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AR077485A2 - Difenilureas substituidas con carboxiarilo como inhibidores de raf quinasa - Google Patents

Difenilureas substituidas con carboxiarilo como inhibidores de raf quinasa

Info

Publication number
AR077485A2
AR077485A2 ARP100102601A ARP100102601A AR077485A2 AR 077485 A2 AR077485 A2 AR 077485A2 AR P100102601 A ARP100102601 A AR P100102601A AR P100102601 A ARP100102601 A AR P100102601A AR 077485 A2 AR077485 A2 AR 077485A2
Authority
AR
Argentina
Prior art keywords
substituted
group
linear
halogen
raf
Prior art date
Application number
ARP100102601A
Other languages
English (en)
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30442271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR077485(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of AR077485A2 publication Critical patent/AR077485A2/es

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
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    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se relaciona con el uso de un grupo de arilureas en el tratamiento de enfermedades mediadas por raf y con composiciones farmacéuticas para su uso en dicha terapia. Reivindicacion 1: Un compuesto caracterizado porque es de Formula: A-D-B o una sal farmacéuticamente aceptable del mismo, en donde D es -NH-C(O)-NH-, A es de la formula: -L-M-L1, en donde L es fenilo, opcionalmente sustituido con 1 a 3 sustituyentes independientemente seleccionados del grupo conformado por C1-5-alquilo lineal o ramificado, haloalquilo C1-5 hasta perhalo lineal o ramificado, C1-3-alcoxi y halogeno; L1 es piridinilo, sustituido por -C(O)Rx; en donde Rx es NRaRb y Ra y Rb son independientemente hidrogeno, C1-10-alquilo, C6-arilo, piridinilo, C1-10-alquilo sustituido, C6-arilo sustituido, o piridinilo sustituido, donde Ra y Rb son un grupo sustituido, están sustituidos por halogeno hasta perhalo; y M se selecciona del grupo conformado por oxígeno y azufre y B es fenilo, sustituido con 1 a 3 sustituyentes independientemente seleccionados del grupo conformado por R7 y halogeno; y R7 es (a) C1-6-alquilo lineal o ramificado, opcionalmente sustituido con 1 a 3 sustituyentes de halogeno; o (b) C1-6-alcoxi lineal o ramificado.
ARP100102601A 1999-01-13 2010-07-15 Difenilureas substituidas con carboxiarilo como inhibidores de raf quinasa AR077485A2 (es)

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