AR076681A1 - Procesos para producir y purificar esteres alquilicos del acido 3-difluorometil-1-metil-1h-pirazol-4-carboxilico utiles como intermediarios en la produccion de funguicidas. - Google Patents
Procesos para producir y purificar esteres alquilicos del acido 3-difluorometil-1-metil-1h-pirazol-4-carboxilico utiles como intermediarios en la produccion de funguicidas.Info
- Publication number
- AR076681A1 AR076681A1 ARP100101667A ARP100101667A AR076681A1 AR 076681 A1 AR076681 A1 AR 076681A1 AR P100101667 A ARP100101667 A AR P100101667A AR P100101667 A ARP100101667 A AR P100101667A AR 076681 A1 AR076681 A1 AR 076681A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- cfh2
- cf2h
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 12
- 101100495923 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr2 gene Proteins 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- RLOHOBNEYHBZID-UHFFFAOYSA-N 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid Chemical compound CN1C=C(C(O)=O)C(C(F)F)=N1 RLOHOBNEYHBZID-UHFFFAOYSA-N 0.000 abstract 1
- -1 B is a direct bond Chemical group 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- CVXBEEMKQHEXEN-UHFFFAOYSA-N carbaryl Chemical compound C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 CVXBEEMKQHEXEN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004980 cyclopropylene group Chemical group 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a mejoras en los procesos orientados a la produccion de ácido 3-difluorometil-1-metil-1H-pirazol-4-carboxílico, el cual es un intermediario util en la produccion funguicida. En particular, se refiere a un proceso para tratar un compuesto de la formula (3) donde R1 es alquilo C1-6 y R2 es CF3, CF2H o CFH2, que comprende los pasos de a) poner en contacto un compuesto de la formula (3) con base, y b) separar el compuesto de la formula (3) y la base. Reivindicacion 11: Un método para producir un compuesto de la formula (1) donde R2 es CF3, CF2H o CFH2, que comprende ii) tratar un compuesto de la formula (3) donde R1 es alquilo C1-6 y R2 es CF3, CF2H o CFH2, segun se definio en cualquiera de las reivindicaciones 1 a 8, y iii) hidrolizar el compuesto de la formula (3) a fin de producir el compuesto de la formula 1. Reivindicacion 12: Un método para producir un compuesto de la formula (4) donde R2 es CF3, CF2H o CFH2, A es tienilo, fenilo, o etileno cada uno opcionalmente sustituido con uno a tres grupos seleccionados de manera independiente de halogeno, metilo y metoxi, B es un enlace directo, ciclopropileno, un anillo biciclo[2.2.1]heptano- o biciclo[2.2.1]septeno fusionado, D es hidrogeno, halogeno, alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, cicloalquilo C3-6, alquilideno C1-6, haloalquilideno C1-6, fenilo o fenilo opcionalmente sustituido con uno a tres sustituyentes seleccionados de manera independiente de halogeno y trihalometiltio, que comprende producir un compuesto de la formula (1) donde R2 es CF3, CF2H o CFH2, segun se definio en la reivindicacion 11, y iv) hacer reaccionar el compuesto de la formula (1) o el correspondiente haluro ácido con un compuesto de la formula (5) H2N-A-B-D, donde A, B y D son segun se definio para el compuesto de la formula (4).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0908435.1A GB0908435D0 (en) | 2009-05-15 | 2009-05-15 | Processes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076681A1 true AR076681A1 (es) | 2011-06-29 |
Family
ID=40834104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101667A AR076681A1 (es) | 2009-05-15 | 2010-05-13 | Procesos para producir y purificar esteres alquilicos del acido 3-difluorometil-1-metil-1h-pirazol-4-carboxilico utiles como intermediarios en la produccion de funguicidas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8735600B2 (es) |
| EP (1) | EP2429999A1 (es) |
| JP (1) | JP5815507B2 (es) |
| CN (1) | CN102428072B (es) |
| AR (1) | AR076681A1 (es) |
| BR (1) | BRPI1014503A2 (es) |
| GB (1) | GB0908435D0 (es) |
| IL (1) | IL215870A0 (es) |
| MX (1) | MX2011012006A (es) |
| TW (1) | TW201100386A (es) |
| WO (1) | WO2010130532A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103416417B (zh) * | 2012-05-25 | 2016-06-08 | 陕西韦尔奇作物保护有限公司 | 一种含氟唑菌酰胺的杀菌组合物 |
| CN102731402A (zh) * | 2012-06-29 | 2012-10-17 | 上海康鹏化学有限公司 | 3-三氟甲基吡唑-4-羧酸和3-二氟甲基吡唑-4-羧酸的制备方法 |
| JP5140776B1 (ja) * | 2012-09-05 | 2013-02-13 | タマ化学工業株式会社 | １−置換−３−フルオロアルキルピラゾール−４−カルボン酸エステルの製造方法 |
| US8871947B2 (en) | 2013-02-04 | 2014-10-28 | KingChem LLC | Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester |
| US9139507B2 (en) | 2013-12-09 | 2015-09-22 | KingChem LLC. | Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs |
| WO2024014780A1 (ko) * | 2022-07-11 | 2024-01-18 | 주식회사 엘지에너지솔루션 | 리튬 이차전지용 비수 전해액 및 이를 포함하는 리튬 이차전지 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223526A (en) | 1991-12-06 | 1993-06-29 | Monsanto Company | Pyrazole carboxanilide fungicides and use |
| JP3533134B2 (ja) * | 1999-02-15 | 2004-05-31 | 三井化学株式会社 | フッ素化剤及びその製法と使用 |
| DE10215292A1 (de) | 2002-02-19 | 2003-08-28 | Bayer Cropscience Ag | Disubstitutierte Pyrazolylcarbocanilide |
| BR0308230B1 (pt) * | 2002-03-05 | 2014-05-20 | Syngenta Participations Ag | O-ciclopropil-carboxanilida, composição e método de controle ou prevenção de infestação de plantas cultivadas por microorganismos fitopatogênicos |
| JP2004099567A (ja) * | 2002-09-12 | 2004-04-02 | Teijin Chem Ltd | ペンタエリスリトールジホスファイトの製造方法 |
| GB0224316D0 (en) * | 2002-10-18 | 2002-11-27 | Syngenta Participations Ag | Chemical compounds |
| DE102005007160A1 (de) * | 2005-02-16 | 2006-08-24 | Basf Ag | Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen |
| CN101133031B (zh) * | 2005-02-25 | 2010-07-21 | 财团法人相模中央化学研究所 | 1-取代-3-氟代烷基吡唑-4-羧酸酯的制造方法 |
| EP1881964A1 (de) * | 2005-05-11 | 2008-01-30 | Basf Aktiengesellschaft | Pyrazolcarbonsäureamide als fungizide |
| US20100222217A1 (en) * | 2005-08-05 | 2010-09-02 | Markus Gewehr | Fungicidal N-[2-(Haloalkoxy)Phenyl]Heteroarylcarboxamides |
| CA2626312C (en) | 2005-10-25 | 2014-10-07 | Hans Tobler | Heterocyclic amide derivatives useful as microbiocides |
| DE102006039909A1 (de) * | 2006-08-25 | 2008-03-13 | Bayer Cropscience Ag | Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten |
| WO2008053044A2 (de) | 2006-11-03 | 2008-05-08 | Basf Se | Hetarylcarbonsäure-n-(biphen-2-yl)amid-verbindungen |
| US8115012B2 (en) | 2006-11-03 | 2012-02-14 | Basf Se | Process for preparing difluoromethylpyrazolyl carboxylates |
| EP2150536A1 (en) * | 2007-05-31 | 2010-02-10 | Syngeta Participations AG | Process for the production of pyrazoles |
| EP2008996A1 (en) * | 2007-06-27 | 2008-12-31 | Syngeta Participations AG | Process for the production of pyrazoles |
| US8344156B2 (en) * | 2008-03-18 | 2013-01-01 | Mitsui Chemicals Agro, Inc. | Method for producing fluorine-containing acylacetic acid derivative, method for producing fluorine-containing pyrazolecarboxylic acid ester derivative, and method for producing fluorine-containing pyrazolecarboxylic acid derivative |
| EP2285779B1 (de) | 2008-05-08 | 2013-03-27 | Basf Se | Verfahren zur Herstellung von Arylcarboxamiden |
| GB0812028D0 (en) | 2008-07-01 | 2008-08-06 | Syngenta Participations Ag | Fungicidal compositions |
-
2009
- 2009-05-15 GB GBGB0908435.1A patent/GB0908435D0/en not_active Ceased
-
2010
- 2010-04-20 US US13/320,730 patent/US8735600B2/en not_active Expired - Fee Related
- 2010-04-20 JP JP2012510188A patent/JP5815507B2/ja not_active Expired - Fee Related
- 2010-04-20 CN CN201080021151.5A patent/CN102428072B/zh not_active Expired - Fee Related
- 2010-04-20 WO PCT/EP2010/055174 patent/WO2010130532A1/en not_active Ceased
- 2010-04-20 EP EP10714288A patent/EP2429999A1/en not_active Withdrawn
- 2010-04-20 BR BRPI1014503-6A patent/BRPI1014503A2/pt not_active IP Right Cessation
- 2010-04-20 MX MX2011012006A patent/MX2011012006A/es not_active Application Discontinuation
- 2010-05-13 TW TW099115253A patent/TW201100386A/zh unknown
- 2010-05-13 AR ARP100101667A patent/AR076681A1/es unknown
-
2011
- 2011-10-23 IL IL215870A patent/IL215870A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120065407A1 (en) | 2012-03-15 |
| MX2011012006A (es) | 2011-12-08 |
| CN102428072A (zh) | 2012-04-25 |
| GB0908435D0 (en) | 2009-06-24 |
| JP5815507B2 (ja) | 2015-11-17 |
| IL215870A0 (en) | 2012-01-31 |
| BRPI1014503A2 (pt) | 2015-08-25 |
| US8735600B2 (en) | 2014-05-27 |
| WO2010130532A1 (en) | 2010-11-18 |
| CN102428072B (zh) | 2015-02-18 |
| TW201100386A (en) | 2011-01-01 |
| JP2012526740A (ja) | 2012-11-01 |
| EP2429999A1 (en) | 2012-03-21 |
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