AR078542A1 - Moduladores de gpr40 de pirrolidina - Google Patents
Moduladores de gpr40 de pirrolidinaInfo
- Publication number
- AR078542A1 AR078542A1 ARP100103635A ARP100103635A AR078542A1 AR 078542 A1 AR078542 A1 AR 078542A1 AR P100103635 A ARP100103635 A AR P100103635A AR P100103635 A ARP100103635 A AR P100103635A AR 078542 A1 AR078542 A1 AR 078542A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- occurrence
- substituted
- halo
- Prior art date
Links
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 title abstract 2
- 101000912510 Homo sapiens Free fatty acid receptor 1 Proteins 0.000 title abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 108091006027 G proteins Proteins 0.000 abstract 1
- 102000030782 GTP binding Human genes 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24889609P | 2009-10-06 | 2009-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078542A1 true AR078542A1 (es) | 2011-11-16 |
Family
ID=43242297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103635A AR078542A1 (es) | 2009-10-06 | 2010-10-06 | Moduladores de gpr40 de pirrolidina |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8288404B2 (de) |
| EP (1) | EP2486005B1 (de) |
| JP (1) | JP2013506714A (de) |
| KR (1) | KR20120104534A (de) |
| CN (1) | CN102639495A (de) |
| AR (1) | AR078542A1 (de) |
| AU (1) | AU2010303670A1 (de) |
| BR (1) | BR112012007979A2 (de) |
| CA (1) | CA2777041A1 (de) |
| MX (1) | MX2012003389A (de) |
| RU (1) | RU2012118504A (de) |
| TW (1) | TW201116510A (de) |
| WO (1) | WO2011044073A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2643303A1 (de) * | 2010-11-24 | 2013-10-02 | Allergan, Inc. | Modulatoren von s1p-rezeptoren |
| CA2878625A1 (en) | 2012-07-11 | 2014-01-16 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| KR101942752B1 (ko) * | 2012-11-05 | 2019-01-28 | 주식회사 엘지화학 | Ｇｐｒ120 효능제로서의 티오아릴 유도체 |
| SG11201503556PA (en) | 2012-11-16 | 2015-06-29 | Bristol Myers Squibb Co | Dihydropyrazole gpr40 modulators |
| AU2013344602A1 (en) * | 2012-11-16 | 2015-07-02 | Bristol-Myers Squibb Company | Dihydropyrazole GPR40 modulators |
| EP2925741B1 (de) * | 2012-11-16 | 2016-10-26 | Bristol-Myers Squibb Company | Pyrrolidin-gpr40-modulatoren |
| WO2014078610A1 (en) | 2012-11-16 | 2014-05-22 | Bristol-Myers Squibb Company | Dihydropyrazole gpr40 modulators |
| US8962660B2 (en) | 2013-03-14 | 2015-02-24 | Bristol-Myers Squibb Company | Oxabicyclo [2.2.2] acid GPR120 modulators |
| AU2014282769A1 (en) | 2013-06-21 | 2015-12-17 | Lupin Limited | Substituted heterocyclic compounds as CRAC modulators |
| AU2014300629A1 (en) | 2013-06-24 | 2015-12-24 | Lupin Limited | Chromane and chromene derivatives and their use as CRAC modulators |
| HK1221465A1 (zh) | 2013-11-14 | 2017-06-02 | Cadila Healthcare Limited | 新型杂环化合物 |
| CN105814035B (zh) | 2013-12-13 | 2018-02-02 | 豪夫迈·罗氏有限公司 | 布鲁顿氏酪氨酸激酶抑制剂 |
| ES2674531T3 (es) * | 2014-05-07 | 2018-07-02 | Bristol-Myers Squibb Company | Moduladores del receptor acoplado a la proteína g 40 (gpr40) de pirrolidina para el tratamiento de enfermedades como la diabetes |
| WO2015171757A1 (en) * | 2014-05-07 | 2015-11-12 | Bristol-Myers Squibb Company | Pyrrolidine gpr40 modulators |
| CA2948175A1 (en) | 2014-05-07 | 2015-11-12 | Bristol-Myers Squibb Company | Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes |
| CN110023298B (zh) * | 2016-11-24 | 2022-12-16 | 浙江迈同生物医药有限公司 | 异柠檬酸脱氢酶(idh)抑制剂 |
| CR20200347A (es) | 2018-02-13 | 2020-09-23 | Gilead Sciences Inc | Inhibidores pd-1/pd-l1 |
| SMT202200134T1 (it) | 2018-03-08 | 2022-05-12 | Incyte Corp | Composti di amminopirazindiolo come inibitori di pi3k-y |
| KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| PT3820572T (pt) | 2018-07-13 | 2023-11-10 | Gilead Sciences Inc | Inibidores pd-1/pd-l1 |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
| CN110041269A (zh) * | 2019-05-16 | 2019-07-23 | 海门瑞一医药科技有限公司 | 一种2-氯-5-羟基嘧啶的制备方法 |
| CN111253223A (zh) * | 2020-03-20 | 2020-06-09 | 重庆医科大学 | 一类大位阻三芳基甲烷衍生物及其合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003259131A1 (en) | 2002-07-09 | 2004-01-23 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| DE10309929B4 (de) * | 2003-03-07 | 2006-02-23 | Sanofi-Aventis Deutschland Gmbh | Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung |
| US7501440B2 (en) | 2003-03-07 | 2009-03-10 | Sanofi-Aventis Deutschland Gmbh | Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use |
| AU2007293028B2 (en) | 2006-09-07 | 2012-05-31 | Amgen Inc. | Heterocyclic GPR40 modulators |
-
2010
- 2010-10-05 KR KR1020127011617A patent/KR20120104534A/ko not_active Withdrawn
- 2010-10-05 EP EP10763955.1A patent/EP2486005B1/de not_active Not-in-force
- 2010-10-05 RU RU2012118504/04A patent/RU2012118504A/ru unknown
- 2010-10-05 AU AU2010303670A patent/AU2010303670A1/en not_active Abandoned
- 2010-10-05 CA CA2777041A patent/CA2777041A1/en not_active Abandoned
- 2010-10-05 MX MX2012003389A patent/MX2012003389A/es not_active Application Discontinuation
- 2010-10-05 WO PCT/US2010/051389 patent/WO2011044073A1/en not_active Ceased
- 2010-10-05 US US12/897,913 patent/US8288404B2/en active Active
- 2010-10-05 CN CN2010800552581A patent/CN102639495A/zh active Pending
- 2010-10-05 BR BR112012007979A patent/BR112012007979A2/pt not_active Application Discontinuation
- 2010-10-05 JP JP2012533240A patent/JP2013506714A/ja active Pending
- 2010-10-06 AR ARP100103635A patent/AR078542A1/es not_active Application Discontinuation
- 2010-10-06 TW TW099134095A patent/TW201116510A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120104534A (ko) | 2012-09-21 |
| TW201116510A (en) | 2011-05-16 |
| JP2013506714A (ja) | 2013-02-28 |
| AU2010303670A1 (en) | 2012-03-29 |
| US8288404B2 (en) | 2012-10-16 |
| EP2486005B1 (de) | 2014-06-18 |
| RU2012118504A (ru) | 2013-11-20 |
| US20110082165A1 (en) | 2011-04-07 |
| CA2777041A1 (en) | 2011-04-14 |
| BR112012007979A2 (pt) | 2016-03-29 |
| CN102639495A (zh) | 2012-08-15 |
| MX2012003389A (es) | 2012-04-10 |
| WO2011044073A1 (en) | 2011-04-14 |
| EP2486005A1 (de) | 2012-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |