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AR076170A1 - Derivados heterociclicos imidazolicos y/o oxazolicos utiles como agentes antivirales para hepatitis c y composiciones farmaceuticas que los comprenden. - Google Patents

Derivados heterociclicos imidazolicos y/o oxazolicos utiles como agentes antivirales para hepatitis c y composiciones farmaceuticas que los comprenden.

Info

Publication number
AR076170A1
AR076170A1 ARP100101039A ARP100101039A AR076170A1 AR 076170 A1 AR076170 A1 AR 076170A1 AR P100101039 A ARP100101039 A AR P100101039A AR P100101039 A ARP100101039 A AR P100101039A AR 076170 A1 AR076170 A1 AR 076170A1
Authority
AR
Argentina
Prior art keywords
alkyl
independently selected
arylalkyl
hydrogen
cycloalkyl
Prior art date
Application number
ARP100101039A
Other languages
English (en)
Inventor
Omar D Lopez
Lawrence G Hamann
Makonen Belema
Qi Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42313493&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR076170(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR076170A1 publication Critical patent/AR076170A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicacion 1: Un compuesto caracterizado por que tiene la Formula (1): o una de sus sales farmacéuticamente aceptables, en la que: s es 0 o 1; L es -L1-L2-, en los que L1 y L2 se seleccionan independientemente del grupo de formulas 2 con la condicion de que al menos uno de L1 y L2 sea distinto de la formula 3; Y e Y' son independientemente oxígeno (O) o NH; R1 es hidrogeno o -C(O)Rx; R2 es hidrogeno o -C(O)Ry; Rx y Ry se seleccionan independientemente de cicloalquilo, heteroarilo, heterociclilo, alcoxi y alquilo sustituido con uno o más sustituyentes seleccionados independientemente de arilo, alquenilo, cicloalquilo, heterociclilo, heteroarilo, -OR3, -C(O)OR4, -NRaRb y -C(O)NRcRd, en los que arilo y heteroarilo pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de alquilo, haloalquilo, arilalquilo, heterociclilo, heterociclilalquilo, halogeno, ciano, nitro, -C(O)OR4, OR5, -NRaRb, (NRaRb)alquilo y (MeO)(HO)P(O)O-, y en los que cicloalquilo y heterociclilo pueden estar opcionalmente condensados con un anillo aromático y pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de alquilo, hidroxilo, halogeno, arilo, NRaRb, oxo, y -C(O)OR4; R3 es hidrogeno, alquilo o arilalquilo; R4 es alquilo o arilalquilo; R5 es hidrogeno, alquilo o arilalquilo; Ra y Rb se seleccionan independientemente de hidrogeno, alquilo, cicloalquilo, arilalquilo, heteroarilo, -C(O)R6, -C(O)OR7, -C(O)NRcRd, y (NRcRd)alquilo, o como alternativa, Ra y Rb, junto con el átomo de nitrogeno al que están unidos, forman un anillo de cinco o seis miembros o una estructura de anillo bicíclica con puente, pudiendo contener dicho anillo de cinco o seis miembros o dicha estructura de anillo bicíclica con puente opcionalmente uno o dos heteroátomos adicionales seleccionados independientemente de nitrogeno, oxígeno y azufre y pudiendo contener uno, dos o tres sustituyentes seleccionados independientemente de alquilo C1 a C6, haloalquilo C1 a C4, arilo, hidroxilo, alcoxi C1 a C6, haloalcoxi C1 a C4 y halogeno; R6 es alquilo; R7 es alquilo, arilalquilo, cicloalquilo o haloalquilo; R100 y R110 se seleccionan independientemente de hidrogeno, alquilo, cianoalquilo y halo; Rc y Rd se seleccionan independientemente de hidrogeno, alquilo, arilalquilo cicloalquilo.
ARP100101039A 2009-03-30 2010-03-30 Derivados heterociclicos imidazolicos y/o oxazolicos utiles como agentes antivirales para hepatitis c y composiciones farmaceuticas que los comprenden. AR076170A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16457909P 2009-03-30 2009-03-30

Publications (1)

Publication Number Publication Date
AR076170A1 true AR076170A1 (es) 2011-05-26

Family

ID=42313493

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101039A AR076170A1 (es) 2009-03-30 2010-03-30 Derivados heterociclicos imidazolicos y/o oxazolicos utiles como agentes antivirales para hepatitis c y composiciones farmaceuticas que los comprenden.

Country Status (20)

Country Link
US (2) US20100249190A1 (es)
EP (1) EP2414352B1 (es)
JP (1) JP5612661B2 (es)
KR (1) KR20110134497A (es)
CN (1) CN102378762B (es)
AR (1) AR076170A1 (es)
AU (1) AU2010234861A1 (es)
BR (1) BRPI1014084A2 (es)
CA (1) CA2758047C (es)
CL (1) CL2011002453A1 (es)
CO (1) CO6361922A2 (es)
EA (1) EA021260B1 (es)
ES (1) ES2524542T3 (es)
IL (1) IL214939A0 (es)
MX (1) MX2011009644A (es)
NZ (1) NZ594981A (es)
PE (1) PE20120517A1 (es)
TW (1) TWI476190B (es)
WO (1) WO2010117704A1 (es)
ZA (1) ZA201106669B (es)

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Also Published As

Publication number Publication date
EA201101240A1 (ru) 2012-05-30
MX2011009644A (es) 2011-09-28
TW201038555A (en) 2010-11-01
CA2758047A1 (en) 2010-10-14
KR20110134497A (ko) 2011-12-14
CN102378762A (zh) 2012-03-14
BRPI1014084A2 (pt) 2016-04-19
ZA201106669B (en) 2013-02-27
US8822444B2 (en) 2014-09-02
US20120277266A1 (en) 2012-11-01
CO6361922A2 (es) 2012-01-20
PE20120517A1 (es) 2012-05-09
NZ594981A (en) 2013-05-31
IL214939A0 (en) 2011-11-30
CA2758047C (en) 2016-05-17
JP2012522056A (ja) 2012-09-20
CN102378762B (zh) 2014-10-29
JP5612661B2 (ja) 2014-10-22
ES2524542T3 (es) 2014-12-10
EP2414352B1 (en) 2014-10-01
EA021260B1 (ru) 2015-05-29
EP2414352A1 (en) 2012-02-08
TWI476190B (zh) 2015-03-11
AU2010234861A1 (en) 2011-09-22
CL2011002453A1 (es) 2012-03-02
WO2010117704A1 (en) 2010-10-14
US20100249190A1 (en) 2010-09-30

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