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AR078569A1 - Metodos de tratamiento con anticuerpos neutralizantes anti-ngf humanos como inhibidores selectivos de la via de ngf - Google Patents

Metodos de tratamiento con anticuerpos neutralizantes anti-ngf humanos como inhibidores selectivos de la via de ngf

Info

Publication number
AR078569A1
AR078569A1 ARP100103675A ARP100103675A AR078569A1 AR 078569 A1 AR078569 A1 AR 078569A1 AR P100103675 A ARP100103675 A AR P100103675A AR P100103675 A ARP100103675 A AR P100103675A AR 078569 A1 AR078569 A1 AR 078569A1
Authority
AR
Argentina
Prior art keywords
ngf
antibodies
treatment methods
neutralizing antibodies
human anti
Prior art date
Application number
ARP100103675A
Other languages
English (en)
Inventor
James Treanor
Heather Inoue
Kenneth Wild
Zhang Tie
Huang Haichun
Original Assignee
Amgen Inc
Medarex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43466840&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR078569(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc, Medarex Inc filed Critical Amgen Inc
Publication of AR078569A1 publication Critical patent/AR078569A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Virology (AREA)
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  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)

Abstract

Se proporcionan anticuerpos que interactuan o se unen al factor de crecimiento nervioso (NGF) y neutralizan la funcion de NGF de ese modo. También composiciones farmacéuticas de dichos anticuerpos y métodos para neutralizar la funcion de NGF y particularmente para tratar trastornos relacionados con NGF (por ejemplo, dolor cronico) administrando una cantidad farmacéuticamente eficaz de anticuerpos anti-NGF. También se han proporcionado métodos de deteccion de la cantidad de NGF en una muestra usando anticuerpos anti-NGF. Reivindicacion 1: Un método para tratar una condicion provocada por la expresion aumentada del factor de crecimiento nervioso (NGF) o la sensibilidad aumentada a NGF, caracterizado porque comprende administrar a un paciente por vía oral, a través de inyeccion por vías intravenosa, intraperitoneal, intracerebral (intra-parénquima), intracerebroventricular, intramuscular, intraocular, intraarterial, intraportal, intralesion o subcutánea, mediante sistemas de liberacion sostenida o mediante aparatos de implantacion, una cantidad terapéuticamente eficaz de anticuerpo de NGF.
ARP100103675A 2009-10-09 2010-10-08 Metodos de tratamiento con anticuerpos neutralizantes anti-ngf humanos como inhibidores selectivos de la via de ngf AR078569A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/576,522 US9260514B2 (en) 2003-07-15 2009-10-09 Methods of treating conditions caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF using anti-NGF neutralizing antibodies as selective NGF pathway inhibitors

Publications (1)

Publication Number Publication Date
AR078569A1 true AR078569A1 (es) 2011-11-16

Family

ID=43466840

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100103675A AR078569A1 (es) 2009-10-09 2010-10-08 Metodos de tratamiento con anticuerpos neutralizantes anti-ngf humanos como inhibidores selectivos de la via de ngf

Country Status (28)

Country Link
US (1) US9260514B2 (es)
EP (2) EP3028717A1 (es)
JP (3) JP2013507385A (es)
KR (1) KR101528393B1 (es)
CN (1) CN102762228A (es)
AR (1) AR078569A1 (es)
AU (2) AU2010308418A1 (es)
BR (1) BR112012008282A2 (es)
CA (1) CA2775924A1 (es)
CL (1) CL2012000881A1 (es)
CO (1) CO6541558A2 (es)
CR (1) CR20120198A (es)
EA (1) EA201290189A1 (es)
IL (1) IL218885A0 (es)
MA (1) MA33724B1 (es)
ME (1) ME00226B (es)
MT (1) MTP4289B (es)
MX (1) MX343748B (es)
MY (1) MY172283A (es)
NZ (2) NZ625391A (es)
PE (1) PE20121028A1 (es)
PH (1) PH12012500668A1 (es)
SG (1) SG10201603945RA (es)
TN (1) TN2012000136A1 (es)
TW (1) TW201125581A (es)
UA (1) UA102775C2 (es)
WO (1) WO2011049758A1 (es)
ZA (1) ZA201203135B (es)

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US8435523B2 (en) 2009-05-04 2013-05-07 Abbott Research B.V. Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
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BR112019010331A2 (pt) 2016-11-29 2019-10-22 Regeneron Pharma composição farmacêutica para evitar a dependência de opioides
EP3765516A2 (en) * 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
MX2021001549A (es) 2018-08-10 2021-04-13 Regeneron Pharma Una composicion farmaceutica para el tratamiento seguro y efectivo del dolor de rodilla y/o cadera.
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