AR076276A1 - Derivados de n-[(7-aza-biciclo[2.2.1]hept-1-il)-aril-metil]-benzamida, su prepara-cion y su aplicacion en terapeutica - Google Patents
Derivados de n-[(7-aza-biciclo[2.2.1]hept-1-il)-aril-metil]-benzamida, su prepara-cion y su aplicacion en terapeuticaInfo
- Publication number
- AR076276A1 AR076276A1 ARP100101220A ARP100101220A AR076276A1 AR 076276 A1 AR076276 A1 AR 076276A1 AR P100101220 A ARP100101220 A AR P100101220A AR P100101220 A ARP100101220 A AR P100101220A AR 076276 A1 AR076276 A1 AR 076276A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- groups
- cycloalkyl
- alkoxy
- halo
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- -1 halo- C1-6 alkyl Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos de formula (1) en la que R representa un átomo de hidrogeno o un grupo elegido entre los grupos alquilo C1-6, cicloalquilo C3-7, opcionalmente sustituido con uno o varios grupos elegidos independientemente entre sí entre el átomo de fluor, los grupos cicloalquilo C3-7, alquenilo C2-4, fenilo, alcoxi C1-6, hidroxi; el grupo fenilo está opcionalmente sustituido con uno o varios grupos alcoxi C1-6; R1 representa un grupo fenilo opcionalmente sustituido con uno o varios sustituyentes elegidos independientemente entre sí entre los átomos de halogeno, los grupos alquilo C1-6, alcoxi C1-6, halo-alquilo C1-6, hidroxi, halo-alcoxi C1-6, alquil C1-6-tio, alquil C1-6-SO2, R2 representa uno o varios sustituyentes elegidos entre el átomo de hidrogeno, los átomos de halogeno, los grupos halo-alquilo C1-6, alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-3, alcoxi C1-6, alquil C1-6-tio, alquil C1-6-SO2 en forma de base o de sal de adicion a un ácido. Utilizacion en terapéutica y procedimiento de síntesis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901809A FR2944284A1 (fr) | 2009-04-14 | 2009-04-14 | Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076276A1 true AR076276A1 (es) | 2011-06-01 |
Family
ID=41228015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101220A AR076276A1 (es) | 2009-04-14 | 2010-04-12 | Derivados de n-[(7-aza-biciclo[2.2.1]hept-1-il)-aril-metil]-benzamida, su prepara-cion y su aplicacion en terapeutica |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP2419431A1 (es) |
| JP (1) | JP2012523448A (es) |
| KR (1) | KR20120013378A (es) |
| AR (1) | AR076276A1 (es) |
| AU (1) | AU2010238409A1 (es) |
| BR (1) | BRPI1015484A2 (es) |
| CA (1) | CA2758367A1 (es) |
| FR (1) | FR2944284A1 (es) |
| IL (1) | IL215673A0 (es) |
| MX (1) | MX2011010929A (es) |
| SG (1) | SG175222A1 (es) |
| TW (1) | TW201041581A (es) |
| UY (1) | UY32561A (es) |
| WO (1) | WO2010119222A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160045182A (ko) | 2014-10-16 | 2016-04-27 | 현대자동차주식회사 | 실린더 라이너용 회주철 및 이를 이용한 실린더 라이너의 제조방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2842804B1 (fr) * | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
| WO2008065500A2 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
| TW200911808A (en) * | 2007-07-23 | 2009-03-16 | Astrazeneca Ab | Novel compounds |
-
2009
- 2009-04-14 FR FR0901809A patent/FR2944284A1/fr not_active Withdrawn
-
2010
- 2010-04-12 AR ARP100101220A patent/AR076276A1/es unknown
- 2010-04-13 MX MX2011010929A patent/MX2011010929A/es not_active Application Discontinuation
- 2010-04-13 KR KR1020117026894A patent/KR20120013378A/ko not_active Withdrawn
- 2010-04-13 JP JP2012505205A patent/JP2012523448A/ja not_active Withdrawn
- 2010-04-13 BR BRPI1015484A patent/BRPI1015484A2/pt not_active Application Discontinuation
- 2010-04-13 AU AU2010238409A patent/AU2010238409A1/en not_active Abandoned
- 2010-04-13 WO PCT/FR2010/050711 patent/WO2010119222A1/fr not_active Ceased
- 2010-04-13 SG SG2011075017A patent/SG175222A1/en unknown
- 2010-04-13 EP EP10723665A patent/EP2419431A1/fr not_active Withdrawn
- 2010-04-13 CA CA2758367A patent/CA2758367A1/fr not_active Abandoned
- 2010-04-13 TW TW099111503A patent/TW201041581A/zh unknown
- 2010-04-14 UY UY0001032561A patent/UY32561A/es not_active Application Discontinuation
-
2011
- 2011-10-10 IL IL215673A patent/IL215673A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2419431A1 (fr) | 2012-02-22 |
| IL215673A0 (en) | 2012-01-31 |
| JP2012523448A (ja) | 2012-10-04 |
| UY32561A (es) | 2010-11-30 |
| CA2758367A1 (fr) | 2010-10-21 |
| AU2010238409A1 (en) | 2011-11-03 |
| WO2010119222A1 (fr) | 2010-10-21 |
| KR20120013378A (ko) | 2012-02-14 |
| SG175222A1 (en) | 2011-11-28 |
| FR2944284A1 (fr) | 2010-10-15 |
| TW201041581A (en) | 2010-12-01 |
| MX2011010929A (es) | 2011-11-02 |
| BRPI1015484A2 (pt) | 2016-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |