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AR078627A1 - N-((1r,2s,5r)-5-terc-butilamino)-2-((s)-3-(7-terc-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, forma cristalina, procedimiento de preparacion, composiciones farmaceuticas que los comprenden y uso del mismo para tratar diabetes, obesidad, enfermedades alerg - Google Patents

N-((1r,2s,5r)-5-terc-butilamino)-2-((s)-3-(7-terc-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, forma cristalina, procedimiento de preparacion, composiciones farmaceuticas que los comprenden y uso del mismo para tratar diabetes, obesidad, enfermedades alerg

Info

Publication number
AR078627A1
AR078627A1 ARP100103741A ARP100103741A AR078627A1 AR 078627 A1 AR078627 A1 AR 078627A1 AR P100103741 A ARP100103741 A AR P100103741A AR P100103741 A ARP100103741 A AR P100103741A AR 078627 A1 AR078627 A1 AR 078627A1
Authority
AR
Argentina
Prior art keywords
terc
crystalline form
oxopirrolidin
butilpirazolo
butilamino
Prior art date
Application number
ARP100103741A
Other languages
English (en)
Inventor
Percy H Carter
Robert J Cherney
Victor W Rosso
Jun Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR078627A1 publication Critical patent/AR078627A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07B2200/13—Crystalline forms, e.g. polymorphs

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Abstract

Reivindicacion 1. Un compuesto caracterizado porque tiene la formula (1) o su sal. Reivindicacion 2: El compuesto de la reivindicacion 1, caracterizado porque que es una forma cristalina de dicho compuesto. Reivindicacion 3: La forma cristalina de la reivindicacion 2, caracterizada porque la forma cristalina comprende la forma N-1. Reivindicacion 4: La forma cristalina de acuerdo con la reivindicacion 3, caracterizada porque dicha forma N-1 está en forma sustancialmente pura. Reivindicacion 5: La forma cristalina de la reivindicacion 3, caracterizada porque la forma N-1 se caracteriza por parámetros de celda unitaria sustancialmente igual a las siguientes dimensiones: Dimensiones de la celda a = 7,3085(6), b = 16,257(1), c = 22,688(2), alfas = 90, betas = 90, gamma° = 90, Grupo de espacio P212121, Moléculas/celda unitaria (Z):1, Densidad, calc g-cm-3:1,194 en la que dicho cristal está a una temperatura de aproximadamente -70sC.
ARP100103741A 2009-10-13 2010-10-13 N-((1r,2s,5r)-5-terc-butilamino)-2-((s)-3-(7-terc-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, forma cristalina, procedimiento de preparacion, composiciones farmaceuticas que los comprenden y uso del mismo para tratar diabetes, obesidad, enfermedades alerg AR078627A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25097809P 2009-10-13 2009-10-13

Publications (1)

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AR078627A1 true AR078627A1 (es) 2011-11-23

Family

ID=43063940

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ARP100103741A AR078627A1 (es) 2009-10-13 2010-10-13 N-((1r,2s,5r)-5-terc-butilamino)-2-((s)-3-(7-terc-butilpirazolo[1,5-a][1,3,5]triazin-4-ilamino)-2-oxopirrolidin-1-il)ciclohexil)acetamida, forma cristalina, procedimiento de preparacion, composiciones farmaceuticas que los comprenden y uso del mismo para tratar diabetes, obesidad, enfermedades alerg

Country Status (28)

Country Link
US (3) US8383812B2 (es)
EP (2) EP2664620A3 (es)
JP (1) JP5759999B2 (es)
KR (1) KR20120102052A (es)
CN (1) CN102648201B (es)
AR (1) AR078627A1 (es)
AU (1) AU2010306968B2 (es)
BR (1) BR112012008650B1 (es)
CA (1) CA2777563A1 (es)
CL (1) CL2014000753A1 (es)
CO (1) CO6460737A2 (es)
DK (1) DK2488523T3 (es)
EA (2) EA020486B1 (es)
ES (1) ES2442897T3 (es)
HR (1) HRP20140072T1 (es)
IL (2) IL219121A0 (es)
MX (1) MX2012003720A (es)
NZ (2) NZ599311A (es)
PE (1) PE20121349A1 (es)
PL (1) PL2488523T3 (es)
PT (1) PT2488523E (es)
RS (1) RS53131B (es)
SI (1) SI2488523T1 (es)
SM (1) SMT201400020B (es)
TN (1) TN2012000132A1 (es)
TW (1) TW201120042A (es)
WO (1) WO2011046916A1 (es)
ZA (1) ZA201305994B (es)

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