A (es) |
| MX (1) | MX2012004997A (es) |
| PL (1) | PL2493876T3 (es) |
| PT (1) | PT2493876E (es) |
| RS (1) | RS53246B (es) |
| SI (1) | SI2493876T1 (es) |
| TW (1) | TW201125864A (es) |
| UY (1) | UY32977A (es) |
| WO (1) | WO2011051858A1 (es) |
| ZA (1) | ZA201202776B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010509919A (ja) | 2006-11-15 | 2010-04-02 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 内耳細胞の生成 |
| ES2623387T3 (es) * | 2010-12-20 | 2017-07-11 | Pfizer Inc. | Nuevos compuestos de piridina condensada como inhibidores de la cinasa de caseína |
| JP2015527398A (ja) | 2012-09-07 | 2015-09-17 | マサチューセッツ アイ アンド イヤー インファーマリー | 聴覚喪失治療 |
| CN105073751B (zh) | 2012-12-21 | 2018-11-30 | 百时美施贵宝公司 | 作为酪蛋白激酶1δ/ε抑制剂的新的取代的咪唑 |
| JP6370294B2 (ja) * | 2013-05-30 | 2018-08-08 | 大日本住友製薬株式会社 | 環状アミノメチルピリミジン誘導体 |
| SG11201606427SA (en) | 2014-02-07 | 2016-09-29 | Agency Science Tech & Res | 2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis |
| US20170314027A1 (en) | 2014-08-06 | 2017-11-02 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
| EP4591936A3 (en) | 2015-03-23 | 2025-10-15 | Tianli Biotech Pty Ltd | Treatment of respiratory diseases |
| WO2017096233A1 (en) | 2015-12-04 | 2017-06-08 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| KR20180117628A (ko) | 2016-01-29 | 2018-10-29 | 매사추세츠 아이 앤드 이어 인퍼머리 | 내이 지지 세포의 확장 및 분화 및 그의 사용 방법 |
| WO2018201192A1 (en) * | 2017-05-03 | 2018-11-08 | The University Of Melbourne | Compounds for the treatment of respiratory diseases |
| US10973820B2 (en) | 2017-12-13 | 2021-04-13 | Facio Intellectual Property B.V. | Compounds for treatment of diseases related to DUX4 expression |
| CA3111848A1 (en) * | 2018-09-09 | 2020-03-12 | Qanatpharma Ag | Use of casein kinase 1 inhibitors for treating vascular diseases |
| EP3877382A4 (en) * | 2018-11-07 | 2022-07-27 | The University of Melbourne | NOVEL COMPOUNDS TO TREAT RESPIRATORY DISEASES |
| TW202112368A (zh) | 2019-06-13 | 2021-04-01 | 荷蘭商法西歐知識產權股份有限公司 | 用於治療有關dux4表現之疾病的抑制劑組合 |
| WO2021190616A1 (en) * | 2020-03-27 | 2021-09-30 | Gritscience Biopharmaceuticals Co., Ltd. | Methods for inhibiting casein kinases |
| CN115298183A (zh) * | 2020-03-27 | 2022-11-04 | 北京原基华毅生物科技有限公司 | 作为酪蛋白激酶抑制剂的化合物 |
| AR122711A1 (es) * | 2020-06-25 | 2022-09-28 | Alchemedicine Inc | COMPUESTO HETEROCÍCLICO COMO INHIBIDOR DE CASEÍNA QUINASA 1d Y/O QUINASA 5 TIPO RECEPTOR DE ACTIVINA |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992012154A1 (en) * | 1990-12-31 | 1992-07-23 | Fujisawa Pharmaceutical Co., Ltd. | Imidazotriazine derivatives |
| IL110296A (en) * | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
| WO1997035856A1 (en) | 1996-03-25 | 1997-10-02 | Smithkline Beecham Corporation | Novel treatment for cns injuries |
| US6239279B1 (en) | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
| GB0108770D0 (en) * | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| AU2002316279B2 (en) * | 2001-06-18 | 2007-08-23 | The Rockefeller University | Regulation of neuronal function through metabotropic glutamate receptor signaling pathways |
| US7402672B2 (en) * | 2003-12-11 | 2008-07-22 | Aventis Pharmaceuticals Inc. | Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon |
| BRPI0514397A (pt) * | 2004-08-19 | 2008-06-10 | Aventis Pharma Inc | derivados de 3-ariltioindol-2-carboxamida e análogos destes como inibidores de caseìna cinase iépsilon |
| JO2629B1 (en) * | 2004-08-19 | 2012-06-24 | افينتيس فارما سوتيكالز انك | Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon |
| JP5376950B2 (ja) * | 2005-10-21 | 2013-12-25 | エクセリクシス， インク． | カゼインキナーゼｉｉ（ｃｋ２）モジュレーターとしてのピリミジオン類 |
| EP2308866A1 (de) * | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| ES2623387T3 (es) * | 2010-12-20 | 2017-07-11 | Pfizer Inc. | Nuevos compuestos de piridina condensada como inhibidores de la cinasa de caseína |
-
2010
- 2010-10-20 ES ES10774282.7T patent/ES2460065T3/es active Active
- 2010-10-20 SI SI201030539T patent/SI2493876T1/sl unknown
- 2010-10-20 RS RS20140157A patent/RS53246B/sr unknown
- 2010-10-20 WO PCT/IB2010/054749 patent/WO2011051858A1/en not_active Ceased
- 2010-10-20 PT PT107742827T patent/PT2493876E/pt unknown
- 2010-10-20 CN CN201080059759.7A patent/CN102686580B/zh not_active Expired - Fee Related
- 2010-10-20 DK DK10774282.7T patent/DK2493876T3/en active
- 2010-10-20 MX MX2012004997A patent/MX2012004997A/es active IP Right Grant
- 2010-10-20 AU AU2010311035A patent/AU2010311035B2/en not_active Ceased
- 2010-10-20 JP JP2012535977A patent/JP5784620B2/ja active Active
- 2010-10-20 KR KR1020127013537A patent/KR101421852B1/ko not_active Expired - Fee Related
- 2010-10-20 IN IN3182DEN2012 patent/IN2012DN03182A/en unknown
- 2010-10-20 CA CA2777632A patent/CA2777632C/en not_active Expired - Fee Related
- 2010-10-20 HR HRP20140252AT patent/HRP20140252T1/hr unknown
- 2010-10-20 EP EP10774282.7A patent/EP2493876B1/en active Active
- 2010-10-20 PL PL10774282T patent/PL2493876T3/pl unknown
- 2010-10-25 US US12/911,030 patent/US8518944B2/en active Active
- 2010-10-25 TW TW099136328A patent/TW201125864A/zh unknown
- 2010-10-27 UY UY0001032977A patent/UY32977A/es not_active Application Discontinuation
- 2010-10-28 AR ARP100103948A patent/AR078797A1/es not_active Application Discontinuation
-
2012
- 2012-04-15 IL IL219190A patent/IL219190A0/en unknown
- 2012-04-16 ZA ZA2012/02776A patent/ZA201202776B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2493876T3 (pl) | 2014-06-30 |
| AU2010311035A1 (en) | 2012-05-03 |
| PT2493876E (pt) | 2014-03-20 |
| IL219190A0 (en) | 2012-06-28 |
| CN102686580B (zh) | 2014-09-10 |
| CN102686580A (zh) | 2012-09-19 |
| IN2012DN03182A (es) | 2015-09-25 |
| JP5784620B2 (ja) | 2015-09-24 |
| WO2011051858A1 (en) | 2011-05-05 |
| KR101421852B1 (ko) | 2014-07-22 |
| CA2777632C (en) | 2014-02-25 |
| MX2012004997A (es) | 2012-06-12 |
| AU2010311035B2 (en) | 2013-05-16 |
| TW201125864A (en) | 2011-08-01 |
| ES2460065T3 (es) | 2014-05-13 |
| UY32977A (es) | 2011-05-31 |
| RS53246B (sr) | 2014-08-29 |
| EP2493876A1 (en) | 2012-09-05 |
| EP2493876B1 (en) | 2014-02-12 |
| DK2493876T3 (en) | 2014-03-10 |
| HRP20140252T1 (hr) | 2014-04-25 |
| US20110098272A1 (en) | 2011-04-28 |
| US8518944B2 (en) | 2013-08-27 |
| HK1171220A1 (en) | 2013-03-22 |
| KR20120088759A (ko) | 2012-08-08 |
| JP2013509392A (ja) | 2013-03-14 |
| CA2777632A1 (en) | 2011-05-05 |
| SI2493876T1 (sl) | 2014-04-30 |
| ZA201202776B (en) | 2013-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |