AR077941A1 - Anticuerpos contra osteopontina - Google Patents
Anticuerpos contra osteopontinaInfo
- Publication number
- AR077941A1 AR077941A1 ARP100103026A ARP100103026A AR077941A1 AR 077941 A1 AR077941 A1 AR 077941A1 AR P100103026 A ARP100103026 A AR P100103026A AR P100103026 A ARP100103026 A AR P100103026A AR 077941 A1 AR077941 A1 AR 077941A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- set forth
- cdr1
- cdr2
- cdr3
- Prior art date
Links
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 2
- 102000004264 Osteopontin Human genes 0.000 abstract 2
- 108010081689 Osteopontin Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente divulgacion proporciona anticuerpos aislados, particularmente anticuerpos humanos o porciones de union a antígeno de los mismos, que se unen a osteopontina con alta afinidad. También se proporcionan moléculas de ácido nucleico que codifican los anticuerpos de la divulgacion, vectores de expresion, células huésped y procedimientos para expresar los anticuerpos de la divulgacion. También se proporcionan inmunoconjugados, moléculas biespecíficas y composiciones farmacéuticas que comprenden los anticuerpos o porciones de union a antígeno de los mismos. La divulgacion también proporciona procedimientos para tratar diversos cánceres usando los anticuerpos anti-osteopontina o porciones de union a antígeno de los mismos descritos en el presente documento. Reivindicacion 1: Un anticuerpo aislado, o porcion de union a antígeno del mismo que se une específicamente a osteopontina, en el que dicho anticuerpo o porcion de union a antígeno comprende: (a) una H-CDR1 como se expone en la SEC ID N°: 1, una H-CDR2 como se expone en la SEC ID N°: 2, una H-CDR3 como se expone en la SEC ID N°: 3, una L-CDR1 como se expone en la SEC ID N°: 4, una L-CDR2 como se expone en la SEC ID N°: 5 y una L-CDR1 como se expone en la SEC ID N°: 6; (b) una H-CDR1 como se expone en la SEC ID N°: 15, una H-CDR2 como se expone en la SEC ID N°: 16, una H-CDR3 como se expone en la SEC ID N°: 17, una L-CDR1 como se expone en la SEC ID N°: 18, una L-CDR2 como se expone en la SEC ID N°: 19 y una L-CDR3 como se expone en la SEC ID N°: 20; (c) una H-CDR1 como se expone en la SEC ID N°: 29, una H-CDR2 como se expone en la SEC ID N°: 30, una H-CDR3 como se expone en la SEC ID N°: 31, una L-CDR1 como se expone en la SEC ID N°: 32, una L-CDR2 como se expone en la SEC ID N°: 33 y una L-CDR3 como se expone en la SEC ID N°: 34; o (d) una H-CDR1 como se expone en la SEC ID N°: 1, una H-CDR2 como se expone en la SEC ID N°: 2, una H-CDR3 como se expone en la SEC ID N°: 3, una L-CDR1 como se expone en la SEC ID N°: 4, una L-CDR2 como se expone en la SEC ID N°: 5 y una L-CDR3 como se expone en la SEC ID N°: 75.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23554209P | 2009-08-20 | 2009-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077941A1 true AR077941A1 (es) | 2011-10-05 |
Family
ID=42938188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103026A AR077941A1 (es) | 2009-08-20 | 2010-08-18 | Anticuerpos contra osteopontina |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110165170A1 (es) |
| AR (1) | AR077941A1 (es) |
| TW (1) | TW201110982A (es) |
| WO (1) | WO2011021146A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120189633A1 (en) | 2011-01-26 | 2012-07-26 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
| NZ630363A (en) | 2012-07-25 | 2018-09-28 | Celldex Therapeutics Inc | Anti-kit antibodies and uses thereof |
| JP2018529351A (ja) * | 2015-09-30 | 2018-10-11 | ヤンセン バイオテツク，インコーポレーテツド | ヒトｃｄ４０に特異的に結合するアンタゴニスト抗体及び使用方法 |
| CN112480250B (zh) * | 2020-12-23 | 2022-03-15 | 上海交通大学 | 一种抗人骨桥蛋白的抗体及其应用 |
| WO2025235801A1 (en) | 2024-05-08 | 2025-11-13 | City Of Hope | Antibodies targeted to osteopontin and uses thereof for reducing resistance of solid tumors immune cell therapy |
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| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
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| US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
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| US5476996A (en) | 1988-06-14 | 1995-12-19 | Lidak Pharmaceuticals | Human immune system in non-human animal |
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| DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
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| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
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| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
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| CA2584028A1 (en) * | 2004-10-13 | 2006-04-27 | Genentech, Inc. | Method for treating tumors using anti-osteopontin antibodies |
| CN101066999B (zh) * | 2006-03-17 | 2013-05-15 | 上海中信国健药业股份有限公司 | 一种重组抗opn单克隆抗体及其制备方法和用途 |
| WO2007149948A2 (en) * | 2006-06-20 | 2007-12-27 | The Gov. Of The Usa As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for diagnosis and treatment of tumors |
| CN101293924A (zh) * | 2007-04-24 | 2008-10-29 | 上海国健生物技术研究院 | 骨桥蛋白的功能表位、与其特异性结合的单克隆抗体及其在制备抗肿瘤转移药物中的用途 |
-
2010
- 2010-08-16 WO PCT/IB2010/053696 patent/WO2011021146A1/en not_active Ceased
- 2010-08-18 AR ARP100103026A patent/AR077941A1/es not_active Application Discontinuation
- 2010-08-19 US US12/859,725 patent/US20110165170A1/en not_active Abandoned
- 2010-08-19 TW TW099127862A patent/TW201110982A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110165170A1 (en) | 2011-07-07 |
| WO2011021146A1 (en) | 2011-02-24 |
| TW201110982A (en) | 2011-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |