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AR076274A1 - Inhibidores del virus de la hepatitis c - Google Patents

Inhibidores del virus de la hepatitis c

Info

Publication number
AR076274A1
AR076274A1 ARP100101218A ARP100101218A AR076274A1 AR 076274 A1 AR076274 A1 AR 076274A1 AR P100101218 A ARP100101218 A AR P100101218A AR P100101218 A ARP100101218 A AR P100101218A AR 076274 A1 AR076274 A1 AR 076274A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
independently selected
formula
compounds
Prior art date
Application number
ARP100101218A
Other languages
English (en)
Inventor
John F Kadow
Makonen Belema
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42244128&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR076274(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR076274A1 publication Critical patent/AR076274A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compuestos, composiciones y procedimientos para el tratamiento de infeccion por el virus de la hepatitis C (VHC). También composiciones farmacéuticas que contienen dichos compuestos y procedimientos para usar dichos compuestos en el tratamiento de infeccion por VHC. Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1) o una de sus sales farmacéuticamente aceptables, en la que L se selecciona de un enlace,x:::x, -HC=CH- y x?x; R1 y R2 son como en formula (2) o R1 es formula (3); R2 se selecciona de formula (3) y (4); en las que x denota el punto de union a la molécula principal; R3 y R4 se seleccionan independientemente de hidrogeno y halo; cada R5 se selecciona independientemente de hidrogeno y alquilo; cada R6 se selecciona independientemente de hidrogeno y alquilo; R6a es hidrogeno o alquilo, pudiendo formar el alquilo opcionalmente un anillo de tres miembros condensado y con un átomo de carbono adyacente; cada R7 se selecciona independientemente de hidrogeno y -C(O)R8; y cada R8 se selecciona independientemente de alcoxi, alquilo, arilalcoxi, arilalquilo, cicloalquilo, heterociclilo, heterociclilalquilo, (NRcRd)alquenilo y (NRcRd)alquilo.
ARP100101218A 2009-04-09 2010-04-09 Inhibidores del virus de la hepatitis c AR076274A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16798909P 2009-04-09 2009-04-09

Publications (1)

Publication Number Publication Date
AR076274A1 true AR076274A1 (es) 2011-06-01

Family

ID=42244128

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101218A AR076274A1 (es) 2009-04-09 2010-04-09 Inhibidores del virus de la hepatitis c

Country Status (22)

Country Link
US (1) US8143301B2 (es)
EP (1) EP2417126B1 (es)
JP (1) JP5558556B2 (es)
KR (1) KR20120133366A (es)
CN (1) CN102803249B (es)
AR (1) AR076274A1 (es)
AU (1) AU2010234608B2 (es)
BR (1) BRPI1010506A2 (es)
CA (1) CA2757963A1 (es)
CL (1) CL2011002524A1 (es)
CO (1) CO6440581A2 (es)
EA (1) EA018793B1 (es)
ES (1) ES2502667T3 (es)
IL (1) IL215095A0 (es)
MX (1) MX2011010478A (es)
MY (1) MY152971A (es)
NZ (1) NZ595186A (es)
PE (1) PE20120533A1 (es)
SG (1) SG174582A1 (es)
TW (1) TW201038559A (es)
WO (1) WO2010117977A1 (es)
ZA (1) ZA201107095B (es)

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PE20120533A1 (es) 2012-05-09
MX2011010478A (es) 2011-10-17
KR20120133366A (ko) 2012-12-10
AU2010234608A1 (en) 2011-10-06
EP2417126A1 (en) 2012-02-15
CO6440581A2 (es) 2012-05-15
CN102803249B (zh) 2014-09-10
EA201171208A1 (ru) 2012-05-30
IL215095A0 (en) 2011-11-30
JP5558556B2 (ja) 2014-07-23
CA2757963A1 (en) 2010-10-14
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SG174582A1 (en) 2011-10-28
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AU2010234608B2 (en) 2016-04-14
TW201038559A (en) 2010-11-01
BRPI1010506A2 (pt) 2016-07-26
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ZA201107095B (en) 2013-03-27
US8143301B2 (en) 2012-03-27
MY152971A (en) 2014-12-15

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